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Query: [S] KOG4608 Uncharacterized conserved protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSVDDDEILKVFDIQEQEQIVMKKIRHLENSDLHFERIHVNLAKKERFFDDVQSDEKLAEICDFLSQNCREISNSPRATLDEWIQTGGKFEIQRRREIRAVCHVIKATRQVGITLGELCGKVKIAKEQIAEILADLSGAAQILAAGVDEKRWVMPEYEACWMVRIGDKKWCPRPWIAPEGCISLPVVRWMAESALVLIVSKLGIQLKDVITTYEFAVQPIAIREIVRKEKSAKKSPKICSENLQNRKKNGIFVLKFTLKSKVAEKTRFTPKRTQNFALFSSKMHKNYIFLSFFKAGVMTDPSTSSNSVGWWEWLGWKGSPSSIPGRQAPPPHTEPSTVPTTSVVAVMEPKVIEHVEIVPMTGWERLKSIYERENSMEKDVTFRVVRMSFLGGFLVGGATGYAQARHAYETNNVGRKYLSPSDAVKRKIDYAIVRFAKGGFGVGFKCALISGSIVFLATHITAYRDKFASWYFPAISASVGGVFTFPIGLLGSMKAVGLGVTSGLTLSAVVHLYAMAIDKPVNDAYRLFKRDYEKELKSASEWDSRVSELMEREQITWRQQAVKKLKQQDHEKMAIFDDLast
1 -142.000[S] KOG4608 Uncharacterized conserved protein  ali  100  1MSVDDDEILKVFDIQEQEQIVMKKIRHLENSDLHFERIHVNLAKKERFFDDVQSDEKLAEICDFLSQNCREISNSPRATLDEWIQTGGKFEIQRRREIRAVCHVIKATRQVGITLGELCGKVKIAKEQIAEILADLSGAAQILAAGVDEKRWVMPEYEACWMVRIGDKKWCPRPWIAPEGCISLPVVRWMAESALVLIVSKLGIQLKDVITTYEFAVQPIAIREIVRKEKSAKKSPKICSENLQNRKKNGIFVLKFTLKSKVAEKTRFTPKRTQNFALFSSKMHKNYIFLSFFKAGVMTDPSTSSNSVGWWEWLGWKGSPSSIPGRQAPPPHTEPSTVPTTSVVAVMEPKVIEHVEIVPMTGWERLKSIYERENSMEKDVTFRVVRMSFLGGFLVGGATGYAQARHAYETNNVGRKYLSPSDAVKRKIDYAIVRFAKGGFGVGFKCALISGSIVFLATHITAYRDKFASWYFPAISASVGGVFTFPIGLLGSMKAVGLGVTSGLTLSAVVHLYAMAIDKPVNDAYRLFKRDYEKELKSASEWDSRVSELMEREQITWRQQAVKKLKQQDHEKMAIFDD 578
2 -35.900[O] COG5596 Mitochondrial import inner membrane translocase, subunit TIM22  ali follow..  11  2.....................................................................................................................................................................................................................................................................................................................................................SLSGLLPPNLGGNSPNADGNLTPEEKAALQQAKIIGYESCVFKSSMAGVLGFGLGGIFGMFISSLDLQHIDPKIYEKP----FREQIRIQARDMGSRSFSTAKNFGLLGLIYSGSECCIEAFRAKTDIYNAIAAGVFTGGALAVRSGPKAIVLGGAGFGLFSYGIEKYM.................................................................... 171
3 -34.700[U] KOG3324 Mitochondrial import inner membrane translocase, subunit TIM23  ali follow..  11  1......................................................................................................................................................................................................................................................................................................................................MADPMNHSTGHQQQQKYRQYNPYQQVNLPYRKLYELPTSPEFLFEEEATKKGENLTFFTGWGYCTGSVLGAFKGTIAGMRAAERG----------ESLKIRTNRILNSGGLVARRGGNCLGSVGLMFAAMESGVTYMRDGDGSLTTVIAGLATGVLYRAASGPRSAVVAGAVGGVAALAAVAGRRIVKRFV............................................................. 186
4 -34.600[U] KOG1652 Mitochondrial import inner membrane translocase, subunit TIM17  ali follow..  11  1................................................................................................................................................................................................................................................................................................................................................................................MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAIKG------------FRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFAED--PSQLPSTQLPSSPFGDYRQYQ......................... 171
5 -31.500[U] KOG3225 Mitochondrial import inner membrane translocase, subunit TIM22  ali follow..  11  4......................................................................................................................................................................................................................................................................................................................................................................TGFGLEQISPAQKKPYNELMTSCPGKSVVSGVTGFALGGVLGLFMASMAYDTPLHTPTPANSDLPFRQQMKLQFTDMGKKSYSSAKNFGYIGMIYAGVECVIESLRAKNDIYNGVTAGFFTGAGLAYKAGPQAALMGGAGFAAFSAAIDLYMKSEDGRPPQNFKE....................................................... 207
6 -13.100[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  11  98...................................................................................FRITERADVFENSNRARIYEYIKTRP--GAYLSEIIEKAGIDRGAARYHIKILKAHHKIYRESGKTRYFQNNSTYG-----------------EEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIG--VSRATISWYVKNLKETGLIDET.................................................................................................................................................................................................................................................................................................................................................... 233
7 -12.800[K] KOG3233 RNA polymerase III, subunit C34  ali follow..  11  1..MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQE----KLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLI-----KAVKSVAASKKKVYML-QPDRSVTGGAWYS-DQDFESEFVEVLNQQCFKFLQSKA-ASSHEVWKYICELLSMEDIETILNTLIYDGKVEMT.................................................................................................................................................................................................................................................................................................................................................... 251
8 -12.800[K] COG5111 DNA-directed RNA polymerase III, subunit C34  ali follow..  10  1MADQLRTLPKNAK------VIYEHCLKQIPNSLSQQDLVEAIGASISVNDLSSALNILLSRRLLDPLRQGNVLVYRAVRLDEAKTVSTMEGDEQI-----VYSFIKNSGNEGIWRKTLTLRTNLHVSVVDRCLKSLESKNLV-----KSIKSVKNPTRKIYML-VPSTELTGGPWFT-DQELDVEFIENLKKVIYRYVHSKS-PTALQIHNWLRSTLSLANVISLVDVLIYDGKVEKR.................................................................................................................................................................................................................................................................................................................................................... 249
9 -6.850[FH] KOG2466 Uridine permease/thiamine transporter/allantoin transport  ali follow..  8  3...DNLSLHLSGSSKRLNSRQLMESSNETFAPNNVDLEKEYKSSQSNITTEVYEASSFEEKVSSEKPQYSSFWKKIYYEYVVVDKSILGVSILDSFMYNQDLKPVEKERQLGLNWWQCW---------ITIWIGYGFVGAFVVLASRVGSAYISSRAS---LWPVINRVVMAIVWYSVQAYIAATPVSLMLKSIFPDHFGSPNATTYEFMCFFIFWAASLPFLHKIRHLFTVKSFGFLIWAIRRAHGRIALGSLTDVQPHGSAFSWAFLRSLMGCMANFSTMVINAPDFSRFSKNPNSALWSQLVCIPFLFSITCLIGILVTAAGYEIYGINY---------------------------SPLDVLEKFLQTTYNKGTRAGVFLISFVFAVAQLGTNISANSLSC----GTDMSAIFPKFINIKRGSLFCAAMALCICPWNLMATSSKFTMALSAYAIFLSSIRGYIKLMYGNRFGINWRALAAYLCGVAPCLPGFILSYWVGYGLSFSSYTALCYFFPVPGCPVNNIIKDKGWFQRWANVDDFEEEWKDTIERDDLVDDNISVYEHEHEKTF..... 632
10 -6.650[A] COG5213 Polyadenylation factor I complex, subunit FIP1  ali follow..  13  8MDVDEDEYLYGETIEERNDGVTVS----NAKSPEQASEESDDSDIEFIIETKPGERAEPLGGSIATLGSTRPSAKPQVEKTAVEVKTTEPQDLSTAETAPKVDIDAVPTIDGKNIFEI--------------LESFDD----------------------------------KPW------------------------RKPGA---DISDYFNYGFDEFT-----AYCAKQTTLRDDFSPQKFMASLAQ........................................................................................................................................................................................................................................................................................................................................ 176
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 2 5 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.