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Query: [T] KOG3697 Adaptor protein SHC and related proteins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQLast
1 -205.000[T] KOG3697 Adaptor protein SHC and related proteins  ali  100  1MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 594
2 -45.000[T] KOG3535 Adaptor protein Disabled  ali follow..  10  6................................................GRSCAPKGADHDFTLLSHSIPHHH----ILFGLTFVPKSFVILLVFFYCSLETMAQKSDISVETANATSGKPNPPSPKSRLAMLKRTKKASNASSDPFRFQNNGISYKGKLIGEQDVDKA-------RGDAMCAEAMRTAKSII---KAAGAHKT--------------------RITLQINIDGIKVLDEKSGAVLHNFPVSRISFIA-RDSSDARAFGLVYGEPGGKYKFYGIKTAQ-AADQAVLAIRDMFQVVFEMKKKQIEQVKQQQIQDGGAEISSKKEGGVAVADQQLSTVPTNCDAFGASPFGDPFVDSFNSTATSNGTANMSGTQVPFGGLQLPQVQQMQMPMVQIPQQSHQNWPTSGAGSFDAWGQQQQQQQMHHAHSTPAFGTNGFSDTNPFASAFNTQARHHHFQLLLQHNTVIHSLYIPLLFQIQILIGLELGLRKRIWHHLLISNNSSHHCITPALLPTLEIINSGP.................................................................. 466
3 -34.900[T] KOG4637 Adaptor for phosphoinositide 3-kinase  ali follow..  12  137.................................................................................................................................................EAIEKKGLECSTLY-SSSNLAELRQLLDCDPSVDLEMIDVHVL---ADAFKRYLLDLPNPSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKH-FFKLSQTSSKNLLNARVLSFLVRDASTKMH----FSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATGYGFAEPLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQ 722
4 -34.600[T] KOG3537 Adaptor protein NUMB  ali follow..  15  1...........................................................................MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRK--SSKPHQWQADEEAVRSATCSFSVKYLGCVEVFES-------RGMQVCEEALKVL-------RQSRRRPV--------------------RGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCA--DRNHERGFSYICRDGTTRRMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQT................................................................................................................................................................................................................................................................ 232
5 -33.600[R] KOG3536 Adaptor protein CED-6, contains PTB domain  ali follow..  14  4...............................................LTDNPEAVAIKLNQTALQAVTPITSF-NLKNSEMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPATEFLDQNRGSRRTNPFGETEDESFPEAEDSLL--QQMFIVRFLGSMAVKT-------DSTTEVIYEAMRQVLAARAIHNIF----------------------RMTESHLMVTSQSLRLIDPQTQVSRANFELTSVTQFA--HQENKRLVGFVIRVPESTGESTYIFESNSEGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDGKYVLLNDQPDDDDGNPNEHRGAESEA.................................................................................................................................................................................................................................................. 289
6 -33.000[T] KOG4566 Cytokine-inducible SH2 protein  ali follow..  31  373.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEELKKLAKQGWYWGPITRWEAEGKLANDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFDVEGHTSIVDLIEHSIRDSENGASATYPVRLTNPVSRFM 495
7 -30.500[T] KOG4458 Nitric oxide synthase-binding protein, contains PTB domain  ali follow..  16  13......................................................................................................................................GHDLRIPLHNEDAFQ-HGICFEAKYVGSLDVPRP-------NSRVEIVAAMRRIRYEFKAKNIKKKK-----------------------VSIMVSVDGVKVILKESKMLVMQDPIYRIFYVS-HDSQDLKIFSYIARDGASNIFRC......................................................................................................................................................................................................................................................................................................................... 143
8 -28.400[T] KOG3775 Mitogen-activated protein kinase scaffold protein JIP  ali follow..  16  548.......................................................................................................................................TKEPEHMAALAKNSDWVDQFRVKFLGSVQVPY-------HKGNDVLCAAMQKIATTRRLTVHFNPP---------------------SSCVLEISVRGVKIGEAKGNKCSHFFQLKNISFCG--HPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYT.......................................................................................................................................................................................................................................................................................... 702
9 -28.000[S] KOG4448 Uncharacterized conserved protein, contains phosphotyrosine interaction (PI) domain  ali follow..  10  250............................................................................................................................................RRTHSVDISTPDPEFKVSYLGNVLTGWA-------KGEGCVEKQLNTLWRNYTQHSK-----------------------PDVIMRLKVCASGLKAT--TRQHGLTEYWAHRITYCCA-PKNYPRVFCWIYRHEGRKLRCHAVLCKEKIAQDICDTLRENLESALREFKREKILKQNARLSLAN.............................................................................................................................................................................................................................................................................. 405
10 -23.500[T] KOG4792 Crk family adapters  ali follow..  31  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAGNFDSEERSSWYWGRLSRQEAVALLQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGSRLRIGDQEFDSLPALLEFYKIHYW................... 109
11 -20.300[T] KOG0194 Protein tyrosine kinase  ali follow..  19  54.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IKSFLLQRNWYHGMMFGKAAEKLLKWESSYIVRRSMGPTHKLCITARVEDKYFHFQFNWNSESCPILYEKFPRIPVKRYEHIYQL--LDAWSLVVNQLVPISRCS 159
12 -19.900[T] KOG0197 Tyrosine kinases  ali follow..  28  109...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSNFVARVESLEMERWFFRSQGRKEAERQLNKAGSFLIRESETNKGAFSLSVKDGELIKHYKILDEGGYYISPRITFPSLQALVQHYSKKGDGLCQR-----LTLPCVRPA 224
13 -18.300[T] KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains  ali follow..  25  266............................................................................................................................................................................................................................................................................................................................................................................................................................................................................PRNYIEVVVNDSSSSKASHQDFAPQYSGNGEIPMEQQPWYFGRISRERAEDLLLHEGEFLVRDSESNPGDLSISMRGIERNKHFKVQNVDGLLKIGNRTFVDMNALINHYTTSPI-FSSPTEKLFLTGPLPK.. 398
14 -14.000[T] KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains  ali follow..  22  54............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RVKPHPWYSGRISRQLAEEILMKRGAFLIRESESSPGEFSVSVNYGDQVQHFKVLRESGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPG 159
15 -13.800[U] KOG2320 RAS effector RIN1 (contains VPS domain)  ali follow..  25  91.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LHTHPWLQLSLSEEEAAEVLQAQGIFLVHKS-TKMQKKVLSLRLPCELKEFAIKESTYTFSLEGSSFADLFRLIAFYCISRDVL------FTLKLP..... 189
16 -12.800[T] KOG3557 Epidermal growth factor receptor kinase substrate  ali follow..  14  12.....................................................................................GATLRSALLPLAATQDTMSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVI-MHETSQYHVQHLATF-------IMDKSEAITSVDDAIRKL---------------------VQLSSKEKI---TQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQ-TVLNQLRYPSVLLLVCQDSEQSKDVHFFHCDEVEAELVHEDIESALA.................................................................................................................................................................................................................................................................................................... 200
17 -12.600[T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes  ali follow..  22  4..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................WFHRDLSGLDAETLLKVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGEKFATLTELVEYYTQQQGVLQDDGTIIHLKYPLNCSD 104
18 -9.610[KT] KOG3667 STAT protein  ali follow..  13  577...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LALWNEGYIMGFISKERERAILSTKGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEE 681
19 -9.020[S] COG5373 Predicted membrane protein  ali follow..  9  21...RRSAERLDRE-IESLKAEIARLAKEGMGEPGPDLATGRPSEAGVPSVAGTEATADGPWSR-------------------------------AREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWP-----ALALGGYFLVQY-----------SIEAGLLSPAVRLTLAAIFGLA-VAGEVIRRRDVPAIADRFRNAMIPGVLTAAGAVTGAAFVLLALVSLATVGLSLLHGLAGLGLLASGEPRPWVLFGFLA................................................................................................................................................................................................................................................................................................................................... 275
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 3 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.