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Query: [P] KOG3733 Mucolipidin and related proteins (TRML subfamily of transient receptor potential proteins), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSRIFRSQASRSMRLEQIPLESMSRRSTTDRSDFNDNASNASSNASRRPTINFQEIMEDLPHHERETGERLRRHLQFFFMNPMEKWKVRHQLPYKLVLQVLKIVFVTMQLILFAEMRMSHVDFLEDTTTVMRHRFLKEWNDDRDALQYPPAEGRYSVYDDQGLSEHLSFLINSYYSIRNDSFASFSYDVVSHPSGNLGAQISFESIPPIEVLIDRISNVTVNNNTYNFDIREVKDTKRLNLTETEVFQIGQSDDAVRDILATRGITFLPEDALKISTVQFKFRLRTIHYSPTAGDQKPECYKISVSIKFDNSRHTGQVHVTLSTVVSYVNVCNGRIIKVSGVGWSFDTLLIGGTDIFVLILCILSLILCCRALIKAHLLQIKTSDYFENVLKNKITVTDQLDFLNLWYVMIVVNDALIIIGTVAKISIEFQDFDNSLFTLTSIFLGMGALLVYVGVLRYFGFFSQYNILMLTLKRSAPNIMRFMTCAIVLYAGFLIAGWVIIGPYSMKFRTLAESSEALFSLLNGDDMFATFYTINDSNTVIKVFGTVYIYLFVSLFIYVVLSLFIAIIMDAYEVVKDRYSDGLRAIEKRGCLRDFVESNPPPSELGSPTTRSAYAPSNLLNLGRCVPVEVTRIFLCSGFLHTFSFFLHLCTPNKLGCLast
1 -163.000[P] KOG3733 Mucolipidin and related proteins (TRML subfamily of transient receptor potential proteins)  ali  100  1MSRIFRSQASRSMRLEQIPLESMSRRSTTDRSDFNDNASNASSNASRRPTINFQEIMEDLPHHERETGERLRRHLQFFFMNPMEKWKVRHQLPYKLVLQVLKIVFVTMQLILFAEMRMSHVDFLEDTTTVMRHRFLKEWNDDRDALQYPPAEGRYSVYDDQGLSEHLSFLINSYYSIRNDSFASFSYDVVSHPSGNLGAQISFESIPPIEVLIDRISNVTVNNNTYNFDIREVKDTKRLNLTETEVFQIGQSDDAVRDILATRGITFLPEDALKISTVQFKFRLRTIHYSPTAGDQKPECYKISVSIKFDNSRHTGQVHVTLSTVVSYVNVCNGRIIKVSGVGWSFDTLLIGGTDIFVLILCILSLILCCRALIKAHLLQIKTSDYFENVLKNKITVTDQLDFLNLWYVMIVVNDALIIIGTVAKISIEFQDFDNSLFTLTSIFLGMGALLVYVGVLRYFGFFSQYNILMLTLKRSAPNIMRFMTCAIVLYAGFLIAGWVIIGPYSMKFRTLAESSEALFSLLNGDDMFATFYTINDSNTVIKVFGTVYIYLFVSLFIYVVLSLFIAIIMDAYEVVKDRYSDGLRAIEKRGCLRDFVESNPPPSELGSPTTRSAYAPSNLLNLGRCVPVEVTRIFLCSGFLHTFSFFLHLCTPNKLGC 658
2 -27.400[PT] KOG3676 Ca2+-permeable cation channel OSM-9 and related channels (OTRPC family)  ali follow..  15  514........................................................................................................................................................................................................................................................................................................................................................................................................................MLFFLQSLFMLATVVLYFS----------LKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMIRDLCRFMFVYIVFLFGFSTAVVTLIEDGDSSYNSLYSTCLELFKFTIGMGDLEFTENYD-----FKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILD................................................................ 708
3 -12.100[P] KOG3713 Voltage-gated K+ channel KCNB/KCNC  ali follow..  11  221....................................................................................................................................................................................................................................................................................................................................................................TLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMN--------------------IVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTM-SHPETLFKSIPQAIITMTTVGYGDIYPKT------------TLGKL-NAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSGGEGKTGGSRSDLDNLPP........................................ 454
4 -10.000[P] KOG4390 Voltage-gated A-type K+ channel KCND  ali follow..  8  10.................................................................................PFARAAAIGWMP-LIVLNVTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGK--LHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDA--------------------------------DTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPG--------------------------------------------HIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMS--------------------IIDVVAILPYYIGLVMTDNEDVSG-------AFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYA-GSSASKFTSIPATIVTMTTLGYGDMVPKT------------IAGKI-FGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLS........................................ 454
5 -9.800[T] KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit  ali follow..  11  97.............................................................................................................................................................................................................................................................................................................................................................................................................KVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALNIYLIIYIFTFFLQ........................................................................................ 309
6 -8.130[I] KOG1362 Choline transporter-like protein  ali follow..  13  313..............................................................................................................................................................................................................................................................................................................................RVALTIALFHVAGKV--------FIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACMTVAGAVVTYYFTRDKRNLPFTPILTVAKG-SFIITLVKIPRMI-----LMYIHSQLKGKENACARCVLKSCICCLAYTATA--INS------TNFCTSAKDAFVILVENAL--RVATINTVGDFMLFLGKVLILIIVCLFAFLVAHCFLSIYEMVVDVLKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSREL........................................ 647
7 -7.820[K] KOG3423 Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA)  ali follow..  8  1MNDPEQYEPSSSTESVLMPPPALPQRPAAAPQVYSTLEPSVQNLRSSLHKPLTGNQQQFVQKTLENVQKNPSQDDTHEFINQLADYP----IPDSVT-RVTRMISLAAQKHVSDIILDAMTSARMKG----------------LGQTKKGTKDTKYTLTEELLDEILKE---PYHT.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 176
8 -7.650[T] KOG1630 Growth hormone-induced protein and related proteins  ali follow..  10  82.................................................................................................................................................................................................................................................................................................................................................................................................................DRIHATYAYFGASCGVTAASAVAFFQSDAMMALMTRSGWVASLVTLGLVMLSGSIAQGLEYQPGFGVLAPMCLLGGPILTKALLYTSGIVGALSTVAAC---APSEKFLHMGGPLAIGLGVVFASSLASMWAVGAGLASMSLYGGLILFSGFLLLAIYMALNIFIRIA-----IILAGDQKRKN......................................................................... 305
9 -7.580[U] KOG0866 Ran-binding protein RANBP3  ali follow..  14  259MSERVLSPPKLNEVSSDANRENAAAESGSESPFQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEMQCKL-FVFDKTSQSWVERGRGLLRLNDM-SRLVM-SLRLIL--------------NTKLWAQMQIDKASEKS--TAMDTEDQGVKVFDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSDDD..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 474
10 -7.550[C] COG2181 Nitrate reductase gamma subunit  ali follow..  12  1...............................................................................................................................................................................................................................................................................................................................................................MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKKKLAAGSTLFHWGLLCVVGGHVMGILEGVYASLGISEHMYHKMAIGAGLPAGIAACTGLVILT-----YRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGPWFREIVLFRPDASLMESVPLW-----FHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVVYRKRS.............................................................................. 223
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.