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Query: [I] KOG3030 Lipid phosphate phosphatase and related enzymes of the PAP2 family, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFDKTRLPYVALDVLCVLLASMPMAVLKLGQIYPFQRGFFCKDNSINYPYHDSTVTSTVLILVGVGLPISSIILGETLSVYCNLLHSNSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQPLast
1 -112.000[I] KOG3030 Lipid phosphate phosphatase and related enzymes of the PAP2 family  ali  100  1MFDKTRLPYVALDVLCVLLASMPMAVLKLGQIYPFQRGFFCKDNSINYPYHDSTVTSTVLILVGVGLPISSIILGETLSVYCNLLHSNSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP 285
2 -35.100[S] KOG4268 Uncharacterized conserved protein containing PAP2 domain  ali follow..  25  70.................................................................................................AGQEVLMNLLLALLLDIMTVAGVQKLIKRRGP---------------------YETSPSLLDYLTMDIYAFPAGHASRAAMVSKFFLSHLVLAVP----------LRVLLVLWALCVGLSRVMIGRHHVTDVLSGFVIGYLQFRLVELVW...................................... 188
3 -35.100[I] KOG3146 Dolichyl pyrophosphate phosphatase and related acid phosphatases  ali follow..  16  14...........................................THVRYRPGDQLGHFLAWISLVPVFISLGGFVSHFLFRRELQ------------------GIFFGIGLVISQFINEFIKTSVEQARP-------------------------ETCTLLEACDSHGWPSSHSQFMFFFATYFSLMGCKGIGFWFGLRSRWIMNLLHWSLAVVTMYSRVYLGYHTVAQVFAGAALGGIVGASWFWVV...................................... 174
4 -32.700[R] COG3907 PAP2 (acid phosphatase) superfamily protein  ali follow..  12  46LYSLPLSFYFWQVFGLLLVGLLFLALSRSEQLDWLISNYWFDPVGQNFPWEHNKWLDLLNHRLLKMALIATAIAALLWGIYRRNGR----------------LVTTALLFGLGPLVIGILKATSAHSCPWDLVEYGGKALNYVLMDTAPPGA----------GPGHCFPGGHASSGFAVMALFFLFYPER------PRLAMLCWFAGIGLGMLMGFGQIMRGAHFLTHNLWAGWWVWLSQLAAFWIISGYYQRIKGTE........................... 271
5 -31.300[I] COG0671 Membrane-associated phospholipid phosphatase  ali follow..  13  35.............FFCCLAIVGLLIALGHNFKEVNDLKEIAFDIAFLHKVIPEAMAPFWIKVYKGTGVELTATMIAITLGFLAWKRYWS-----------EIKYLVFATLGILLVIDQVLKPFFNRTRP---------------------------LPRLVDVDGRSFPSGHAAGGVVFYFYLAFLLAAHFPQY-----RWQIYLGATLWVGFIGIASMYCRVHWATDILAGYGVGFIWLTLSLFLL...................................... 228
6 -23.500[I] KOG2822 Sphingoid base-phosphate phosphatase  ali follow..  16  104.........................................................................................................MTLLIAFCDYLGNCIKDVVSAPRPSCPPVRRITATKD----------------EEDNAMEYGLPSSHTLNTVCLSGYLLHYVLSSLE-YESVSIQYYGFALACLLVALIAFGRVYLGMHSVVDIVSGLAIGVLILGLWLTVN...................................... 228
7 -16.000[I] KOG3750 Inositol phospholipid synthesis protein, Scs3p  ali follow..  11  10LLRGTLVRAAVRRYLPWALVASMLAGSLLKELSPLPESYLSNKRNV------------NVYFVKVAWAWTFCLLLPFIALTNYHLTGKAGLVLRRLSTLLVGTAIWYICTS----IFSNIEHYTG-------SCYQSPALEGVRKEHQSKQQCHQEGGF----------SGHSFLLTFCALMIVEEMRSHCLHTAITTLVVALGILTFIWVLMFLCTAV--YFHNLSQKVFGTLFGLLSWYGTYGFWYPK................................... 240
8 -12.900[S] COG1963 Uncharacterized protein conserved in bacteria  ali follow..  16  8.........................................................................................................PLLSSLAAIIFAQVIKVPIQFIVSRKLDW-----------------------SLVTSTG--GMPSSHSAAVTALSTGVALE-----HGLDSSLFAVSAIFAVITMFDATGVRRHAGEQHQPIEVFFGGLTGILLTLVLAYFFM..................................... 158
9 -11.000[R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)  ali follow..  13  144..................................................................................................MHFSLMHILFNLLWWWYLGGAVEKRLGSGK--LIVI------------TVISALLSGYVQQKFSGPWFGGLSG-VVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAH-----IAGLIVGLAMAFVD.......................................... 268
10 -9.930[T] KOG2289 Rhomboid family proteins  ali follow..  15  119..................................................................................................LHAGIIHLLTNMLSLIFIGIRLEQQFGFIRVGLI--------------YLISGLGGSILSSLFLQESISVGASGALFGLLGAMLSELLTNWTIYANKAAALITLLFI--IAINLALGMLPRVDNFAHIGGFLTGFCLGFVLL............................................. 244
11 -9.720[T] KOG2290 Rhomboid family proteins  ali follow..  17  662..................................................................................................LHAGILHCLVSICFQMTVLRDLEKLAGWHRIAII--------------YLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAV--VLFLFTFGLLPWIDNFAH----ISGFISGLFLSFAFLPYI...................................... 790
12 -9.600[U] KOG1278 Endosomal membrane proteins, EMP70  ali follow..  15  474IPARSLFFIILLWFLVSVPLSFAGSIVAHKQCNWDEHPTKTNQIARQIPYQPWYLRTAQATLIAGIFSFGSIAVELYFIYSSL-----------WFNKIFYMFGFLLFSFLLLTLTTSLVTILI------YYSLCLENWL-------------------------RSFIIGGLG--CSIYTFIHSILFTKFKLGGVITVVLYLGYSLIISALC---------------VVTGA-IGFFSSMFFIRKIYSAIK................................. 670
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;