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Query: [K] KOG3298 DNA-directed RNA polymerase subunit E`, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPFFLKELSLTISLHPSYFGPRMQDYLKAKLLADVEGTCSGQYGYIICVLDSNTIDIDKGRVVPGQGFAEFEVKYRAVLWRPFRGEVVDAIVTTVNKMGFFANIGPLNVFVSSHLVPPDMKFDPTANPPNYSGEDQVIEKGSNVRLKIVGTRTDATEIFAIATMKEDYLGVLLast
1 -87.500[K] KOG3298 DNA-directed RNA polymerase subunit E`  ali  100  1MPFFLKELSLTISLHPSYFGPRMQDYLKAKLLADVEGTCSGQYGYIICVLDSNTIDIDKGRVVPGQGFAEFEVKYRAVLWRPFRGEVVDAIVTTVNKMGFFANIGPLNVFVSSHLVPPDMKFDPTANPPNYSGEDQVIEKGSNVRLKIVGTRTDATEIFAIATMKEDYLGVL 172
2 -66.800[K] KOG3297 DNA-directed RNA polymerase subunit E`  ali follow..  16  1.MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLL--TVEEGQLKPGDGSSYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIDIFIPQNMLFEGCYYTPEESAWIWEETKLYFDVNEKIRFRIEREVFVDVAYALLGSCQTDGMGLV 208
3 -65.500[K] COG1095 DNA-directed RNA polymerase, subunit E`  ali follow..  25  1.MYMLVEDKYIARVPPEMLGEDYDVAVREVTKRSLEGRLVDVKYLVISVLYT--ESIGEGTIVHGDGGVYQEVKYRALVYYPEMQEIVDGEVVSVQKFGAFIKFSSFEGLLHISQIMDDIDIDLENKRFIGKETKRDLKVGDRVRVRIVAMNLASSSIKIGFTMKQVGLGKL 183
4 -44.100[K] KOG4134 DNA-dependent RNA polymerase I  ali follow..  16  47.CLVAGPHQRHIALSPRYLN-RKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVG-ELGDIYDDQGHIHLNIEADFVIFCPEPGQKLMGIVNKVSSSHIGCLVGCFNASIPKPEQLSAEQWQTME-----------INMGDELEFEVFRLDSDAAGVFCIRGKLNI..... 200
5 -13.100[K] COG0557 Exoribonuclease R  ali follow..  12  572................AHFTSPIRRYLHRGIKYLLAKLDTGGYHYTLDDMDVLGDHCSMTERRADDATRDVADWLKCEYMQDHVGEEFTGVISSVTGFGLFVRLDFIDGLVHISTLDNDYQFDLARQRLIGENSGMIYRIGDKVKIRVEAVSLEQRQVDFS........... 731
6 -12.600[J] COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain)  ali follow..  16  5...................................................................................VGSKLQGKITGITNFGAFVELPGSTGLVHISEVADNYV----------KDINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDR..... 79
7 -11.600[J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)  ali follow..  13  7.................................................................................PEVGDLVVVKITEVKNFGANGILPGVEGYIHISEVATGWV----------KHIRSYLREGQRVVCKVINVNQERKNVDLS........... 79
8 -11.600[A] KOG3013 Exosomal 3`-5` exoribonuclease complex, subunit Rrp4  ali follow..  10  62................................QLVTDDPQFMRGHGTYFEDGGIYASVAGSVQRVNKLISVKPLRSKYV--PEIGDLIIGKIAEVQPKRWKVDIGAKNAVLMLSSINLPGGIQRRKLETDELQMRSFFQEGDLLVAEVQQYF---SDGSVSIHTRSLKYGKL 197
9 -11.600[J] KOG2916 Translation initiation factor 2, alpha subunit (eIF-2alpha)  ali follow..  13  14.................................................................................PEVEDVVMVNVRSIAEMGAYVSLNNIEGMILLSELSRRRI----------RSINKLIRIGRNECVVVIRVDKEKGYIDL............ 85
10 -11.500[J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)  ali follow..  15  21................................DYLGVIEEYLPGEGVIVEDGNLYSARAGWVKINKDKVEISEPASSVPPIPKKGDIVYARVIDVKQQAVLLRMIKIEGQENREIATSKLAGIHISQV---EDLRNEFKIGDIVRARVIADEKSPIQL----TTKDPDLGVV 159
11 -10.800[J] KOG3409 Exosomal 3`-5` exoribonuclease complex, subunit ski4 (Csl4)  ali follow..  14  69.................................................................................PATGDVVTARVLVTTPKFAKCAIFCVRNVLLESSYRGLLRKEDVRETEKDRVDYKSFRPGDVILARVINQLEQSFLL----TTAENELGVV 156
12 -10.500[K] COG4776 Exoribonuclease II  ali follow..  12  493................ATWTSPIRKYNHRLLKAVIKGEAIARP------QEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGTRFAAEIIDVSRGGMRVRLVDAIAFIPAPFLHAVRDVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIAR........... 641
13 -10.100[J] COG0539 Ribosomal protein S1  ali follow..  12  142....................RDTAHLENKELEFKVIKLDQKRNNVVVSRRAVIESESSV--------------ERDELLETLQEGTEVKGIVKNLTDYGAFVDLGGVDGLLHITDMAWKRVKHPSE----------IVNVGDEILVKVLKFDRDRTRVSL............ 257
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.