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Query: [U] KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTGPPRGERARKGEGYYLQRREHTQNNGYAIKRVFKRQKDEEAKETQISQKASEELSELDKQITERKETSKKLVGTQDDAICQICQKTKFADGIGHKCFYCQLRSCARCGGRAQSKNKAIWACSLCQKRQQILAKTGKWFQPEEQPQPKISGSEPSPSPQPLTDDNVPEPQQRRAEPPDKMNTPNYQNNQQPRGMGMQPNHNQTQQNFMNQNQNSNQHPNQNHNQNQMQNPHQNQNHVQNNHQGANNHQQNNRRAMQQQPMSQNQANQINQMNQNQNQQQSHNQNMTQNQRNQTGPQNQQRTNDSRTMKQTPQQQPSQYQNNVGAAHQHHNQHGQQEQHHQQMNEQRTDNNRMRENTNGQGGMFNRQPSLEQTTPMNKYNHVEDDGMNQRPTFYTGNSENDQRQFDGQMQQGSQQNNQNQNQNNRNLRKNTVSRVTEEDYASSSNFESKKQRNNSSQSQSNTQGVRACPSTDDHLNRVKNRLHRQLRSMSSSEEDIIAGGGGNTLKMSTSAVVASGGKTAFHDDMGASNVQRLSEECNSEKGLCAYSLast
1 -129.000[U] KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain  ali  100  1MTGPPRGERARKGEGYYLQRREHTQNNGYAIKRVFKRQKDEEAKETQISQKASEELSELDKQITERKETSKKLVGTQDDAICQICQKTKFADGIGHKCFYCQLRSCARCGGRAQSKNKAIWACSLCQKRQQILAKTGKWFQPEEQPQPKISGSEPSPSPQPLTDDNVPEPQQRRAEPPDKMNTPNYQNNQQPRGMGMQPNHNQTQQNFMNQNQNSNQHPNQNHNQNQMQNPHQNQNHVQNNHQGANNHQQNNRRAMQQQPMSQNQANQINQMNQNQNQQQSHNQNMTQNQRNQTGPQNQQRTNDSRTMKQTPQQQPSQYQNNVGAAHQHHNQHGQQEQHHQQMNEQRTDNNRMRENTNGQGGMFNRQPSLEQTTPMNKYNHVEDDGMNQRPTFYTGNSENDQRQFDGQMQQGSQQNNQNQNQNNRNLRKNTVSRVTEEDYASSSNFESKKQRNNSSQSQSNTQGVRACPSTDDHLNRVKNRLHRQLRSMSSSEEDIIAGGGGNTLKMSTSAVVASGGKTAFHDDMGASNVQRLSEECNSEKGLCAYS 547
2 -14.500[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  13  237............................STISAILVAFIAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKE--CGHVC------LCEDCAQKISVT------CPVCRGS.................................................................................................................................................................................................................................................................................................................................................................................................................................. 328
3 -14.400[O] KOG0802 E3 ubiquitin ligase  ali follow..  6  314.............................LFLNIRALLSAILKRIKGYIKLRI-----ALGALHAALPDATSEELRAYDDECAICREPMAK------CNHLFHLGCLR----LDQGLNEVYSCPTCR--KPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVN........................................................................................................................................................................................................................................... 586
4 -13.100[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  9  298......................MLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSAND--------DNICIICMDELIHSPNQQTCGHILHLSCLK-----------NWMCPICR--LPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQH............................................................................................................................................................................................................................................................................ 550
5 -12.700[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  8  3.................................................................................CESCG-VEFT----RACFDCKRYYCANC------------RCKRCSEKEELVG-------THVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSERVSISLKTDTSGRRVNAAAEPSPVDLANVDNGPAGNTAPSPGCSKPGSSSSKADASSQSSFEELGAIGGISDESKANTDTNSS........................................................................................................................................................... 336
6 -11.900[S] KOG4610 Uncharacterized conserved protein  ali follow..  8  307..........................................................................................................................................................................................................................................................................................................................................QLYRLYVVNAEFWKNRRESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSDTSSGDSSSSSSSSSSSDSS 523
7 -11.200[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  13  131...................DDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLS---FCDGCNSPYHQLCDDATVQDVDAEWFCMKCQYRRA................................................................................................................................................................................................................................................................................................................................................................................................................................ 248
8 -11.000[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  7  188.............................IIMVIYMIYKCIREQRRLRRHRLPKSLKKLPVLRYTKNN------ANNKYDTCVIC--EDFIED-------CSHPYHTHC----------PWLCPICK--RKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLTESRRSVWSRINFASFFRRQPAVISVAAPPYLERVESGTSAMGLPVTGTIAVASPASNNILNPNLSGSFKDEDDMPPHRSIYEPIAISTPAADSATVDDSAFLQTPTQGGIGVAALPHSASDRQ.................................................................................................................................................................. 533
9 -10.700[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  11  225...........................EKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-ENSDNSNECVVCLSDL----CRHLC------LCTSCADTLRYQANN---CPICRL................................................................................................................................................................................................................................................................................................................................................................................................................................... 318
10 -10.700[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  22  328...............................................................................KCCNICGTSENDDQL--FCDDCDRGYHMYC---MSEPPEGSWSCHLCLD................................................................................................................................................................................................................................................................................................................................................................................................................................... 376
11 -10.600[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  13  1..........................................................MNASTSSPSQQLQQAINSTIDKECAVCYSE--------TIPSCGHKFCFICLKGVSVSNNGD--CPICRGP.................................................................................................................................................................................................................................................................................................................................................................................................................................. 66
12 -10.300[R] KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger  ali follow..  14  54....................TFWIDADKDEIE--IVNQNDYEIFLAKCESNMHVQVAPLAPVEEPKATDDPSNFTIHDAVECDGCGLAPLI-GFRYKCVQCNYDLCQKCELAHKHPEHLM........................................................................................................................................................................................................................................................................................................................................................................................................................................... 165
13 -10.300[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  12  2.........................EKNTAPFVVDTAPTTPPDKLVAPSIEEVNSNPNELRALRGQGRDDDKDAIKEAAPKCNNCSQR------GHLCSKCDEV-CTLCKSKKHSKER----CYNCGGKGHFGDDCKEKRSSRVPNEDGSAFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVSSISENMYGSRYNPSTYVDNNSISNSSNYRNYNSYQPYRSGTLGKRR.................................................................................................................................................................................................................................................... 344
14 -10.200[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  16  266.....................RTKSKTRRFIEDLPSRTISREGFYSE-----EEEIENSTQNGELVPLMDESTRRATFGVECVIC-LESFTKGDKVVALPCKHEFHRPC---------AKWICPTCNTE.................................................................................................................................................................................................................................................................................................................................................................................................................................. 365
15 -9.970[KTDL] KOG2043 Signaling protein SWIFT and related BRCT domain proteins  ali follow..  9  241.............................................................................................................................................EKSKGELMFDDSSDSSPEKQERNLNWTPAEVPQLAAAKRRLPQGKEPGLINLCANVPPVPGNILPPEVRGNLMAAGQNLQSSERSEMIATWSPAVRTLRNITNNADIQQMNRPSNVAHILQTLSAPTKNLEQQVNHSQQGHTNANAVLFSQVKVTPETHMLQQQQQAQQQQQQHPVLHLQPQQIMQLQQQQQQQISQQPYPQQPPHPFSQQQQQQQQAHPHQFSQQQLQFPQQQLHPPQQLHRPQQQLQPFQQQHALQQQFHQLQQHQLQQQQLAQLQQQHSLLQQQQQQQIQQQQLQRMHQQQQQQQMQSQTAPHLSQTSQALQHQVPPQQPPQQQQQQQPPPSPQQHQLFGHDPA................................................. 597
16 -9.900[P] KOG4505 Na+/H+ antiporter  ali follow..  5  439...........................................................................................................................................................................RINTLALSFTRTRDSHFAFNLPRVRQGQSLPIKRVDALRSSANSIASSIRRRHPVNIQEDEDADISTVSLPEAAHLREERAESPRGGHYDAEEFPSEDYESRQPRRSNEEDREEEMNPGDETYLIGEDLVVEDSQGNIISHTSSRDANGPSIDEKLAQGDPKAKSFGRKFRSFLRRSYDTFQRNLHEPDDERQREPTLGHIESSIENHRPRYSRQNSESHLRENSVERRRREQVLTNIGDSESEDDNIPRPGIVPFYNENNESSSDTRNGLLSDNVSESRSRRPSRAPSAAVSSEGSPVEEDNEAQHRPNIRFLELTRAWE....................................................... 759
17 -9.750[K] KOG2857 Predicted MYND Zn-finger protein/hormone receptor interactor  ali follow..  28  2..........................................................................CPRATQTCEICEKVVSK----YKCPSCLVPYCSGC...................................................................................................................................................................................................................................................................................................................................................................................................................................................... 33
18 -9.740[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  17  778....................VSSSEKEYEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVCGVCFKEVVIVKCYHLCQQCRHRKCPGCGTAFGQND.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 893
19 -9.730[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  6  160.....................SNHSPIFRLLGLTLRYPSEPPKEDSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPTAGYVCWKCEHGTCPVTHYPISLDD.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 290
20 -9.520[R] KOG3002 Zn finger protein  ali follow..  13  1MAPGGSALKEALESNSTGVD-YEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLE------------------------CPVCTNL-HQCPNGHLCSSCKLRVCPTCRYELGNIRC............................................................................................................................................................................................................................................................................................................................................................................................................................................. 101
21 -9.440[S] KOG3726 Uncharacterized conserved protein  ali follow..  9  583......................FPKREKKRINDLLKKRAAFTKLRRAAILRRERQQKAPRHPLADILHRGCPLLRRWLCRRCVVCQAPETPESYVCRTLDCEAVYCWSCWDDMRQ------RCPVCTPREELSSSAFSDSNDDTAYA................................................................................................................................................................................................................................................................................................................................................................................................................ 705
22 -9.100[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  13  117........EMSGPALAVIENLEKASTQEDMASALF--ASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVC-QIGTTQGLRYLCNLCETE-CSNCEQSGKLHAIKAESCDDCGTYLKILYQEKE......................................................................................................................................................................................................................................................................................................................................................................................................................... 270
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.