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Query: [R] KOG3953 SOCS box protein SSB-1, contains SPRY domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSDVEVDPQQAHPHPIAAIAPRRRRPTGRRGGVTGGLSSGSLDASSSTSPPPRFCPLPNGVEDNWTWSKRHRSKEVVLRGPNSRTVHFHPNWSKGTAGVQGKRSLNNGRHYWELHVSQRVFGTSIMFGIGTKSARLHANAFRNMLGENEHGWGLSHKGVLWHEGVALLYTKRFRENQPTQIGVLFDGIEGTLTFYKDGKCLGVAFRGLDQIDEPLYPIVCSTAAKTEMTLKCTRREFVNLQDRCRAVIMRRVRSAAQLEKLKLPLPIADYLSEVIDEKKPLRQVDNYDILCDLLast
1 -106.000[R] KOG3953 SOCS box protein SSB-1, contains SPRY domain  ali  100  1MSDVEVDPQQAHPHPIAAIAPRRRRPTGRRGGVTGGLSSGSLDASSSTSPPPRFCPLPNGVEDNWTWSKRHRSKEVVLRGPNSRTVHFHPNWSKGTAGVQGKRSLNNGRHYWELHVSQRVFGTSIMFGIGTKSARLHANAFRNMLGENEHGWGLSHKGVLWHEGVALLYTKRFRENQPTQIGVLFDGIEGTLTFYKDGKCLGVAFRGLDQIDEPLYPIVCSTAAKTEMTLKCTRREFVNLQDRCRAVIMRRVRSAAQLEKLKLPLPIADYLSEVIDEKKPLRQVDNYDILCDL 293
2 -39.100[S] KOG4030 Uncharacterized conserved protein, contains SPRY domain  ali follow..  20  27...............................................................AVQLDTQHMGTDVVIVKNGRR--------ICGTGGCLASAPLHQNKSYFEFKIQST---GIWGIGVATQKVNLNQIP----LGRDMHSLVMRNDGALYHNNEEKNRLPNSLPQEGDVVGITYD--HVELNVYLNGKNMHCPASGIR---GTVYPVVYVDDSAI................................................................... 170
3 -23.300[A] KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain  ali follow..  13  148.GAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFA-WSGARASYGVRRGRVCFEMKINEEPDPHVVRIGWSLDSCSTQ-------LGEEPFSYGYGGTGKKSTNSRFENYGDKF--AENDVIGCFADFNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEF............................................................... 381
4 -22.900[BK] KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2  ali follow..  15  302.................................................................TVNVSSNDRAFQLSINGNSI-----TGFEGYSMARASHGVSKGTWYFEVNFDDQPDDSHIRIGWSQSYASLQA------VGYNKFSYGWSKHGTKFHEAKGKKYHFG-GFKQGDVLGCLIHLPVSYIEFFHNGKSCGKAYENI--YAGAYYPSISI-FKSATATM-IHARADEQQHEQTLSDMLYLVSKEVNLDHPPRVKREDDDDVKDI----------KKEIKQEI 572
5 -18.400[R] KOG1477 SPRY domain-containing proteins  ali follow..  12  189....................................................................DEYGNFLPSFIVQDKLDIQFSKF--NKSSSTVMNYPLRKDAVYFEVKIFRHIQKSNFSIGLTTVPYPYFR-----VPGMAKYSIAYESTGKLRINNPFTASTLLPKLEEGDTVGFGYRYKTGTIFITHNGKKLMDVTQNIGI---DLFIGIGAFNAAYTRTY............................................................... 345
6 -14.700[S] KOG4367 Predicted Zn-finger protein  ali follow..  20  538................................................................FAFDPGSAHSDIILSNDNLTV----TCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKD-----VMLGKDDKAWAMNNRSWFMHNNSHTNRTEG-GITKGATIGVLLDLNRKNLTFFINDEQQGPI--AFDNVEGLFFPAVSLNRNVQ-VTLHTGLPVPDFYSS................................................... 705
7 -12.200[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  7  230LEKQKSKSAELKLFMEMSNADLLAVNSVMDASNETEIWNDVSPGITNVEPEVFDATLAFPEIDRLAIQVSKVSRMNSLPWEFEEALININDSLTTTHHICTCKFMLISGHIIITSYKS---ARAYHRGAIISDSEMYRI---------IFSCLVGHLEANCIAKAPMKETIISERSMPLAVKCSKECLNPPVEKPEDSRVTGYIQKNF--YTEGCSIGCGCGALTFQVSFCLVLGTIWCQRVLFRLDLRKKLASGETVPQLPVPLFTQNFKCEDTGF--KVQNITQFICSYE. 549
8 -11.100[O] KOG2177 Predicted E3 ubiquitin ligase  ali follow..  10  140WEKACENLRNLNMETTRTRCWKSFGDILQRYESLLLQVSEPVNPDFSAGPIIGLMDRLKRFRVDFTLQPERDNSHIFLYGDDPQDDPDITAKSE-CFLVWGAQTFTSGKYYWEVHVGDS---WNWAFGVCNNYWKEKRQ--NDKIDGEEGLFLLECVKEDTHCSTTSPLVVQYVPRPTSTVGLFLDCEGEDNEANEIFGGKNSKPKKAKREEQENQPVNSKSESEQ................................................................... 370
9 -10.600[O] KOG4710 E3 ubiquitin ligase, VHL component (von Hippel-Lindau tumor suppressor in humans)  ali follow..  12  1.............MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLP-----------VW------NFDGEPQPYPTLPPGTGRRIHSYRG------HLW------------------------------LFRDAGTHDGLLVNQT--------------ELFVPSLNVDGQPIFANI---TLPVYTLKERCLQVVRSLVKP-ENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIA... 207
10 -10.300[T] KOG4566 Cytokine-inducible SH2 protein  ali follow..  17  377......................................................................................................KKLAKQGWYWEGKLANVPDGSFLV-----RDSSDDRYLL---------SLSFRSHGKTLH--------------------TRIEHSNGRFSFYEQPDV---GHTSIVDLIE--SIRDSEGSATYPVRLTN-FMQVRSLQYLCRFVIRQYTR-IDLIQKLPLPNKMKDYLQE.................... 532
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.