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Query: [R] KOG4323 Polycomb-like PHD Zn-finger protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSQKNFFDEGKSYGVNDYAGFHFENGADSSLPQVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVFCDGCNSPYHQLCHHPPIDDATVQDVDAEWFCMKCQYRRAKQPLETGMTAQDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKDEIFNWLAQNVPLLPTFHDSASEAIRWMVNKGQLVRSGSIYQIATVEEYPHLQPSLLPTFQRNRKVPKLVPVSFPTDDPQNLCATVLLast
1 -118.000[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali  100  1MSQKNFFDEGKSYGVNDYAGFHFENGADSSLPQVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVFCDGCNSPYHQLCHHPPIDDATVQDVDAEWFCMKCQYRRAKQPLETGMTAQDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKDEIFNWLAQNVPLLPTFHDSASEAIRWMVNKGQLVRSGSIYQIATVEEYPHLQPSLLPTFQRNRKVPKLVPVSFPTDDPQNLCATVL 461
2 -37.500[R] KOG4299 PHD Zn-finger protein  ali follow..  10  75.SKDDLDYSPSVKRKHVNGEGAEKGDHDTSNNGPSITKLRRKVRRTYDTKDGFVAWNTLDDDFRPIVPDQERSRKINPQKGNNNNLLKENKSLKTTAKDLSDISSSSMKKANNSSKPLFSGKLTFKANIPVPTSEVVTENNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEEYPYRYNNDYCSACHGP-----GNFLCCETCPNSFHFTCIDPPIEEK--NLPDDAWYCNECKHH....................................................................................................................................................................................................................... 312
3 -30.500[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  30  326............................................................................................................................................................................................ECKCCNIC--GTSENDDQLLFCDDCDRGYHMYCLTPSMSE----PPEGSWSCHLCL......................................................................................................................................................................................................................... 375
4 -28.200[R] COG5141 PHD zinc finger-containing protein  ali follow..  12  118............................................................................................................................AIHPYSKTSFPVSYDLDELDTLSSNSEWENVSKEFLEIVLTIIERE-YLEAWMPKIEPVRVEDELDGRCVICNEAECENSNAIVFCDNCNTSVHQNCYGIPF------VPEGQWFCKKCLLAPHEVICCAFCPDRDGAFCTTLDGRWCH-----------TICAIAIPEISFHDTSRLDLVRNIASIPKSRWKLVCCICKLRWGTDKNCYAAYHITCARRAGFFYKIYSHSASYDSVDMETYCDKHTPPDYLNGLMKRLFPLAELYYKRMATDVPLNFQATKA...................................................... 399
5 -23.800[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  9  49MRKLDDRAQTAMKSIDSHAKDFMRKLGENGAMSEDERRERQEDIKALFGKAKEYSDDKVQLAIQTAKSKTVPKYLFFHKLTPSFDSICTEGRKKTKDSKTTGKKKKSASSDEETGRGNNQSNANSSVNSSSNAGQGSKKKKSKVNQEKETRKGGAQKKTVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYC-LCHQVS----GEMIGCDNCPI-FHFACVG------LTTKPKGKWFCPKCTQDRKKK................................................................................................................................................................................................................... 328
6 -23.200[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  10  33LKEIDAQVRDIRQNVIQLKEILPYSDSKICLATDAMNNIKSCIDRLDAGFEYVELEIPQQLRLGYPDDRALMNYHSTVTPQTSERRRETRRHQNNQHSQQYSSQERSSSYNNFEDASSPQSSYHTPTKRRKNAVPRKSSSPPLSSTKHAPQSTERRPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YCQQ----SYGQMIGCDNCKR-FHLPCVG------LVEPPKGIWYCKECEELAKSS................................................................................................................................................................................................................... 301
7 -18.500[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  15  263............................................................................................................................RTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELV----------PLMDESTRRATFGVECVICLESFTKGDKVVAL---CKHEFHRPCIAK-------------WICPTCNTE....................................................................................................................................................................................................................... 365
8 -18.400[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  9  1MGGKQSTAARSRG----------PFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMDPSTAGGVPFGLYTPASRGTGDSERAPGGGGSASDSTYAHGNGYQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDA-CVICLE-ELLQGDTI-----CLCIYHKSCIDS-------------WFCPEHPAD....................................................................................................................................................................................................................... 227
9 -17.500[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  7  308.......................................................................................................................................................LALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDNKNKKPKRL-----CGHILHLSCLK-------------NWMCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQH................................................................... 550
10 -17.400[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  23  90......................................................................................................................................................................................KESFTVMDSQCSVC--GDYQPNDKLQQIPVCKHTFHMDCID-------------LWLCPLCRLA....................................................................................................................................................................................................................... 144
11 -17.000[R] KOG1844 PHD Zn-finger proteins  ali follow..  12  10...................................................................................DTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVC-ICG---THDDGYMICCDKCSVWQHIDCMGIDRQHI-----PDTYLCERCQPRN...................................................................................................................................................................................................................... 167
12 -17.000[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  5  2.........................................................................................PPRRSYPFSGHGGTIARFIEFGEAFGHYGEEEDEEEEDEEEAYVDYGEVQEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSV---KFGPAVANTKSGILDSIVFPV-------------DTCFSSDEVEGSLRDVRKIYASRVAAVDDEAHKRILFLEAKLRSIE................................................................................................................................................................................... 188
13 -16.600[O] KOG0802 E3 ubiquitin ligase  ali follow..  8  327..............................................................................................................................................................KRIKGYIKLRIALGALHAALPDATSEELRAYDDECAICRE-PMAKAKRL-----CNHLFHLGCL-------------RSWLCPTCRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNN---------PVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVNFKCILDYL................. 594
14 -16.200[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  13  9.....................................................................................PSSDSESPGGLMTALSPMLEELESAQERIQERIRQLEVIVSRIREREITTTTTPALVSPNEHRDSTAGVIHERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNIC---EKAEDPILTCC-------HLFCWG-------------QLPCPVCDGE....................................................................................................................................................................................................................... 159
15 -15.900[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  10  102..............................................................................................................................................................ILAMVSRAEDSKDHKSGSTEEYPYDYLLYYPAIKCSTCRIVKPARSKHCSICNRCVLVAH-HC---------------IWI-NNC-------------------IGKGNYLQFYLFLISNIFSMCYAFLRLWYISLNSTSTLPRAVLTLTILCGCFTIICAIFTYLQLAIVKEGMTTNEQDKWYTIQEYMREGKLVRSLDDDCPSWFFKCTEQKDDAAEPLQDQHVTFYSTNAYDHKHYNLTHYITIKDASEIPNIYDKGT.......................................... 327
16 -15.600[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  22  294...................................................................................................................................................................................ARAILEKSDFTMDCGICYAYQLDGTIPDQVCDQCGQPFHQICL--------------EWLCPYCSKP....................................................................................................................................................................................................................... 365
17 -15.500[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  15  256..............................................................................................................................................................KQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKE--GHVCLCEDCAQKISVTC---PV-------------CRG........................................................................................................................................................................................................................... 327
18 -15.300[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  13  681..............................................................................................................................................................................SNEYISEHGGGTAEHTVDCAICIPETHKVDQHSYMVTPCNHVFHTSCLE-------------NWMCPVCRSP....................................................................................................................................................................................................................... 754
19 -15.200[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  17  202...............................................................................................................................................................QRRLRRHRLPKSMLKKLPVLRYTKNNANNKYDTCVIC--EDFIEDDKLVL---CSHPYHTHCIDP-------------WLCPICKRK....................................................................................................................................................................................................................... 279
20 -15.100[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  9  656IAEMETIGQAEDMQTQNQHLLQQVAERDDYNIKLVSESVKTKHAYNTHLSEKQVMEKQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEDRHLVISLETTKWEVADADKEFRWLKSAVSSSEKEYEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESV--EAAIVRLQEEVKNCKNILKCGVCFD---RPKEVVI----C---YHLFCQQ----QRSLEIRHRK--CPGCGTA....................................................................................................................................................................................................................... 888
21 -15.100[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  14  1.........................................................................................................................................................MSSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTC----IENQNCQIDKTQ--CPYCRFQK...................................................................................................................................................................................................................... 99
22 -14.600[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  10  666........................................................................................EGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFTEEGLCDHCKQTECDKKDGFGKCYRCSEAVHIKC---PLCHENFSPGEEAW--AGCTMNLRKTHILQKAPALQPGKSSAVAAS............................................................................................................................................................................................... 896
23 -14.100[R] KOG1632 Uncharacterized PHD Zn-finger protein  ali follow..  8  34...................................................................ENEAEQQCGLLTPWRKARARPHRAAKPKAEVKKEVINPADITLGGDTYDYVKEQKPTESIATNVSRRRRTSANLSKSEDDRDKPESQSTAPKSKERRTSEPPASHVAFHTPGSATPHDINLSIEHCTCQKIFD--ASKLYIQCELCARWYHGDCVGVAEQT----ILGLHWSCEECIEEQERV................................................................................................................................................................................................................... 211
24 -13.900[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  6  75.PVERDLSVESDSSSATNTSESSVGEASNQLQSPQSNNPLNMANLSVSTEDAHSQIRSLTQDVIQMEAELDRMNRYCEEVVAQIDTFATRTSTPTTRRIRRRTSPVEVIDLSHLDRAPPVRSARNRDPDAFIDLCTPEGPRSRTVNLHSNDSLTILPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVSKREPVSTKC-------HVFCRE-------------TAICPICNKK....................................................................................................................................................................................................................... 308
25 -13.600[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  18  45........................................................................................................................................................................................TDQDYDPNCSLCKT-TLAEGDTIRL---CLHLLHWKCFDEWAANFPATTAPAGYRCPCCSQE....................................................................................................................................................................................................................... 103
26 -13.500[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  11  1MEQKNLNINGSKINTELAVPIFQSRRRHRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDNIPIVSGRKKTVRLNRLQRESEQFENSALKDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIMVKNEKKEDIPFVCLICKK-----RSPIAT--TCG---HHFCEQ-------------TRYCIQCGAD....................................................................................................................................................................................................................... 294
27 -13.400[T] KOG3575 FOG: Hormone receptors  ali follow..  11  2..............................................................................................................................................................SPLKMHVNMLQSDHALIMSSFPEPSPSSKRPTENCKVCGDRPNNDRYGASACLGCTVFFRRACMK----EQNCLISCTY--CRYCRFQK...................................................................................................................................................................................................................... 95
28 -13.400[D] KOG3056 Protein required for S-phase initiation or completion  ali follow..  12  285LKEENERFEKKKQAEGHVLGSDNKKESEAGTPAVSMPTTPVPDKFKNRGFSFDASLTPKLSGSENFSFEINVGSRQAQNAKLKAAALLKKKPLEKINPNSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSAS------DRCKEQKHPQCKDCGNRTTTVFLPKQS--CKNC-QRTAMIREKKILTGRETLSVRGDEETFMGCLAGSANLNLLV------PD........................................................................................................................................................................ 579
29 -13.100[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  9  128.QDLSSNVQQHHFDIDRLISNHVER-------RMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNALRSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEA--------------------------QDTKKMCRVGMSMCRSCGKGEAS--RHMCLCSVCGSSLNT-C---PI-------------CKS........................................................................................................................................................................................................................... 323
30 -13.100[S] COG4393 Predicted membrane protein  ali follow..  11  224....................................................................RVHLARQHAVEQETHPIEKRKKRATLLTSSRLLQWGGVCVLFIFTAQLYWDKVASQPPRLSEAIPVHMDDKNQVYIPIEQVKDGKLHRFVWIADDGKAVR----FFLINRLPDRLSLAAVFDA-CILCGDQGYVMEGDQVICVGCGVRMFIPCNPVPIENWQQTDTQ.................................................................................................................................................................................................................................. 392
31 -13.100[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  21  259.............................................................................................................................................................................KNNQETKPSDDENSDNSNECVVC----SDLRDTLIL---CR---HL-CTS----ADTLRYQANN--CPICRLF....................................................................................................................................................................................................................... 319
32 -13.100[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  11  1..............................................................................................................................................................................................MPCESCGVE--------VFCFDCKRYYCANCIASRR-------------CKRCSVFAQRP----LSRTDLLKLKPKDLIFYLQSLEKEELVGLVLTHVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSD...................... 239
33 -13.000[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  17  3.............................................................................................................................................................................................NLNCVICAE-LFGQADEVF----CGHMFHHNCLNQ-------------WLCPQCRNK....................................................................................................................................................................................................................... 49
34 -12.600[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  7  2................................................................................................NEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARSSSTCSSLSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSC-----RQKNCLIDRTS--CQHCRLQK...................................................................................................................................................................................................................... 157
35 -12.500[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  18  107...............................................................................................................................................................................YGTHPGVGNGALNNYTFCNYCSKPKSPRTHHCRTCGMCDMDHH--C---P------------FI-GNC-------------------VGAGNHKYFIAFLISAVISTSYAAV.............................................................................................................................................................................. 183
36 -12.500[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  15  3................................................................................................................................................................................................CKKCKSNEYTNKQLVMMINECGHPLCKNCVDNIFALNSGN-------CHVC.......................................................................................................................................................................................................................... 46
37 -12.400[R] KOG4602 Nanos and related proteins  ali follow..  11  62.......................HWFTGVITPSPAIAIRLHCETPPASCPPPPEAPGWGALPSPPTPHIAMPGPRPPHPLTHPQCPLCDLRSERAVQEPLLLLRDQEAASRLHRRSLSPGSALAFGLPLAQLTSLPPFDMWKDYFNLSQVVWALIASRGQRLETQEIEEPSP-LGQDQGLGAPGANGGLGTLCNFCHNGESTPDGVVVVCPVCGAT-HKYC---PLNGG........................................................................................................................................................................................................................................ 289
38 -12.400[R] KOG1315 Predicted DHHC-type Zn-finger protein  ali follow..  13  78...........................................................................................................................................TLPQQPNQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCHLIKPDRCHHCSVCAMCVLKMDHHC---P------------WV-NNC-------------------IGFSNYKFFLQFLAYSVLYCLYIATTVFSYFIKYWRGELPSVRSKFHVLFLLFVACMFFVSLVILFGYHCWLVSRNKTTLEAFCTPVFTSGPEKNGFNL--GFIKNIQQVFGDKKKFWLIPIGSSPGDGHSFPMRSMNESQNPLLANEETWEDNEDDNQDYPEGSSSLAVETET......................... 337
39 -12.300[R] KOG1819 FYVE finger-containing proteins  ali follow..  8  380.GTNSNSSNEVTESPETIEEPDNVDMEESSESEVDTHIDETRNESDDEITDDVQASDVLQVETKKCKSSRLLEQKKFDKSVKTIIPMQTDPRSQIDPKNLRSRFRSSEDLVHRLFVCIAGVADQLQTNYSSEIRKVLKLILQPSEIIPVYEVVNAQVANSQTEGEETGVEAQETLPLPAFMGVRWVPDEDCQCTACSMPFNFVRRR---CRNCGRIFCHKC-----SCNTISIPE---VSSPQLLTRQDQFSCNLLHQSHHIHHLFNRSLVPHTYP......................................................................................................................................................................................... 658
40 -12.300[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  10  258................................................................................................................................................................EDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGG-----RQPVKTC--CNIDFSKEALENAL--------ESDFVCPNCETRDILLD---------------------SLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK...................................................................................... 441
41 -12.300[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  10  57.KSESSILQNLKKVAKPDSKLYFSSGPSKSSTTTSGAPERSVFHYDSSKEIQVQNDSGATATLETETDFNQDARAIRERVLKKADEALKGNKKKASDEKLYKGIHGYTDHKAGFRREQTISSEKAGGSHGPLRASAHIRVSARFDYQPDICKDYKEEEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICRE-----VDPVVT---CK---HYFCEH-------------KHHCFVCNQP....................................................................................................................................................................................................................... 317
42 -12.300[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  10  2..........................................................................................................................EQQIQMDEQENDESQGNDDQQNMSMSSSELHTMQDDHPGILLKTNTRMSITVKKLHVCGEWKWLQGGEDTCGICRMEKFPGDDCPLVLGICRHAFHRHCID-------------KWICPLCRQD....................................................................................................................................................................................................................... 130
43 -12.200[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  13  2..........................................................................................................................................................................NASTSSPSQQLQQAINSTIDKECAVCYS---------TTIPSCG---HKFCFI--LKG------SNNGDCPICRGP....................................................................................................................................................................................................................... 66
44 -12.100[TZR] KOG1704 FOG: LIM domain  ali follow..  7  204...............................................................................................................................................................................................QCAQCNDVLADQKANKPVCLKC---FHSSCRLS--DTPHMSQGDLHWHCCVCSKN------------LGVKYSRVGESLFCGYQTCGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQRPKPPQRAPPPPPSENIYETVLPCSSNNKYSHELPTSPNHHNYYSKTPNNLLTGYPEMDGYSTSSSSDSDDEISNIMAAASLSRVPAKSSSRKSKKNEPMMMSGGGVRMAKKKKSSRCTV 488
45 -12.100[K] KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors  ali follow..  13  2...............................................................................................................................................DMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSCRF---RQCVVDKDKRN--CRYCRLKK...................................................................................................................................................................................................................... 110
46 -12.100[R] KOG3138 Predicted N-acetyltransferase  ali follow..  19  2....................................................................................................................................................................................NRPSNWDDPQGPCRYC--ESPVEDDNYLECQECRRMVHIKCL------PHACTPG-EFTCVKCVLDKAKESVIPSDLEPIKEVIVRQRIPWLLVL-TLTLYNLSIK............................................................................................................................................................................... 105
47 -12.100[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  11  2...........................................................................................................................................SNEVDRMDVDEDESQNIAQSSNQSAPVETKKKRFEIKKWTAVAFWSWDIAVDNCAICRNHTDTDNECVAAWGVCNHAFHLHCIN-------------KWICPLDNQP....................................................................................................................................................................................................................... 113
48 -12.100[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  11  2..........SIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGQIGTTQGLRYLHCNLCETEWHSNCEQSGKLHYWSLDDEQA-SCDDC.......................................................................................................................................................................................................................... 258
49 -12.000[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  18  20........................................................................................................................................................................................YQLDTLLRCHICKD-----KVPVLT--PCG---HTFC----IRTHLNNQPN----CPLCLFE....................................................................................................................................................................................................................... 68
50 -12.000[L] KOG0287 Postreplication repair protein RAD18  ali follow..  18  20........................................................................................................................................................................................YQLDTLLRCHICKD-----KVPVLT--PCG---HTFC----IRTHLNNQPN----CPLCLFE....................................................................................................................................................................................................................... 68
51 -12.000[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  11  313.EANGANGSKAVARTARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAP-------------------------LCCTLCHE----EDTHFVQC---SVPSHKFCF--PCSRQSIK-ASGEVYCPKCPLVGSNVP----------AFMQGE.................................................................................................................................................................................................. 543
52 -12.000[BK] KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2  ali follow..  18  3.............................................................................................................................................................................SSKGGRGRQAAPKTAPTTVC-YCD-GKRELGSVEVVCSTCLKWFHGRCLK----HEFSRNSN-TFTCKQCRPTAED----------------KAKKADLVQMCVTVLATLSAE............................................................................................................................................................................... 103
53 -11.800[R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins  ali follow..  10  1MNEQQLLENASLAGAINQYKNEKAEPTQVLDAAKANKNTRSYPYSVSRNYSFILNKSNRSKSTAASPPYVIPSTSSNADDANKEPEKQSTSDYVSRKNRHMQLIKKNILEHDLQARKANLESYRAKLEKEYKTLAENKIQQRLSDGTKQLVTIDGLQYITGVSDTKWLE-KSYLLKKKRFLKEVGNSPSAVYCRICGKGAAHEPTRKTICEDCNLS-HENC---RYVHIHYSENA---FCELCKNQ....................................................................................................................................................................................................................... 309
54 -11.800[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  18  2.................................................................................................................................EKNTAPFVVDTAPTTPPDKLVAPSIEEVNSNPNELRALRGQGRYFGVSD--DDKDAIKEAAPKCNNCSQ-QCPHKWKKVQCTLCKSKKHERC--PSIWRAYILVDDNE-YCYNC.......................................................................................................................................................................................................................... 167
55 -11.700[R] KOG3002 Zn finger protein  ali follow..  17  2.........................................................................................................................................APGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTN-----YPPIHQCPN-----HTLCSSLRVQNT----------CPTCRYE....................................................................................................................................................................................................................... 95
56 -11.600[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  9  228......................................................................................................................................SWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILC---MNMSDPSCAPCG------HLFCWS--LMSWCKERPE----CPLCRQH....................................................................................................................................................................................................................... 326
57 -11.200[U] KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain  ali follow..  13  20..................................................................................................................................RREHTQNNGYAIKRVFKRQKDEEAKETQISQKASEELSELDKQITERKETSKKLVGTQDDAICQICQKTKFADG----KCFYCQLRSCARC-----GGRAQSKNKAIWACSLCQKRQQ..................................................................................................................................................................................................................... 131
58 -11.200[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  13  271.....................................................................................................................................................TARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLDDSEHVHDADAVVTTKMVEDEDEKLYKLS-CGHVFHEFCIR-------------GWVCPYCKERVDLQ-------------RMFKNPWEKPHLFYGKLLDWIRYLVCWQPLI....................................................................................................................................................................... 395
59 -11.200[T] KOG4846 Nuclear receptor  ali follow..  6  4.............................................ETKPNYLLLTNPDTPLSVCTSPYYSPSGKTASIPSSEASKPEGTNGQWSHLPTGATYVTDEFSSEFQIQNGSTAAQSGNANNYADPLSHRRYFNNVNGYNHHQFYDTASQASVSSPATSVTSSLSPPDSLSNGHTTQRHHIGKAISFCKVCGDKASGYHYGVTSCEGCKGFFRRSCLK----QQVCEIKRES--CQYCRFKK...................................................................................................................................................................................................................... 210
60 -11.100[S] KOG2846 Predicted membrane protein  ali follow..  8  109LTRLKEDKRKILEQVMDKETYKVAVNLLERFGDKKQLRISGLPTGSTPNRPQVERSPLTVAAVARTSSAGGQQQQQRSLAPYTSVYRNNNNNQNTSLNSSVISTHSLGQMTSASPQLRAVQELRRRSPFPIVDDRSRSAIDR-----------------------------------------------DFIV-----GDSPKDRFGMICKACHA--HN--MLPKEEYEYT-----TFRCAFC-----------------NVLNPARKKRPVAPRLSLEAPSDTANKRNDSSESESSDDDSDKEPSARRALLQKLPSGGADMDATAETEDLAMETETIETGSAAPSTAEVAASS........................................................................................................... 387
61 -11.100[O] KOG2813 Predicted molecular chaperone, contains DnaJ domain  ali follow..  11  1MDKPLLSGSEKTNESERLDSYQYLQRNSSSARNPSFAGAGVVTVEEIRTASAVSSDPPSLYPPVIKTPVSLPIPQAIGYPSASGAGHELQQRQFLDEIEIRELLIDHIGHRCCWGSRPARTWKIHAVEDCNEEREALTQTVPFTGGEFNGKKHGSEPGLWELDLRPQFPTLFVPYKETQVLVPNSETVEKVVCPTCNADGFYKENQMMKCSTCYDGSDTIC-------------KGKLPCPTC.......................................................................................................................................................................................................................... 265
62 -10.900[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  16  702.......................................................................................................................................................VDYTNHAELQQCCYDSTLNDLNVQGLISAADESVSVNIVSRCSLCAQITKKFSDIKVF--KCGHIFHLACST---SEMERRQSIEEGLCIACSDQIELI................................................................................................................................................................................................................... 805
63 -10.900[R] KOG2752 Uncharacterized conserved protein, contains N-recognin-type Zn-finger  ali follow..  10  2.............................................................................................................SESNATDGVHEVEESNPLEQSTITMLDVLEQEKELEDEYAAVLGASDEKSCTYAKGPIGRQALYSCLTCCPEAREDLDKAAGVCLACSYPDRTVEEVMLQCAICEDWFHLPHMKAPGASDKWLDVCSEMICDGCM----------------------DAKPFLKDYTGLALQPVLEDAKEDKPEADDSQLKNELDRSICDIMKVPEGESQPDEGEPSQKRAKLDDCRRPKPTKEHQGAAFWTNDWRKSL----SECLSLYKELAVEFLLDVEDSAKTYEERGMKRAEENSSYEQGIRALASIDRTQQIDAITEYNRMKDKLKEYLQAFAASKKVVT----EEDINRFFAGM. 389
64 -10.800[S] KOG3740 Uncharacterized conserved protein  ali follow..  8  2IKQLKEEEEAKLVLLKKLRQSQIQKEATAQKPTGSVGSTVTTPPPLVRGTQNIPAGKPSLQTSSARMPGSVIPPPLRASVPSVQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTPASLKGTTATSAQANSTPTSVASVVTSAESPASRQAAAKLALRKQLEKTLLEIPPPKNFLPSAANNE-------EEVVQNLLETQGRMSAAT-YMCAQCKTDF------TCR-----------WMCENCMTTNQKKALKV-------EHTSRLKAAFVKALQQEQEIEQRLLQQGTAPAQAKAEPTAAPHPVLKQVIKPRRKLAFRSGEARDWSNGAVLQASSQLSRGSATTP.................................................................................................................. 395
65 -10.800[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  16  208............................................................................................................................................................SNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPT---VFCWKCIVSHHGTC---PVTHYPISLDD.................................................................................................................................................................................................................................. 290
66 -10.800[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  20  276....................................................................................................................................................................FRILGEEQYNRYQQYGAEECVLQMGGVLC--CGAGLLPEPDQFAFCRECKEAYHE-S----AEQARWEAASKETICPRCHVPVEKNGGCM............................................................................................................................................................................................................... 404
67 -10.800[A] COG5183 Protein involved in mRNA turnover and stability  ali follow..  16  2....................................................................................................................................................DVDSDVNVSRLRDELHKV-------ANEETDTATFNDDAPSGATCRIC-RGEATEDNPLFHC-KCRGSMHESCLL-------------EWVCDICHYP---------------QFKTIYAENMPEKIPFSLLLSKSI................................................................................................................................................................................ 121
68 -10.800[K] KOG2845 Activating signal cointegrator 1  ali follow..  9  73..............................................................................................KNDQELISDPLQQCFKKDEILDGQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTRERQDRLAVALPGRHPCD-CLG----QKHKLI-CLICGRIV---C-----------EQEGSGPCLFC.......................................................................................................................................................................................................................... 203
69 -10.700[R] COG5048 FOG: Zn-finger  ali follow..  21  525.....................................................................................................................................................................KITRKLTTLPRGSIDKYVKEMPDKTFECLFCTKTFKRRYN----CDGCDKAFHKKSHQ-----------EKAYAC-PC.......................................................................................................................................................................................................................... 613
70 -10.700[R] KOG1314 DHHC-type Zn-finger protein  ali follow..  20  84...............................................................................................................................................................................PLGWKPEISQDTMYLQYCKVCQAYKAPRSHHCRKCNRCKMDHH--C---P------------WI-NNC-------------------CGYQNHASFTLFLLLAPLGCIHAAF.............................................................................................................................................................................. 160
71 -10.600[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  18  30..............................................................................................................................................................................................VQCCECKSEKCFSREGKLYCKGCSKVFHLNCF-----------------CMVC.......................................................................................................................................................................................................................... 95
72 -10.500[S] KOG4791 Uncharacterized conserved protein  ali follow..  25  8................................................................................................................................................................................................CSTCTKG-----------DSCP---HCEC----------------WQCRVC.......................................................................................................................................................................................................................... 50
73 -10.400[B] KOG4718 Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1)  ali follow..  11  181................................................................................................................................................................................................CNIC--------HSLLICETCGIRMHLPCVAKYFQSNAEPR------CPHCNDYWPHEIPKVFDPEKERESGVLKSNK............................................................................................................................................................................................... 248
74 -10.400[S] KOG4317 Predicted Zn-finger protein  ali follow..  18  1......................................................................................................................................................................MMPEKTIISSESSNSSPLNPSSTRIICHVCNKQFSQ-------CPRCNFRY----------------------CSPCYKSHSVQ................................................................................................................................................................................................................... 58
75 -10.300[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  10  2...................................................................................................................ARITNMGKRKRFLEATPYESKVLEQPKNSSNTNEESSSQDNMKASFGSSKRYDERQKKKRSEYRRLRRINQRNRDKFCFACRQQDCPEAKD--ICFRCGSKEHNACSKKGPLKFAK--------CFIC.......................................................................................................................................................................................................................... 129
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Godzik A. Fold recognition methods. Methods Biochem Anal. 2003;44:525-46. Review.