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Query: [T] KOG4269 Rac GTPase-activating protein BCR/ABR, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDVLast
1 -192.000[T] KOG4269 Rac GTPase-activating protein BCR/ABR  ali  100  1MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV 859
2 -69.100[T] KOG1450 Predicted Rho GTPase-activating protein  ali follow..  16  2..............................................................EETAKKPASATVSAKSSHDGGTDDLAHLFSTPEIKKVLNSD----VAINALLSRLK---------QSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFFN-IQGSTNSSLKKMIHEVLGFDGKMAQVKQSYITALQKMYSEISSLLLTMTKLRKSVKENSKRLEKD--VSDAIHSAEKAQSRYNSLCQDWDKLRMTDPTKTKLTLRGSKTTKEQEEELLRKIDNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQK-------------YTIWTENLVLNTGVTISPLDSTKSMKSFAGSVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKKHPSMNHGQKNKSPPKFAVDPSRNSIPKRMISTHNESPFLSSSSNTAAVPNANLNSATPSLNTNKQLPPTMAS---------------------------------------------------------------------------------------SISSTSNAAGAMSPSSSIVTSDTTSSITKTLDPGNNSPQIPEELINSLDSDRPISHIQTNNNMPPGKNFKTFGVPLESLIEFEQDMVPAIVRQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMPHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDDAN------------DVNFQIMAMEVLLEVSDQAFEPE........... 666
3 -64.200[T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins  ali follow..  17  3..................................................................................................................................LPALEFSDCCLDSPHFRE-HEAELDKTNKFIKEL-----------------------IKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSL--------QEFATVLRNLEDERIRENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKT-------------------SPYTMEGYLYVQEKRHFGTSWVKHYCTYQR----------------------------------------------------------------------------------------------------------DSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGRPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASEDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETV---------AAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQL. 581
4 -61.300[T] KOG4270 GTPase-activator protein  ali follow..  27  140..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RRVAGTPCGVFGQRLDETVAYEQKLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSF--DRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTDEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMR--------GTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ. 359
5 -60.200[TZ] KOG2710 Rho GTPase-activating protein  ali follow..  25  188................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSL--EEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEP-EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSAR-AEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISL 413
6 -56.900[T] KOG4370 Ral-GTPase effector RLIP76  ali follow..  28  169...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKKPIQEPEVPQIDVPNLKPIFGIPLADAVERDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREE---STNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISN-----------------------RVLYVFFTHVQELFGNVVLKQVMKPLR. 381
7 -52.100[TZ] KOG4406 CDC42 Rho GTPase-activating protein  ali follow..  25  237..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PPAQPLPTQQFGVPLEFILSHCGGNIPPIVDQLIEYLEAHALTMEGVFRKSANIGSIKRLQDRINKGEKDFENDPEYKDNEYVSVLLKTFFRSLGEPLTTNRLYPKLAALSEVSK-TEKSAAVKEFVKLLPRENYILLKTVIKFLTRVAENSKVNLMTANNLSVVFGPNLTWPTDQEVP----------ISQLNNLNNFCYKLIVDYDSVFDH............ 444
8 -47.800[T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1  ali follow..  22  533..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQ--SAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATENLAAAQGLAHMIMECDRLFEVPHE......... 755
9 -46.600[T] KOG4637 Adaptor for phosphoinositide 3-kinase  ali follow..  20  101.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSKTEADVEQQALTLPDLAEQFAPPDI-APPLLIKLVEAIEKKGLECSTLYRTQSS-SNLAELRQLLDCDTPSVDL--EMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISAPEVQSSEEYIQLLKKLIRSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEIL.................................. 293
10 -44.700[T] KOG4724 Predicted Rho GTPase-activating protein  ali follow..  21  137..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SPTSPMPGQLFGISLPNIC--ENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGV---EVHLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENE-------FTKKVSLLIQFLIENCLRIFGEE........... 338
11 -40.100[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  11  288...............EDNFALPTGKLHRKPLESSSVSSPIGKSLRSQNSRSLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKEALECEI-SHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNNDDKNLDFAQVWIDAKEEMKAYPQYINSYDTIKRLFDKQDRENSKFHTFCKAKE------SNPEFHRLKLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKNN--AEEAAKAIDEVLKTANKTREKNDNFIPILVAANRMFIRELVVSPIASQQFAKMKLFLFHDVLIITKIRSEKNTMQR..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 637
12 -38.900[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali follow..  16  116IQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQFYCKLL--EEANRGSFPAEMVNKIFSNISSINAFHSKFLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQ------KQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSEIYEMLGEEEDIVNPSNELIKEGQILKLANTSAQERYLFLFNNMLLYCVPKFSLVG--SKFTVRTRVGIDGMKIVETQNEEGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVS........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 545
13 -35.800[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali follow..  16  132..............................EESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKFMAPLK-------RFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKN-DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECS------KRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTT-DPTEKANLKLALDAMKDLAQYVNEQFQLSIENLNQPVLLFGRPQGDG-ITTLDKHTKQERHIFLFDLAVIVCKRKGD------NYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKEQFEMALSNIRPDYADSNF........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 513
14 -33.100[T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases  ali follow..  13  395....................................RRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREW--KRQEIIFEVIYTERDFVRDLEYIRDWIKPLSTSNVIPENNRQ-QFIRCVFHNIMQIHAVNSRLSNALNRTQTLQPVVNTIGDLFLDYVPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHEVE------RLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSTLFDPSRLLIFKGVVKLKASSYSNGDHMFLLDNFLLLCKIKIQMKRRVHKLHLR--LPLELLSISYIEDSPSRGSLPRRPSSALLTNPISITKSNPPPVK------------------------------GLQLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTGNKLLCAVA--------------------------YDAGRKLLFGTYKGLYISSRKSNNGSCLEPIFKLQLPNISQLDVIEEHNVLLLLAEKI---------------------ELPLDALDSVEQINSKSLRRVTGHVSFVKTGFCMQRILVCAVKSTVLNTTLRI-YEADRALKNKKMPHFLKTKLCVGSFKGFDIISL-----ENAVFQSL----NPADTSFRFLEKREDIRPIA-----MFRLRGEFLLCYSDFAFFV------NTNGWKSRQSWMINWEGQPQGCALCYIL-EIRNAETAELVQIIMGQNIKLLTDGRGLISEGGEILYSTEPIPFSSGENP-----IVHSLIL.................... 1148
15 -33.000[F] KOG2070 Guanine nucleotide exchange factor  ali follow..  15  213.....................................................PSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSYLRPLQ-----TSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMTLYLTYCANHPSAVNVLTEHSEELGEFME----------TKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELDDIKTLGNVTYMSQVLIQCAGSEENERYLLLFPNVLLMLSASPRMS----GFIYQGKLPTTGMTITKLEDSENMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPS.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 578
16 -25.700[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  16  486................................NNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKYLQDWK-----ERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRD---PGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQAT-HTYSLLASTQ-------KLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC-----DVKEVVEAHVIMRQVAHNIDQVKRKQEQQLGPELTVLGELRQEG---LLMEQHNKQRLVLLFATMLIITKQKEDG-----RLQFKTYISQNNLMLSEHLPGEPTS-----------------DEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGEC....................................................................................................................................................................................................................................................................................................................................................................................................................................... 863
17 -23.600[T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases  ali follow..  16  142LPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEFMKRIEEK-GVPEDMRGKDKI--VFGNIHQIYDWHKDFLAELEKCIQE---QDRLAQLFIKHERKLHIYVWYCQNKPRSEYIV---AEYDAYFEEVKQEI-----------NQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNGRLQGFEGTLTAQGKLLQQDTFYVIELDAGKERRVFLFEQIVIFSELLRKGSLTP-GYMFKRSIKMNYLVLEENVDNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRK................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 547
18 -9.330[T] KOG0521 Putative GTPase activating proteins (GAPs)  ali follow..  13  32.....................................................................................EQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKNA--HNALGKLIHCFQEMNKFHTILLDQASRTVLK---SVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPEMQEAANIL-----SASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYCDSNTNSTKIEGYLF----------KKKSKGFKTWCRRWFY-----------------------------LSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEV--------ISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPNNSLPAKRRIH---------------------------------------------------------------------------------------------------------------------------------------------------------------WEEFLKIPGNA---YCCDCINLGITLCIECSGVHRSLGHYSKVRSLTDAWESENVKVMMELGNEVVNRIARIGDDCGLKKPTEQCEIGVREAWIKAKYVE---------RRFVCGMPKPQ........................................................................................... 504
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.