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Query: [K] KOG4210 Nuclear localization sequence binding protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSETELSKEDAVTKKDNEEQVKKALLDPTKKRKAEDEIEIDLKSSIPLSKKQKRLLRRGKVTLEELNAKYNIDPKSIEEYKEDAEKKKSGASEKDAQGEESTINTPTGDESGEVVKKKKKDENKYGVWIGNLSFDTTKDDLVRFFIAKTKDNEDEKSRVTEQDITRLSMPRVAAKNSNAMKNKGFCYMFFKNVEQMKAVLELSESHLNGRNMLIKDSENYSGRPDKDDLVAMSKNPPSRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFEDSGKCKGFAFIDFKNEEGSTNELKDKSCRKIAGRPLRMEYGEDRSKRQVRKKVENVSRNNSSSFDISNNKGYDRAGQDNGSKPEYKRSNANRRPPVDSNNRTKSSVALATAQRGSAAIVPSQGKKVKFDLast
1 -88.400[K] KOG4210 Nuclear localization sequence binding protein  ali  100  1MSETELSKEDAVTKKDNEEQVKKALLDPTKKRKAEDEIEIDLKSSIPLSKKQKRLLRRGKVTLEELNAKYNIDPKSIEEYKEDAEKKKSGASEKDAQGEESTINTPTGDESGEVVKKKKKDENKYGVWIGNLSFDTTKDDLVRFFIAKTKDNEDEKSRVTEQDITRLSMPRVAAKNSNAMKNKGFCYMFFKNVEQMKAVLELSESHLNGRNMLIKDSENYSGRPDKDDLVAMSKNPPSRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFEDSGKCKGFAFIDFKNEEGSTNELKDKSCRKIAGRPLRMEYGEDRSKRQVRKKVENVSRNNSSSFDISNNKGYDRAGQDNGSKPEYKRSNANRRPPVDSNNRTKSSVALATAQRGSAAIVPSQGKKVKFD 403
2 -57.800[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali follow..  17  27.RKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSNRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVR-----------------IISDRNSRRSKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNGGPMRLYVGSLHFNITEDMLRGIFEPFGKIDNIVLMKDSDTGRSKGYGFITFSDSECARRALEQLNGFELAGRPMRVGHVTERLDGGTD............................................................................... 332
3 -54.400[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  13  1MATATIALQVNGQQGGGSEPAAAAAVVAAGDKWKPPQGTDSIKMENGQSTAAKL-TPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSID-----------------MSWDSVTMKHKGFAFVEYEVPEAAQLALEMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEA-RAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTP--ATPGGLPPAAAVAAAAATAKITAQEAVAGAAVLGTLGTPGLVSPALTLAQPLGTLPQAVMAAQAPGVITG...... 382
4 -51.600[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  13  2................................................................................................................SGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKN--------------------RHGLVPFAFVRFEDPRDAEDAIYRNGYDYGQCRLRVEFPRTYGGRGGRGGRNGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADV-------QKDGVGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGR.................................................................. 202
5 -51.600[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  18  484...............EREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPAPAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEGVASIRFARKAN-------------------SDLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKF-----STTLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHK-DGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKDKSHGKPAAIGASLEE.................................................................. 780
6 -50.600[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  12  1MSGARRDNRRSNGRDDSSRVAKAENDRKPGRENRGGDEK---------RGNSNNAARSGGGGGGNRGGAERGIAPAQQPYDNNGGHRSGGGGGRSGGGGTSFNGAAFTESQLMDEVPKKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYL------------------------SGKGFAFLRLDTRAHAESAKAIDGRIIHGRQVRVRFAVH------------------GAAIRVKELSPTVSNEMLYHAFSHFGDVERAVHIVD-EKGRPTGEGIVEFERKPNCNEAMAAIRDKVFSPKPLICEVLEPRDED------------DGLAERMIPRTPGLSKERELGPRFPTPNSFEMKWKELYVVEQKRRAQLDEELRESRRRLESDM....... 341
7 -49.500[AJ] KOG0123 Polyadenylate-binding protein (RRM superfamily)  ali follow..  13  2...................................................................................................................NAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIR-----------------VCRDMITRRSLGYAYVNFQQPADAERALDMNFDVIKGKPIRIMWSQRDPSLRKSG----------VGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCD--ENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAEL----GAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRD-PNGKSKGFGFVSYEKHEDANKAVEGKII... 261
8 -49.000[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  15  5..........................................................VEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEVGEVTYVELLM------------------DAEGKSRGCAVVEFKMEESMKKAAELNKHSLSGRPLKVKEDPDGEHARRAMQKHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDK-DGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQ....................................................................... 296
9 -48.800[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  15  6............................................................................ATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELT-----------------VLKDRFTGMHKGCAFLTYCERESALKAQSLHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGP-DGNSKGCAFVKYSSHAEAQAAINALHGSQTASSSLVVKFADTDKERTMRRMQQ........................................................................... 243
10 -48.500[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  11  9.......................................................................................EPQVSNGPTSNTSNGPSSNNRNCPSPMQTGATTDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCK-----------------LVRDKITGQSLGYGFVNYIDPKDAEKAINLNGLRLQTKTIKVSYARPSSASIR------------DANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAIASLNGYRL... 363
11 -48.500[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  12  4...................................DDRERDRERRRHRSRSRDRHRERSRDRRHHRNSRRKPSLYWDVPPPGFEHITPMQYKAMQASGQIPASVVPDTPQTAVPVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQ------------AAGSPVLACQINLDKNFAFLEFRSIDETTQAMAFDGINLKGQSLKIRRPHDYQPMPGITDTPSTVVPDSPHKIFIGGLPNYLNDDQVKELLLSFGKLRAFNLVKDAATGLSKGYAFCEYVDLSITDQSIAGLNGMQLGDKKLIVQRASVGAKNAQNAANTTQSVMLQTPDELRDEEEYEDILEDIKEECTKYGVVRSVEIPRPIEGVEVPGCGFNSVLDCQKAQQALTGRKF... 396
12 -47.900[R] KOG0118 FOG: RRM domain  ali follow..  11  18VVIQPPPSSPPSSMTSQDSGVSSDDQNHHSRIDQVLRHDQGLYSKIGSHVARSDGVDGGESFKRDMRELQESAGSFFRNNGFAGTGNGGYGNENGGFRRKKSFGQGKRRMNARTSMAQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICG-------------------DPNSVLRFAFIEFTDEEGAMTALNLSGTMLGFYPVKVLPSKTAIAPVNPTPRTEDEREMCARTIYCTNIDKKVTQSDVKIFFESFCGEVY-RLRLLGDYQHSTRIAFVEFVMAESAIAALN-CSGVVLGSLPIRVSPSKTPVRPRSPRH............................................................................. 355
13 -47.900[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  14  10.............................................................................................................GANLLGQHSAERNQDATVYVGGLDAQLSEELLWELFVQAGPVVNVY-----------------VPKDRVTNLHQNYGFIEYRSEEDADYAIKLNMIKLHGKPIRVNKASQDKKSLDVGA-----------NLFIGNLDPDVDEKLLYDTFSAFGVIASNPIMRDPDTGNSRGFGFISYDSFEASDAAIESMTGQYLSNRQITVSYAYKKDTKGERHGTPAERQKSRPHTLFAMGPPSSAPQVNGLPRPFANGSMQPVPIPAPRQPPPPPPQVYQTQPPSWPS............ 274
14 -47.000[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  13  2........................................................................................................................................................................ESRHFATALVFLASKGFVDILYWVYRFQASSMAFCTKL--GGHWKQGVNVPVSSMLGSLR-------YMSTKLYIGGLSPGTDEHSLKDAFSSFNGVTEARVMTNKVTGRSRGYGFVNFISEDSANSAISAMNGQELNGFNISVNVAKDWPSLPLSKENKMMSRSVWKDPFVDAFLMKKKNAALNRKIWSRRSTILPEYV--DSAVRIYNGKTHVRCKITEGKVGHKFGE..... 230
15 -46.700[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  17  2.......................................................................................................................EDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIM-------------------DTAGNDPYCFVEFHEHRHAAAALAMNGRKIMGKEVKVNWATTPSSQKKDTS--------NHFHVFVGDLSPQITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD------KGYSFVRFESAAHAIVSVNGTTI... 263
16 -44.800[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  16  2....................................................................................................................LTADIPPNQSIYIQNLNERIKKEELKRLFSQFGRILDVVALK--------------------TPKLRGQAWVTFSEVTAAGHAVRMQNFPFYDKPMRLQYAKAKSDCLAKAEGTGQETMPPNNILFIQNLPHETTSMMLQLLFEQYPGFKEIRMIDAK-----PGIAFVEYEDDVQASIAMQPLQGFKITPQPMVISFAKK...................................................................................... 232
17 -43.700[R] KOG0226 RNA-binding proteins  ali follow..  75.....................................................................................................AATIAVSPFINPALGRLPTMPPVPPSIFMPPQLRAAPIMFPPRVLGIPAPATIE-----------------GAPALYETPAVNAIPQELLRTQALQSDIDMNFKKQTDPFKKKIKEQQAKKKQVWEDPSLAEWDENDFRVFCGDLGNEVSDELLAKAFRKYPSFQKAKVVRESRTNKSKGYGFVSFRDSEDYVRAMREMDGKYVGNRPIKLRKSAWKERNIDVIKQKRKQKK...................................................................... 297
18 -43.600[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  14  2..............................................................................................................NGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEIN-----------------VLRDRSQNQSKGCCFVTFYTRKAALEAQALHNMKVLPGMHHPIQMKPADSEKNNAV--------EDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGP-DGLSRGCAFVTFTTRAMAQTAIKAMHQAQTCSSPMVVKFADTQKDKEQKRMAQQLQQQ...................................................................... 204
19 -43.200[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  12  437LLPSKDIEKNPKEDLDENDASLSFKEKKALKLKKNAQKPIGWNTLFLGANAVAEILAKQFKTSKER-----------DTSDGGSSAAVRLALGETQVVIEMKRFLEEEGVRLDAFDEPAKKRSNTVILAKNLPAATEISEITPIFSRFGPIGRIVLP-----------------------PSGVTALIEYCDPLEARQAFKLAYSKFKNAPLYLEWADAKPDEEDSRAEDADDEPEPNTTLFLRNLNFKTVQETVEKHFRHLGSIHTVEIAKRRDPFKSLGYGFIQFKKSSVAEHALKNLQLTHIDGNPVELKRSDRVLKTQDNQRRLASQKKQTGTKILVRNIPFQAQYREVRDIFKAFGELRSLRIPKKATTDAHRGFGFVDYMSKAEAKRAFDGRRLVLE 862
20 -42.800[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  15  1................................................................................................................................................MSDNDIIDD-----------------DVLNIEDMTGDDADLSAIELNEIEEEQKKLKAIQNEMVGHMNLNTSSQSNSSQSLLTP--EEKAEADAKSVYVGNVDYGATAEEIEQHFHGCGSVSRVTIQCDRFSGHPKGFAYVEFTEKEGMQNALA-MTDSLLRGRQIKVDPKRTNKPGMSTTNRPPFRGRGGRGR................................................................. 176
21 -42.400[A] KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1  ali follow..  14  6.....................................................................................STGATAVATLRETSPPVDGHEEARLNADSDDGSHGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNEC-----------------MVMRDPATKRARGFGFITFVDPSSVDKVLNNREHELDGKKIDPKVAFPKRTQAKLVT--------KTKKVFIGGLSATSTLEDMKQYFETYGKVEDAMLMFDKATQRHRGFGFVTFDSDEVADKVCEI-HFHEINGKMVECKKAQPKEVMLPVQLNKSRAAAARNLYGMPPE-----TLLAYAQYLPRFGGNLMYPNFTNVFNNMPGGYSGLSTPGGSSNRPPHQF...... 286
22 -42.200[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  12  3IDSQQKTSKFRWGEMDEDEDLDFLLPPKQVIGPDENGLKTTIEYKFNDEENKVKITTR------------------RVRKLASARLNKRAMERRNWPKFGDAANEEAGSHLTMVSTEEILLERPRAPGTKADESKATGDGLSQLGKGGAVLMVCR-----------------ICHKKGDHWTSKCPYKDLAAPTDVFIDKPPTGESSTMSAAPGTGKAARAGADRSAVGSDMRRRNDENSVRVTNLSEDTREPDLMELFHPFGAVTRVYVAIDQKTGVSRGFGFVNFVSREDAQRAINKLNGYGYDNLILRVEWATPRPT................................................................................... 294
23 -40.600[R] KOG4733 FOG: RRM domain  ali follow..  16  22....................................................................................LQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTK-----------------AILDKTTNKCKGYGFVDFDSPAAAQKAVSLKASGVQAQMAKQQEQDP-------------------TNLYISNLPLSMDEQELENMLKPFGQVISTRILRDS-SGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPN..................................................................... 235
24 -40.400[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  11  4.....................................................................................................................GTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQ---------------GIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALK-KHKERIGHRYIEIFKSSRAEVRTHYDPPRSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVR-------GPDGRVTGEADVEFATHEDAVAAMSKDKANMQ 353
25 -40.200[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  16  17..............................................................................................................................................................................................EDGDQGIVRLKEKAKHRKGRGFGSDSNTREAIHSDDELEPGPQRSVEGWILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDRRTGFSKGYALVEYETHKQALAAKEALNGAEIMGQTIQVDWCFVKGPKRVKKSEKRRR........................................................................ 165
26 -39.800[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  13  15...................................................................................QKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMM------------------DFNGNNRGYAFVTFSNKVEAKNAIKLNNYEIRNGRLLGVCASV-----------------DNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSDKTKNRGFAFVEYESHRAAAMARRKLLPGRIQGHGIAVDWAEPEVEVDEDTMSS-------VKILYVRNLMLSTSEEMIEKEFNNIKPGAVERV------KKIRDYAFVHFSNREDAVEAMKGSPIEVT 299
27 -39.700[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  15  3.............................................................................................................................RVYIGRLPNRASDRDVEHFFRGYGKLSDVIM-------------------------KNGFGFVDFQDQRDADDAVDLNGKELCGERVILEFPRRKVGYNEERSGSGFRGRSTRFRLVIDNLSTRYSWQDIKDHIRKLGIEPTY----SEAHKRNVNQAIVCFTSHDDLRDAMNKLQGEDLNGRKLKCTDETRDRSRSRSPRRRSRSRSPTRS.................................................................. 206
28 -39.400[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  16  4....................................................................................................................................................................................................................SVELSSYRDQHFKGSRSEQERSLRDSCTLYVGNLSFYTTEEQIHELFSRCGDVRVIVMGLDKYKKTPCGFCFVEYYVRSEAEAAMRFVNGTRLDDRLIRVDWDAGFVEGRQYGRGK------------TGGQVRDEYRTDYDAGRGGYGKLLSQKIAPNTDNR............................ 154
29 -39.300[AR] KOG1365 RNA-binding protein Fusilli, contains RRM domain  ali follow..  13  131..............................................................................EDDVAIARAILDMDDELLEKTHQFVNIEYQPAPILEDQEVGADGDNVVCRARGLPWQASDHHVAQFFAGLDIVPG-----------------GIALCLSSEGRRNGEVLVQFSSQESRDLALKRHRNFLLSRYIEVYKAGLDEFMHGSSTEAMEFVSANAIIVRMRGLPYDCTDAQIRTFFEPLKLTDKILFITRTD-GRPTGDAFVQFETEEDAQQGLLK-HRQVIGQRYIELFKSTAAEVQQAVANAVEAPEEKKKDCVRLRGLPYEATVQHIVTFLGDFATMVKFQGVH-NNQGHPSGEAFIQMINEQAASACAAGVH.... 449
30 -39.200[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  10  2........................................................................................................EKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGV--------------------PHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTNGSLTQTEGGAQTDGQQSQTQSSENS-----ESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNE--RGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANG....................................................................... 203
31 -38.000[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  17  2.........................................................................................................................................................................................................................................SMTAGNVVFVGNIPYDVSEQQMTEIFNQVGPVKTFKLVLDPETGSGKGYGFCEFFDSETTAMAVRKLNNSELGPRKIRVEFPSNDPRRNQSYEYTERTDRYMEQ.................................................................. 105
32 -37.500[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  17  2..................................................................................................................................................................................................................................SCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPLEPHTKAPRGFAFVRFHDRSDAQDAEAAMDGAVLDERELRVRMARYGRRDLPRSSQEEPRGRSWGG.................................................................. 112
33 -37.200[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  19  2.................................................................................................................................................................................................................................NKRNHIRLPPEVNRLLYVRNLPYKITSDEMYDIFGKFGAIRQIRV---GNTPETRGTAFVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYQSNKAFKRVDMDKKQEELNNIKA................................................................. 111
34 -36.300[D] KOG4660 Protein Mei2, essential for commitment to meiosis, and related proteins  ali follow..  14  62FDESSPNLNKLVIGNSEKDSLEDVEPDALEILLPEDENELLPGLIDELNFTGLPDELDDLEECDVFCT---GMELDVESQDNHAVDASGMQISDRGAANAFVPRKRPNTAGRVSVEHPNGEHPSRTLFVRNINSSVEDSELSALFEPFGEIRSLYT----------------------ACKSRGFVMISYYDIRAAHAAMRLQNTLLRKRTLDIHFSIPKENPSEKDM--------NQGTLVIFNVDTTVSNDELLQLFGAYGEIREIR-----ETPNRRFHRFIEYYDVRDAETALKALNRSEIGGKCIKLELSRPGGARRLSVPSQSQDLERTE................................................................... 362
35 -35.700[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  11  56......................................................................VTAEATEGKESSNGEDRHTKRLYESTSAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKNID----------NGTPRIKIYRTEDGTPKGDALIVFFRSESVELAEQFDDTEFRYGSGQKMRVQKANIDYKKEKTVNKDVGGANKIVVLKHI-LIDLKDDITEEAEKCGRVTNVVLYDKE----PDGVVTVRFSNNEEAEACVRLMQGRYFDGRVVEASIYDGKVRFQKSGKHTLDDEEDEEKR................................................................. 355
36 -34.700[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  15  2.........................................................................................................................................................................................................................................AAFSRSAGPILSLN--QEDAELQKEVAQCDTVTRFRLSRKKRTGNSKGYAFVEFESEDVAKIVTETMNSYLFGERLLECHFMPPEKKMESISKTNHRMSTKGQVLRKKKKKVLGTPD..................................................... 117
37 -34.200[J] KOG0129 Predicted RNA-binding protein (RRM superfamily)  ali follow..  331ISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHK----------------ESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISA-RFVQLQHGEIDKRVEVKP..................................................................................... 642
38 -33.700[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  19  170.........................................................................................................................................................................................................................RAGARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLRELLFPFAPIPRVSVVRNKETGKSRGLAFVTFSSEEVAEQALRFLDGRGYMNLILRVEWSKPKVKE.................................................................................. 274
39 -33.700[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  10  102..SGENKSSRSPSWAREARRSRSRSRDRRGGRSRSRSPSRRRTSRDRRDDRSSRRRRDRSHSRSRSPPSSANGSSHWSSSNRHSRRRRSRSYSRERDRNSRRDDRRSNLSNNDRYSDWNPGVPSNKLAILNMPNDVDNTKITLSLGKCGYLPQ--------------DVRTMTKFDKNTKQIRTFAFVEFSNRETAEQWMTDYEGWLDGRTLAVEYAKGDPAAGSGNKGDHMVGMTPCDTLLIRGLPDGINNSLIFDSLGALVCLSSISMIK---LSESKRFAYLQMKSADEAKMLLNLTYKSRIKDKDVQVSWCRD...................................................................................... 440
40 -32.900[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  12  185FDAEQQKRQSTQHSTVDKKDYSKQQIEVDINVGLSNCYNVKATCQQNLLSHANGRKHRENVELFDATQQQQLEKTTVDKKDTTVNASDGNSEQKKVDLLVSSGVANGYSQAHKKRKLETCDETWKREVVQAEEAKGGGEQKSESKKAKKQDKE-----------------KRKKDKKQTKSDSDFEHDKEDIKQLLVAYSKEELVNL------IYKTAEKGSRLISAILESADRDIAQRNIFVRGFGWDTTQENLKTAFESYGEIEECSVVMDKDTGRGKGYGFVMFKTRKGAREALKRPE-KRMYNRIVVCNLASEKPGKAGKEQDMAEP........................................................................ 499
41 -32.700[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  13  32.................................................................................................SSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLM------------------------KGKNQAFIEMNTEEAANTMVNYTSVTPRGQPIYIQFSNHKELKTDSSPNQARAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQ----FQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRD...................................................................... 274
42 -32.500[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  17  2...................................................................................................................................................................................................................................EIKPTPSPPEERTIYVANFSEEVDEELLEELFIQAGPVVKVILRDV--RDSNAKFALVEFEDELSVLFAIELMNGVRLFNQELQVKPRNGTNQEELYKRKKGEIEERVRS.................................................................. 109
43 -32.300[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  16  4........................................................................................................QPVPGSGFHYLNSPFGDTTFTKVFVGGLAWETQSETLRQHFEQYGEILE-----------------AVVIADKNTGRSKGYGFVTFRDPEAARRACADPTPIIDGRRANCNLASLGRPRPPL----------PYAVIPNMPDLLPRTLEMCRVLEVHLLEIIRISNHFHITTSKELSILMVTAYGPEYMYSQ........................................................................................................... 168
44 -32.100[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  20  2..............................................................................................................................................................................................................................................SRVYVGNLDPRVTERELEDEFRSFGVIRSVWVARR-----PPGYAFLDFEDSRDARDAIREVDGKNGWRVEQSHNRGGGGGRGGGRGGGDGGRGRGGSD.................................................................. 95
45 -29.000[R] KOG4307 RNA binding protein RBM12/SWAN  ali follow..  480VFGPGGIHMHTIIRLDSIADYATMMRRNGEQKIQQSDKKSFDTAIDGIPIPSVSMVPSKEQRSHEDDDKKSRRSRWENTSPIRSPRRSPLRRDNRDRSRSRSPPRRRRRSRSPRRREEHTDPTRWCVQVTNVPFRMKDEELLEWFSE------------------KVRPAKLTRTFYSDGNASDRWVAEFSSESLMKRSFGIRTL-CTGRTLRLRYIDNAKADESELMELIKSIGPRGTVLSCNGFPKDVTLEDVVEFFNDYE--NSIRIRRGDD-GVMTGECMLACQNQENARRASMDLDGQKLRNSVISV........................................................................................... 945
46 -28.200[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  22  29.......................................................................................................................................................................................................................................HSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYRAPKDSEEIDDVTRQLQEK.................................................................. 134
47 -27.700[AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains  ali follow..  14  259.................................................................................SVRDKEDQWTVSVQRQLVYRPSTEAGHNNKELPPPLPPRGACPDDEAVHQKPAPGHRAGDPLSFQAVGKVLECDI--------------------------KNYGFVHIEDKTAAEDTIHLHHYKLHGVNINVEASKNKSKA--------------STKLHVGNISPTCTNQELQAKFEKYGPVIECDIV--------KDYVLIHFIHMECCPQARLRTAPGMGDQCGCYQCKKEGHWSKECPVDRTGRVAD...................................................................... 465
48 -25.200[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  13  13.................................................................................................................................................................................STGTGSGAGSGGALEEEPQNLGFRGQSCELEAGIHRGIIQWDHPPPPCHRFVHELKTRPGVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTAR----QPVGFVIFDSRAGAEAAKNALNGIRFDPQTLRLEFAKANTKMAKSKLMATPNPSNA.................................................................... 188
49 -24.200[A] KOG0533 RRM motif-containing protein  ali follow..  54..........................................................................................................................................................................................................................KDLDAVQNHGISSRGNDSKVIRVNISNLAPTVISSDLEELFGDYR-LSSVSVNFNE-HGDSLGTGDISLTKRD-AERLVQKFSGVALDGKIMKFAVIDSSNMAGRVDFGNRSRSSPGRSSRGFQSGPRRNNGKPEDFLRDGVHAGDIKRGGAGRGGFRKGGRGGARDAKPKKTEAELDAELEAY. 234
50 -21.500[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  18  208........................................................................................................................................................................................................................AEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPR------QQCAFVQYTKRNAAELAAERTNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFD....................................................................... 318
51 -20.400[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  17  71........................................................................................................................................................................................................................SGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGDLQEVKFFENRANGQSKGFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQKTRPVPPPQQ.................................................................. 193
52 -20.100[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  12  233.ESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKF----------------------------------------------------------------DFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSS................................................................. 505
53 -19.800[R] KOG1995 Conserved Zn-finger protein  ali follow..  13  258........................................................................................................................................................................................................................YEDAATEKVKQCDADCDDNCDNARIYISNLPPDVTTDELKDLFGGIGQVGNIKIYTD-EKGNYKGDACLAYEDPSAAHSAGGFFNNYEMRGNKISVTMAEKSAPRAPTFDQSFIILVGNMSFCNAKFMFLVSEDCLDLVSYWGFALYTHLGMECRRGGGRGGGGGGYGGGGGDRRRDNYSSRKLIFN 484
54 -18.800[T] KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains  ali follow..  11  154.VQPTEQVDEVAEPVTIPTQQPEAKQTTENTVKKPERAVANGHPKTQEDNVVNDKSNGVDAPKKSFAHIVQDLAQNGATFNAKASPAKPKSKPVTKPSAARESKAPAPVSEHSSAATIDQQAEGYTIFVANLLMDATPEQLNETFKGFGAITKDG-----------------IQVRSYRLKGNCFGFVTFASAEAVKLVLQESAIRIGNRRVSIEEKRGNNDNGRPAMRNGGYRNDNGY.................................................................................................................................................................... 377
55 -17.900[K] KOG2068 MOT2 transcription factor  ali follow..  12  60.............................................................................................................................................................................................YDKEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRKPLTSVRVVQRNLVYIVGLPLNLADEDLKEYFGQYGKVLKVSMSRTQQFPNNTCSVYITYGKEEEAIRCIQSVHGFILDGKALKACFGTTK..................................................................................... 196
56 -17.600[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  12  13....................................................................................RKHRSRNTEKKKKPRRRERRMKQLVCIKSPWNRFKGIMLQLRLLLNDNKLKPDSQGMFPPFSPHHWHLRVKDQRIRDEERSK---------EMEKGKTRNIHFVEELKREQEIRERRSRDHNSDNTSSSRFDELPDYFDPSGRLGSLDDGDPQTTNLYVVNLSSKVDENFLLRTFGRFGPIASVKIMTEEEKRRERHCGFVAFMNRADGEAAKEKMQGIIVYEYELKIGWGKVVF.................................................................................... 254
57 -17.500[K] KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif)  ali follow..  13  1.............................................................................................................................................................................................MQSEESHELTDGISEEKESKETMKSQKADRKKKKLKEKLLKEASKADNRGVCYLSRIPPHMDHVRLRHILAQYGELGRIYLAAGGFRGQRFSEGWVEFAKKSVAKRVADMLNGEQIGGKKKS............................................................................................ 143
58 -16.900[R] KOG2135 Proteins containing the RNA recognition motif  ali follow..  345.......................................................................................................NIRGRGGFARGGFTGAINRDNCTLQVAKIPPENTIAKLNEHFATFGTVDNIQV---------------------RYNGEIDSALVTYASKFDAGKAYKSPTPVLNNRFIKVFWHNPGGEGSENATGKPSSPTSPPSVVIVRGVTDE-LVTDLMAHMEKFGEVFDHSVKADDDGLIT---AVFPFRKTGDALKAMA--DGKVLNGVDLEMELKTERIEEIPSTDTNMSADQLLAA.................................................................. 703
59 -16.800[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  24  99...........................................................................................................................................................................................................................................DPFRTLFIARINYDTSESKLRREFEFYGPIKKIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKIDSKRVLVDVERARTVKGWLPRRLGGGLGGTRR.................................................................. 200
60 -16.800[A] KOG1996 mRNA splicing factor  ali follow..  10  88.SAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPDRPRSPTGPSNSFLANMGGTVAHK-----------------IMQKYGFREGQGLG----KHEQGLSTALSVEKTSKRGGKIIVGDATEKGEAQDASKKSDSNPKCPTKVVLLRNM--EVDEDETKEECEKYGKVGKCVIFEIPGAPDDEVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDK.................................................................................... 395
61 -16.700[TR] KOG4019 Calcineurin-mediated signaling pathway inhibitor DSCR1  ali follow..  10  5........................................................................................................................................................................................................................................DLQDLPSATIACHLDPRVFVDGFESLFRTYDKDITFQYF------KSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQ...................................................................... 104
62 -16.100[A] KOG2202 U2 snRNP splicing factor, small subunit, and related proteins  ali follow..  17  43.............................................................................................................................................................................................................................................SPTLLLSNMHFEDFFEDLFEELGKFGEIESLNICDNL-ADHMIGNVYVQFKEEDQAAAALQALQGRFYSGRPIIADFSPVTDFREATCRQYEENNCNRGGY................................................................. 167
63 -14.300[R] KOG2295 C2H2 Zn-finger protein  ali follow..  10  288.AEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEK--------DRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPE-------IKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNLAPSITRSEIEAVCNRFSGYLRVAIADPLVERRWYRRGWITFMRDVNIKEICWGLNNQRLRDCEMGAIVNRDLSRR.................................................................................. 597
64 -13.800[J] KOG2314 Translation initiation factor 3, subunit b (eIF-3b)  ali follow..  16  1..........................................................................................................................................................................................MAAVVDIDVLTAQLGINWSDVNLDSIQLPPGNDFGIESDDESVYQDDQSE-GNIIVVDHLPFEKLEGVVKKIYNQLGVIKGLLMPVDPDTKMTLGYCFIEFNTPQEAQNAKEKSHGYKLDKSHI............................................................................................. 136
65 -13.000[A] KOG4676 Splicing factor, arginine/serine-rich  ali follow..  18  32.............................................................................................................................................................................................................................................TEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPVSSRVCFVKFHDPDSAVVAQH-LTNTVFVDRALIVV.......................................................................................... 108
66 -12.200[A] KOG4213 RNA-binding protein La  ali follow..  12  19..........................................................................................................................................HQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISE---DKTKIR-----RSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHK-AFKGSIFVVFDSIESAKKFVETPG...................................................................................................... 172
67 -11.300[R] KOG4198 RNA-binding Ran Zn-finger protein and related proteins  ali follow..  15  220......................................................................................................................................................................................................................SLPSVLTQPINCQADARSFYAERSKIVHVAGLTNDVTQLELESWFTNHGHPVALWTLKTPEPYKSTGTGFVLFASHEDAADALA-FNGYCLGDRMLEIIPSSTKVLDKASDILIPFPSSKNRPR................................................................. 343
68 -11.200[R] KOG1855 Predicted RNA-binding protein  ali follow..  13  255................................................................................................HQEQDTEPQGPNEIDTLDPSLIPSEELAAEI-TDAVEFYFSNESIKDAF-----------------------LLKHVRRNKE-------GFVSFKRVRQLTREWKVVGDAVRRKSRKIELNDVGTKVRRIEPLPSFDETMPSRTIVACDLPLDLTIEKVSDLFSPCGEIALIRILKPGMAIPVKECALVEYLESSSARDARHLNG...................................................................................................... 450
69 -10.200[A] KOG4008 rRNA processing protein RRP7  ali follow..  10  39.......................................................................................................................................................................................................................................KKDPSKENSIIVSNIPAFVGEGVVLAIIDQFASFEVEESFVQRSN-QGQLTMSITFDKPEAVIQTLALCQ...................................................................................................... 114

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.