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Query: [R] KOG3036 Protein involved in cell differentiation/sexual development, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MANLPSSLSMGTPFGGPSTSAQNPTGAPANKDRNLASAEQLVLDLSNPELRENALLELSKKRELFQDLAPLLWNSFGTIAALLQEIVSIYSVLAPPNLTPAQSNRVCNSLALLQCVASHSDTRMLFLKAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALVKVDDTEVISFLLSTEIIPLCLRTMEMGSELSKTVATFIVQKILLDDVGMDYICTTAERFFAVGRVLGNMVQSLVEQPSPRLLKHIIRCYLRLSDNPRACAALASCLPDSLRDGSFSNCLREDPTARRWLQQLVHNVGVGRVPTHQGGGFEHMLLast
1 -103.000[R] KOG3036 Protein involved in cell differentiation/sexual development  ali  100  1MANLPSSLSMGTPFGGPSTSAQNPTGAPANKDRNLASAEQLVLDLSNPELRENALLELSKKRELFQDLAPLLWNSFGTIAALLQEIVSIYSVLAPPNLTPAQSNRVCNSLALLQCVASHSDTRMLFLKAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALVKVDDTEVISFLLSTEIIPLCLRTMEMGSELSKTVATFIVQKILLDDVGMDYICTTAERFFAVGRVLGNMVQSLVEQPSPRLLKHIIRCYLRLSDNPRACAALASCLPDSLRDGSFSNCLREDPTARRWLQQLVHNVGVGRVPTHQGGGFEHML 316
2 -93.600[R] COG5209 Uncharacterized protein involved in cell differentiation/sexual development  ali follow..  61  2.........................ENLESPNYEPALVYEWIIQLVSGTSREQALVELSRKREQYEDLALILWHSYGVMTALLQEIISVYPLLNPPTLTGPTSNRVCNALALLQCIASHPETRIHFLNAHITLFLYPFLNTLSKSKPFEYLRLTSLGVIGALVKNDSPEVINFLLSTEIIPLCLRIMENGSELSKTVAIFIVQKFLCDDVGLQYICQTYERFYAVASVLNNMVMQLVDSFAFRLLKHVIRCYLRLSDNPRAREALRHCLPEPLRDATFAQVLKDDHNTKKCLAQLLINLSDVAVV........... 281
3 -10.500[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  13  17..................................LQALVTEFQETQSQDAKEQVLANLANFAYDPSNYEYLR--QLQVLDLFLD-------------LSEENETLVEFAIGGLCNLCPDRANKEHILHAGGVPLIINCLSSPN-----EETVLSAITTLMHLSP-PGRSFLPELTATPVVQCMLRFSLSASARLRNLAQIFLEDFCSPRQ.......................................................................................................... 172
4 -9.910[S] COG5369 Uncharacterized conserved protein  ali follow..  10  292LFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILISREAKQIAPRILAIIINENEIMQKTAVNA-GFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSSVYILRTGLADADVSEPLIKLLSDPDTR-----VKSTATSAICNLVLKFSP-LREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGD-------DETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTQKEESVDFLLKMVPMELLAKILLEKLESNPILIEPSIYILVHIAASDGELRD........ 593
5 -9.910[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  10  292LFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILISREAKQIAPRILAIIINENEIMQKTAVNA-GFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSSVYILRTGLADADVSEPLIKLLSDPDTR-----VKSTATSAICNLVLKFSP-LREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGD-------DETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTQKEESVDFLLKMVPMELLAKILLEKLESNPILIEPSIYILVHIAASDGELRD........ 593
6 -8.710[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  11  90VLFLLQSPDAEIQRAASVALGNLAVNAENKALVVKLNGLDLLIRQMHVEVQCNAVGCITNLATLDENKSKIA--HSGALGPLTR-------------AKSKDIRVQRNATGALLNMTHSYENRQQLVSAGTIPVLVSLLPSSDTD-----VQYYCTTSISNIAVDAVHRKRLAQSEPKLVRSLIQLMDTSSPKVQCQAALALRNLASDERYQIEIVQ--------SNALPSLL-RLLRSSYLPLILASVACIRNISIHPLNESPIIDALVDLLSCTENEEIQCH---AVSTLRNLAASSERNKRAIIEANAIQKLR 382
7 -8.660[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  11  5.....................................IDDLIEKLKTTSVSPANTTNLLCEISATKDPKLF------DKHELAECFLGL--------TKCDDTNVRKEAAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDEA--DLILELEGDAVLLRLLDITTIEDVKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGIIDILSRILAASTNPDLAEMCLELLHYQAESDEVKLILAKDIYNLLEKYKTLASTSEARALMKLACELIVLILTGDD............ 306
8 -7.750[O] KOG2160 Armadillo/beta-catenin-like repeat-containing protein  ali follow..  10  109.....SIRRVKEQKKSYAELRKAYKEFQKNFRTDGELIVQLIDQFREMRSKLDCLENLEYLLHQI-DNALMFIDNGGLDDVLLPIVVN----------DTSTSLRVSAMRVLGSLASNNPKAQIKVFEKNFGSHLAQILTSSGNVG----EISAALHAFGALLR-KFPLAQQRVLSTSGTQALIKVLQSPDVELRSKVVTLISDLVLEKRSVLDVSKDDPEASSTMAQYVLL-DFESWLKTPGYCAAVDTVLTKEFLLLLEQPEVVEQFATALETDMCTSTWSQSSGLRHALLTVRNRYANSTDE........... 404
9 -7.710[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  10  9.......................GGQSAGPQHTEAETIQKLCDRVASSDDRRNAVRALKSLSKKYRLE------GIQAMEHLIHVLQT----------DRSDSEIIGYALDILYNIISNEETEIFIKQQENVTLLLSLLEEFD-----FHVRWPGVKLLTSLLKQLGPQVQQIILSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISE-----GNSDGGIVVEDCLILLQNLLKNNNSNQNF................................................... 249
10 -7.430[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  10  1............................................MEDVNQLFDAAFEFAHYPGAQNETSVKEFLDRFPLPVIFNALQT----------DPDIPGFENTLVTCLERLFKTKYGAS--LIPQYMPVLQVGLKADSAV-----VKSLACKTVLCLLETNDVSSVQLVVNNGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVIFPSETNDPTHLRNLAARCSSLARVRVLSLIVKLFSISRLVASEVKKSGLLDLLE-AEMKGT-------KDTLVILNVLELYYELMEVEHS........... 239
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.