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Query: [T] KOG3575 FOG: Hormone receptors, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSPLKMHVNMLQSDHALIMSSFPEPSPSSKRPTENCKVCGDRPNNDRYGASACLGCTVFFRRAVVKNLKYKCMKEQNCLISCTYRNACRYCRFQKCFAVGMHSSAIQRRDLVGPRKISGDGEVIICENNTFLDDFASFQRTQFAEHLQYFTEHQVDVAFHVDQANVVKFRRRARAHDVNVMLKLCLKQATEWANRLKLFKSLPAESKRSILAEYCLAFNLIDQGYKTSKEADLGIWLLQNGSFMHPDYFFGLNVTSVDEESMKVKIQLHHNFVAEMINCLSTPFRRLEIDEVECAALKVILLLTPSCSKRAIYAGREGVLAGLYTNCTEELMDHCMRKFPENGAVRFGEILLLLSGIRCGIKTMYNQTRVSDLFNFMKFDNSVKILIILSGRRSAALQNDALSFVQCDTFQQNDVFKSIKNSKTYFLSHFHFFHKKSNSSSIFETYYKSLSALCQKVCGLRVCICEIDIGQENGGYQDPDVPLIWELNLSEMWKASTELast
1 -194.000[T] KOG3575 FOG: Hormone receptors  ali  100  1MSPLKMHVNMLQSDHALIMSSFPEPSPSSKRPTENCKVCGDRPNNDRYGASACLGCTVFFRRAVVKNLKYKCMKEQNCLISCTYRNACRYCRFQKCFAVGMHSSAIQRRDLVGPRKISGDGEVIICENNTFLDDFASFQRTQFAEHLQYFTEHQVDVAFHVDQANVVKFRRRARAHDVNVMLKLCLKQATEWANRLKLFKSLPAESKRSILAEYCLAFNLIDQGYKTSKEADLGIWLLQNGSFMHPDYFFGLNVTSVDEESMKVKIQLHHNFVAEMINCLSTPFRRLEIDEVECAALKVILLLTPSCSKRAIYAGREGVLAGLYTNCTEELMDHCMRKFPENGAVRFGEILLLLSGIRCGIKTMYNQTRVSDLFNFMKFDNSVKILIILSGRRSAALQNDALSFVQCDTFQQNDVFKSIKNSKTYFLSHFHFFHKKSNSSSIFETYYKSLSALCQKVCGLRVCICEIDIGQENGGYQDPDVPLIWELNLSEMWKASTE 498
2 -115.000[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  19  6.DTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSAEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNN-------------LMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNL----ENFQLVEGVQEQVNAALLDYTMCNYPQQ-TEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA.......................................................................................................... 495
3 -115.000[K] KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors  ali follow..  21  17.LEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV---------------SGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVF--KDVLLLGNDYIVPRHCPELAEM---------------SRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGL----SDPGKIKRLRSQVQVSLEDYINDRQYDS-RGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGASGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI........... 465
4 -96.100[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  18  64.INWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYINKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDS---QNNTVYFDGKYASPDVFKSLGCED----------------FISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWL----QEKVKIEKLQQKIQLALQHVLQKNHREDG--ILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIFPPLYKELFTSEFEPAMQIDG................................................................................................... 548
5 -94.000[T] KOG4846 Nuclear receptor  ali follow..  15  117.SSPATSVTSSLSPPDSLSNGHTTQRHHIGKAISFCKVCGDKASGYHYGVTSCEGCKGFFRRSIQRKIDYRCLKQQVCEIKRESRNRCQYCRFKKCLDSGMSKDSVRQMKFRNAMRDDKSPDSVFVPEISTLERQEEVDAVTFSFYTDIKIRSIVARPFNVRINEDSKMNRLNAWQIYAHEIDVDIKEVVNFVKEIPKFNFINGNDKAVLLRKNAFPLYLLRIVRGM----SNRGLMLRDGRLIDFKSLQLL-----------------YGSLADEMLAFANHIITIGCTDGDIALFIVLILCQPLT-----TEQQFSTNFKSQLQLLEMFDFYKKMTCRIDGCDTYKQLMKCIHELNRLNELHKQQLNILRELSFLNLPPLVVEMFQLSTLPLPVNHNNQENQYTPAPEHQSPQPQQPTPNQQQ......................................................................... 529
6 -81.900[K] KOG4217 Nuclear receptors of the nerve growth factor-induced protein B type  ali follow..  20  258.PLGLTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEHVQQFYNLLTASIDVSRSWAERIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTA--EDKFVFCNGLVLHRLQCLRG-----------------FGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITER-----HGLKEPKRVEELCNKITSSLKDHQSKGQALEP--NESKVLVALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLFLDT............................................................................................................ 623
7 -15.800[R] KOG3002 Zn finger protein  ali follow..  15  1MAPGGSALKEALESNSTGVDYEVKMAKVEANSKPTCPVCTNLMYPPIHGHTLCSSCRCLALEKVAESLEVPCRYQNLCQ--LKHEQHCRFCPYAECSVTGDIPTLVDH...................................................................................................................................................................................................................................................................................................................................................................................................... 164
8 -15.000[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  14  239.EDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFC-NKKTGQPEELVSCSDCRSGHPSCLQKTYRWQCIECKCCNICGTSENDCDDC--MYCLTPSMSE........................................................................................................................................................................................................................................................................................................................................................................................................... 363
9 -14.300[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  14  243VDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRD----ILPCR-C--------------LC---TSCA--RYQANNCPICRPGPPADPGGAEEARS....................................................................................................................................................................................................................................................................................................................................................................................................... 334
10 -14.200[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  13  259....REEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKE-H--VCLCEDCA------------------------QKISVTCPVCRIVSKAAAFIA............................................................................................................................................................................................................................................................................................................................................................................................................ 338
11 -13.400[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  11  159.MKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVFCDGCNSPYHQL--------CHHDATVQDVDAE---CMKCQYRR................................................................................................................................................................................................................................................................................................................................................................................................................... 247
12 -12.900[K] KOG3815 Transcription factor Doublesex  ali follow..  14  1MNGYGSPYLYMGGPVSQPPRAPLQRTPK-------CARCRN-----H-GVLS----KG-HKR---------CR--KDC--------TCEKCILQRVMQVALRRQQANESLE................................................................................................................................................................................................................................................................................................................................................................................................... 84
13 -12.700[R] KOG4299 PHD Zn-finger protein  ali follow..  14  232.SENFNDMEGRAEDISSNELLPTPEEYPYRYNNDYCSACHGPGN-----FLCCETCPNSFH--------FTCID----PIEEKN---CNECKHHS................................................................................................................................................................................................................................................................................................................................................................................................................... 313
14 -12.600[O] KOG2813 Predicted molecular chaperone, contains DnaJ domain  ali follow..  11  209................................DVVCPTCGEPGFYKENQMMKCSTCYGRGLVAHKDGSDTICT---NC--NGKGKLPCPTCQ-QTCDSTGSLLTSSIAVVKWKTLSKRKVSATRGAGSVP-----------------EEVFDRAEGVQLCNTQAYQCTPAYFADSYFLNRFSSEVISLRAE-----------VPPTANVVCERHTISVVPVTRVTMEDRGKAFSFYIIGFGKEI.............................................................................................................................................................................................................................................................. 396
15 -12.500[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  12  82.SRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKAED----ILTC--CGHLF-----------C----GCFYQYLNIKECPVCDVIPIYGNGDDCDGTKPKLEDCGISLPPRPNAKRVES.................................................................................................................................................................................................................................................................................................................................................................................. 200
16 -12.400[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  16  3........QSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDWHSSCLKCADCQRCFSR---AGSVY-CKEDTACAQDFVYHLHCFAC--IICLATGDEFYLMEDGR.................................................................................................................................................................................................................................................................................................................................................................................................... 137
17 -12.400[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  16  50......................DDDKDAIKEAAPKCNNCSQRG---HL-KKDCPHIICSYCGATDDHYSRHCPKAIQCS-HKWKKVQCTLCK-ERC.................................................................................................................................................................................................................................................................................................................................................................................................................. 136
18 -12.300[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  17  232.RSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVSKREPVSTKC-G---VF-----------C---REC-IETRATHKCPICN...................................................................................................................................................................................................................................................................................................................................................................................................................... 306
19 -12.200[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  19  2..................................PCESCG-----VEFTVFACFDCKRYY-----------C---ANCI----ASRRCKRCSV-------FAQRPLSR-------------------------------------------------------------------TDLLKLKPKDLIFYLQ-SKHISTEGCLEKEELVGLV............................................................................................................................................................................................................................................................................................... 84
20 -12.200[R] KOG4602 Nanos and related proteins  ali follow..  12  199.RLETQEIEEPSPGPPLGQDQGLGAPGANGGLGTLCNFCKHNGESRH-GVVVC-----ILRH-------YVCP----CGATGDQAHTLKYCPLNG----GQQSLYRRSGRNSAGRRVKR........................................................................................................................................................................................................................................................................................................................................................................................... 308
21 -12.200[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  4  71.IDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWKFGP---VANTKSGILDSIV--------F-------PVDASTSGFSSDE-VEGSLRDVRKAAVDDEAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTKGSQSQSNVAS.................................................................................................................................................................................................................................................................................................................................... 237
22 -12.000[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  17  287.GFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESTKGDKVVALPC-------------KHEF----HRPC-IAKDYRHACPTCNTE.................................................................................................................................................................................................................................................................................................................................................................................................................... 365
23 -11.900[K] KOG2494 C3H1-type Zn-finger protein  ali follow..  12  142LVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRG------NCNDCR--YAHEASDNTVTICMDKGRC-----SREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGAT....................................................................................................................................................................................................................................................................................................................................................................... 280
24 -11.900[S] KOG4317 Predicted Zn-finger protein  ali follow..  10  1.........MMPEKTIISSESSNSSPLNPSSTRIICHVCNKQFS--QY---TCPRC----------NFRY-CS---PC---KSHSVQCTESFMRDNVNDELKQVRSDDQTKRKMLEILKRFHEEEEEDDGGIDSITDDEGLSLPEEIIQKIMNGDEVSLDDLSLEERKGFQRALASG----LSKMIQPWDPWDTPLISLSKLTSTNPSPLLPIHLIDIAYIYNGEWQSDSLGAATMVLTVSSVLGHNGQPETIKEVLSFCLEQTCSSAYKNLGGKFGLNLVDDVICF-LSLGSGAMVCLLGLILGAIKEVKSSSGRKKKLKLAERKVF--MMCWVNEQNSEVWEALEPSVRAEKNSVVELNDYRGFPEMKKKDQFRKGGGVVIEEI................................................................................................................ 405
25 -11.800[R] KOG4377 Zn-finger protein  ali follow..  13  273.VAATTINSGQRTAAKRNRDHDIPSGYLKFRFNEDC--CGYRNHQSHF----CRDCYSFCDKT-RKTSHFHC---RKCKVVAHRREQCPGCSYAQCVTCDLSRAQLAAHKHRTGFPKQEA.......................................................................................................................................................................................................................................................................................................................................................................................... 489
26 -11.700[R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins  ali follow..  12  229............................EPTRKTICPRCAEDCNLSHFLLGKCNNCFEFAKYGF-------CELGTSC--KNQHILQCTDCNNPQCSLYHGAVSADVPEQTEAPISKTAGSINPEDSGSEIGSNSLESNL...................................................................................................................................................................................................................................................................................................................................................................... 372
27 -11.700[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  19  2.............NASTSSPSQQLQQAINSTIDKECAVCYSEMI------TTIPSCGHKF-----------CF---ICLKGVSNNGDCPICR...................................................................................................................................................................................................................................................................................................................................................................................................................... 64
28 -11.600[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  18  5...................................CAGCERPILDWHIKCVQCCECKTNLSEKSREGKLY-CKNDTKCARSKVFHLNCFTC--MVCLSTG.............................................................................................................................................................................................................................................................................................................................................................................................................. 102
29 -11.400[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  12  250........NKAMGVEDEDDEADKDSDEDENALPFACFICREPFV-----VVT---CKHYF-----------C---EHCALKHHTKNKCFVCNIKKRMAEERSKAEQGLRRLWPVGEVVPKSK........................................................................................................................................................................................................................................................................................................................................................................................ 357
30 -11.300[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  11  230...........KYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYR-----IAT---CGHHF-----------CE---QCAITRYRKTTCIQCGFDRLLKNRKSKNDEAVKQKVGGFESNNSATTEVSERKD................................................................................................................................................................................................................................................................................................................................................................................ 342
31 -11.300[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  11  150.KSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICGDTIA-----------CLCIYHK--------------SC-IDSEVNRSCPEHPAD.................................................................................................................................................................................................................................................................................................................................................................................................................... 227
32 -11.200[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  13  97.SLHHILPKNQVKNNGQTMDANCNNNVSNDANVPVCKNCLTSTT----GAMLCNACGLFLK------------------LHGKPR-------------ISLKTDVIKSRNRKSNTNHAHNLDNFRNQTLI................................................................................................................................................................................................................................................................................................................................................................................ 199
33 -11.000[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  11  90.........................KESFTVMDSQCSVCGDYQPNDKLQQIP---CKHTFH---------------DC-IDLTSHTTCPLCR-----------LALIPSRSRQSQDDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPVNHINDGHEQQCDQDVEGFKEMEEDERNNIGTSS-----------ACCSCRTVHYCCVSRDNQIMYAYNNAGDHRNNESLAALCLEKTPPFH-----------FETRGKKTFGFLMKDDFVYFAIVDDVFKKS-SVLDFLEKLRDE--------------------LKEANKKNSRGSFSGSISFSN----------VQDQIVRRLIASLEFDHTCLPLSSPSIDGAEQSYASNSKAPLLGRSNKQDKKKGRDHAHSLRGIEIEEHRKSNDRG--------NVTECSNASSESATYVPRRGRSGGSQSIERKWRRQVK 479
34 -10.900[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  15  62..................SEYRRLRRINQRNRDKFCFACRQQG---HINVSICFRCKEHSLNACSKKGPFICHENGQCEQNPKKGGCCKFCS-KDC.................................................................................................................................................................................................................................................................................................................................................................................................................. 166
35 -10.900[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  24  190...................................CPVCGSMPQGLRY--LHCNLCET-VVRV-------KCSN---CEQSGKLHESCDDCGYLKILYQEKEPKV......................................................................................................................................................................................................................................................................................................................................................................................................... 273
36 -10.800[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  15  244.TVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYC-LCHQVS----YGMIGCDNCP-WFH--------FACVG-----LTTKPKGKCPKCTQDR................................................................................................................................................................................................................................................................................................................................................................................................................... 325
37 -10.700[R] COG3582 Predicted nucleic acid binding protein containing the AN1-type Zn-finger  ali follow..  8  1..................MSAAIEKETGMLDVGKHCAYCRD------FLPFHCSFCNEDFCSNHRLKEDHHCRWNDEAYFKSLLPERASVRIQRVSETNSKTLDKIFKFFQRNEKRKSNNKSKKNFGSSSNKIIQLANLKKIAKGDPKIPMQNRIYIWCYLVDGDETDIAKEDTRMPLYINKMWPVGRAMDYLSIQLNVKSST-NDKFQLCKLKEGKQVIGASLRVTNEIKDLDTLYLVHNN................................................................................................................................................................................................................................................................ 268
38 -10.700[K] KOG2857 Predicted MYND Zn-finger protein/hormone receptor interactor  ali follow..  22  2............................CPRATQTCEICEKVVS------------------------KYKCP---SCLV--------PYCSL-GCFKIHKVCNLINNAETPCAKPSDPSSTEEKPVVQC................................................................................................................................................................................................................................................................................................................................................................................ 67
39 -10.600[R] KOG2858 Uncharacterized conserved protein  ali follow..  25  2................................AVLCGVCGIKEF--KY---KCPRCL-----------VQTCS---ECSKKHKTRDNCS----------GQTHDPKE....................................................................................................................................................................................................................................................................................................................................................................................................... 48
40 -10.600[R] KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger  ali follow..  20  116........................................PSNFTIHDAV-ECDGCG---LAPLI-GFRYKCV---QCS------DLCQKCELAH................................................................................................................................................................................................................................................................................................................................................................................................................... 158
41 -10.500[TZR] KOG1704 FOG: LIM domain  ali follow..  22  205...................................CAQCNDVLADQKYNKPVCLKC---FHSSSST---FSC---TTCRMSQGDLHECFCC--CVC.................................................................................................................................................................................................................................................................................................................................................................................................................. 272
42 -10.400[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  15  256....SNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEAS----LLPCR-C--------------LC---SVCG------NTCPICKKTASLHVNLSS........................................................................................................................................................................................................................................................................................................................................................................................................... 335
43 -10.400[R] COG5048 FOG: Zn-finger  ali follow..  12  552...................................CLFCTKTFK-THLE-YSCDGCKAFVRNHSHQEKAYAC----PC--KKFNREDALVVHRSRMICSGGKKENVVIKRSPRKRGRPRKDGTSSVSSSPIKENINKDHNGQLMFKLEDQLRRE........................................................................................................................................................................................................................................................................................................................................................ 689
44 -10.400[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  12  14..................................................LSCSICDNILRDA----TTI-SE---KCIITEDEIETCPVCNIDEKLRPDHNLQDLRAKIFALKRRKVKAPGI....................................................................................................................................................................................................................................................................................................................................................................................... 87
45 -10.400[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  13  217.RRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YCQQVS----YGMIGCDNCK-WFH--------LPCVG-----LVEPPKGICKECEELA................................................................................................................................................................................................................................................................................................................................................................................................................... 298
46 -10.400[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  7  263........KRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQ----TSKC--CNIDF-----------S---KEALENAESDFVCPNCEKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATIT................................................................................................................................................................................................................................................................................................................................. 430
47 -10.300[R] KOG3183 Predicted Zn-finger protein  ali follow..  11  13...................................CSVCKD------FLPFTCDRCLQVYCLDHRSYMKHDCPKKKKCPVPRCRELKCRDCSIDHCLKHRFGPDHSCSGPKKPESSFSFMGFLSTNTKEAPASSSSSSRWSSLFASAEASISRLGNDISQKLQFASGNDGNSEKTQERNGKQNCGKVTVDVCPKCSRGFR-----DPVDLLKH............................................................................................................................................................................................................................................................................................. 238
48 -10.300[C] COG0348 Polyferredoxin  ali follow..  16  197...................................CGLC---PIGAAYGVIGCDNCM-------------DC--YNVCPEPQVLRDDCISC---RCIDV-CPEKVFIFTTRFNHSVNHSGE......................................................................................................................................................................................................................................................................................................................................................................................... 291
49 -10.300[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  23  252.EHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMS-------SCAPCGHLF-----------C----SCLMS-KERPECPLCR...................................................................................................................................................................................................................................................................................................................................................................................................................... 324
50 -10.300[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  9  26..................................................LRCHICKDFLKVPVLTPCGHTC---SLC-IRTNNQPNCPLCLVSEIIQS-LRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKK-NEQMAQCPICQQFYPLKALEKTHLDECLTLQSLGKKPKISTTF---RTPEVDKSSCGETSHVDKYLNSMMSAEHQRLPKINFTSMTQIKQKLSSLGLSTNHY-----EMLWNSNFCDSLEPVDEAELKRQLLS-------DVSHNKTPQNSSNKGGISKLMIMKSNGKSSSYRKLLENFK--FRKDFARLIREAKMKIKTGSSDSSGSVGHSNDGDGVEKVQSDQGTEDQQMEKDQDTVINEDRVAGERNLPNEDSTDADLSRELMDLNEYSKDPPGNN........................... 487
51 -10.300[L] KOG0287 Postreplication repair protein RAD18  ali follow..  9  26..................................................LRCHICKDFLKVPVLTPCGHTC---SLC-IRTNNQPNCPLCLVSEIIQS-LRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKK-NEQMAQCPICQQFYPLKALEKTHLDECLTLQSLGKKPKISTTF---RTPEVDKSSCGETSHVDKYLNSMMSAEHQRLPKINFTSMTQIKQKLSSLGLSTNHY-----EMLWNSNFCDSLEPVDEAELKRQLLS-------DVSHNKTPQNSSNKGGISKLMIMKSNGKSSSYRKLLENFK--FRKDFARLIREAKMKIKTGSSDSSGSVGHSNDGDGVEKVQSDQGTEDQQMEKDQDTVINEDRVAGERNLPNEDSTDADLSRELMDLNEYSKDPPGNN........................... 487
52 -10.300[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  32  847...................................CGVCFDRPKE----VIV---CYHLF-----------C---QQCI--EIRHRKCPGCG...................................................................................................................................................................................................................................................................................................................................................................................................................... 886
53 -10.100[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  10  720.ESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGEEGLDLHY-LTRCDHCKQVVE-SLTEHLLTECDKKDKCYVFKEEHKDCNRCPL--C-EEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASG....................................................................................................................................................................................................................................................................................................................................................................... 897
54 -10.100[S] KOG4260 Uncharacterized conserved protein  ali follow..  14  187........RDEKKLLCTQCHAACGEGGCTGGGPKSCRKC---KKGWSMGSFSCLECDR------------SCD---GC--DGDGPDMCRKCA-GKCHDI............................................................................................................................................................................................................................................................................................................................................................................................................... 294
55 -10.000[S] KOG4791 Uncharacterized conserved protein  ali follow..  25  8......................................C------YFFFYSTCKGCP--FRHCAALGNETVCTQEGRC------RRVCRFCYWENC.................................................................................................................................................................................................................................................................................................................................................................................................................. 80
56 -10.000[U] KOG4173 Alpha-SNAP protein  ali follow..  14  62...............QDVIMQVADVPEKPRVPAFACQVCCQVFDAHHYHTLHCSFCRAFFQILSERQDMYQCLVEG-CTSRDRKDHMVRMHLYPAFDKPKKSRSPASAEAPGDSGERSEGEAMEICSEPVAASPAPAGERRIYRHR................................................................................................................................................................................................................................................................................................................................................................ 227
57 -10.000[S] KOG4149 Uncharacterized conserved protein  ali follow..  10  165.GKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCPCLGGMAHG---------PCGEEFKAAF------------SCFVYSKSEPKGMECAMQACFQK-VGESEEEDAETNEKPSTTSDENNQPQSPPSDNASNPEEDVMNMEKEIVNLTPMSVIKEI................................................................................................................................................................................................................................................................................................................................................... 313
58 -9.970[W] KOG4004 Matricellular protein Osteonectin/SPARC/BM-40  ali follow..  9  26.............DETEVVEETVAEVTEVSVGANPVQVFDDGAEETEEEVVAENPCQ-----------NHHCKHGKVCELDENNTPMCSSCHFFACTKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMY-IFPVHWQ-----FGQLDQHPIDGYLSHTELAPLRTTRFFETCDLDNDKYIALDE.................................................................................................................................................................................................................................................................. 285
59 -9.950[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  11  89STFILVAFKCAGKPTNILYGTHPGVGNGALNNYTFCNYCS-KSPRTHH----CRTC----GMCVLD-MDHHCPFIGNCVGAGNHK............................................................................................................................................................................................................................................................................................................................................................................................................................. 165
60 -9.930[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  11  445.REVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTLCHERLEDTHF----CFPCS---RQSIKQQ-VY-CPSGEKCPLV----SNVPWAFMQGEIATILAGDVVKKER.................................................................................................................................................................................................................................................................................................................................................................................................... 558
61 -9.920[R] KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger  ali follow..  17  24.TAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRVCQNLDGKLHQHVVKCTVCN---KKYVRTSRRIGCPRP-NCR-PEGTRVVCGHCGLAKCPHCKKICSSSVGSALPRRR............................................................................................................................................................................................................................................................................................................................................................................................... 193
62 -9.330[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  15  416...................................CARCGENVVGFHVDCFTCIICQPFYSKPIMERI-FTCV---MC-VDAGGLIHCIEDFHKRCSVCK.............................................................................................................................................................................................................................................................................................................................................................................................................. 540
63 -9.330[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  9  1.................................KECKKCKSNEYTNKQLVMMINECGHPL-----------C---KNC-VDNLNSGNCHVCN-RVLRKNNFREQIYEDPLIDKETFLRRKLRKIYNLKQDDFENLREFGDY----------------------------------RKFFEPLKFPVKIKISNFRRFKNFKNFFYEFSIRY-----------------------------------------------SNSPSFSWSNPEFSAQNSKIAPSNSKFQFFRFETVVYNLVFETNVNETNAEIQAFEEKHKEQIDRNKRRLDDD-QKWIEDQLREERAMKARMTDHMEMDAKEQEAASAVT----------DTRKIMDELRDSNVAAEVILDRERKKQIEKELEEKEEQEKRKRRNKEMLQTRKRAAENMSFNTVIRVAGRAYVHQVGHENSEEIEKMQLFHSKFQIFKSIFPPMPNVSEIELAHIRQPTAE 377
64 -9.310[L] COG0551 Zn-finger domain associated with topoisomerase type I  ali follow..  15  2..............................ETDIKCPTCGRNMTASTGVFLGCTGCGTDSYVIDAHRKIHICGNNPNCDGYLIEEGSCDKCKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEK.................................................................................................................................................................................................................................................................................................................................................................................. 170
65 -9.300[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  13  41...................................CYQCG-----------TCTGCPGLVDEVIKSDELWMCT-------------TCYTCY-ERCAVKAARNLAAKKGYMAKAHRM............................................................................................................................................................................................................................................................................................................................................................................................. 124
66 -9.230[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  10  101GILAMVSRAEDSKDHKSGSTEEYPYDYLLYYPAIKCSTC---ARSKH-----CSICN----RCVLV-ADHHCIWINNCI----KGNYLQFYLF--IVKEGMTTEQDKWYTIQEYMREGKLVRSLDDDCPSWFFKCTEQKDDAAEPLQDQHVTFYSTNAYDHKHYNLTHYITIKDASEIPNIYDKG-----TFLANL.............................................................................................................................................................................................................................................................................................................. 332
67 -9.230[R] COG5141 PHD zinc finger-containing protein  ali follow..  9  182....................PKIEPVRVEDELDGRCVICNEAECSVHYGIPFCKKCLGAFCTTLDGRWCHICRWKLVCCICKLRWGTCVQCSDKNCYAAGFFYKIYSHSASYDSKHTPPDYLNGLMKRLFPLAELYYKRMATDVPLNFQATKAPDFVPEGPWKSHPLPAFIVDKVTKVLLSYNVKRQDLPSIVTDICKFYHMKRRSRAPLLKSQLLMDSLENLPVRASKDRVRSLEVAKA---LQDQ------------------------QSLLTLVESTAKRQLLKCQLSNLFLNLNYFPAQRLLQDTLVKIIDLDVDGLFNMPLWVELKRQVFSYQIGSISSLEKKLEPIWDVDGVIQCIDDMEQLTAMVQFAQKTEGEVKKLFIKAKIYFESLSLDERGNLKVPSLGINGLEYDNWPGLNELEMSQLDIPSQGNLKSLHDFIEGLDLNEKIGKFPISMFQNQVAQFSTIEIPKM.................... 709
68 -9.210[R] COG0727 Predicted Fe-S-cluster oxidoreductase  ali follow..  18  42...................................CELCA-----------RC--CTKAPYYALKTKPDGSCLENKRCRIYESRPSICRVYPHRQISGLNEHGS.......................................................................................................................................................................................................................................................................................................................................................................................................... 153
69 -9.150[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  19  222...................HEMEKAFAFQASQDKVCSICMEVASERRFGILSCLSCIRQWRCAFENPIIKSCP---ECRVQGMGKKACKYCPFSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNS.................................................................................................................................................................................................................................................................................................................................................................................. 375
70 -9.110[R] KOG4398 Predicted coiled-coil protein  ali follow..  6  36.YTTKRRPTAATKELLKDANAKDRNATTGMGAHMRCPLCHSCSASRFH----CRNCNGNITHSQAERPESLTEKQQRYINLQAGLKTFST-RYERLIGQHRSNEDRLMAIKAKRKQLELLQQLISGTGQ---------RLRVLGERRDELRRANAEKRKNLPKYPDKVKMLENYVLDRVEKIEKLRETHLGLLDSI-------KQAARRSIQQLVTYVFPIAEVVLKEEQQRRAS---------VERTEEAETIAALADAKNTSYIRGKWVFHGSGISEVQYRIVGPSLANGDYTAYLDWLADNKDDVPKATANEITPSRFEAYRQLTQLLSFYLNVRLPHKNEEQFRRKISRLNNIMYLA--YTQQVKLRALIEQHTLENLL-AILDLERSDLGRYGHLDVNNAPLMKSVDSLLIGIETATESESEDENSLRMDWEAVPSLTPQPE----------------LADPNLMPAANQQSTIAFVRMAATSVLRWIK.... 503
71 -9.020[R] COG5063 CCCH-type Zn-finger protein  ali follow..  11  119.VPKSSQLPLTSQNLQQLSQQKPKNDASFSSEKESSAQPKVKSQ-QLY---KTELCESFTLKG-------SCPYGSKCQFKNFRTKPCVYCPYRRCCFKHGDDNDIAVYVKAGTYCNVSSTSKQSDEKRSNGRGSAKKKNLNVKVKALQRMT.......................................................................................................................................................................................................................................................................................................................................................... 284
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Bourne PE, Allerston CK, Krebs W, Li W, Shindyalov IN, Godzik A.,Friedberg I, Liu T, Wild D, Hwang S, Ghahramani Z, Chen L, Westbrook J. The status of structural genomics defined through the analysis of current targets and structures. Pac Symp Biocomput. 2004;:375-86.