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Query: [T] KOG4225 Sorbin and SH3 domain-containing protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYLLast
1 -164.000[T] KOG4225 Sorbin and SH3 domain-containing protein  ali  100  1MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
2 -61.400[T] KOG4348 Adaptor protein CMS/SETA  ali follow..  24  3..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHERCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKIDVGWWEGEL--NGRRGVFPDNFVKLLP. 327
3 -59.800[S] KOG2995 FOG: SH3 domain  ali follow..  30  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVSVPLPMPQCIA-----------MYDFKMGPNDEEGCLEFKKSTVIQVMRRVDHNWAEGRIGQ--TIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPSTALKPTSAPQTSRVLKTTVQQQMQPNLPWGYLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGK-NWLDITGVFPGNYLTPLR. 342
4 -47.700[T] KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains  ali follow..  19  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEDYVVVKYDYLAQEEQELTIKKNERLKLLDDSKNWWKVMNDSNSVGFVPSNYVRKESIVDKAKGTIKGLARGRNRSKAVVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEA-PNGGVGWFPSNYVEEVEASTNGNQGS------IENRNPAAAAVPAPIMMQAPPPKLQASRSSFEIQVVVALYSFDASSSEELSFKKGERLEIVDHPDPDWWMAR-NASGTTGLVPRNYIEVVV. 274
5 -47.700[T] KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains  ali follow..  22  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ESVALYSFQATESDELAFNKGDTLKILNMEDDQWYKAELRGVEGFIPKNYIRVKPHRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-----FLWEEKFNSLNELV----------------------DFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRS--CGRVGFFPRSYVQPVHL 217
6 -43.800[Z] KOG3565 Cdc42-interacting protein CIP4  ali follow..  14  334...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSML--------QSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNK-DDGFWEGEF--NGRIGVFPSVLVEELS. 572
7 -42.800[T] KOG4792 Crk family adapters  ali follow..  15  53..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPAPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAE-DSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGPPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGGC--NGKRGHFPFTHVRLLD. 295
8 -39.800[C] KOG4773 NADPH oxidase  ali follow..  16  4....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IKRTWKTHSRILDKDPFSIEPPRKVIRALYDYTARKATEVSFAKGDFFHVIGRNDKAWYEVCNPAAGTRGFVPVSHFEEIGKTVKSERD--------SDGSGQISFTDLTTNSSTTRSSISELHSGSQPLFGIVQFDFAAERPDELEAKAGEAIIIIARSNHEWLVAKPIRLGGPGLIPLSFIQLRD. 184
9 -31.600[T] KOG3775 Mitogen-activated protein kinase scaffold protein JIP  ali follow..  12  302.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGWRGSLGEPPPPPRASLSSDTSALSYDS------------VKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVT. 548
10 -30.300[TZ] KOG2546 Abl interactor ABI-1, contains SH3 domain  ali follow..  24  369....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SQSPPLPPPPPPEDEHQDFGRPRTSTGPQLAPIVPEDQNLPGWVPKNFIEKVVAIYDYYADKDDELSFQESSVLYVLKKNDDGWWEGVM--DGVTGLFPGNYVEPC.. 472
11 -30.000[IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation  ali follow..  29  262......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGM--LDGQSGFFPLSYVEVLPL 366
12 -28.900[Z] KOG3655 Drebrins and related actin binding proteins  ali follow..  19  426....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEVRTKVSVTVQQSQSVKSSGMSTLERNALTDLVNEDDFICQETLGDLGQRARALYDYQAADETEITFDPGDVITHIDQIDEGWWQGLGP-DGTYGLFPANYVEIIN. 531
13 -25.000[U] KOG3875 Peroxisomal biogenesis protein peroxin  ali follow..  21  255.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STHSDEVTDSINWASGEDDHVVARAEYDFAAVSEEEISFRAGDMLNLALKEQQGWLLASLD-GQTTGLIPANYVKILG. 335
14 -24.900[G] KOG3734 Predicted phosphoglycerate mutase  ali follow..  16  65...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQNKAHNIFP--------------HITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKEDSAEVLFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVSRDIRFANHETLQVIYPYTPQNDDELELVPGDFIFMSPSTSEGWIYGTSLTTGCSGLLPENYITKAD. 307
15 -24.200[T] KOG3725 SH3 domain protein SH3GLB  ali follow..  12  255..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QLMADLQRELSGTMSFRGSSAILVNNSGDPPNGRTMAAAIAAAKPSGLLPDDLGTKQAKVIMDYDAVLPQEISVTQNDILIVYRGMDAEYVMAE--KGGKRGKLPVSYIELL.. 366
16 -24.200[TUZ] KOG2856 Adaptor protein PACSIN  ali follow..  24  380....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDQGWCKGRLD-NGQVGLYPANYVEAIQ. 486
17 -24.000[U] KOG3771 Amphiphysin  ali follow..  19  363....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPF-DEGWLMGHKELEKCRGVFPENFTERVP. 482
18 -22.700[S] KOG1843 Uncharacterized conserved protein  ali follow..  26  325....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YSDEDEESVYSSDVSTESSSQFSSRSSEYSKPSRPTAPKPKFKQDSLGPNQARAMYSFAGEQPGDLSFQKGDIIDIVERSGDDWWTGRI--GYREGIFPANYVKL... 429
19 -22.700[D] COG5279 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain  ali follow..  33  14.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VKARYGWSGQTKGDLGFLEGDIMEVTR-IAGSWFYGKLLRNKKSGYFPHNFVILLE. 69
20 -21.200[TZ] KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover  ali follow..  17  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKALYDFQAVYPKTISFDEGEYFILYQT-QRNWWQVV-SMKGNIGFVPSNYVMKIK. 58
21 -17.900[T] KOG3557 Epidermal growth factor receptor kinase substrate  ali follow..  16  474....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRS--RSGQAGYVPCNILGEAR. 578
22 -15.300[U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins  ali follow..  24  4......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGRALYDFHSENKEEISIQQDEDLVIFSESLDGWLQGQNS-RGETGLFPASYVEIVR. 60
23 -14.100[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali follow..  16  610..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ALHEGPPLQLQAGDTVELLKGDAHSLFRNLASGEVGFFPSDAVKPCPCVAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRD---------GFFHIAENRKFKSLMEEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMANGWWRGEV--NGRVGWFPSTYVE.... 844
24 -13.600[T] KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase  ali follow..  10  33....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKFSPSRRLESRELALAQPHFRALLRAHDALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEQLVVARILAGG--VIDKQSMLHVGILEVNGTPVRTPDELQVEVSRAKENPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSDLPFKSGDILQIINVKDPNWWQAKNAESDKIGLIPSQELE.... 286
25 -12.200[PT] KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit  ali follow..  15  5............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SYLPGFEDS------------EAGSADSYTSRPSLDSDVLEEDRESARREV---------------------ESQAQQQLERAKHKPEAFAVRTNVSYCGVLDEEVNFEAKDFLHIKEKYSNDWWIGRVKEGGDIAFIPSP....... 120
26 -11.100[T] KOG0197 Tyrosine kinases  ali follow..  21  12....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLA-RSLVTGREGYVPSNFVARVE. 117
27 -10.800[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  8  633IAAETVYKTVQKLQGLLSKYAAGQELMQRQREEQLKYWLD-KKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAAAPTHPHPHRPPPPPPP................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 954
28 -9.830[T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins  ali follow..  22  710....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDVHPSQEPGWLEGTL--NGKTGLIPENYVEFL.. 814
29 -9.050[S] COG5373 Predicted membrane protein  ali follow..  11  19........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GGRRSAERLDREIESLKAEIARLAKEGMGEPGPDLATGRPSEAGVPSVAGTEATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWP------WVGG--------------------------------------------LALALGGYFLVQYSIEAGLLSPAVR----FGLALGVAGEVIRRRDVPAIADRFRNAMIPGVLTAAGAVT------------------GVVYAAYGIYDFIGTG---LSLLHGQALAGL---------------GLLASLP-GFLAVAWL 279
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.