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Query: [F] COG0005 Purine nucleoside phosphorylase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLKYEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALGVEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDKDLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVANHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYELast
1 -19.900IDP04345 uridine phosphorylase [Vibrio cholerae O1 biovar eltor str. N16961] VC1034 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  14  23...................ATLAIIPGD-VQKIAELMDNPVFLASH------------REYTVYRAELDGQSVVVCS------TGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVP---------DFDVATAMKAAAQESGATVHMGVTASSDT---RFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRT--QKEIPDHATLKETEARSIKVVVEAARKMLK... 258
2 -19.600IDP02397 gene: udp; uridine phosphorylase [Francisella tularensis subsp. tularensis SCHU S4] FTT1326 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  13  22...........LSEEMINSATIAILPGD-SEYLAKMLDTDATFLASN-----------REYTSYLAKVANQNVIVIS------TGMGGPSVAICIEELAMIGVKKFIRVGTCGAIQENIEIGDLILSTASVRLDGTSYHYAPIEYPAVA---------SFSLNTSLYRSAQTLNKKIHCGITGSSDT---HFINSLNEWRKLNVLNFEMESSALFTVCATFGLEASCLCTVLAKRT--TSEYIDKSKYDEGMYNIMMIIKHSIENNFFS.. 267
3 -19.000IDP90930 gene: mtn; 5`-methylthioadenosine/S-adenosylhomocysteine nucleosidase [Yersinia pestis CO92] YPO3384 [Yersinia pestis CO92]  ali follow..  18  2....................KVGIIGAEEVTLLRDRIENRQTLARAGC-------------EIYTGQLNGIDVALLKSGI------KVAAAMGTTLLLEHCQPDLVINTGSAGGLDSSLKVGDIVVSNEVRYHDAD--VTAFGYEPGQMAGCPAAFVADEDLIALAENCIQQLKLNAVRGLIC--SGDAFINGAEPLARAFPTVAAVEMEAAAIGHVCYLFNTPFVVVRAISDVA-----DQASHLSFEEFLVVAAKQSTLMIKAMLTTLA 230
4 -18.400IDP04004 gene: mtnN; 5`-methylthioadenosine/S-adenosylhomocysteine nucleosidase [Clostridium perfringens ATCC 13124] CPF_1305 [Clostridium perfringens ATCC 13124]  ali follow..  18  30............VEASKEENTIGIIGAMNLEVLLKDMKNQKEVKRNDL-------------TFYEGDLWGQHVVAVVSGV------KVNAASCTQILASEFNVKSLINIGVAGGVSKDIYPGDIVIGDTYVQHDVDASVFGDKIGQIPRMDVYDFKADEKLLNLAKEAAKNVPEVKTYVGRIV--SGDQFIADSNKVLDEEFNAKAVEMESAAIAQVAYLNKIPFVIIRSISDNA-----NNGAHMDYKEFIPVGVKNSTSILKSMFENM. 266
5 -16.700IDP02254 gene: deoD; purine nucleoside phosphorylase [Francisella tularensis subsp. tularensis SCHU S4] FTT0766 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  15  12..............RKEEFAKTVIMPGD-AKYIADNYLENVVRVNAV-----------RNMFGYTGTYKGKKVSVMG------SGMGMPSMGIYAYLFKYYDVDNIIRVGSAGSYKAEFKVYDVVLIEESYCESNFIEIVTGSK--------TIDVRSSEELNKELIASAQRQDIELKKAKAHCTDVFYRKNSDDYKIVKKYNCDLVEMETAALFATAAELGKKASAVVTISDSFI--TGESTTAQQREQSFTNMMEVALGTIKE...... 239
6 -16.600IDP01602 gene: amn; AMP nucleosidase [Yersinia pestis CO92] YPO2288 [Yersinia pestis CO92]  ali follow..  9  274.............................................................AYHLIAKNGQGITLVN------IGVGPSNAKTICDHLAVLRPHVWLMIGHCGGLRESQSIGDYVLAHAYLRDDHVLDAVLPPDIPI-PSIAEIQRALYDATKAVSGMPGVEVKQRLRTGTVVTSDDRNWELRFSASSFSLSRAVAVDMESATIAAQGYRFRVPYGTLLCVSDKPL--HGEIKLPGQANHFYEGAISEHLQIGIRAIDLIG 476
7 -16.500IDP92603 uridine phosphorylase, putative [Toxoplasma gondii ME49] TGME49_110640 [Toxoplasma gondii ME49]  ali follow..  12  14.....DGRTYHLGVKKGDLASLIVTVGC-ARVLAAKFLTDVTE---------VSSSRQFYTFTGKYIKGGQRMSIVC------IGMGAPMADFFIREASFVEPLAVVRIGSCGIVDYATRPGTLMLSDESMYCYRNYCHFDGEAALGNKRECGRDPRPDKRLTDLIEANLNAQGAAVKRGLNCSAET---NNANLLKDMTDLGVVSLEMETHQIFHLMHQRQHSIPNMIGLVNRSNPNLTAHVTAEDQDKATLAAGEAAFDALVTLVSE.. 296
8 -10.800IDP90370 hypothetical protein [Chlamydia trachomatis D/UW-3/CX] CT_263 [Chlamydia trachomatis D/UW-3/CX]  ali follow..  15  58................................................................................................SPPPSGYDLWINAGFAGAGNPNIPLLKTYTITSVKELTPT--------------------------TSVEEELEVTPIPRLPLAQLTSVRSPYRDGFHE-------HLQLVDMEGFFIAKQASLVACPCSMIKVSSDYTTREGQDFLK-NNKVKLSQKLAEAIFPIYSSFID... 195
9 -7.540IDP01968 gene: fliY; cystine transporter subunit [Salmonella typhimurium LT2] STM1954 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  15  39..........................................................ERGTLLVGLEGTYPPFSFQGEDGKLTGFEVDFAEA---LAKHLGVKASLKPTKWDGMLASLDAKRIDVVINQVTISDVRK-----------KKYDFSTPYTVSGIQALVKKGNEGTIKTAADLQGKKVGVGLGTNYEEWLRQHVGVDIRTYDDDPTKYQDLRVG------AILVDRLAAVTGDAFSRQESGVALRKGNEDLLKAVDNAIAEMQ 247
10 -7.320IDP04547 amino acid ABC transporter, amino acid-binding protein [Clostridium perfringens ATCC 13124] CPF_0581 [Clostridium perfringens ATCC 13124]  ali follow..  13  44..........................................................ESGKLVVGLSADYAPYEFHIIKDGKDQIVGLDIDIAKEVAKNLGVDLEIKEMEFGAIIQSVKNGMIDMGISGITPDEKRK-----------EAVDFSDIYYEAEQGILINKDNKESIKGIGDLKGKKVGAQMGSIQAEIAKGIEGADVKLLDNVNTLILELKTGVAKIASEVNSELAVADEVIKNSEGGSAIAIQKGNKDLVDEVNSTIKELK 255
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.