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Query: [T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQEIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCDNEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDESNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDLAFDMYQDPEVAQIIRKLDERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEVEKRCAVEKEDYDLAKEKKQQMEQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTENQFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYGEAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSYREDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKLSKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQIIPSYLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYEVRETAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFTEEGLDLHYWKHCLMLTRCDHCKQVVEISSLTEHLLTECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRTYAKRLast
1 -260.000[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali  100  1MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQEIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCDNEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDESNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDLAFDMYQDPEVAQIIRKLDERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEVEKRCAVEKEDYDLAKEKKQQMEQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTENQFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYGEAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSYREDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKLSKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQIIPSYLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYEVRETAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFTEEGLDLHYWKHCLMLTRCDHCKQVVEISSLTEHLLTECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRTYAKR 925
2 -25.300[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  13  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKNTAPFVVDTAPTTPPDKLVAPSIEEVNSNPNELRALRGQGRYFGVSDDDKDAIKEAAPKCNNCSQRGHLKKD-ATDDHYSRHCPKAIQCSKCDE-------VGHYRSQCPHKWKKVQCTLCKS-------KKHSKER-CKPKVLPFHTIYCYNC------GGKG---HFGDD--CKEKRSSRVPNEDGSAFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLP 233
3 -21.100[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  15  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ARITNMGKRKRFLEATPYESKVLEQPKNSSNTNEESSSQDNMKASFGSSKRYDERQKKKRSEYRRLRRINQRNRDKFCFACRQQG----------HIVQDCPEAKDCFRCGS-------KEHSLNACSKKGKFAKCFICHE-------NGHLSGQ-CEQNPKGPKGGCCKFCSS---------VHHLAKD--CDQVNKDDVSFGHVVGVAGTTGADEDVYHEYAKTVAAPTKKRPVKPVKK........ 214
4 -18.400[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  19  4................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HCAGCERPLDRFLLNVLDRAWHIKC---VQCCECKT-----NLSEKCFSRC--KNDFTKCAGCAQGISPSDL--HL---NC----------TCMVCNKQLSTGEE-----YVIDENCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPKETDNSTSSDKE...... 165
5 -17.400[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  16  3......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHLDKFILKVLDRHWHSSC----KCADCQ-----MQLADRCFSRC--KEDFTKCTACQQGIPPTQV--HL---HC----------ACIICNRQLATGDE----FYLMEDGCKEDYETAKQNDDSEAGAKRPRTTITAKQ............................ 168
6 -16.700[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  10  1...................................................................................................MSTVEDVEIERLRAERELLRRQKE------KNSSTNGSVNIEGTQDSN-HLFKSSNPKEEYDSAIDVRNDISQDEDDYKRTNDVNDSYRLVRQYEAPKELLNEYADESYD----MQERQSKKQIQDRESDYQKQRYDRTRVDAFQPDGTQSNG-EVMRQVELEKEERRVHMELNQRRREGTLKEVEEEESISDKKRELELNNTEISQKPKRSRWDQAPPSVTQVSTTKRRSRWDKAPENFTEEKLRPPVRLLTEEELNELLPSEGYAILEPPPGYLESIHPELLQKGTTLDTYHVPQEQELPLEKELPAALPTEIPGVGDLAFFKQEDVKYFGKLL-LRLLLKVKNGTPPMRKSALRQLTDQARDFGAAALFNQILPLLHKILVVIEPLLIDEDYYARAEGREIISNLAKASG-------------LAHMIATMRPDIDHVDEYVRNTTARAFSVVASALGVPA---LLPFLKAVCRSKKSWQARHTGVRIIQQIALLLGCSILP-HLKNLVDCIGHGLEDEQQKVRIMTALSLSALAEAATPYGIEAFDSVLKP-----LWSGVQRHRGKSLAAFLKA....................................................................................................................................................................................................................................................... 633
7 -16.300[R] KOG3002 Zn finger protein  ali follow..  13  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMYPPIHQCPNGHTLSSCRVQNTCPTCRYELALEKVAESLEVPCRYQNL------CQDIFPYYSKLKH--EQHCR------RSYSCPYC--SVTGDIPTLVDHLKDDH.......................................................... 169
8 -15.400[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  13  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SESVKENVTPTRNFRRTQGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKLTYVSLTPCHHKTCHICGF-KSCLICRTENEFKKYNEHLKSE-HNRMICLICATHKHAFPCEQLRNHQTKGN---SEGFKGHPMCAFCSGKRFYSDDELYIHMRNQH-CDKM..................................................... 255
9 -15.300[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  16  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QNGKPRSSARPSFHRRPKDGVANTTTDNAAVKPEALESYTGNDDNACVVCFKNVEIFSIGDCD-H--NECPICRHCPKCDAPPTFEGLRNHV----RSEHKLLYCDLCRRCYTQAELQLHNTKGD-PDNRSHRGHPLCEYCNKRYVDRDELFR-HLRREH-CDADGCNE................................................. 243
10 -15.300[R] KOG4377 Zn-finger protein  ali follow..  11  219............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSFLAAASQPLALPGSAAGPGVSGPLLDMRILLENAAQQKLMLLNAAASATASAVAATTINSGQRTAAKRNRDHDIPSGYLKFRFNEDCGFERCGYRN--HQSHF--------HCRDCHYSFDKTRFVQHTNMQCSRKTSHFHCRKCDYVCDSNKVVAHRRLEQCDSPGCSYAQRHCVTCDGGVLSRAQ--HRT--KQEAD-TTP.................................................... 493
11 -15.200[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  18  4...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRCGRDIKLLALDKQWHLGC-------KCKSCGKVLTGEYISKD-GAPYCEKDYQGLFGVKCEACHQFITGKDKHYHPSCARCSRCNQ...................................................... 164
12 -15.100[R] KOG3183 Predicted Zn-finger protein  ali follow..  15  8...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DLGKH-VDYCKQI-TCDRCLQVY-----LDHRSHDCPKGNRGDVCPLCAKGVRLNPWEKHVNTDRCRELLTFSNTIKCRDCSIDHCLKHRFGPDH-----SCSGPKKPESSFSFMGFLSTNTKEAPASSSSSSRWSSLFASAEASISRLGNDISQKLQ 193
13 -15.000[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  11  372.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAPL--CCTLCHERLE----DTHFV-QCPSVPSHKFCFPCRQSIKQQGASGEV----C------PSGEKCPLVGSNVP-----WAATILAGDVKVKKERDS................................................. 560
14 -14.900[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  9  349............................................................................................................................................................................................................ASQEYNLSLSRQCQDIENELKDDQYIYSSRLYSLINDRIHHWNAELDRYK------------ILTEAIQAERSFVMRRDKELNLRAESLEAANHKTTTVGSRIEVLEKKLQSCIIEKNGLELETEEAIQDSERQDIKSEFIAMASTLSKEMEMMEAQLKRWKDTAQDALYLREQAQSLRVSLSNKADEQKGLEDKCAKQMAEIKSLKALIEKLLKEKLQLQNLASICTRECNDDRGLAEIKDSQRKAQAQAEELKNVLDEHFLELRVKAAHETESACQERLAT--AKAEIAELRTQLDLSEREVLELKEGIKVKEQEAEASIAE-----METIGQAYEDMQTQNQHLLQQVAERDDY-----NIKLVSESVKTKHAYNTHLSEKQVMEKQLHQ---------VNASVENFKARIAHNEEQMKGCFSEA-------------------------YKLIQEDRHLVISLETTKWEVADADKEFRWLKSAVSSSEKEYEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEE-----------------------KNCKNILKCGVCFD-----RPKEVVIVKC---HLF--CQQC--------IQRSLEIRH----------RKCPGCGTAFGQND---LVKM.............................................................. 899
15 -14.700[DO] COG5156 Anaphase-promoting complex (APC), subunit 10  ali follow..  16  114MINVTHLALWKPSSFKLGNPVDFALDDNYDT--WQSD--GGQPHQLDIMFSKRMDICVMAIFADESYAPSLVKVYAGHSPSDARFYKMLEVRNVNGWVALR---------LDNREDDQLLKCQFIRLLFPVNHENGKDTH----LRGIRLYVPSNEPHQDTHEWAQT...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 269
16 -14.600[R] KOG4602 Nanos and related proteins  ali follow..  23  233..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CNFCKHNGESRHVSSHQLKTPDGV----VCPILRHYV-------------------------CPVC------GATGDQAHTLK---CPLNGGQQSLYRRSGRNSAGRRVKR................................ 308
17 -14.600[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  10  89.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTL-------------CSVCQR------------GHSPLSNRIVFCDGCNSPY-------HQL---------------CPIDDATVQDVDAEW-------MKCQYRRAKQPLETGMTAQDLGLSESDKKM............................. 270
18 -14.400[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  9  2................................AFQ-------PDQHELE-----QVIQLHAHSTDRDVQRNVQVQLVQLNEHQKFC------CYLVYILSDMKEMIDATSRSLAGLLLQDVKFFVRTTCLKSIGDQEPLIRATVGIIVTTIVMEENMCDWPDLLDTLATVLMQPDELMQEGALGALQKVFED--------------DRYESEFLRPIMPKLLVFYEHHAAKMRALAMNCVNCILMIDFAIDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEKMM-------------PHLPNVIEYIIKKTQDHNESIALEACEFWLSIAENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKANDEDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDDDDGGGDWNIRRCSAASLDVLASIFGKDLKDTLMNDNWLVKESGILALGAIAEGC-----MDGVVPHLGELIPFMLAMMFDKKPLVRSITCWTLSRYSSHIASDENFRQQF----FKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLIPFLGEILLVKAFQCYQAKNLLILYDAIGTLANSVGDALSHPVVQMLMPPLMEKWERLSDEELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNQQHIMAPDQVEA....................................................................................................................................................................................................................................................... 627
19 -14.400[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  20  415................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RCARCGEVGEGTGCTAMDQVFHVDC----TCIICNNKLRGQPFYAV----CEPINTLEQCNVCSKPIMERILRAHPH-VMCHRSLDGIPAPRCSVCKEPIMPADRDFHVHCYRCEDCGGL..................................................... 575
20 -14.400[TZR] KOG1704 FOG: LIM domain  ali follow..  11  192..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAEGRSWHFHH----QCAQCNDVLA----QKYMQRACLKHSSSSSCTTCRLSFSSDT---H-ASAEC-----------CCVCSKNLLG-----VKYSRVGESCGYQTCGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHV........ 338
21 -14.300[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  14  139...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FDIDRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNARSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEASV--------------LLLPC-------------RHM---C--------CSVCGSSLNT-----------------------CPICKSPK---TASLHVNLSS............................................................ 335
22 -14.200[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  15  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCG-------DKVSGYHY------LLTCESCKGFFK--TVQNNKRYTCIENQN---CQ-----IDKTQ------RKRCP---------YCRFC-------SVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNI. 170
23 -14.000[U] KOG4173 Alpha-SNAP protein  ali follow..  14  81.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ACAGCCQVFDLDDYEHHY-----HTLHGNVCSFCKRAFPSGHLDAHILEWH-QILSERQDMYQCLVCTEKFKTSRD--KDHMVRMHLFDKPKKSRSPASAEAPGDSGERSEGEAMEICSEPVAASPAPAGERRIYRHRSV.... 229
24 -14.000[R] KOG4299 PHD Zn-finger protein  ali follow..  9  162.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENKSLKTTAKDLSDISSSSMKKANNSSKPLFSGKLTFKANIPVPTSEVVTENNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEEYPYRYNNDYCSACHGPGN-----------------FLCCETCPNSF-------HF--TCEEKN----CNECKHHSLYNELDEQEELESC---------DYCNSC-ATLPSNLRKWK--------CPNHSDHVTPRYRLPEKAK...................................... 471
25 -13.800[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  13  28.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EELESAQERIQERIRQLEVIVSRIREREITTTTTPALVSPNEHRDSTAGVIHERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKAED--------------PILTCC-------------GHLF-----------CWGC--------------------PLIYLNIKECPVCDGEVTDAE------IYGNGDDCDGTKPKLEDCGISLPPRPNAKRVESVRQKIINRGN.................... 210
26 -13.700[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  10  12.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDLLILGLCAREYVHYKRTAKVLKAAPQNIDGDLKSVVERQRDKKIPYAVIRGTVTPIGVPLRSSLVPSVSGVLQIVKLHEHRVLLHESANEMPFELRNQSHGVEDNYEPSNLSLFDHVFGFFSGVRQRGLQTTEEVLREGSFLTAIGELELDGDTLRMQPSNEGPLFLTTATKSTLIKRFEDAKTTTILKLVVCSTISAILVAFIAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQL-------------CVVC-----STNPKEIILLPC---GHVCLCEDCAQKISVT----------------------CPVCRGSIVSKAAAFIA................................................................ 338
27 -13.700[R] KOG3608 Zn finger proteins  ali follow..  24  215...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RTKTTLFDHLRRQPENNTNSFQCAQCFKF----TKKLLKSHVVRH-----KCTMCDMTCS-SSLTTHIRYRHLKDKPL-KCSECDTRCRESDLAKHVEHPDCHYSVRTYTQMRCHCCERFFKSGKS--SAHLMKKHG......................................................... 374
28 -13.700[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  13  72............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IELGLSKELREMLPIVSQCSVC-------------LGDYQPNDKLQQIPVCK----------HTFHMDCIDL---TSHTTCPLCRLALIPSRSR-DDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPV 220
29 -13.700[S] COG5369 Uncharacterized conserved protein  ali follow..  8  1..........................................................MVAINDSTDSSFFKENPKIFKDEH----------ELLRYIVPFKNWVIGRPDRKEYAIRNGAPKLLLNLF------SLENLSMNEKYQVFVVLNSLMSEDQDPFVQ----------------------------------------------HEDLLSV-----QMISKRDSTPYGMLNITLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTL--PILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSRSVYILRTGLADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKLESKNPIL.............................................................................................................................................................................................................................................................. 573
30 -13.700[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  8  1..........................................................MVAINDSTDSSFFKENPKIFKDEH----------ELLRYIVPFKNWVIGRPDRKEYAIRNGAPKLLLNLF------SLENLSMNEKYQVFVVLNSLMSEDQDPFVQ----------------------------------------------HEDLLSV-----QMISKRDSTPYGMLNITLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTL--PILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSRSVYILRTGLADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKLESKNPIL.............................................................................................................................................................................................................................................................. 573
31 -13.600[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  10  1MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAA---QLKNHL-----TSKDEKVSQQYQDRWHQF-----PSEIRELIKNNILAALGTENT-MLIQTLVNKVVSEGSSEHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAA-----TTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTMEPYMAQALFPITLAAMKSDNDAVALQGIEF---------------------------------------------------------------------------SNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLE----TNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAETPETYALSPYFEYIITQLLETTDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTNNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNGKSGVVQEEAFLAVSTLVELLGAQFAKYM-----PAFKDFLVMGLKNF.................................................................................................................................................................................................................................................................. 667
32 -13.600[K] KOG3815 Transcription factor Doublesex  ali follow..  22  24......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QRTP---KCARCRN---LSWLKGH--RYCR----FKDC-TCE---------------------------KCILIIE---------RQRVMAAQ------RRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAE 126
33 -13.600[S] KOG3931 Uncharacterized conserved protein  ali follow..  10  471............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PIVNLVESSSDEEEMKMPAGRKTMTSQERTQIIKRQVMEDELTLCEDDILLIDDEYDDEVAANESLTAATELADQSIIDDIFGEDTLLKEFQRENDVQPSCSSYAKRIENDIVSCPICFEKMRRTELSNH-FDGCSSKGILRSSGYTEGEIDKLNLSSSTDSST-RQRNLFKETVGCPRCGLEIMPLH---KVHG---SVCAGRKKR.................................................. 724
34 -13.600[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  18  257............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENKNNQETKPSDDENSDNSNECVVCLSDLRD---------------LILPC-------------RHL---C--------CTSCADTLRYQ-------------------ANNCPICRLFP--------GPPAD---PGGAEEARSPVPRVLQPRPGPEPGA................................ 350
35 -13.600[S] KOG1949 Uncharacterized conserved protein  ali follow..  11  63........................................................................................................................................................................................................................................................................................................................................................................................................................................KKASGKILEAIENDCIQDFMFHGIHLPRRKVREVLSYFHHQKKVRQGVE-EMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFP--IRDPNLHAIEMDSKIQKQFEELYSLLEDPYPMVRSTGILGVCKITSMPPTILIDLLKKVTGELAFDTSSADVRCSVFKCLPMILDN---KLSHPLLEQLLPALRYSLHDNSEKVRVAFVDMLLKIKAVRAEHILVRLETDSRPVSRRLVSLIFNSFLPVNQPEEV......................................................................................................................................................................................................................................................... 327
36 -13.500[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  14  163...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RTSTPTTRRIRRRTSPVEVIDLSHLDRAPPVRSARNRDPDAFIDLCTPEGPRSRTVNLHSNDSLTILPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELY--------KCPIC---MDSVSKREPVSTKC---HVF--CRECETAIRATH--------------------KCPICNKKLTARQ---RIYL.............................................................. 319
37 -13.200[R] COG5048 FOG: Zn-finger  ali follow..  12  551.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECPGCTKTFRRYNIRSHIQTHLEDR----SCD-CDKAFRNHDLIRHKKSHQ-------EKAYACP-CGKKFNREDA--SRMICSGG-IKRSRKRGRPRKDGTSSVSSSPIKENINKDHNGQLMFKLEDQLRRERSYDGNGT... 697
38 -12.800[K] KOG2845 Activating signal cointegrator 1  ali follow..  12  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAVAGAVSGEPLVHWCTQQLRKTFG---------VSEEIIQYVLSI--ESAEEIREYVTDLL----------------QGNEGKKGQFIEELITKWQKNDQELISDPLQQCFKKDEILDGQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTRERQDRLAVALPG-----------HPC----DCLG----------QKHKL--------INNCLICGRIV-------------CEQ----EGSGPCLFCGTLVCTHEE--QDILQRD---SNKSQKLLKKLMSGVENSGKVDISTKDLLPHQELRIKSGLEKAIKHKDKDRTSIRR 279
39 -12.800[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  25  653..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CKICDAPIECVFLEGHMAT----------CTSCGKVLNE-----------------------CPICRQYIVRVVRFFRA................................................................ 700
40 -12.800[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  8  3............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PRRSYPFSGHGGTIARFIEFGEAFGHYGEEEDEEEEDEEEAYVDYGEVQEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTL------------RDCLVLS-------FGPAVA----------NTKSG----------ILDSIVF--MDIPASTSGFSSDEVEGSLRD--YASRVAAVDD-EAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTK 227
41 -12.800[U] COG5215 Karyopherin (importin) beta  ali follow..  10  6FAQLLENSILSPDQNIRLTSETQLKKLSNDN----FLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIAELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAA---LNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSMKPYMEQALYALTIATMKSPNDKVASMTVEF-------------------------------------------------------------------------------STICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPD----KVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQSPIYNFYPALVDGLIGAANDNEFNARASAFSALTTMVEYATDTVAETSASISFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKY-LETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYS-----DAMMNVLAQMISNPNARRELKPA......................................................................................................................................................................................................................................................... 701
42 -12.800[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  8  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLL---ELRLIEHEHIFERLPFTIINTL-HERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYL--QVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDN------------------------------ICIICMDELIHSP-NQQTWKNKNKKPKRLPC-------------GHILHLSCLKN---ERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTS. 475
43 -12.700[TZ] KOG2272 Focal adhesion protein PINCH-1, contains LIM domains  ali follow..  18  6............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MHCTRCADGFEVNSNGELWHTQC-------VCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKCGEFVIGRSASWHPQCFRCQLCAK...................................................... 100
44 -12.500[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  10 1244....................................................................................................................................................................................................................................................................................................................................................................................................................................................EFFPSLCNSNDLQMESVCMKFLREKLSHELKELTVYYMVE-------------YEPDVSLCPELLSLAIDFPGDPFVMVSKMEKYEHALRVYLLVLIFYHFEETTYNIKLSIINQL--------------------------HAMDLLRPLLNTLVEILNLSYDRPINVDKYPKIDYNLMDYSSATDRIRCLAIHIYYQCLRHLSSSVRSYWSEVKNRAFTSTVESFTGYNVSPLLISASLDDVERSIESEDFQSVGDVNVKVNRNTREISFIYNVDEHKLEMAIKIPSVYPQNVQVEGIERVGVNERQWRSWILASQSILSSQNGSITDKNISMHF------VEECAICYSVLS----VERTLPN-------KRCGTCRHKF-------H---ASC----KSSNSSRCPLCRSSFT........................................................................ 1608
45 -12.400[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  12  181.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKGKSKGKGVGSARKKLDASILEDRDKPYACDICGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEE-------LVSCSDCGRSGHPSCLQFTPVMQC------IECKCC---------------NICGTSENDDQLLFCDDC-------DRGY--HM-----CLTPSMSEPPEGSWSCHLCLDLLKEKASIYQNQNSS..................... 391
46 -12.400[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  12  13............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEARVPWSIMGHCLRTGQARMSATPTPAGEGARSSSTCSSLSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGI-------HY------VITCEGCKGFFR--SQQSNATYSCPRQK---NCL-----IDR------TSRNRCQ---------HCRLC-------AVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNY. 228
47 -12.400[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  14  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VWFQCDDCGENLKKPRLPRHM--MCTATK---SCIDCGNMFGQVSVHYHNQ---CITEAEKYGPM-CSLCNATM-TCEQDYFAHV-------YGKKHQEKANEVADMDYSKQQSEHPAVDKNNLTQQPDLDIYVGLSNDYP...... 153
48 -12.400[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  12  26.......................................................................................................................................................................................................................................................................................................................................................................................................................................TLRTQEGFETDILRALNIILTVKK---GNSNADRVLRFLVTVNYLQQKDPEIDIVQPILKHILRGLDAKDKTVRYRCCQIIARVVNCV-------KEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEENDVR-NILLFLLQNDPSSEVRRSVLLNIEARVLPKIGDFRYLSIKKRVRILKWGLNDRDESVEKAAADMLAYQWENADNNLLELLERLDVSNNSDVAVLAIKKFFDV............................................................................................................................................................................................................................................................... 288
49 -12.200[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  15  309.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CGAGLLPEPDQRKVTCEGGNGLGCGFA--CRECKE-------AYHEGECSAVKKTTKPCPRCHVPVEKNGGCMHM---KCPQPQ---RLEWCWNCGCE-------WNRV............................................................... 428
50 -12.000[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  11  31.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AHQKDEQIQGLLIMKVTELCKLIKSQLFVNSYPKELSIFAKLLYLLFTTGRRGRTLGEEYVD------LTYTNRKGTRLAGRLKMIVFAFAY--------PLCPYFITKLYKKIMKNNKESKIEDTESVAAFC------------------------KGLLDFILDVHMTLFYFKGASISKRIFGMRYVFKHILSKNEANFREEGSQVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSD--------------PSCAPC-------------GHLF-----------CWSC--------LMSWCKERP-----------ECPLCRQHCQPQE..................................................................... 331
51 -11.800[DO] KOG3437 Anaphase-promoting complex (APC), subunit 10  ali follow..  16  26VREVGAQAVWSLSSCKPGFGVERLRDNIMDT--WQSDG--QLPHLVNIQFHKRTNISQIYIYLDESYTPSRISIRSGTNFNDLQELQVMDLTEPTGWVQIPIKDGNVKSIR----------TFMLQIAVISNHQNGRDTH----MRQIRIHAPVEGKHYP............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 172
52 -11.800[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  14  43...........................................................................................................................................................................................................................................................................................................................................................................................................................................................YQRSWDIQEDAEGSLVGVIAGLIQSGKRKRLLRIIRHMVLVLSMEERDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAHRITDLHGNPQSHIQK------------------------------------------------LKSLRDCSGNFSLQNALEMARASLSHIASHGTREVLIIFGSILSSDPGDIFKTIDALVHDSIR--------RIVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGFHCPRCKA---------------KVCTLPIECPSCSLVLHLARSYHHLFIPWSANPKSTHCFACQLPFPKP-------PVSPFDESTSSMRYACPSCKNHFCLDCDVF-AHLHECYGCQCS..................................................... 419
53 -11.800[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  14  43...........................................................................................................................................................................................................................................................................................................................................................................................................................................................YQRSWDIQEDAEGSLVGVIAGLIQSGKRKRLLRIIRHMVLVLSMEERDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAHRITDLHGNPQSHIQK------------------------------------------------LKSLRDCSGNFSLQNALEMARASLSHIASHGTREVLIIFGSILSSDPGDIFKTIDALVHDSIR--------RIVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGFHCPRCKA---------------KVCTLPIECPSCSLVLHLARSYHHLFIPWSANPKSTHCFACQLPFPKP-------PVSPFDESTSSMRYACPSCKNHFCLDCDVF-AHLHECYGCQCS..................................................... 419
54 -11.300[L] COG0551 Zn-finger domain associated with topoisomerase type I  ali follow..  13  6.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KCPTCGRNMAIRTASTGVFLGCTGYALPPRCTKCGTAMDSYVIDAHRKIHICKIKGYDGPVVECDKCGADMHLKLGRFGKYM----GCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGV.......... 184
55 -11.300[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  9  7............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDTEEEYDDDAFVIPRSTSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEERIASMFATQENQWEQTQEEMSAMCYRCGGRD----------HWIKNCPT-LKCPLTGGLLRQPVK----TSKC--------CNISKE---------------ALENALVESDFVCPNCETSLVPDQD---ETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPF 415
56 -11.300[K] KOG2482 Predicted C2H2-type Zn-finger protein  ali follow..  15  139.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QKQRLREILEQQQQERNDTNFHGVCMFCNEEFLGNRSVILN-HMARE----LQCLYCEKTFR-NTLKDHMRKK-EEHPASAVCLFCEKQAETEKLYVHMEDAH-NFIRRQVHQCRCYGCHVKF-KSKADLRTHMEETKHTSLLPDRK................................................. 377
57 -11.200[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  9  108............................................................................................................................................................................................................................................................................................................................................................................................................................................KRSQASLVRALLRPYENRAWGQSNWLLLRFWMKDSRQPSVWQGGSLPLHQGLCRSRSRNETHTGLLHNVANPSKHFQRLIGAKLLEDEPFATAFLNSVLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLM------RCLEMVITTAPEIVTDESRPNSDLLLNRICQLISQVLSRVTVPVDMCSADLNAVTHYPIVTAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGNFDPSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPIC-----CAKPITAVFTPCKHQ-----CSDC--------IMQHMMNSK-----------VCFYCKTTIQTIETLDGTVIFSNDDVVQTPMIERA............................................... 538
58 -11.200[R] KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger  ali follow..  11  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRVCQSL-----DGKLHQH-------VVKCTVCNEATPIKNPPTNCLLICKDTSRRIGCPRCRRIINLGPVMLISEEQPCGNTLRFNTLAKCPHCKKICSSS...................................................................... 184
59 -11.200[K] KOG2461 Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains  ali follow..  9  408...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QPIDVQPVLAATAGAHFGNYAAIYGSQDFQHELSKPLYTSASPAFGGGGGMGGGFGMGGSAHTSSFHQLPFVNHSSSSHNDSSFNGVPNYVQQQENGKTRYACKDCNKT----QLSNLKVHHTGERPF--KCEICKEFTQLAHLQKHHLVHTGER----RCDICDKRFSTSNLKTHLRLHN------GQKPYTCDVCDAKFTQYVH--RLHKRLHANCGKKISPSGLRTHWKTTTCKEEDMKDSMRDDLMDIKGEIDEGSMSGSGYGNLGIFEN 682
60 -11.100[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  26  183.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECVIC-------------LEELLQGDTIARLP-C----------LCIYHKSC------EVNRSCPEHPAD.......................................................................... 227
61 -11.100[T] KOG4846 Nuclear receptor  ali follow..  11  63.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEFSSEFQIQNGSTAAQSGNANNYADPLSHRRYFNNVNGYNHHQFYDTASQASVSSPATSVTSSLSPPDSLSNGHTTQRHHIGKAISFCKVCGDKASGY-------HY------VTSCEGCKGFFR--SIQRKIDYRCLKQQ---VCE-----IKR------ESRNRCQ---------YCRFC-------DSGMSKDSVRQMKFRNAMRDDKSPDSVFVPEISTLERQEEVDAVYEAVLRA................... 263
62 -11.100[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  15  26............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRCHICKDF-----LKVPVLTPCGHT-----CSLC--------IRTHLNNQP-----------NCPLCLFEFRESLQSYTSDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILP 159
63 -11.100[L] KOG0287 Postreplication repair protein RAD18  ali follow..  15  26............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRCHICKDF-----LKVPVLTPCGHT-----CSLC--------IRTHLNNQP-----------NCPLCLFEFRESLQSYTSDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILP 159
64 -11.100[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  17  208..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HRLPKSMLKKLPVLRTCVIC-------------LEDFIEDDKLRVLP-CS----------HPYHTHCIDPWLTENRRVCPIC-----------KRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAA 342
65 -11.100[S] KOG0212 Uncharacterized conserved protein  ali follow..  10  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................MDNLLVRGLTHKLYDKRKATAYELERVVKGYLENDETEKIRAVISQLANDFVYS-PARGPNATFGGLIGLAAVAIAL-------GPKIDSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGEVFLIFDVLCKLFADTEITVKNGAELLRLIKDIVMQQAATMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLEFISYL-----PFLLDGLMNYLSDPNESI.............................................................................................................................................................................................................................................................. 261
66 -11.000[S] COG4357 Uncharacterized conserved protein  ali follow..  20  7.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YGKTVDDQSRCVHWHLPCDKYYACFECHQELS-----SHPLEKYDLLDDANKCGVCRHEMTFAEYYDYNSNL------------ICPNCRSPFNPGCKLHYHQNPPPAMC........................................................ 116
67 -10.900[U] KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3  ali follow..  9  458.....................................................................................................................................................................................................................................................................................................................................................................................................................................EDEKAKLLLTLRVVDTTLLKCYIKTK--------MLVDSLIRLQSNACTFEDAKKILESEGRLRSLFILYETRKKHEMALDLFIDQSSR-----PDADPFFDDAIQQIVE-YLQSLGNSNLPLAKNLEAGVQIFTSDETEMARNLNRKAVVEFLKSECP----DALIPYLEHVIFKWEEPSSYFHETLLEFYVARVNTGELGLYRKRLLKFLEVSHSYSPQTVLLQLAPHAFYEERALILGRLKQHEQALATLKNVPAAEEYCRLYYNAHDETNSQVYLMLFRTLVHPNQQQLHSIPYHADSTPFGSYRDDVSEASTLVNSTSSYQPDVNTAIKILAKHADKIDTVG----------ALNMLPATTPLRVVFSAINAVIQTTGRQASTRKMEKSVSQCAMSKKLERKNKAQSTKII--NFSSECVVCEKKIAVSPDGRLAHL----YCHNDSQGGNR............................................... 922
68 -10.900[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  20  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECAVCYSEMILPTT----IPSCGHK-----CFICLKGVSVSN------------------NGDCPICRGPIDSQ...................................................................... 70
69 -10.900[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  10  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................LEVEVESDNKHLVADELIALQSIYPEIHLDGNNYGRLNIPVNTESDYFLSFKSPDESTLTDTIVVFPDLVMEFPPTFFLKSSWLPLKQKRVLTSSLIKLWNEIHDVRSIATIAFHLPTEMVFPGGFDDLKKEILAFDKNAKLLEFQIRKFQCNVCFDEFNGTDCFQLTQSCLRDYYTMCIQEGMSQIKCIDLDCGKDAPVLTLKELESIVGVQLTNRYKELEEKRRYENDSNIIFCPRSFCQGPSKRDPGQKLAICQKCDFAFCSFCQATWHGDLSPCKLEGDSKKLVEMYLNYQENEPEKALELEKRYGKRIIDRLVEQVKNDEEAEKWVLLN-------GQRCPTCDRVVERIDGCCHMNCLCGTH-----CFLCGAYLMEQNPYKHFNDPVSS-------------CYGMLQRFSENW.................................................................. 434
70 -10.800[IG] KOG1340 Prosaposin  ali follow..  9  441...................................................................................................................................................................................................................................................................................................................................................................................................................................................................EYMLHFIQETLATPST---DDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVQDPPTCPLCLFAVEQAQMKIRDSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYLIDMLITDFKPQEICVQLKLCPKTTYALWDLRISLECEELVKTLEKRMGKHPDSIKHILEESCDRMRKPMNTKCHKVI-----DKYGDKIADLLLKEMDPKL--------------------------------------TELGMCILADLDDLEVDEALKYDVIALPRQDNKLSSSIKEPPTCVLCADLKNKTEQDDIKRAIEAVCNRLPA-KQCDTFVDVLKLLSDVLQLCFSVAVTDECHGVTQAL--LPFLREKKDNVSEVTALQMTSVGCENCSEMISIYGSSIKNLAKRP--CFESEKSSLAFARISA......................................... 953
71 -10.800[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  30  136..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CSTCRIV---PARSKH----CS-------CNRC-----VLVADHH-----------------CI------------WINN------CKGNYL................................................... 177
72 -10.800[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  11  36....................................................................................................................................................................................................................................................................................................................................................................................................................................................PVIFNALQTDP-GFENTLVTCLERLFKTKYG-------ASLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVVN--NGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVIFPSETHLRNLAARCSSLARVRVLSLIVKLFSISRLVASEVKKSGLLDLLEAEMKGTKDTVILNVLELYYELMEVPQTSLIQLLCSIISGTSTGPYEKLR..................................................................................................................................................................................................................................................................... 268
73 -10.800[R] KOG2785 C2H2-type Zn-finger protein  ali follow..  12  5.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TCITCRVAFDADMQRAHYKTD--HRYNLRRKVASMAPVTAEGFQERVRAQR-AEEESKGSATYCTVCSKKFA-SFNAYENHLKSRRHVELEKKAVQAVNRKVEMMNEKNLEKGLGVDSVDKDAM.................... 128
74 -10.700[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  25  320.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECVIC-------------LESFTKGDKVVALP-CK----------HEFHRPCIAKWIVDYRHACPTCNTEVPPPK..................................................................... 370
75 -10.500[S] KOG4623 Uncharacterized conserved protein  ali follow..  14  38.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DARVNCWFCNGNVRVP----------QDRNSW-TCPSCEQ--KDGDYNRDITSQRDCSLGSQKNSSKCDQCNSQFEPKNEVYRERLEKQSSCERHVNKVLHEKKKMVLSSKFLNYIIKGASLLKQPHFNRLAAAQ............. 213
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;