current user: public
If you have questions about the server, please let us know.

Query: [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .  760    .
# Score Template Links and tools%idFirst MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDADKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSECLast
1 -143.000[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali  100  1MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDADKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC 766
2 -68.900[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali follow..  16  110...........................................................................................................................ETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR-----FLTAAEFDSVFINIPELVKLHRNL-MQEIHDSIVNKND-QNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRK----GDNYEMKEIIDLQQYKIANNENKKWSYGFYLIQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNF-------------------HDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGT.......................................................................................................................... 606
3 -60.400[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  11  287.................................................................................................................................IEDNFALPTGKLHRKPLESSSVSSPIGKSLRSQNSRSLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKEALECEISHNEFMSRSDVAMMFGKLDPILELHER-IFARLTVMSNEDDKNLDFAQVWIDAKEEMKAYPQYINSYDTIKRLFDKQDRENSKFHTFCKAKESNPEFHRLKLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKN--NAEEAAKAIDEVLKTANKTREKNDNFISHLSKFTDIENVPILVAANRMFIRELVVSPIASTSQQFAKMKLFLFHDVLIITKIRSE-KNTMQRLARHASFASLHSRQRRPYRYIDQIQLNTMRSAFRI--RAPDEIAKCLELQQQNGSTKPNVFVWCLIHRDEQGGDIDTVFESNDDEEVRDFLDDIHVKILSDCGRFF-YSSDPSDMNEINDAMVSDMTTRYFRNLCGAKPQYGHGSQMNITEWSHNESFMPPPQSQSRMRRAFSNAQLTLATTLGFGRNQSRN............................................................................................................ 826
4 -55.600[F] KOG2070 Guanine nucleotide exchange factor  ali follow..  17  45LERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTS---EKLSSANISYLMGNLEEICSFQQML-VQSLEECTKLPEAQQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSEELGEF-----ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNGDDIKTLG-NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPR--MSGFIYQGKLPTTGMTITKLEDSEHRNAFEISGSIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP.............................................................................................................................................................................................................................. 580
5 -49.600[T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases  ali follow..  18  409.......................................................................................................................................................................PVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSN-PENNRQQFIRCVFHNIMQIHAVNSR-LSNALNRTQTLQPVVNTIGDLFLDYVPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHEVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLSCSPTLFDPSRLLIFKGVVKLKASNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHKLLRPLPLELLSISYIEDSPSRGSVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQS................................................................................................................................................................................................................................... 821
6 -48.800[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  17  433..............................................................................................KASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERAC---LRVDELQILFANIEEIYEFNSML-LQRLINTGRD----GRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQ-ATHTYSLLASTQKL---HRLPLGSYLLKPVQRILKYHLLLDSLRKHC-----DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLG-LTVLGELRQEGLLME-----QHNKQRLVLLFATMLIITKQKE---DGRLQFKTYISQNNLMLSEHLPGE-PTSFYVDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKEL......................................................................................................................................................................................................................................... 852
7 -44.400[T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases  ali follow..  16  14LGWLFAKCCCCFPCRDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKK-TSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKD-KIVFGNIHQIYDWHKDFFLAELEKCIQE----DRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE-------YDAYFEEVKQE---QRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMM----NLGRLQGFEGTLTAQGKLLQQDTFYVIELD----AGMQSRTKERRVFLFEQIVIFSELRKGSLTPGYMFKRSIKMNYLVLEENVDND-PCKFALRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST............................................................................................................................................................................................................................... 551
8 -39.000[T] KOG4269 Rac GTPase-activating protein BCR/ABR  ali follow..  16  1...................................................................................................................MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLL-PMKPLKATTSQPVLTIQQIETIFYKIQDIYEIHKEFY-DNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINE------------DIDPRRTAVTTPKGETRQLVKDGFLVEVS--ESSRKLRHVFLFTDVLLCAKLKKTSAGQQYDCKWYIPLADLVFPSPEESE--------ASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEF............................................................................................................................................................................................................................. 416
9 -20.100[F] KOG1738 Membrane-associated guanylate kinase-interacting protein/connector enhancer of KSR-like  ali follow..  10  13..................................................................................................................................................................................................................PSQVVD----WMKGLDDCLQQYIKNFEREK----ISGDQLLRI-QELEDL---HQELILEAVDLLCA---------------------YGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPAAVTDYSVTRNNVQLCLELTTIVQQDCTVYETENKILHVCKTLSG-DHIISLSSDVSQSAHLEVIQLANIKPSEGLGMYIGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---YEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDDCEGWLWKKKDAKQKWKKYWFVLKDA---SLYWYINEEDEKAEGFISLPEFKID-RASECRKKYAFKACHPKKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADT. 694
10 -16.100[U] KOG2215 Exocyst complex subunit  ali follow..  10  1.....................................................................................................................................................................................................................MLSNEDGLFQTDAFSPSDYIRDRLKGVKIG--ETRKLRHLRSEMGAL----NHASQETLKNNV-------------------FRNYQQFID----------------------------------------ASKEISHLEREIYQLTHSLIEQKQVIENLIMMTGDDKSSIHTVSSHSTTTSTTNPIQILMQKMEGIGGILNNMSTSEKVILYGEMEQFDVETKKPVQKMLILLSHRLIIGNINA---AGKYVMESTLSLNSVAPVNVKDREAGKVLKLLIFPESRCYLCESARIRTLWFDELEQAKREILHKGSLVRQATIRGKRQTVKERKAA.......................................................................................................................................................................................................................... 274
11 -15.000[T] KOG0521 Putative GTPase activating proteins (GAPs)  ali follow..  15  25.................................................................................................................................................................................................ESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMS-LWDLQQHFLDNKNAHNALGKLIHCFQEMNKFHTILVLKNLSVFVKD----------INQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQMQEAANILSASKSCFQHTALDYVITLAQARKVPSI-LSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRG-KAMQNRHMSVNRYCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLDNQLVYRKRSNEDSFSVM----EEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDST-HHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSP-----EPRWASINLGITLCIECSGVHRSLGVHYSKVRSL............................................................................................................................................................ 436
12 -14.200[R] KOG1819 FYVE finger-containing proteins  ali follow..  16  470...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RSQIDPKNLRSRFRSSEDLVHRLFVCIAGVADQLQTNYSSEIRKVLKLILQPSEIIPVYEVVNAQVANSQTEVEAQETLPLPAFMGVRWVPDEDCEQCTACSMPF-NFVRRRHHCRNCGRIFCHKCSCNTISIPEHGDRKPVVSSPQSNLSLLTRQDQFSCNLLHQSHHIHHLFNRS.......................................................................................................................... 651
13 -14.100[T] KOG4381 RUN domain-containing protein  ali follow..  14  410..................................................................................................................................................................................................................VRDLVRTHRAWLR-MQKKLSDYLQALIEHEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTELMTKLVQKEDMASTIDQLEKKWSHDKSNLGEILKTTSQTLTTQVTASEERAARAEAESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLSVSKLKVSEMQDQERRQRQLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREF-NLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGKPVRVLLGSLGRSCCSSAKSGFKIQPSCISKIWFGPMPK.......................................................................................................................... 950
14 -12.200[TV] KOG1739 Serine/threonine protein kinase GPBP  ali follow..  14  2............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKN----ALSYYKSEDETGCRGSICLSKAVITPHDFDECR---FDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASG. 142
15 -10.000[T] KOG3723 PH domain protein Melted  ali follow..  9  328AHLNPNNSENIMSYDIKEQSTESLLSKNSKVFGNLITSGGRTVFEVCDSPTVELCELDRNTHSLAMQYQNNRSSGSLSRRSHASIAHSLGAGTHGPYSDINESRELSMISMPSSSRTNVLLAQPTSSSTSRIQTLPHAFAPQAMTQIQMGKDGRVRPVGGGRRPVQWPAGSTETTFPAHLGPITTSKMCALNEEDEKWINNDRNDVVYKFVEHRKNKIRRYIGEVNARFPVPVQCTVEGSKN---SKHRMVIHFS----VFTKEYLFAFKTKYPAF--------LHFMFLQECSAITQFGEVVGKDSQQYQTLEHCWKCLPSSITK---------------------------------VPFDTMITAAFPNSKDQNKLIKELDEAGFFACFTMDSTNNMWNCISCTNPEKVKYFVEEGGAEKVLEGQLKEKKGRWR--NTKYFTLSSAALNYSTQHMPTDSPSIDLRSIRSVRSLGRGKKARKSLRKAFEIFTADTSMILKAKDEKNAEEWLHCLQIAMAHARRELA.............................................................................................................................................................................................................................................. 827
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 2 6 8   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.