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Query: [A] KOG3013 Exosomal 3`-5` exoribonuclease complex, subunit Rrp4, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVTILKPEEFYVSSEADIVNDVSMTEMEDEIMEDEQMGLVDGEDVLEEFDKSIHQNLVTPGQLVTDDPQFMRGHGTYFEDGGIYASVAGSVQRVNKLISVKPLRSKYVPEIGDLIIGKIAEVQPKRWKVDIGAKQNAVLMLSSINLPGGIQRRKLETDELQMRSFFQEGDLLVAEVQQYFSDGSVSIHTRSLKYGKLRNGVFLKVPPALVVRSKSHAYALAGGVDIILSVNGYVWVSKHNENQHSSVSITRLEEEASESIYSNENDEIDGYTRLNISRVSICIKGLASRSLPLTQASITNFYESSLVFSNLQDLTVPKNMDQIAMEAMQLast
1 -113.000[A] KOG3013 Exosomal 3`-5` exoribonuclease complex, subunit Rrp4  ali  100  1MVTILKPEEFYVSSEADIVNDVSMTEMEDEIMEDEQMGLVDGEDVLEEFDKSIHQNLVTPGQLVTDDPQFMRGHGTYFEDGGIYASVAGSVQRVNKLISVKPLRSKYVPEIGDLIIGKIAEVQPKRWKVDIGAKQNAVLMLSSINLPGGIQRRKLETDELQMRSFFQEGDLLVAEVQQYFSDGSVSIHTRSLKYGKLRNGVFLKVPPALVVRSKSHAYALAGGVDIILSVNGYVWVSKHNENQHSSVSITRLEEEASESIYSNENDEIDGYTRLNISRVSICIKGLASRSLPLTQASITNFYESSLVFSNLQDLTVPKNMDQIAMEAMQ 329
2 -75.000[J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)  ali follow..  21  1....................................................MDKKIVIPGDLLSE-NQKKAGYGTYVKNDKIYSSLCGIENLKEDKVGVIPLAGAYIPSANDVVIGIVIVVTPSNWIFDIAAPYDGLLHVSE---------YPRRVESREMPEILNVGDSVILRVKDVDSSMKVELALRDPSLHKLKTGQIIKVESVKVPRVIGHGGSMETNCSIFVGQNGRIWIDGKDEDIELLSKALRKIELEAQRSGLTKNERIRQKESKPVGFFKNETEGVTATKEDHSEEIY-RKIDVLLDPKN................... 260
3 -56.400[J] KOG1004 Exosomal 3`-5` exoribonuclease complex subunit Rrp40  ali follow..  18  1.............................................MAEVEEKGLLSYYFPGERIPQDGSIRLGPGLVDREEEIVVSKAGRLHQTGKAMLIDSRTKRYIPATNDQVIGQIISRFAEGYRVDIGSAHIAQLNAL-----------AFENVTRKSRPNLNVGSLVYARVSLADRDMEPELECFDATTGKKNGYMITGLSLSHCRKLILPKNTLYIPFEIAVGMNGRVWVNSENLSTTVLICTAIRNCEFMSD-------------EEQIKYCKDLIKKL........................................... 240
4 -55.700[J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)  ali follow..  17  1.........................................MEEGEERKKTIKNGDFVLPGDYLGVIEEYLPGEGVIVEDGNLYSARAGWVKINKDKVEIPASSVPPIPKKGDIVYARVIDVKQQAVLLRMIKIEGQENREIATSKLAGIHISQVKDGFVDLRNEFKIGDIVRARVIADEKS-PIQLTTKDPDLGVVYALCSKCRTP--LVRKGNQLVCPRCG.......................................................................................................... 183
5 -52.700[J] KOG3409 Exosomal 3`-5` exoribonuclease complex, subunit ski4 (Csl4)  ali follow..  22  2................................................SEQQDETVVCLPGERLCRTEDIVLGIGTYEQNGYIYASKSGIVNIEDSVSVHKPGFHLTIPATGDVVTARVLVTTPKFAKCAIFCVRNVLLESSYRGLLRKEDVRETEKDRVDIYKSFRPGDVILARVINQLEQ-SFLLTTAENELGVVIAYAYRKTRVPMVPVGWSEMQCPQTT.......................................................................................................... 184
6 -14.000[J] COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain)  ali follow..  13  4.............................................................................................................EVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVA----------DNYVKDINDHLKVGDQVEVKVINVEKDGKIGLSIKKARPKESFEQKMNKF----LKDSEDRLSSLKRNTESKRGGRGAR............................................................................................... 126
7 -12.500[K] COG1095 DNA-directed RNA polymerase, subunit E`  ali follow..  11  40.............................................................DVINEKTSQNEGKYLVISVLYTESIGEGTIVHGDGGVYQEVKYRALVPEMQEIVDGEVVSVQKFGAFIKFSSFEGLLHISQIMDDRIDIDLENKRFIGKETKRDLKVGDRVRVRIVAMNSDSKIGFTMKQVGLGKLD................................................................................................................................... 184
8 -11.600[K] KOG3298 DNA-directed RNA polymerase subunit E`  ali follow..  10  33.............................................................ADVEGTCSGQYGYIICVLDSNTIDIDKGRVVPGQGFAEFEVKYRAVLPFRGEVVDAIVTTVNKMGFFANIGPL-NVFVSSHLVPPDMKFDPTANPPNYSGEDQVIEKGSNVRLKIVGTRTEIFAIATMKEDYLGVL.................................................................................................................................... 172
9 -10.300[K] KOG3297 DNA-directed RNA polymerase subunit E`  ali follow..  10  6...................................................KIADLVRIPPDQFHRDNKIIPNVGLCITIYDLLTVEEGQLKPGDGSSYVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCYYTPEESPMDEETKLYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEGKNEETPQNEKPPAYALLGSCQTDGMGLVW.............................................................................................. 210
10 -9.980[J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)  ali follow..  21  1......................................................................................................MNIKLLPEVGDLVVVKITEVKNFGANGILEEYPEGYIHISEVA----------TGWVKHIRSYLREGQRVVCKVINVNQEKNVDLSLKR.......................................................................................................................................... 82
11 -9.070[J] KOG2916 Translation initiation factor 2, alpha subunit (eIF-2alpha)  ali follow..  11  10........................................................................................................QHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNEGMILLSELS----------RRRIRSINKLIRIGRNECVVVIRVDKEKGIDLSKRR.......................................................................................................................................... 89
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW,Osterman AL, Godzik A. CutDB: a proteolytic event database. Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9. Epub 2006 Nov 16.