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Query: [T] KOG4566 Cytokine-inducible SH2 protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLIGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHTSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHYLast
1 -116.000[T] KOG4566 Cytokine-inducible SH2 protein  ali  100  1MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLIGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHTSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
2 -33.000[T] KOG3697 Adaptor protein SHC and related proteins  ali follow..  31  488....................................................................................................................................................................................................................................................................................................................................................................................AKMLEELQAETWYQGEMSRKEAEGLLEK--DGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQT----KDRVFDSISHLINHHLESSLPIV----------SAGSELCLQQPVERKQ........................................ 594
3 -31.900[T] KOG4637 Adaptor for phosphoinositide 3-kinase  ali follow..  24  601........................................................................................................................................................................................................................................................................................................................................................................ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSK-QGCYACSVVVDGEVKHCVINKTATGYGFAEPYNL--YSSLKELVLHYQHTS-----------VQHNDSLNVTLAYPVYAQQR....................................... 723
4 -25.000[T] KOG0197 Tyrosine kinases  ali follow..  12  6......................................................................................................................................................................................................................................................................SKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQV----KGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLANKAGSFLIRESETNKGAFSLSVKQGELIKHYKIRCLDEGGYYISPRI--TFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQQSLRLVRKLGS--AIKTLKELGEANMMKALQHERLVRLPI-GCLLDFLKT... 326
5 -20.500[T] KOG0194 Protein tyrosine kinase  ali follow..  17  2.................................................................................................................................................................................................................................................................................................................................KTPDQKSCETAESSNTKYSPNLIDGAAVSNEDVAGKVADLEYAHSFPDLEYIKS--FLLQRNWYHGMMFGKAAEKLLK--WESSYIVRRSMGPTHFLCITARVEDKYFHFQFNWNSEGWSCPILYE--KFPRIPVKRYEHIYQLLDAWSLVVNQLVPISRCSSIALENQLGR--AVKRLIGCNEANIMTLLEHKNIVALPI-GDLRKYLQR... 260
6 -18.500[T] KOG4792 Crk family adapters  ali follow..  18  1...................................................................................................................................................................................................................................................................................................................................................................................MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQQEFDSLPALLEFYKIHYWD------------TTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKDILRIRDK... 164
7 -18.100[U] KOG2320 RAS effector RIN1 (contains VPS domain)  ali follow..  20  84....................................................................................................................................................................................................................................................................................................................................................................................LSILDRLLHT-WLQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQ--KVLSLRLPCELKEFAIKESTYTFSL--EGSGISFADLFRLIAFYCISRD---------------VLPFTLKLPAKSEAQLEELAQM................................ 207
8 -12.900[T] KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains  ali follow..  12  2..............................................................................................................................................................................................................................................................................................................................ESVALYSFQATESDELAFNKGDTLKILNMEDDQ----------KAELRGVEGFIPKNYIRVKPHPWYSGRISRQLAEEILMKRNHGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEEK---FNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLS-IEVLERPDPH------FP---RSYVQPVHL 217
9 -11.900[T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes  ali follow..  20  4...............................................................................................................................................................................................................................................................................................................................................................................................WFHRDLSGLDAETLLKGGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEK---FATLTELVEYYTQQQGV---------LQDRDGTIIHLKYPLN------CSDPTSERWYHGHMSGGQAETL............... 123
10 -11.100[T] KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains  ali follow..  20  196.........................................................................................................................................................................................................................................................................................................PIMMQAPPPKLQASRSSFEIQVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDVNDSSSSKASHQDFAPQYSGNGEIPMEQQPWYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIERNKHFKVQNVDGLL------GNRTFVDMNALINHYTTSP-----------IFSSPTEKLFLTGPLPK.......................................... 398
11 -10.300[R] KOG3953 SOCS box protein SSB-1, contains SPRY domain  ali follow..  17  103........................................................................................................................................................................................................................................................................................................................................................................................RSLNNGRHYW--------ELHVSQRVFGTSIMKSARLHANAFGWGLSHKGVLWHVLFDGIEGTLTFYKDGKC-AFRGLDQIDE-YPIVCS------------TAAKTEMTLKC----RREFVNLQDRCRAVIMRRVRAAQLEKLKLPLPIADYLSE... 273
12 -9.970[KT] KOG3667 STAT protein  ali follow..  14  572...................................................................................................................................................................................................................................................................................................................................................................................VKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFWVEKDISGKTQIQSVE-------TKQQLNNMSFAEIIMGYKIMDATNILV------------PLVYLYPIPKEEAFGKYC.................................. 687
13 -9.890[S] COG5373 Predicted membrane protein  ali follow..  11  25..........................................................................................................................................................................................................................................................................................ERLDREIESLKAEIARLAKEGMGEPGPDLATGRPSEAGVPSVAGTEATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWP-GGLA------LALG---GYFLVQYSIEAGAIFGLALGVAGEVIRRRDVPAIAD-VLTAAGAVTLFGVVYAAYGIY-----------------IGTGAAFVLLALVSLATVGLSLLHLAGLGL--------LASLLTP-VLFGFL..... 274
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 3 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.