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Query: [K] KOG3766 Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MESTLSASNMQDPSSSPLEKCLGSANGNGDLDSEEGSSLEETGFNWGEYLEETGASAAPHTSFKHVEISIQSNFQPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVVIADLHPVGWCTQNNKVLMPPDAIKEKYTDWTEFLIRDLTGSRTAPANLLEGPLRGKGPIDLITVGSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEDTESYDQWLFYLDYRLRPVGWCQENKYRMDPPSEIYPLKMASEWKCTLEKSLIDAAKFPLPMEVFKDHADLRSHFFTVGMKLETVNMCEPFYISPASVTKVFNNHFFQVTIDDLRPEPSKLSMLCHADSLGILPVQWCLKNGVSLTPPKGYSGQDFDWADYHKQHGAQEAPPFCFRNTSFSRGFTKNMKLEAVNPRNPGELCVASVVSVKGRLMWLHLEGLQTPVPEVIVDVESMDIFPVGWCEANSYPLTAPHKTVSQKKRKIAVVQPEKQLPPTVPVKKIPHDLCLFPHLDTTGTVNGKYCCPQLFINHRCFSGPYLNKGRIAELPQSVGPGKCVLVLKEVLSMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKIVRTSDQVANFCRRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKISKPPIGESNPDSGHPKPARRRKRRKSIFVQKKRRSSAVDFTAGSGEESEEEDADAMDDDTASEETGSELRDDQTDTSSAEVPSARPRRAVTLRSGSEPVRRPPPERTRRGRGAPAASSAEEGEKCPPTKPEGTEDTKQEEEERLVLESNPLEWTVTDVVRFIKLTDCAPLAKIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYAQYANLast
1 -288.000[K] KOG3766 Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans)  ali  100  1MESTLSASNMQDPSSSPLEKCLGSANGNGDLDSEEGSSLEETGFNWGEYLEETGASAAPHTSFKHVEISIQSNFQPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVVIADLHPVGWCTQNNKVLMPPDAIKEKYTDWTEFLIRDLTGSRTAPANLLEGPLRGKGPIDLITVGSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEDTESYDQWLFYLDYRLRPVGWCQENKYRMDPPSEIYPLKMASEWKCTLEKSLIDAAKFPLPMEVFKDHADLRSHFFTVGMKLETVNMCEPFYISPASVTKVFNNHFFQVTIDDLRPEPSKLSMLCHADSLGILPVQWCLKNGVSLTPPKGYSGQDFDWADYHKQHGAQEAPPFCFRNTSFSRGFTKNMKLEAVNPRNPGELCVASVVSVKGRLMWLHLEGLQTPVPEVIVDVESMDIFPVGWCEANSYPLTAPHKTVSQKKRKIAVVQPEKQLPPTVPVKKIPHDLCLFPHLDTTGTVNGKYCCPQLFINHRCFSGPYLNKGRIAELPQSVGPGKCVLVLKEVLSMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKIVRTSDQVANFCRRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKISKPPIGESNPDSGHPKPARRRKRRKSIFVQKKRRSSAVDFTAGSGEESEEEDADAMDDDTASEETGSELRDDQTDTSSAEVPSARPRRAVTLRSGSEPVRRPPPERTRRGRGAPAASSAEEGEKCPPTKPEGTEDTKQEEEERLVLESNPLEWTVTDVVRFIKLTDCAPLAKIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYAQYAN 894
2 -28.000[A] KOG4374 RNA-binding protein Bicaudal-C  ali follow..  11  44..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RLGEIGGDQYQQQHHHHAAAAAYDSQGRKSKWTPTTTSGNRKDTSKSSRTRTLTNLSSGYENIGTLDDEREGNVDSFGVGSWRVKKRVGSSAAAKRVRSNWVSKVGDGDEKISGGEELEGGFRDFSREDSESPIKEESLDRDGGGFYGRRRYESNNSSGNREFESNMDGGGKEGVKIWLQELGLGRYWPMFEIHEVDEEVLPLLTLEDLKD-MGIAVGSRRKMFCAIQKLGRE....... 276
3 -14.900[S] KOG3930 Uncharacterized conserved protein  ali follow..  23  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSKSSAARW-----VKFIPSPAAAGYAHVFVENRIQDDMLLDLNKEYLRE-MGITMGDIIAILRHSKTVCEQNARE... 76
4 -12.400[KB] KOG4161 Methyl-CpG binding transcription regulators  ali follow..  8  104..................................................PGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEG--NWLPARIVEV-EQTLLVRFERNHKSGSFQEWMAIKSERLRQR----------------------------------------------LSNRVLPVFELDEKCMAR---SGPRKFPGTIRKLLNDTYEVLFDGYVKN--------VRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIV-PPGWIKH---------------------MYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAKDINAYVYTH------------------GYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSH-CPKMQELAVKRTHPSSID------QVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGEL--------------------IR----IVRMRQE....... 827
5 -12.300[R] KOG1899 LAR transmembrane tyrosine phosphatase-interacting protein liprin  ali follow..  8  2....................................................................................................................................................................................................................................................................................................ASDASHALEAA--LEQMDASPASYMNPFPVLHLIEDLRLALEMLELPQERAALLSQIPGPTAAYI-KEWFEESLSQVNSAASNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKI-RDLEVCLEGHQVKL--NAAEEMLQQELLSRTS-LETQKLDLMTEVSELKL-----VGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPSERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDSPFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFWGKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATPQDMEKELGIK-HPLKKLVLAVKAINTK-LPQYKD 649
6 -11.800[F] KOG1738 Membrane-associated guanylate kinase-interacting protein/connector enhancer of KSR-like  ali follow..  18  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ALIMEPVSKWSPSQVVDWMKGLDLQQYIKNFEREKISGDQLLRITHQELED-LGVRIGHQELILEAVDLLCA........ 75
7 -11.100[JT] KOG3791 Predicted RNA-binding protein involved in translational regulation  ali follow..  9  468.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DRSQPPPNLQQQLLQPPPYASILMGNVGDQFGEINRWSLDSKIAALKTRRSNSLTTQTISSCSSSSNSSVITVNDNCSNSTENLAQFANKPRSFSLSIEHQRGALMNSGSDTRLDEFKPNYIKFHTRNVGMSGIGLWLKSLRLHKYIELF--KNMTYEEMLLITEDFLQS-VGVTKGASHKLALCIDKLKER....... 656
8 -10.500[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  11  4.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLALKRRGKDSEPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEEDIRNTVGNIPMHWQGDQIDEFLRKIEDPDFWRTVKDPLTGQD--VRLTDEDIALIKRIVSGPSVRVSRMVHALKMGWMKT... 296
9 -10.300[U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6  ali follow..  6  306.................................................................................................................................................................................................................................................................................................................LAVVDSS-------------LHSHLVELGVE-----------------PQYFGLRWLRGREFLLQ-----------WDEIILADNSARTDED---SRNQNFRIFDCPRGTLVL------MTVSMILYLRSS--LLSTENATCCLQRLLNFPENIDLNKI----QKAKLLQALVLDTDMLSALSINGVFDQSNFVPARTKSCSTSPRSPLIIAPESYWEKKW--RVLHKAEEEENKICLEKQTPPTQKKKRWLNVTKLFRAVIDLSHHKLGIGERKANSSPVTQSLLEDSSEQLNVDCHVTVNKENIHPQETEENIMEFHSADEESIVSGSSPSEESSFVSLDPTSPVRCSTKIENDSVSSAGSNLLPDEDDKSIVSISEENSSVSSDPISPAIDSNYSGKYLDCCTGSENDKDQQTSVNSPLSVSPHRRNEYPVTQSDEDVSTDKSVGITKEYKLLHGIVQWFRKLKRTLSSEETSHRKASDATKTNDVKIKKNQIGCYSESHPQALSSGDSSQNLRK---QSMLKHIEAIE-----LVFQQEPVPAGLIGNLAKTNLIEKGQVTATTALKLSNLLSEM.......... 840
10 -9.790[M] COG3061 Cell envelope opacity-associated protein A  ali follow..  8  28.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KVLPDAKNTDEQNLISEINAPEQRVDPDNVTEPALAPTQRKGVQSIKELWLKIWHLPDSFQWMEPLPFFHRRGVIIATTVLLLALLWPASRDNTDLSFPVSAPSTSVPLQAQLQDNNDVPVPPKVSPSETTQGNWQSYQVQT-------KTLAQLFRDNNLPVNDVMAQVEGSDKPLSNLKAGQEVKI-GAVTALAIET...... 226
11 -9.520[S] KOG2827 Uncharacterized conserved protein  ali follow..  8  175...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GSLLRSFRVNKSTNKLMMRDLNGRRMASVDEEAKLKRYLEKQARKEQELKEKRKAKLEKLTAGPAKHMFEDQDYLSRREEIINKTEDACEAGFALMLEMKRNSRKSKEQENKNDEDEDDDVNAEDVTDLFNDRGGRKRKIAAPSIGEDGGNKRINDESDDSEDDSENEVDPEELEAIRQYFEAKKQDEKDNGEGTSEAVPEVLVDEQEIEPAKRPRLDSASNIDDLPKIDVKTPCEYGPISLDDFTSA------------EDLELLGLEHLKSA--LNDRGLKCGGSLRLWCVPREYPKNILTP... 473
12 -9.350[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  10  10..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AEDLDKDFAGQAQDEFGGDGVDLYDDIGGPTESAASGGGGGGTPSADGAAGPGSGEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDDIANSLRDIGVSDLQEVFFENRANGQSVISLGSESSLRAVLDQL-PKKEMHGVVTYPSKQALTQFES 181
13 -9.110[S] KOG4791 Uncharacterized conserved protein  ali follow..  8  586................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASCNTQVAEKPVLTAVPGITWHLTKQLPTKSSQKVEVETSGIADSLLNVKWSAQTLEKRGEAKPTVNVKQSVVKVVSSPKLAPKRKAVEMHPAVTAAVKPLSSSSVLQEPPAKKAAVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLTWE---------ISGGKLEAE---------------IDLDPGKDEDDLPLEL.......... 805
14 -9.110[K] KOG3804 Transcription factor NERF and related proteins, contain ETS domain  ali follow..  8  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKYEPRKGADDEESSYLEQSVRKLEVLYFPNSPALACPAPIFAPAPQRASPWPAALASPQQTTFTSPTGLSSSGPSAFTAVSPTNSANSLTTSTATIYNRLMCIPKLLQEISNNKVLRTRMNNTAYKPIPNNEKVDLARFRVKDPNEWLVDDVVAWMLDV--FEEMNMHKFAMLSGQEMLTMSERCFIERDP-VFGN--LIFNEFRKTLEN....... 214
15 -9.070[K] COG5118 Transcription initiation factor TFIIIB, Bdp1 subunit  ali follow..  7  288...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QISENFEKSKMAKKAKLEKRRHLRELRMRARQEFKPLHSLTKEEQEEEEEKRKEERDKLLNADIPESDRKAHTAIQLKLNPDGTMAIDEETMVVDRHKNASIENEYKEKVDENPFANLYNYGSYGRGSYTDPWTVEEMIKFLSMTDFNLISQLYSRKQVKAK----FVNEE-------KKRPI-LIELALRSKLPPNFDEYCC 486
16 -9.030[M] COG5632 N-acetylmuramoyl-L-alanine amidase  ali follow..  9  496....KTPITTWYQFSIDG---IGWVDTRALDTFYKQSMEQSTNLTRYVTANKTGEAYYKVPVADSDVKWGTLATYKNEKLTVDSQATVEG----------QLWYRVRTST--------------------IGWTKAENLTTTPPFDAIEYDKGVTAYARVKTAPGNAVWTKPYRTEGSKLVNQLSVYQGKNMRILREAKTVI----------TTWYQFSIDG--------------------IGWVDTRALDTFYKQSMEKDTNLTRYVIANKVNEAYYKVPVV----------------DADVRWGTLAAYKGQKLTVDKQATVEGQLWYRIRTSSTF-------------------IGWTKASNLS.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 767
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.