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Query: [O] KOG4413 26S proteasome regulatory complex, subunit PSMD5, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEDVNQLFDAAFEFAHYPGAQNETSVKEFLDRFPLPVIFNALQTDPDIPGFENTLVTCLERLFKTKYGASLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVVNNGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVIFPSETNDPTHLRNLAARCSSLARVRVLSLIVKLFSISRLVASEVKKSGLLDLLEAEMKGTKDTLVILNVLELYYELMEVEHSSEFVPQTSLIQLLCSIISGTSTGPYEKLRAMMISGRLLSKENIYKVVEEASVKALISAIDGSLESVEMNDTDAQEAAIDALGQMGSTTKGADLVLSTSPPAARHVVASAFDRNAHGKQLAALHALANIAGETRPKSNRIVDGKAEESLRCLIYDAAAQSTKLTPSGLFLSVLQQSSEIRLAGYRTLTALVARPWCLVEILAKEEIINIVTDATTETAKIAMEARYNCCKAIHEAFLCSNFVDDPRRLKTGDKLQEAVRSGPYMSKKHRGARPEVMTGEGFLast
1 -109.000[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali  100  1MEDVNQLFDAAFEFAHYPGAQNETSVKEFLDRFPLPVIFNALQTDPDIPGFENTLVTCLERLFKTKYGASLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVVNNGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVIFPSETNDPTHLRNLAARCSSLARVRVLSLIVKLFSISRLVASEVKKSGLLDLLEAEMKGTKDTLVILNVLELYYELMEVEHSSEFVPQTSLIQLLCSIISGTSTGPYEKLRAMMISGRLLSKENIYKVVEEASVKALISAIDGSLESVEMNDTDAQEAAIDALGQMGSTTKGADLVLSTSPPAARHVVASAFDRNAHGKQLAALHALANIAGETRPKSNRIVDGKAEESLRCLIYDAAAQSTKLTPSGLFLSVLQQSSEIRLAGYRTLTALVARPWCLVEILAKEEIINIVTDATTETAKIAMEARYNCCKAIHEAFLCSNFVDDPRRLKTGDKLQEAVRSGPYMSKKHRGARPEVMTGEGF 519
2 -37.500[U] COG5064 Karyopherin (importin) alpha  ali follow..  10  89.DDIELQLGAVTKFRKYLSKETHPPIDQVIACGVVDRFVQFLES--EHHLLQFEAAWALTNIASGTTDQVVDSGAVPRFIQLLSSPEKDVREQVVWALGNIAGDSSAC----RDYVLGNGVLQPLLNILQSSASDMLRNATWTLSNLCRGKNPPPNWSTISV-AVPILAKLLYSEDVEIIVDACWAISYLSDGPNEKIGAILDVGCAPRLVELL-SSPSVNIQTPALRSVGNIVTTDAQTQIIIDCGALNAFPSLLSHQKENIRKEACWTISNITAGNTQQIQAIIES-------NLIPPLVHLLSYADYKTKKEACWAISNATSGLGQPDQIRYLVSQGVIKPLCDMLNGSDNKIIQVALDAIENILKVGEMDRTMDLENINQYAVYVE--------EAGGMDMIHDLQSSGNNDIYLKAYSIIEKYFSDEDAVEDLAPETENGAFTFGNGPQAQG.............................................................. 528
3 -37.400[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  14  97.PDAEIQRAASVALGNL--AVNAENKALVVKLNGLDLLIRQMMSPH--VEVQCNAVGCITNLATLDENKSKISGALGPLTRLAKSKDIRVQRNATGALLNMTHSYEN-----RQQLVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRKRLAQSEPKLVRSLIQLMDTSSPKVQCQAALALRNLAS-DERYQIEIVQSNALPSLLRLL-RSSYLPLILASVACIRNISIHPLNESPIIDAGFLRPLVDLLSCTENEEIQCHAVSTLRNLAASSERNKRAIIEA------NAIQKLRCLILDAPVSVQSEMTACLAVLALSDEFKSYLLNFG---ICNVLIPLTDSMSIEVQGNSAAALGNLSSNVDDYSRFIECWDSPA--------------GGIHGYLVRFLSSEDSTFAHIAAWTIVQLLEAG--LTAFIQSSDDIIELLNDIVARDANNGEYEDGEGDVILLSGRALHLIEQD.................................... 547
4 -31.000[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  12LKTTSVSPANTTNLLCEISATKDPKL--FDKHELAECFLGLTKCDD--TNVRKEAAKCIAEITKSEVQRKKFRNIIAAFLECLSDGSMELPIQICRALGNICYLNDEAR----DLILELEGDAVLLRLLDINAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLIIDIGASNVEQHEDLLLNTLPLLSILTENVSDLNFDSSLNIQLSRILAASTNPDLAEMCLELLHYQAESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDSMHYLYTTPLLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQ---TMNKLLEVLAKDDVRLQHALLSALRNLVIPKPNKNAV--------------------IQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQ--ALELLKNKTLIEQLVH-KSSDYAGVTGESLRLMAWLIKHAYLSKIA....................................... 483
5 -30.400[U] KOG0166 Karyopherin (importin) alpha  ali follow..  10  94.KSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGD----STMCRDYVLDCNILPPLLQLFSKQNLTMTRNAVWALSNLCRGKSPPPEFAKVSP-CLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELL-MHNDYKVVSPALRAVGNIVTDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDA-------NIFPALISILQTAEFRTRKEAAWAITNATSGGS-AEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRL-GEQEAKRNGTGINPYCALIEEA-------YGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPME............................................................ 534
6 -29.900[S] COG5369 Uncharacterized conserved protein  ali follow..  11  340FFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEEQSSAACECLLSLSRSVYTGLADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSP----LREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLESKNPILIEPSIYILVHIAASDGELRILRQTKLLLLVKEIMLQEAQR--LKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDTYEPNSEILLAGIWLCINILPSQEDKERASILQNLGFGECLQMLQNHSSPDVRERVKDALMYINVTD.................................................................................................................................................... 729
7 -29.900[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  11  340FFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEEQSSAACECLLSLSRSVYTGLADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSP----LREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLESKNPILIEPSIYILVHIAASDGELRILRQTKLLLLVKEIMLQEAQR--LKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDTYEPNSEILLAGIWLCINILPSQEDKERASILQNLGFGECLQMLQNHSSPDVRERVKDALMYINVTD.................................................................................................................................................... 729
8 -28.600[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  578LEDEQQKVRTALSLSALAEAATPYGIEAFDSV--LKPLWSGVQ--RHRGKSLAAFLKATGFIIPLMEPEYATRRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLPRQIVERVVNNFKDESEPYRKMTAETVDKVIGS--GVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVNALGTRCKPYLPQ-IVSTILYRLNN-KSANVREQAADLVSSITIVLKACGE---RKLGVVLYEYLGEEYPEVLGSILGAI----------VSVVGMSSMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGKIADRGS--EYVSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDVLAT-KVQERQNRVCTTVAIAIVAETVVPALMADYRTPEMNVQNGVLKSLAFMFEY--GEQARDYVYAITPLLADALMDRDAVHRQTAASVIKHLSLGCVGLGV--EDAMIHLLNILWPNILEESPHVINAVREGIDGIRNC.. 1124
9 -25.000[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  15.........................................................................GYLQALVTEFQEQSQDAKEQVLANLANFAYDPSN-----YEYLRQLQVLDLFLDSLSEENETLVEFAIGGLCNLCPDRANKEHILHAGG--VPLIINCLSSPNEETVLSAITTLMHLSPPGRSFLPELTATPVVQCMLR-FSLSASARLRNLAQIFLEDFCSPRQVAEARSRQAHSALGIPLPRSVAPRQR............................................................................................................................................................................................................................................................... 198
10 -24.500[R] KOG0567 HEAT repeat-containing protein  ali follow..  10  1............................MVSQQQIEAIGGVLNNKERPLKERFRALFTLKNIGG--------GAAIEAISKAFDDDSALLKHELAYCLGQM----------------DAQALDILTKVLKDTTQEVRHEAAEAMGAIGHPD------------VLPILEEYKQDPVVEVAETCAIALDRVRWLQS-------------------GQKVDDSNPYASVDPSPPTAGDKS----------VTELKAIYLDAQQSLFDRYRAMFSLRNLRT----------------EESVLAIAEGLKDSSALFRHEVAFVLGQLQE-------------PCSIPFLQENLEDRLENVRHECAEALGAI-------------------------------TEDCIQILNRYAEDDKRVVKESCVIALDMC-----------EYENSPEFQYADGLAKLDATK........................................................... 302
11 -23.700[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  11  10.....................GQSAGPQHTEAETIQKLCDRVASSTLLDDRRN-AVRALKSLSKKYR-LEVGIQAMEHLIHVLQTDDSEIIGYALDILYNIISNEEEEEVEENSFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISESDGGIVVEDCLILLQNLLKNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVDILTETINTVSEVIRGCQVNQDYFASVNAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTENATQKEQLLRVQLATSIGNPPVSLLQQCQGSKIQTRVGLLMLLCTLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPYMIFDHEF 613
12 -23.300[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  11  364.HMPPSRISAAATFIQHECFQKSEARKRVNQLRGILKLLQLLKVQN--EDVQRAVCGALRNLVNDNKLEVAELNGVPRLLQVLKQTDLETKKQITDHTVNLRSR--NGWPGAVAHACNPSTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLKNLMITEALLTLTENIKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRDGLIDSLVHYVRGT-DDKATENCVCILHNLSSNPKGVEWLWHSIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSGPMPTSVAQTVVQKE-SGLQHTRKMLHVGDPSVKKTAISLLRNLSRNLSLQNEIAKETLPDLVSIIPD--TDLLIETTASACYTLNNIIQNSYQNARDLLNTG-------------------GIQKIMAISAGD-NKASKAASVLLYSLWAHTELHHAYKKAQFKKTDFVNSRTAKAYHSLK.......................................................... 880
13 -22.600[C] COG1413 FOG: HEAT repeat  ali follow..  12  114HSPSETSLLSLVASLIAIVYLSMEMLSDVSGLKTSSEKFTYLT--NLLRELEGWSSSGQMEL----------PGDMELCVQGLEDEKPEVRIAAAQLLGWL----------------DEQAVDALLRKLADKNPRVREAAVEALGRVGDEN------------IVAELIGCLEDKNKGLRLQAVRALSRLG-----------DERAVDPLVKKLED-KAPEVQAAAAEALGNLK----------SQDSMDVLLKKLEESPMAGAPTEFQVQVLTALGKIGD-------------EKALAAILSRLDSPYPDIRKHAAEALGNLRD-------------EKAVPHLVKKLADISPEVRNASVYALGNLGDERAVSPLLRMLEEPDPELRITAVYALGNLRAQAISPLINMLDDDNPWVRKCTAEALGKI-----------GDIKATDPLVKNLDDPDSNVRWAAAEALRMLDKRDLRKDSNG...................................... 506
14 -22.600[S] KOG2734 Uncharacterized conserved protein  ali follow..  10  93.....................NEEADGDVLDEQSLKKLILVFEK-MDSEVELHTVIQELKGVATVPDLYPILVDLLHSLLELLAHQNTDIAVAVVDLLQEVTDVDILGEESLIEALRKEQICALLVQNLVKEEADGVHNTLAIVENLTEIDSEFVKEAAEQGLLAWLLKRLRGKSPDPNKLYCSEILSILIQTENENRLLLGSLDGVDVLLQQLASNEEQEYMQNLFNCLCSALMARENRDRFLSGEGLQLMNLMLREKKMSRNGSLKVLHAMAGQDGRDNCNKFVEILGLRTIFPLFMKTPKRNKQRLISADEHEEHVTSVIAS------MLRNCKGTHRQRMLAKFTENDHEKVDRAKVEAIDKEIDQQAKDPTIDEDEEAENNYIKRLTGGLFTL--QRIDYILLEVSATGDTVKQRVLQILNLRGASMKTIRSIMR--EYAGNLGDGDTDWREQEQNHILSLVDRF................................................. 581
15 -21.400[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  11  91...RTTCLKSIGDQEPLIRATVGIIVTTIVMEEN-PDLLDTLATMQPDELMQEGALGALQKVFEDSADRYELRPIMPKLLVFYEHHAAKMRALAMNCVNCILMVNNDPIDFAID-----QFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEKMMPHLPN--VIEYIIKKTQDHNESIALEACEFWLSIAENSDICRTMVLPDKLIPVLLGSMRGGGDWNIRRCSAASLDVLAS-------IFGKDLLDKLFPLLKDTLMNDNWLVKE----SGILALGAIAEGCMDGVVPHLGELIPFMLAMMFDKKPLVRSITCWTLSRYSSHIASDENFRQQFFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLIPFL--------------------GEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDALSHPVYQMLMPPLMEERLSDEDKELFPLLECISAIVSA.............................................. 588
16 -20.600[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  6AMQLIAILEKTVSPDKNELLSAKNFLEQAAAS--LKALSEILVNTANSAVARMAAGLQLKNHLTSKDPSEIRELIKNNILAALGTENTRPSCAAIQTLVNKVVSEGSSEMHRESALQSNDVLTAIIHGMVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQ-ALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQQFLTPVLVEKLTKQDECDDEDTWSP----AKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLE--TNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICD-------------------IIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQ..................... 565
17 -19.800[U] COG5215 Karyopherin (importin) beta  ali follow..  2..STAEFAQLLENSILSPDQNIRLTSETQLKKL-AGLSSQVLIDENTKLEGRILAALTLKNELVSKDSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGA--------PELMKIMVDNTGAEQPNVKRASLLALGYMCESADPQSQALVSSSLIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPND-KVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIPEDDDWNVSMSAGACLQLFAQNCGNHIL-----EPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDK-------------------VQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADS--SIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANR..................... 509
18 -19.400[S] KOG2973 Uncharacterized conserved protein  ali follow..  12  3..............................................................................IFGLTFDANQTVAKDAVLSLINLTSEEEAAIQLAKQLQPPFAIVEVAAKEITNEQSDLADPWSMVLSNLTRVESLVHEILDTLERDDHTLPRLAKNKKKAKLHYLAPIFCNLTQVSRGRELCCHRKYLLEKLLPFASFEGSVVRRGGTIGILKNVCFDTVYHDVILNESILVAILQPLCGPEEFSDEDNELLPIELQYLPESKT-----------------------REEDPDLRKMLLECLLQLCSTRRSREILRSRGVYEILREYHKWEAKVGKDSDCLACENVVDILIKKEEE................................................................................................................................................. 289
19 -19.000[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  409.EGHKYRIKLSCFLITMLQGPVDIGINLITNDQLTPIMLEMAAS--QDHLMQGIAAELIVATVSKHE-INMLKVGIPVLRALYDSEDPTVKVRALVGLCKI-DDISKATMKEEAVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSLDAD-VKEWIVDDSLLLKALVLLAKKAGALCVYTLATIYANLSNAFEKPVRALVEEGAVPACVA-VSKTESKNALELIARSLLAFAEYEDLRGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGAKADPMIS--------QRAYEVVKPLCDLLHPDVEGKANDSLLTLTNLASVSDSIRGRI-LKEKAIPKIEEFWFMTDHEHLRAAAAELLLNLLFFEK-----------------FYEETVAPGTDRLKLWVLYSAEVEEERLSRASAAGFAILTEDENACARIMEIKSWPEVFKDIAMHEDAETQRRGLMGIANIMHS--SNKLCSEIVSSEVFRVLVAVTKL----INQERAGSTEQAKR... 931
20 -17.200[U] COG5096 Vesicle coat complex, various subunits  ali follow..  11  17..................................VDALKTSLESKNDYVKI-----SAMKTIL--INGDSLPSILMHVIRFVMPSRNKELKKLLYYYWEVCPKYNNDGTMKQEMIL----ACNSFRNDLQHPNEFIRGATLRFLCKL-KEPELLDPLIPT-------VRQCLEHRHAYVRKNAILAVFSIYQVSNHLIP-----DAASLAEDFLAAESEGTCKRNALIVLFTIDPEK--------KAWLLANFEQIPSLNASSLLVIIEFIRKVVLTKADGLEKL----------RFQSLLVSLTATNNSSVVFEAATSVINVFPDAESLKLA-------ASRLLALADREADNNAKLIMLDRISQLAARDKS------------------------ILEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSR-NVEDILNH--FQKELTKSNGETEKD-DGRRRALTKAIHSCAIN-SDFQSKSASSVLSFIKEVMEKFP................... 424
21 -16.900[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  11  1MTDSTNKKGEIFELKAELNNEKKEKRKEAVKKV-FPDVVNCMQTDN---ELKKLVYLYLMNYAKSQPDMAIM--AVNSFVKDCEDPNPLIRALAVRTMGCIRVDK-----------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ----MVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTE--GQIFILDCLSNYNPKDD-----EAQSICERVTPRLSHANSAVVLSAVKVLMKFL------ELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV-----STLLDLIQTKVNYVVQEAIVVIRDIFRK-YPNKYESIIATLDARAAMIWIVERIDNADELLESFLEGFHDESTQV---QLTLLTAIVKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKE... 539
22 -16.600[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  36..SPRKSRRLLSKIAYLIYTGEHFQEKQATE---FFGITKLFQHKD---SLRQFVYIIIKELSVVAEDVIMI--TSSIMKDTATGRETIYRPNAIRSLIRVIDAN-----------TVPAIERILTTGIVDPISAVASAALVSAYHLYPVAKDIVSRWNNE------VQDAVTSHNVGRKVASSPFFTSTLGYTPNASGISQYH--ALGLLYRIRRHDNSHAFVMLIRYISSLMDQNTQ----FRDQMVPFLHGWLKSKGDMVNLEVARNMV------------RLKNISDDDLQPVVSVLKIFLSSHRSATRFSAIRTLNELAMTRPHL--------HSCNLNIESLITDVNRSIATYAITTLLKTGN--------------DESVDRLMKQ------------IVTFMSDISDNFKIIVVDAIRSLCLK--------KQDSMLTFLSN-CDEGGYEFKRAAVDAISDMIKYIPESK-------ERALAELCEFIEDGEE.................. 482
23 -16.500[S] KOG1949 Uncharacterized conserved protein  ali follow..  11  47...QKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFHGIHLPRRSPVHSKVREVLSYFHHQKKEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRDPNLHAIEMDSKIQKQFEELYSLLEDPYPMVRSTGILGVCKITSK-EMMPPTILIDLLKKVTGELAFDTSSADVRCSVFKCLPMILDNKLSHPLL---EQLLPALRYSLHDNSEK-VRVAFVDMLLKIKAVRA----FWKICPMEHILVRLETDSRPVSRRLVSLIFNSFLPVNQPEEVWCERTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENVTVLDKTLSEIIVILWKSIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKSYCLLDCLCSWGQVGHILELVDNWLPTEHAQAKSNTASKGRVQLVYIEYLLTHPKNRECLLSAPRKKLLETSKADLES..................... 593
24 -16.500[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  10  42..DPRRCSQVITKLLYLLNQGESFTKVEA--TEVFFSVTKLFQSKD---GLRRMVYLIIKELSPSSDEVIIVTSS---LMKDMNSKIDMYRANAIRVLCRIIDGT-----------LLTQIERYLKQAIVDKNPVVSSAALVSGLHLLKTNPEIVKRWSNE------VQEGIQSRSALVQFHALALLHQIRQNDRLAVSKLVGS-PFYEFLESCLRHKAEMVILEAARAITELDGVTSRE-----TPAITVLQLFLSSPRPVLRFAAVRTLNKVAMTHPMAVTNCNID------------MESLISDQNRSIATLAITTLLKTGNESS----------ERLMKQITNFMSDIADEFKIVVVDAIRSLCVKFPLKYRSLM-----TFLSNILREEGGFEYKRAIVDSIVTIIRDIPDAKESGLLHLCEFIED----PNTSDPSKYIRYIYNRVHLENATV---RAAAVSTLAK............................................... 485
25 -16.300[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  10  1MSSGEQPCYTLIHVPSDAELPSEAQLKEKFEK-------------GGDKERIEALKKLIYMILNGEKTSQSM--LMYVIRFCLPSNEHTLKKVLLIFWECVPKTDSNGKLLHEMIL----VCDAYRKDLQHPNEFVRGSTLRFLCKL-REPELLEPLMPA-------IRACLEHRHSYVRRNAVCAIFTIYKNFEFLIP-----DAPELVTEYLEQEQDASCKRNAFMMLLHVDQA-------RALDYLSGCIDQVGSFGDILQLVIVELI------------YKVCHNNPNEASRFIRCVYNLLQSSSPAVRYEAAGTLVTLSNVPAAVKAA-------ASAYIDLIVKESDNNVKLIVLDRLVALRGSSSNEKIL----------------------QGLVMDILRVLSSPGLEVRKKTLSLALDLVSSR-NVEDMVMF--LKKEINKTATESNDENGKYRQELVKTLHAATIK-----PDVASTIVPVLMEFLSDTNEKASSYVLQFVREAVHK.. 430
26 -16.000[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  49.KGNSNADRVLRFLVTFVNYLQQKDPEIDIVQPILKHILRGLDAKD--KTVRYRCCQIIARVVNCVKEDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEENDVRNILLSNSTLPFILERARDVDAANRKCVYARVLPKIGDFRYLSI-----KKRVRILKWGLNDRDESVEKAAADMLARQYVSLRDKSSYDESCFIIEQLLYIGLDMVDEIGRRKLLKSLTNSLSTMALPDSLISNDFCSLLVEIITEGYKEAFNELRCLSYVQCLFENITSSLNENLYMVDMLKTLI---IPAVRSHDLPIREKGLECLSLVC-------LLNADLAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLIQHGKAKFTEYEDAISSIL------------------FEALGEFENAELQTLGAEAIAKLL-----VILHYRDELFLKPLIEPNTVDNHALRQVLGYFFPVYAFGAHENQWRIATIFCDALLSLLEIYRD..................... 697
27 -15.500[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  10  25.EERAVVRKECADIRALINEDDPHDRHRNLAKLMFIHMLECLKLIASPGFPEKRIGYLLMLLLDERQEVLML--VTNSLKQDLNHSNQYVVGLALCALGNICSAE-----------MARDLAPEVERLIQFRDPNIRKKAALCSTRIIRKVPDLAENFVNA------AASLLKEKHHGVLITGVQLCYELCTINDEALEYFRTKEGLIKTLRDITNSADPFLHIRLLRLLRVLGQGDAD----ASDLMTDILAQVATKTESNKNAGNAVLYECVETIMAIEDTNSL-------RVLAINILGRFLSNRDNNIRYVALNMLMKAITFDDQA--------QRHRVTILECVKDPDASIRKRALELVTLLVN--------------ENNVTQLTKE------------LIDYLEISDEDFKEDLSAKICFIVE-----KFSPEKLWYIDQMLK-CEAGKFVKDDVWHALIVVISNASELHKSVLTYSEQETLVRVAVWC--GEY.................. 487
28 -14.600[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  11  19.AEVKRINKELANIRSKFKGDKTKYVCKLLFIFLL-EAVNLLSSNKYSEKQIGYLF--ISVLVNTNSDLIRL--IIQSIKNDLQSRNPVHVNLALQCIANIGSRD-----------MAESFSNEIPKLLVSGDTMVKQSAALCLLRLFRSSPD----IIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPDEYKGCVNLSRLSRIVTASYTDPAPWLSVKLLRLLQNYNPVTEEAG--VRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQE----VVILSMKMEKDVSVRQMAVDLLYAMCDRGN---------------------------EEIVQEMLNYLETADYSIREEMVLKVAILAE-----KYATDYTWYVDVILN-RIAGDYVSEEVWYRVIQIVINREEVQEALQAPACHENMVKVGGYI--GEF.................. 499
29 -14.500[O] KOG2160 Armadillo/beta-catenin-like repeat-containing protein  ali follow..  11  146.......................................................................................................................DQFRNFSRTPLESEMRSKLDCLENLEYLLHQIDNALMFIDNGGLDDVLLPIVVNDTSTSLRVSAMRVLGSLASNNPKAQIKVFEKNFGSHLAQILTSSGNVGEISAALHAFGALLRFPLAQQRVLSTSGTQALIKVLQSPDVELRSKAKVVTLISDLVLEKRSVL--DVSKDDPEASSTMAQYVLLDFESWLKTPGYCAAVDTVLTKEFLLLLEQPEVVEQFATALETTEDMCTSTWSRHALLTVRNRYANSTDEYRLEVSQILAKLCERLFNK.............................................................................................................................. 423
30 -14.100[S] KOG0212 Uncharacterized conserved protein  ali follow..  9LTHKDKRKATAYELERVVKGYLENDETEKIRAVISQLANDFVYSPARGPNATFGGLIGLAAVAIALGPKIYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGEVFRYFN-----LIFDVLCKLFADTEITVKNGAELLDRLIKD--------IVMQQAATYMSSAEDIKNFKEGPVSSSIQDVPVMSTEQPRMHTFSLSELVPLLSERLY-VINPNTRMFLVSWIRLLDSIPDLEFISYLPFLLDGLMNYLSDPNESIRIVTSNCLSDYVESSLRDGSFILEAHIQIDYKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPKD---VLLQIPKVLENLLPLMSN-DENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDFRSL----IEVLQKLLSNDNEETRLCALEWVLLLQRRT--GKLINMHDPIFQTLLLQLSDPSDLVVSRTLELLAHIAISH------KSVNLVPFLKSLLQMFAE..................... 526
31 -13.200[S] KOG2676 Uncharacterized conserved protein  ali follow..  13..................................FDSIITMMKNDPCCVEDYEPIVENLNRIFQRTFNDE--QLFWERLRDTLEENSSIPYTRTVRGLILMMRNLAAENQEIPQKLLLQNLVIRGFLHATPLIKHLYIACLTCLFNIQQNYSTVDMTTLQFLQYPYGIKLEDGEEEEHFWLPYLFLFKTYLNNDEFSNEFFRDN-LIEKGRNYLDDSKLEITSIDLSASFGKYLNGLEERQPGKFTTLLQILQLVVTSKEDWNTYELTAIMSWCY-------------PILQRLACKDIPAFFNKSCNDYAPSVACLDIISDLCKFNHVRKFLISYD---SVKILVSLLDTFQKNLLRINFLKGNGDTVNEIKITDHEGNKIEDRLLIFNRVNTNESFIR----------ADNFPHCKLVIIEILASLVYAHPEIQDQIRELGGLALILSNCVDNDPFIKERSIVCLKFLLK--------NNAKNQEYVKKME---AQDVVQDDALSKAGFEISVEK.. 537
32 -12.500[S] KOG1566 Conserved protein Mo25  ali follow..  12  9.KSPVELVKSLKEAINALEAGDRKVEKAQEDSKNLVSIKNMLYGSSDAEPPADYVVAQLSQ-------ELYNSNLLLLLIQNLHRIDFEGKKHVALIFNNVLRRQIGTRSPTVEYICTPEILFTLMAGYEDAHPEIALNSGTMLRECARYEALAKIMLHSD--EFFKFFRYVEVSTFDIASDAFSTFKELLTRHKLLCAEFLDANFFSQHYQRLLNSENYVTRRQSLKLLGELLLDRHNTRYISEPENLKLMMNMLKEKSRN--IQFEAFHVFKVFVANPNKPKPILDILLRNQTKLVDFLTNFHTDRSEDEKAYLIKQIKELKPLPEA.............................................................................................................................................................................................. 339
33 -11.600[O] KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1  ali follow..  452.EDEIVQYGLLLGIGLTGMASRDETL--------YESVKTILF--NDNAVAGSAAGISMGLIMLGTASSAAIDEM---LQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELNNDLVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNA---------LISTVELLVDSYNPHVRYGSAIALGIACANSGSNA--------ALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALQTSLSFSPTALIGLDKNLNAPKFSFISVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNSKKEEPKSETLENF---------------------TRVVPAQLPYISFNLNG-----------RYYPVRKFTGG-----MLIDRESDKAPDLIELNRDAVP--SADTEPGEQEASPPEDF 957
34 -11.600[O] COG5116 26S proteasome regulatory complex component  ali follow..  452.EDEIVQYGLLLGIGLTGMASRDETL--------YESVKTILF--NDNAVAGSAAGISMGLIMLGTASSAAIDEM---LQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELNNDLVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNA---------LISTVELLVDSYNPHVRYGSAIALGIACANSGSNA--------ALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALQTSLSFSPTALIGLDKNLNAPKFSFISVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNSKKEEPKSETLENF---------------------TRVVPAQLPYISFNLNG-----------RYYPVRKFTGG-----MLIDRESDKAPDLIELNRDAVP--SADTEPGEQEASPPEDF 957
35 -11.200[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  480.QSLEVSFYCLCCILEYDTNDSDTLDAWLTR---FETSFAIKASAFQNPQLLKTCSQLLSSCSC-QNHPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCASHLLTEID-----GFMAVVEELTPKLVYVIYSSVGYVTQRIEDIELRISYLMRLLNCILAQLQPSLYPNLEIFENVLKSCLQSVAGVALSQSPIGESP-FQAKLISFLTHLQYSDVVGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCDRFTEFPAAVLLTLGSAILTCPYGQTDIIDKVLIDMCSSIQNSVVIINEESFMNNIDITVELYHFFSIILQKHPSFLETMYPD-QLILNRAINLLGKPERLLESAAGQFIISFITSEKSDLLNTHTDFVNAIRSPLIAKILLGFGGNASRSSLPLLSD-----------ILGKLKAQ--------TRACLTQSLEEEGFPSRNVSNEIKRRFLTDLLKA-----------------RIKDKVKQ--FWILCKGLESTPYGNSS.. 987
36 -11.100[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  10  343LRVFILVIQEFCNTKSSHPETAQVLYNSFLVDNRINNLLDLL-KEEDFEEWTDSPQQWVLEQSTQDVEFNVRPCAEKLLKCFFDAYGDIIVSPFKDMIYSVFECPKTLT----QAVQQDTLISSF------------GVGYTQLKSIFPFAKWLQEAAVPN-----MASINDIGISRVYRRRIAIFLSQWIEDSSSEQLLEVIYKLYCSFLNLTDPCNDAVVILTTIDAFKTVLDDWNFSENSFLENLFVHVLSLFKAFESVDARTSILSLLGTLLARAGEHVAPMESTIASLLSQLWDG-----WKKEPLLRARVLAVMHQFVNAIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTFLMYIQKLPETFTL---------------------LIPHLLYHLSQATSTLP-FVLMIVSSYQLLDNTVLMKDYSFTIFEKLNDLLDDVKNETLQALCKTVCLLIETTPMDMIYESLLNSSLLSRLLLSIATN.................... 802
37 -11.100[T] KOG2999 Regulator of Rac1, required for phagocytosis and cell migration  ali follow..  1MPPPSDIVKVAIEWPG-----ANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLRYADGYITEQTRSDIKNGAARQLMERTQSSNMETRLDAMKELAKLSAD-----VTFATEFINMDGIIVLTRLVESGTKEMLAFTLTAFLELMDHGIVSWDMVSITFIKQIAGYVSQPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHL-QVSNQEIQTYAIALINALFLKAPEANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAESDPSNAPGSGLGFTNHINPAMDFTQTPPGMLALDNMLYLAKVHQDTYIRIVLENSSR------EDKHECPFGRSAIELTKMLCEILQNEGRNDYHPMFFTHDRAFEELFGICIQLLNKTATAEDFNKVMQVVREQITRALPSKPNSKSKLRSLSYSEILRLRQSERMSQ-LREKIQPEILELIKQRLCEGSSFRKIGNR........... 561
38 -10.900[O] COG5656 Importin, protein involved in nuclear import  ali follow..  11  336.........................IEPHLQIIFENVIFPCLCANEQSIELEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKRPEKLNNILPFINDIFTRFDANSSDINMAFKEEGALRTL-LLSQDKYMFLVARSLETIALYSEEFKDMNILSQ---LFELTYTNFLNSNVLPVQIEAADAIKCLIVSNPQIHPAVSAPGMMEKLLKLSKIFEIDILSEVMEALVERFSDELSPFAKDLASNLVEQFLRIAQALVENPSETYSASDQEQEIQASGLLQTMTSMNKVPLIESLAPVVKFVVLHAQISFITEAVDLLDALTISSHLLYNQIAPPIWELLHDILDSFQTYAMDYFEAYSIFFETIVMTGFPQDQTYV-----QPLLEILSAKLESEVDYDSKAIKVSTNDELGLDSKCIVKLGANLFAKPIETLQIMENEGFTINFFTNWFNEKYSVFAIKLQVLVTLLKMPEVPNSVSPLL-NNLTNKLVELTLSLPKAIRNRDAVTEGKSLEG.. 872
39 -10.800[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  11  437...................................ETLVAEAYCKT---SYREDALLALSKKLMEMPVKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKLSKLETAHERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQIIPS----YLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYE-VRETAVRIILDMYR-------QHQASILEYLPPDDSNTRRNILYKTI........................................................................................................................................................................................................................................................... 664
40 -10.600[S] KOG2611 Neurochondrin/leucine-rich protein (Neurochondrin)  ali follow..  10  1MTDVPEPVRKCASLLKGTKSDTEKFA-------ALFMVTKLVKGKDCNAAGKKLLFEAIG---------------FPFLKKLLVSKDLPYKSVALSILTCFCQEEELATHKDI-----IDAIPTLLEIVEEDNLIVVSEAYSCLKSIASHEPGQQALLATGAIPKMSQIYSAQSFQTDEALHLIVLLVKQFGVVSWPEDPTAFHALIQRIALDMETDDTE-RKYELCRILADILITCRREIVINSESLFKGCGDILKAKIGPKQRDPALHLIATTLHVLGIQWAFMDEQLLQLGAIEVRMQMDEKKLETTFKQAELLTCCFSI------------------LEHCIEYMATDQLDLEPKEKQTTYTALKGAFNQVLAVLTRVSQDKIRESSNPKDKKFVFAIVKVLSAWLAQETTAMRPAIYKLLPFMLK-------VANESFQELKTWRAGTREGEPPIDVLRIMLPALCHFAVEEEARRVLFTHKQDEVLLESLEF..................... 472
41 -10.600[O] COG5021 Ubiquitin-protein ligase  ali follow..  10  238.....................................KVTMTTQELCEHSLQQIFDKGMALLPAESWFDFSIKASVAKAFSDDSGENIDLRNIIIEAIAFVNTIFSPPQVSSKLFELDPYAFNSLTDLISLSETELRTDALFTLECISLKHVWCSDIIRNLGGNISLLFQILRYIAKTLR-RFFYLISNLAD-VKPLHESLFAAGLIPTLLEIVSIRNCPYKRTSATHLLETFIDNSETTTEFIENDGFTMLITSVANEIDFTLAHP---------TWQPPKYSVVYYSISFRELAYIRSLLKLVLK----------------LLSTDSGDRIRNLIDSPILVSLKKILENKLLTLITYTLDVVQKVINSEPTIYPVLVEAGLIPYVIDNFPKLI-----------------PSAELLSLLPDVVSAICLNPEGLKQVKEKNNLFDFLLDADHARILTGGDRSTEYGTDIDELARHYPDLKANIVEALCNVIRKMPSTF.................... 687
42 -10.500[U] KOG2081 Nuclear transport regulator  ali follow..  11  1.............................MDTYSVDVVYQAISAQGNNPKEQEKANKWLQDFQKSIYSWTIADELLH------QKRDLHANYFAAQTMRNKIQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPIND-------LLVTLAPHQCAIWP-LLEVLKVLPEEIDSRYLRLGAN-VLKFLCMCLQRLDQQRVWNAALRTYSALVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPHKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVPETTW--ESTEAALFIMQNVAKNILPDENEVIP---KVVEAILNMSEQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQK.. 518
43 -10.200[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  12  944VSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPD-PTIRSNAVLGLGDMA-----NNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILA---------GQVKVKGQLGEMAKCLDNPDQGISDMCRLFFTELASKDNAIYNGFID-------IFSNLSSDDLLGKESFKKIIKFLLTFIDK-----HQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTALLEQGF............................................................................................................................................................................................................................................................................... 1169
44 -10.100[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  10  321VSDIDSFVRAAKGLAKIISRLPWNLAEQVIDA-----IIELMTESITSPLVWHGAILFFAKLAAGLIKYSKCLHILPLIEVGLSYEVQSIRDASCYFVWSFYH---CYSKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIPD--------LSLISHINYVSVTDISNCYGDLCMKVAHFPQ------FRSCVFQRLFTNLQH--DVKVQQLSAFSLRQLSIKYPKE-----SIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGI--LKGIQQIFANDIRVDRAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFDDMEETSKEARIVYIILQNLPNISFRYQKKICKLLLDIYPQLHSIDYQAPVANALQNIIPFTYEKTESIEEQVCSNYLTDTRGDVGSWIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFD..................... 833
45 -10.100[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  94LISSGTTSDRISALTLLVQESPIHAVKA------LETLLSICSKKSRNEATQ--AITTLKDLFIGG--KSFYFKYIQIIEALSFDALLFVKSQMVSTIYDLLKAKPEQ---------EQNLLKLLINKLGDKENKIASKASYSILQLEASHPAMKLVITKEIERFIF-----PSTSRTSCYYTLITLNQTVLTHKQVDVANLLIEIYFVFFTKLLFALEKEEVADAPTLEKKSLQSDSKNKKSQKRKKDEDLRKEAEENVNSRVISAVLTGVNRAYPFAEVNSEK--------FDKHMNTLFAITHTASFNTSVQVLMLIFQASASRDDPRLTTSSKQSLYLNLLYKSLIIDNNIPRVRAF-----------------------------------------IKRMVQVSAWQQPPLVTGLFHVMHQLVIATTALRSMFTNAE--EVFKDVEEDDVSEDQKVDSDKDGKLSDKQSHSAYVVGNVSVSTKKEHLSY-KRDPQYSNADGSCLWEIPFLNHF 600
46 -9.980[T] KOG4464 Signaling protein RIC-8/synembryn (regulates neurotransmitter secretion)  ali follow..  10  6..............................................................................ALYIVRAGEAGAIERVLRDYSD--KHRATFKFESTDEDKRKKLCEGIFKVLIKDPTTCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDPVIVESLKCLCNIVFNSQMAQQLSLELNLAAKLCNLLRKINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVLKNNTMVYNGMNMEAIHVLLNFMESSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDV---TNRPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKER--VDSLLKYTGYAGLLAARDEDTDTEEYKNAKPNINLITPMPNPIDEMTEEQKEYEAMKLDKLSRRA----------DVKDLHQDG. 535
47 -9.580[R] KOG1243 Protein kinase  ali follow..  53.SGSDTKCELAKAALKRLKTLRHPSILQYLDSLAVDPLGTYFSKLGSDNVQKGLYLA-IFQITRALS---FLNNDGNLRHNNVSAWSVFVNASGMWGLGCLVWEAFNGVLKQRSNLKDIEHIPKSLQSLYCELVGASPSNRPNPADIITRCRKPGGFFKNDLVDTLLFLEEIQIKDKAEKNRFFSGLTTHLDNFPD---NVCRHKILPQLITAYEYGDAGSAVLAPMFKLGKLLDEVEYQKRI-----VPCVVKLFASTDRVTRS--------RLLQQLDLFIAHLQPQVVND--QIFPQVAHGFLDTNATIREQTVKSIIHLAPKLNYNNL-----NVEVLRHFARLQARDDQGIRTNTTVCLGKIAPHLHPQVRQ----------------------RVLVSAFIRAMRDPFPPARVAGVLALAATQQY-FLLSEVANR--VLPSLCSLTVDPEKTVRDPAFKTIRGFLGKLEKVS......................................... 541
48 -9.420[C] COG5231 Vacuolar H+-ATPase V1 sector, subunit H  ali follow..  7LMDSTHFNEIRSIIRSRSVAWDALARSEELSEIDAS-TAKALESILVKKNIGDGLSSSNNAHSGFKVNGKTLIPLIHLLSTS---DNEDCKKSVQNLIAELLSSDKYGDDTVKFFQEDPKLEQLFDVSLKGDFQTVLISGFNVVSLLVQNGLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIPEKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKSDFLDLLKLVKITIKEKVSRLCISIILQCCSTRQHKKVIKQLLLLGNALPTVQSLSE--KYSDEELRQDISNLKEILENEYQELTSFFKKDNYKIFRQLIELLQKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKA-------------------DIMELLNHSDSRVKYEALKATQAIIGYTF...................................................................................... 477
49 -9.300[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  6.ANLQTLTEYLKKTLDAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKR--CEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQK---------PDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRNELWTEIKLVLDAFALPLTNLFKATIELLKSQICDNAALYAQKYDEEFQRYLPR-IWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKV---RRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVHKDAAIYLVTSLASKAQTQKHGITQANELV-------------NLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRGPNNATLFTEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAII---PYIPTLITQLTQKLLA..................... 604
50 -9.070[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  355.DDPLEYVRSAIVLVRGLLDHFDQKITSVVSTHINANLQQFSTNPSLEWNKKYVALQLFSAIAIKGQSTDVVAFFENNIKPDLLQPAGVIHPMVLAEDIKYVFTFRNQLNSQQ-----IDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVHIFTSLLIAPHI--------------PALNQLFLIVESASTPQKLAENDYLMKAVMRIIIMSQEAILPAA--------------------SLLLQHLTKITEEVSKNPSNPKFNHYLFESIGALIRSLSKSGPQTVSQLENALLPVFQVLIEDVTEFIPYVLQLLSQLVEASGNEPL--PDFVVNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQI-----------------------ISNKFVEPVLGIFQK--KVNDHFGFDLLDRVFTVFNANILAPYINHIFFLLLSRLKNSRTERFVLRCTIFFFFV................................................ 790

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Functional differentiation of proteins: implications for structural genomics. Structure. 2007 Apr;15(4):405-15.