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Query: [O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSSSSTGYSKNNAAHIKQENTLRQRESSSISVSEELSSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFLLEIYPDYLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQRSKPFSRKWWKWLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLIIVPFCIFLLCFKIHFDLLSHSGTGDANMPSLFQARLVGSDVGQGPRDIALGSSVVSIKNQALGGSLLHSHIQTYPDGSNQQQVTCYGYKDANNEWFFNRERGLPSWSENETDIEYLKPGTSYRLVHKSTGRNLHTHPVAAPVSKTQWEVSGYGDNVVGDNKDNWVIEIMDQRGDEDPEKLHTLTTSFRIKNLEMGCYLAQTGNSLPEWGFRQQEVVCMKNPFKRDKRTWWNIETHENERLPPRPEDFQYPKTNFLKDFIHLNLAMMATNNALVPDPDKFDYLASSAWQWPTLNVGLRLCGWGDDNPKYFLLGTPASTWASSVAVLAFMATVVILLIRWQRQYVDLRNPSNWNVFLMGGFYPLLAWGLHYMPFVIMSRVTYVHHYLPALYFALIILAYCFDAGLQKWSRSKCGRIMRFVLYAGFMALVIGCFWYFSPISFGMEGPSSNFRYLNWFSTWDIADKQEALast
1 -214.000[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali  100  1MSSSSSTGYSKNNAAHIKQENTLRQRESSSISVSEELSSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFLLEIYPDYLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQRSKPFSRKWWKWLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLIIVPFCIFLLCFKIHFDLLSHSGTGDANMPSLFQARLVGSDVGQGPRDIALGSSVVSIKNQALGGSLLHSHIQTYPDGSNQQQVTCYGYKDANNEWFFNRERGLPSWSENETDIEYLKPGTSYRLVHKSTGRNLHTHPVAAPVSKTQWEVSGYGDNVVGDNKDNWVIEIMDQRGDEDPEKLHTLTTSFRIKNLEMGCYLAQTGNSLPEWGFRQQEVVCMKNPFKRDKRTWWNIETHENERLPPRPEDFQYPKTNFLKDFIHLNLAMMATNNALVPDPDKFDYLASSAWQWPTLNVGLRLCGWGDDNPKYFLLGTPASTWASSVAVLAFMATVVILLIRWQRQYVDLRNPSNWNVFLMGGFYPLLAWGLHYMPFVIMSRVTYVHHYLPALYFALIILAYCFDAGLQKWSRSKCGRIMRFVLYAGFMALVIGCFWYFSPISFGMEGPSSNFRYLNWFSTWDIADKQEA 758
2 -202.000[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  63  1MPYRVATGYSEKSTDDDLIWR-------TPIVKEELEDADNFLKDDAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYKIGRNNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFSGEVYPDYIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGKFILLDSMLLFFTVSSYFCLAKFHTMRKSPFSARWWLWLCLTGLNLGCAISVKMVGLFIISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLIIIPVCVFLLCFKIHFDLLSNSGPGDSTMPSLFQASLNGTKVGKGPRDVALGSSIISIKNQALGGALLHSHVQPFPEGSEQQQVTVYGYSDANNEWFFQRIRGVEWTDAENKTIEFVKGGEMYRLMHRLTGKNLHTHEVPAPISKSEYEVSAYGDVDLGDYKDNWIIEIVEQVGEEDPTLLHPLSTSFRIKNSILGCYLAQSGKHLPEWGFRQGEVVCLKHASKRDKRTWWNIETHENERL-PQGEDFVYPKTSFFRNFMQLNSAMMATNNALVPNPEKFDGIASSAWQWPTLNVGVRLCEWSEKSIKYFLLGSPASVWPSSIAVCALIIHVIFLTLKWQRQCVILSDPVERDVFVMAAFYPLLAWLLHYMPFVVMSRVVYAHHYLPTLYFALMILSYYFDMITKRWATRNTGKFLRLGAYIVYGSIVIAGFFYFSPFSFGMDGPVDDYAYLAWLPTWQIVEDIRN 752
3 -55.000[R] KOG3358 Uncharacterized secreted protein SDF2 (Stromal cell-derived factor 2), contains MIR domains  ali follow..  26  2..............................................................................................................................................................................................................................................................................................................................AVVPLLLLGGLWSAVGASSLGVVTCGSVVKLLNTRH--NVRLHSHDVRYGSGSGQQSVTGVTSVDDSNSYWRIRGKSA----TVCERGTPIKCGQPIRLTHVNTGRNLHSHHFTSPLSGNQ-EVSAFGEEGEGDYLDDWTVLC--------NGPYWVRDGEVRFKHSSTEVLLSVTGEQYGRPISGQKEVHGMAQ-PSQNNYWKAMEGIFMKPSELLKAEAHH......................................................................................................................................................................................................................... 208
4 -50.600[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  12  92.................................................................YTRNESQWEDLKLRIWEVAERNSFVEYYSYSNFPGVFYRIHKYLNTEHPFLGKDIIALGMLIED----------------KPFYWRIPGIIEHALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLAL---------------RIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDL-------------KEYLISGLVLPMVSFLIPEITIIKAIGFIP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEEFIASFSWHLSFKGEHPSEAPFWMWFVSLKPFPFHF----DPDVYAVTDPILMISMIVFVFAVPYVSL-----------------RRKGLSEIFWMFWSIIAFFALQYILGGKTQFIFYATPLIPPGAVALGVISYEIIKWEYFERSLR--------IYLNYLRSIAKPLKKVIK.......................... 476
5 -32.300[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  19  14.................................................................AAVVAVTAAALLARLWALGW-RVAHQDEARVADWTLQYMDLGAWQIIHGPFLPHVNGVVFDVFG---------------ATDFTMRLVVAVVGGLLPLTAWLYRTRLSDV--EVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTAVGLFVRFLDTHRAR-------YLYASAVPFALAFTTKENSLLYPLCWLGALAL............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 191
6 -24.700[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  15  7...................................................................LIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHPIAGYWINSIGQWLFG---------------ANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKS---AGFLLLGITCGMGVMTK--GFLALAVPVLSVLPWVA-----TQKRWKDLFIYGWLAVISCVLTVLPWGLAI....................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 226
7 -21.300[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  14  2.............................................NRTPKMLNSKVAGYSSLITFAILLIAWLAGFSSRLFAVIRFESIIFDPWFNYRATAYMVQNGWYFDER-PLGRTSGGIHWLLHVLNIPVHI----------RDICVFLAPIFSGLTSISTYLLTKELW-SAGAGLFAASFIAIVPGYISRSVAGSYDGIAIFALQFTYFLWVRSVKTGS-------VFWSAAAALSYFYMVSA-WGGVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQI................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 255
8 -20.900[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  12  2........................................ANSATITSKKGVKSHQKDWKIPLKVLILICIAVASVSSRLFSVIRYESIIFDPWFNFRASKILVEQGFYFDER-PLGR-LMVTSGII------FKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELK-SDACGLLAAAFMGIAPGYTSRSVAGSYDAIAITLLMSTFALWIKAVKSGSSFWG-------ACTGLLYFYMVTA-WGGVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQV................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 260
9 -19.400[S] COG5305 Predicted membrane protein  ali follow..  14  1......................................................................MFSLGNSFLPVPLD--QAIAPDILL-ASGIGDVIHNLITEDNHPPLYFVLVHLWMKLFPNQGE----------LVSLLAARSFPALLGAVSIPLTYILGRLAFRSSLVGQLAAGMMAVSPYAVYLGQEVRHYTLAMIWVIASLSCLVIATRHIQNRTLLPFWLIILWV-GINALGIATHYFFTLTLCAEALVLIFLAWQ--QSTQAKTLVFFSPLWWRIYAVAAGTAVAGLVWLPSILENRYRSS........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 236
10 -14.300[S] COG5542 Predicted integral membrane protein  ali follow..  9  2..........................KLNESAMKNAEKKSNSYLAIRMTRSGYNYFKGICVCTFLLSTILYLGIAVIMSHLCVFDDTAMLWDAIYFVDMAVNSLEWAFS-----SLWPKIISFLAFRSKDVVLLGIVS-------------FASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMS-VGYTESLFAAFSFLGLLLFIKKQ--------------QYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIIL............................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 266
11 -14.300[S] COG5650 Predicted integral membrane protein  ali follow..  10  2..................DQKLDQQKVDRVSPGDSEPVARDFINAIGGRFGRFAQVGTQRFWTPLRVLITTSLVFLAMGFLTLNWSGSRQYTSACYNDIVPLYGGRGIDAPGYPVLGGIFQWICGIITR-----FLYPVVDVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVELTGNRVWDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAVKRGN--------------PLVAGVLIGAGTAFKLWPLYLLGAYLVLAV---------KNKNLKPFITMAAAAAVTWLVVNVPVMIAYPKAWNEFLRLNRERGAEWTTIYQ................................................................................................................................................................................................................................................................................................................................................................................................................................................ 314
12 -13.400[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  8  23.................................................................FSRLLVLFLTILWRSLLQPYDTSAAWDSVYFLRITECYETYAFL-----PLLPFFISLLSRTVFA----PLVPLIGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILKDTEASFRASIIFCFNPASIFYS-SIYSESLYALFSIGGVYHLLSGT--------------SNVGVLWFALSGCARSNGILNAGYICFQTMHRAYEALYQKRRAYLAMQVFIAGFLRCICICLPFVAFQAYG..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 272
13 -11.800[S] COG5617 Predicted integral membrane protein  ali follow..  8  1...........................................................MKRKLYYLTLATISVIEYIPLYLAPSPPALQINGNGHLFKVHKLMTSGWFLRFYPPLSYLTAGVLGKVLG----------------DTKGYAATLMLTSFLGALALHHYLKSTGRE---PCISPLIFLL-HLTVSYIEGNFPRANAIHLAPLFLLSLYWLREKRERYLIASALGISIVAVLGAVIGLTSFWY-VILAGLYLYLSLGFYYRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKINPYPQDLIKICENIKEEPGDDWRIFVLTDVGEAINSYLPAICKKPTLNGWYHEGSPTKAGERRMIYILTYGGNLTPYLKAYAVRFLITPKEINEMVLRIGKYKVYKGDTSFFQPVSVIVMGKYYELPFDFVYIKDTKIISGQPNVVVLYIGQPSKEEESMLW-------KFIKNGGTVIWVPETKGE----------------------------------------------FLGIKAEIRAISNDELRSSLFNVSRFSPFSYNHRSWPLISVGTLIGEVRIGNGTLYLAGGNLIFHAALIGNMDKSTIVNYKLLERSDGRLVAEINSTERTLIRVSEAYYPYWKGYIVRLFRDYRTGLMIFTFPR-RYSLVGWIILTAYLVIETGKTYKKRYLHSIF.............................................. 752
14 -11.100[OKIT] KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator  ali follow..  8  2............................................TKSKPPRISLPFAAISRKSDFLLGASFSCIHVLLTTIVYHYVPEPYMDEIFHITQTRSYCSGNYSWNTTPPALYVISMPLCGGNERYANSILLFFAI-----PAFCRFRRMFVRVRIPTLKIYLKNTD--LQQDVWLTASIVGMLPILISSSILFYTDLLSLTSVIWGFSIGNP-----------------IASAFLFLISILTRQTNIIWAAIYAFSVIASRIDKSRSKMENLKIIISTAFSLWPFITLAIGFAMFIYFNDFQIVLGDAKAHQPKFH.................................................................................................................................................................................................................................................................................................................................................................................................................................................... 258
15 -10.300[H] COG3201 Nicotinamide mononucleotide transporter  ali follow..  11  30..................................................................TLFGLLCIWFASKEKIINYLFGLINVTLF----AVIFFQIQLY-------ASLLLQLFFFGANIYGWYAWSKQTPDNQAELKIRWAAVCIAGIVLMTLHIDTVFAWLTRVAVTVMQSLGANVQMPELQPDAFPFWDSTMMVLSIAAMILMTR-------KYVENWLIWVVIDVISVAIAMALEYAFLTLIALNGSWL----WIKSAARNHSRP............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 236
16 -10.200[G] KOG3893 Mannosyltransferase  ali follow..  9  368LQYRLTQDEKYLIDLDVKVCSLFNTSAREALIHYAKAMKLLSKYNSRENMITKLRESSLYLLYAPTDAFLLLLLGLLMRLVLLNYGIALKFTDIDYFVFMSPYMRDTYR---YTPMLAILLLPTQYGFPSWGKYLF------------------SISDLIAGWLMIKLLSRRISYKRSLIYSSFWI-LNPFVAIISTRGNCEAILGILSIALLYLIEKKS--------------VWLASLILGFSVHFKIYPFMYGIAFLVYFSKP-----KKGSTFMEKFLSLLSINQLKIVVGSLFMFTICNLLMYYL................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 652
17 -9.730[S] COG5373 Predicted membrane protein  ali follow..  11  58.PSEAGVPSVAGTEATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWPVWVGGLA----------LALGGYFLVQYS---IEAGLL----SPAVRLTLAAIFGLA---GEVIRRRDVPAIADRFRNAMIPGVLTAAGAVTLFGVVYAAYGIYDFIGTGAAFVLLALVSLATVGLSLLHGQALAGLGLLASLLTPLFVSSGEPRPWVLFGFLAVAWLATLAASRLRRWSVVPTLANAGLGLWGLAYVALATPFEAPPVTFALLVMIAGVALIWPGR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 338
18 -9.650[S] COG3815 Predicted membrane protein  ali follow..  13  6..................................................................LIVLISFLIFYLSIF-----------------LAPYFAYLGETSNFWKFISICLYAVYSLICHQMPQRSFFIFGHKMAV-----RCFGIYTGVLVGMIIYPFIKKLDDFKIPNKWYLIIALI----------MAVDGTTQLIGLRESFNELR-----------------FITGFIAGFTVVFYILPIFFEMI.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 151
19 -9.630[C] KOG0232 Vacuolar H+-ATPase V0 sector, subunits c/c`  ali follow..  13  14..........................................................................................................................................................GFLGAAAALVFSCMGAAYGTAKSGVGVASMGVMRPELVMKSIVPVVMAGVLGIYGLIIAVIISTGINPKAKSYYLFDGYAHLSSGLACGLA------GLSAGMAIGIVGDAGVRANAQQPKLFVGMILILIFAEALALYGLIVGIILSS....................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 156
20 -9.390[O] KOG2725 Cytochrome oxidase assembly factor COX15  ali follow..  9  30ASRNISTIRQQIRKTQLYNFKKTVSIRPFSLSSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLGGLTRLTELSITE-PPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIFFM--------------------WIHRLWGRAIGAVFILPAVYFAVSKKTSGHVNKRLFGLAGL-GWWMVKSGLRLTTHLGTAFFLYMGMLWTGLEILRECKWIKN--LAVSFLTAMSGGMVAGLDAGWVTCAYVAFTSVLAAHMYAIKKKAVIPRNAMTSLHVMMGVVTLQATLGILTILYLV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 423
21 -9.180[S] COG2881 Uncharacterized protein conserved in archaea  ali follow..  8  1................................................................................MTLKLSQALFIAGAYIQLVSTFLGFFATWL-----IAAVMHGLSAFFDG-RGEFR-------RTFEFAGYGFMLSLLGSAVIPVSLKYVEEATIP---TIDLQELSANPEILVKSLVSHFPDSYVYSAIFLNLAVTA-------------WSFLIWTFALKNARNVELKQAAVCAAIPTAIFGVYQVMALVRLLQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 175
22 -9.170[GE] KOG2575 Glucosyltransferase - Alg6p  ali follow..  10  2...........................PKKKPAKHSGEDDITIPVSPQTGSSIDTWWWLTHKGTTTSFLCISLFALLIRS---IPPKFGDFEQRHWMEITTNLPVIDWYRNGYPPL-SYIHGIFLRFFNPESVALLSSRGHESYLGKLLMRWTVLSSDAFIFFPAALFFVLVYHRNRTRGGKSEVAWHIAMILLNPCLILIDCISLGLTVGAIAAVLCESE--------------VLTCVLFSLALSHKQMSAYFAPAFFSHLLGKC--LRRKSPILSVIKLGIAVIVTFVIFWWPYV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 286
23 -9.150[S] COG3223 Predicted membrane protein  ali follow..  8  14......................................................................................................................................................TILQNVLNLGLLTLGLILVVFLGKETVHLADALFA-------EQASKYELVEGLVIYFLYFEFIALIVKYFKSGLHFPLRYFVYIGITAIVRLIIVDHKYSAAILLLVITLWLC.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 128
24 -9.040[S] COG4906 Predicted membrane protein  ali follow..  9  184.................................................................TFAIWSIAISLMWSTVFGVSWNYIWGYDINGEYYYANLVLARGIWSIS----NILGPVYSLILNMWIVPIF--------------KIIYPLVFSLVPVILLKAYERLLGNKIWAELSVLFFMFFFQFFVSNMALARMMIVEVYLALLAYATIRKINP--------------LFLILFLASLAVSHYGTAYLTMFALLTLPLIRVLENEQRISNK-------------LIAVFWVVTLLWYAYVG................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 393
25 -9.020[O] COG1612 Uncharacterized protein required for cytochrome oxidase assembly  ali follow..  9  2.....................VHQSATFNRTGQIMAAISASAPYVARDRDLRNRALVRGWLYVVLLVLFALVLVGGATRLTELSITQ---WQPIH---------------VIPPLNDAEWQEEFQRYQQIPQYTELNKGMSIEAFKSIFWRLLARSVGLVFALPLLFFWVSRRIERGLLVGILLLGGLQGAIVSVSQYRLATHLTLAALIFTATMVVARGLAPHSEPAAD--VLLALIQIYLGGLVAGLDAGLSLGAYTVFAVALWHMIAT--RRRLPGSTHARRATLLFVLVLVQASIGIGTLLMQV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 337
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;