current user: public
If you have questions about the server, please let us know.

Query: [S] KOG4463 Uncharacterized conserved protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370
# Score Template Links and tools%idFirst MSSANIVPSNMGITKFLLLTISTSSVVAGVFALKPFFHINFGLHLLSHYQYWRILLWQFIYWNSTEVFQALFIIYQARDVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLFKNLDYIQPGPTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFYHLSLLPGTSWRLPIRFVKPALSPTHVFIRPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDINTVQTIMQTSRAQAIQALSQTNDVQRAVELLLEQTADYLast
1 -124.000[S] KOG4463 Uncharacterized conserved protein  ali  100  1MSSANIVPSNMGITKFLLLTISTSSVVAGVFALKPFFHINFGLHLLSHYQYWRILLWQFIYWNSTEVFQALFIIYQARDVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLFKNLDYIQPGPTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFYHLSLLPGTSWRLPIRFVKPALSPTHVFIRPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDINTVQTIMQTSRAQAIQALSQTNDVQRAVELLLEQTADY 372
2 -65.600[S] KOG2632 Rhomboid family proteins  ali follow..  13  19.......WNAIPLTSSVVVVCGVIYLICLLTGYDTFYEVCFLPSIISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGELERIMGSVRLLYLTVLLATTNAVLHLLIASLAGYNPHLMNECAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVPAKLYPWILLIVFQLLMTNVSLLGHLCGILSGFSYSYGLF--NFLMPGSSFFTTIESASWMLIAGILPAIFPLILHKTQHPGNAWRSLSSWLPQREASNQSSEDSRFPGRGRTLSTARDPTAPAGETDPNLHARLLEDSSSPDRLSDATVNTVADSRQAPIANAAVLPQSQGRVAASEEQIQKLVA-MGFDRTQVEVALAADDDLTVAVEILMSQQ... 410
3 -38.600[S] KOG2890 Predicted membrane protein  ali follow..  11  25..........ALPFRFLVVLRIIGYIISYLHFARLL--LWLHPYQIASIELWRIATSTFCGHNVLDVLWTVWCLHFGNLVRLNNTNESLLKLYAITQGVTTFVIVVFAYLTYILFDSIKFFLVGMTPICASVMVLMKQFLPDTIVLATPLGRIKYAHLPFLAIFVSFILAYFVSFLQITIGVQVSWTYLRFYKPHETDEI--TWASLFPSRTQLFFTLIGKVCFRTLARMGVCKRQVRHVDLHSLQSGSVGINLPALENSAKDSERRRQKALKELNDRLNKTRTAEVASYGNWDDGDDDEPTEVTVVAPPPVSNVHSSKPAMDKESMA............................................ 356
4 -36.600[S] COG5291 Predicted membrane protein  ali follow..  11  9NTFLLGQMLRVPITRYMTLLISAVALLVYV-DAVSPYSLYYSPLFLKRLEIWRVFTSFLYFGKPTDMFMHVVFLYYSRMLEEGCVNTSEYFWLILVISSVLFAISNIYGISALG-----------TSFSATITYIWTKRNPRAIVQIFGFISFPAFYLPFIL-PGFMLLSRRSISIDDVLGIVVGHLFVYPRWGRDILSTPCWVKKLFNEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDE--------------------KWGDSDN------ESECS. 348
5 -32.000[R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)  ali follow..  12  92........RAGPVTWIVMLACVLVYIAMSLIGDQTVMVWAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGAVEKRLGSGKLIVITVISALLSGYVQQKFS----------GPWFGGLSGVVYALMYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAM........................................................................................................................................................................................ 264
6 -31.300[T] KOG2980 Integral membrane protease of the rhomboid family involved in different forms of regulated intramembrane proteolysis  ali follow..  14  143..........KNLVYALLGINVAVFGLWQLPKCWRFLQKYMLLQKDYVTSKISIIGSAFSHQEFWHLGMNMLALWSFGSLATMLGASNFFSLYMNSAIAGSLFSLWYPKLAR---LAIVGPSLGASGALFGVLGCFSYLFPHA-KILLFVFPVPGGAWVAFLASVCALRWGSFDYAAHLGGSMMGVLY........................................................................................................................................................................................ 323
7 -30.100[S] KOG0858 Predicted membrane protein  ali follow..  12  1MDAGVWYRSLPRFTRYWLTATVVLSMLCRFDVIPLHWLHLDRSAVFSKLQLWRCMTSLFVFPISSNTAFHFLINCFFSKLEKDQYSRSPADYLYLLIVSAVLANIGGMIFNVYFLM---------DTLVLAITYIWCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFHFS---LASLVGIFVGHVYYF---GTPLLETPQFLKRLVPDVSGGFGGFGLPPESRAPPRQAT............................................................................................................................................ 232
8 -24.800[T] KOG2289 Rhomboid family proteins  ali follow..  11  51MFVNDCPKKITGPNKECVARFLGRFSFQPLKENPLF--ALEWRKVVHEHQGWRLLSCMWLHAGIIHLLTNMLSLIFIGRLEQQFGFIRVGLIYLISGLGGSILSSLFL----------ESISVGASGALFGLLGAMLSELLTNWTIYANKAAALITLLFIIAINLALGMLPRVDNFAHIGGFLTGFCLGFVLLV.................................................................................................................................................................................. 245
9 -20.700[T] KOG2290 Rhomboid family proteins  ali follow..  19  651................................................DQFYRLWLSLFLHAGILHCLVSICFQMTVRDLEKLAGWHRIAIIYLLSGVTGNLASAIFL----------YRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLP.................................................................................................................................................................................. 788
10 -16.100[OR] KOG0010 Ubiquitin-like protein  ali follow..  15  452..............................................................................................................................................................................................................................................SAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVQLEQL-SAMGFNREANLQALIATGDINAAIERLLGSQPS. 589
11 -12.800[L] KOG0012 DNA damage inducible protein  ali follow..  11  370..................................................................................................................................................................................................................................................................................................TGNSEDSMEQEAISNAIEQSKRESGGAGGGPNTISPQERFTEQDVTDLMALGYPRSDVLTVLRLCGNKQAARSVLLHRNDA. 451
12 -12.400[L] KOG0011 Nucleotide excision repair factor NEF2, RAD23 component  ali follow..  10  210............................................................................................................................................................................................................................HGSVQESQVSEQPATEAAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAFACEKNENLAANFLLSQNFD. 361
13 -11.500[R] COG1645 Uncharacterized Zn-finger containing protein  ali follow..  4  73........................................................................................................................................................................................................................AEVQVPEARSSPERDRPSPEQDRSSPERGRVPAERDRSSSETRKKIQARRPKTRFGQKAPETEGEEDKVLRFAEEEIPEPSYEAETARSTFPEVQAAPAVRTEKRTEQEVVSSVHGEREELENLLFEKMVNIAASLQNEKNPRSIAEQLIEKGIG. 229
14 -11.400[O] KOG4588 Predicted ubiquitin-conjugating enzyme  ali follow..  11  2............................................................................................................................................................................................................................................................................................TSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTMFPMDYDIIECVLRANSAVDATIDQLLQMNLE. 90
15 -10.400[S] KOG4791 Uncharacterized conserved protein  ali follow..  7  658.........................................................................................................................................................................................................................VKVVSSPKLAPKRKAVEMHPAVTAAVKPLSSSSVLQEPPAKKAAVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLTWEISGGK------LEAEIDLDPGKDLPLE..... 804
16 -10.300[R] KOG3450 Huntingtin interacting protein HYPK  ali follow..  15  2........................................................................................................................................................................................................................................................ATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHGNVVEALIALTN..... 121
17 -10.000[K] COG1308 Transcription factor homologous to NACalpha-BTF3  ali follow..  26  70...............................................................................................................................................................................................................................................................................................................................EPEEKKEESFPEDDIKLVMEQASVSREKAIEALKASGEPAQAIMNLMQK.... 119
18 -9.960[B] KOG2266 Chromatin-associated protein Dek and related proteins, contains SAP DNA binding domain  ali follow..  5  565........................................................................................................................................................................................................................SESEEKDESEEHSEEETTKKKRGSRLSAGKKESAGRARNKKAVVAAKSSPPEKITQKRSSAKRKKTDDDSDTSPKASSKRKKSENPIKASPAPSKSASKEKPVKRAGKGKDKPSDKVLKNAIVEI--TFTDILKELAKEFTIKMIIQEELTKLAD. 735
19 -9.340[R] KOG3263 Nucleic acid binding protein  ali follow..  8  76........................................................................................................................................................................................................................ESPRRPVEHERNWQPELKHGRERFRERDYEGRRDRKERRDGVSPFSPEGEGLERKREHEKLQAPSPKEEEERPVDQGDKMDGVKEDKDGSLEVGKSHDAMTRTKSAEEEIVEQEDEATAEMKRIMGFSGFDTTTGKKHGDVGQVYKQ--MNRPGGF 237
20 -9.250[T] KOG4590 Signal transduction protein Enabled, contains WH1 domain  ali follow..  9  274.........................................................................................................................................................................................................................NKLLAKRRKAASQSDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQE----------LSGIST. 417
21 -9.200[OT] KOG2561 Adaptor protein NUB1, contains UBA domain  ali follow..  11  390....................................................................................................................................................................................................................................................ERSERISEERKNSAAERQVNQEMIFAGQGGEWVNPRSIIRLMEMGYERRLVVEALKRTKNNLDRSLDLLQRHSDELRANLPPIPPVDESLLTTLQHLGFSEISARDALETGNSFHKSLKFLLKSFPN. 517
22 -9.120[K] KOG2393 Transcription initiation factor IIF, large subunit (RAP74)  ali follow..  9  460........................................................................................................................................................................................................................KAVKAEPASAPASSSSAATGPVTEDEIRAVLMEKKQVTTQDLVSRFKARLKTKEDKNAFANILRKISKIQKNAGSQNFVVLREKCQPKPGKRESRVNKLNIRSNLQPRKMELVTEDEIRKVLME-QLTTLELVMRLTTTEDKDSFSHILLQKNPG. 624
23 -9.010[S] KOG4556 Predicted membrane protein  ali follow..  8  1MS-----------VRWLLSLLLATWTLLSI-----------------ARLVFDLIGNLWVVFDFVQIVLLISGLF---------GATQKRRPLLYTLLSSNALSVTINVLIFLWYIGV-LSAGLPYSSSF-----FLRFTPYCDAEFDVIRKKWVQKQCLIPFYSVEASQAILHIIFAIVTSIFSILVIVELRK--------------KPIRSNSQSINHYAQICASKVAKAPSSTNNSSSGYLNSQYDDLGSSREKVKVTEKKEVKGQFERNSKKKKKNPRPEMPAPDCAPCSSNRSSEEESNLEDVYTQPIKKKIMPLRRPDLEEENRGTNVTSLVSFDPKSATLLRIRQHLEAEPSDRDTPDYDMYER. 324
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;