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Query: [H] COG0007 Uroporphyrinogen-III methylase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSKADEAAACVIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKRGGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDATGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPPAIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSALast
1 -100.000IDP93866 uroporphyrinogen-III methyltransferase [Yersinia enterocolitica subsp. palearctica Y11] YP_006005134 [Yersinia enterocolitica subsp. palearctica Y11]  ali follow..  38  1.....................MKSGKVWLVGAGPGDAALITVKGLHAIRRAEALVYDRLVCAELLAEAPDGCEMINVGKTPNHHLVPQPQINEILVDCAQRGLNVVRLKGGDPYVFGRGGEEAEALALAEIAFEVIPGISSAIGGLAYAGIPVTHRDYASGFHVVTGHLRQGN--EPQDWATLAKLEGTLIILMGMTQLATICQQLIAGGKAPTTPAAVVMYASHQQQQVASGTLTTLADQVAAQGLSAPALIVIGDVVRLRDILAFTPLSINSTPSLIYPKSLA....... 264
2 -98.100IDP00008 gene: cysG; uroporphyrin-III C-methyltransferase BA_1445 [Bacillus anthracis str. Ames]  ali follow..  38  2........................GKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEADLIYCGKLPNYHTMKQETINTFLIKYAKKGKIVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDA-AEEVKWGNLAKGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREKIHWFETESTYQVSGV............. 257
3 -94.000IDP04084 uroporphyrin-III C-methyltransferase [Vibrio cholerae O1 biovar eltor str. N16961] VC2561 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  41  21RKTPRLAVVEGSGYVRAARSQLQAGEVALVGAGPGDPELLTVKALSYLQQADVVLYDYLVSDEIMALIPSETILVCVGKRAGHHSVPQEKTNQLLVDFARQGYRVVRIKGGDPFMFGRGGEELEVLFEAGVKFQVVPGITAAAGATAYAGIPLTHRDYAQSALFVTGHLKAQA--EDLDWSTLARGKQTLVIYMGLSNAAAIAEQLQLHGRQASTPVAIIERGTQVNQQVLIGTLQTLPSLASQ--AQSPALIVVGEVVALAAKLHWFGGATQQLDAAQSA........... 299
4 -84.500IDP00533 gene: cysG; siroheme synthase YPO0158 [Yersinia pestis CO92]  ali follow..  38  189LANNDHVQADQHVEQLFSAPLTDRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDEVMNLVRRDAERIFVGKQSGHHCVPQEQINQILLQQAQSGKRVVRLKGGDPFIFGRGGEELEELAGYGIPFSVVPGITAASGCSAYSGIPLTHRDHAQSVRLVTGHAKKE---GQLDWANLAAEKQTLVFYMGLSQAGEIQQQLIQHGMPATTQVALVENGTSRHQRVVSGELSQLALLSQ--QVSSPSLIIVGSVVSLREKLNWFSHHDDQPKVTECVAHVG....... 470
5 -83.100IDP00534 gene: cysG; siroheme synthase YPO3367 [Yersinia pestis CO92]  ali follow..  40  191ISRGQLTEAENELQLSLEGQHRALGEVALVGAGPGDAGLLTLRGLQVMQQADVVLYDHLVSPEVLDLVRRDAERICVGKRAGAHSVTQEATNQLLVTLAQQGKRVVRLKGGDPFIFGRGGEELQVVAQAGIPFQVVPGVTAAAGATAYAGIPLTHRDHAQSVTFITGHCRPDG--DDLDWQTLARGRQTLAIYMGTVKAAAISQQLIAHGRSSTTPVAVIGRGTRVDQQVLIGTLAQLESLAQQ--APTPALLVIGEVVNLHHQIAWFGPQTESAISPSVVN.......... 470
6 -82.000IDP00010 uroporphyrin-III C-methyltransferase, putative BA_2144 [Bacillus anthracis str. Ames]  ali follow..  36  2.......................NGYVYLVGAGPGDEGLITKKAIECLKRADIVLYDRLLNPFFLSYTKQTCELMYCGKMPKNHIMRQEMINAHLLQFAQEGKIVVRLKGGDPSIFGRVGEEAETLAAANIPYEIVPGITSSTAASSYAGIPLTHRNYSNSVTLLTGHAKGSL--TDHGKYNSSHNSDTIAYYMGIKNLPTICKNLRQAGKKEDTPVAVIEWGTTGKQRVVTGTLSTIVSIVKNENISNPSMTIVGDVVSLRDQIAWKEPLHGKKVLFTSATNKTSVMKQK. 269
7 -81.700IDP05539 gene: cbiF; precorrin-4 C(11)-methyltransferase [Clostridium difficile 630] CD3426 [Peptoclostridium difficile 630]  ali follow..  24  2........................NKVHFVGAGPGDKELITLKGYKLLSNADVVIYGSLVNPELLEYCKEDCQIHNSAH------MDLQEIIDVMREGIENNKSVVRLQTGDFSIYGSIREQVEDLNKLNIDYDCTPGVSSFLGAASSLGVEYTVPEISQSVIITRMEGRTPV-PEKESIQSYAKHQTSMVIFLSVQEIEKVVSKLLEGGYPKDTPIAVIYKATWADEKIVKGTLSDIAVKVKENNINKTALIMVGRFLGEEYNNSK---LYDKDF................ 244
8 -81.700IDP91250 gene: lmo1201; lmo1201 [Listeria monocytogenes] NT01LM1295 [Listeria monocytogenes EGD-e]  ali follow..  38  2........................GKVMLIGAGPGDAQLLTVKGLAALQKADVIVYDRLVEPAMLQERKASCKLIYVGKEPLHHPIPQDEIERILVREAATNELVVRLKAGDPYVFGRGGEEGETLHKAGIPFEVIPGITSAIGGLAYAGIPVTHRDFASSFHVITGHLKKGR--DPLDWEALARLEGTLVFLMGMTNLPNICANLLEHGQKPETGVAIVQWATRGKQLTVTGNLQTIEQKVAESGISSPALIVVGDVVSLRPQLNFFEPLFHTKVLLPRARAGKSMLAEQ. 268
9 -80.800IDP91222 gene: cysG; siroheme synthase [Shigella flexneri 2a str. 301] SF3387 [Shigella flexneri 2a str. 301]  ali follow..  41  192LANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGG---ELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQ--QMNSPSLIIIGRVVGLRDKLNWFS....................... 455
10 -80.600IDP91293 gene: cysG; siroheme synthase [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150] SPA3343 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]  ali follow..  42  192LANADEKAVNATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTG---GELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVHGVLTQLGELAQ--QVESPALIIVGRVVALRDKLNWFS....................... 455
11 -80.600IDP91226 gene: cysG; Siroheme synthase [Escherichia coli CFT073] NT04EC4239 [Escherichia coli CFT073]  ali follow..  41  192LANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTG---GELDWENLAAEKQTLVFYMGLNQAATIQQKLIEYGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQ--QMNSPSLIIIGRVVGLRDKLNWFS....................... 455
12 -80.600IDP91305 gene: cysG; siroheme synthase STM3477 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  42  192LANADEKAVNATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTG---GELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVHGVLTQLGELAQ--QVESPALIIVGRVVALRDKLNWFS....................... 455
13 -80.300IDP91260 gene: nasF; uroporphyrin-III C-methyl transferase [Staphylococcus aureus subsp. aureus Mu50] NT02SA2397 [Staphylococcus aureus subsp. aureus Mu50]  ali follow..  32  1..................MSVDKYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVGKKPYAKHIQQEKINECIVEAARRYNKVVRLKGGDPAIFGRVQEEVDTLNNFNIAFEIVPGVTSASAAVATMQTGLTMRAVAKSVTFSTGHFKDSE-ENEVDVNALVN-GGTLAIYMGVKRLGKIIAQI-QQYTDIDYPIAIVFQASCFNEFVVKGRLSNIVGKLEHYAIEKPGICIIGEVVGYTENVSTTSNPTQQFYVVSGSRHDALMLCEH. 271
14 -78.000IDP05308 gene: hemD; porphyrin biosynthesis protein [Clostridium difficile 630] CD3420 [Peptoclostridium difficile 630]  ali follow..  37  2.......................KGKVYLVGAGPGDYKLMTLKGLECIRKSDVIVYDRLANSSYLREAKPDCELIYVGKASSNHILPQEDINRIIAEKAKEGKIVTRLKGGDPYVFGRGGEEAETLVDEGIEFEVVPGITSAIGGLCYAGIPITHRDHASSFHVITGHLKGDD-SGELNWNALANNKGTLVFLMGISNLEKISENLMKEGKDKDTPVALISWATRYNQRVVTSTLENVYETAIKEEVKPPTLIVVGSVVGLREKLNFFEPLFGKSIAVTRSRNQNSVLVEK. 270
15 -63.700IDP93846 precorrin-3 C17-methyltransferase [Yersinia enterocolitica subsp. enterocolitica 8081] YP_001006908 [Yersinia enterocolitica subsp. enterocolitica 8081]  ali follow..  19  2..........................LTVIGIGPGSESMMTQDAIAAIREAEIIVGYKTYTHLVKSMTQ-DKQVIKTGMC------KEIERCQAAIDLALAGHNVALISSGDAGIYGMAGLVLELVTQQQLEVRLVAGITASIAAASLLGAPLMHDFCHISLSDLMTPWEV----IEKRIIAAAQADFVICFYNPRSRHLARAFELMQPWKKAATPVGVVKAAGRKKQEKWLTTIGEM----DVEPVDMTSLVIVGNQATYCRNGLMITP...................... 236
16 -53.900IDP93856 cobalt-precorrin-2 C(20)-methyltransferase [Yersinia enterocolitica subsp. enterocolitica 8081] YP_001006905 [Yersinia enterocolitica subsp. enterocolitica 8081]  ali follow..  16  2.......................SGRLYALGVGPGASDLITVRAARLIAKLDVLYADSLALSIVREYLSPNTEIRTMSADDSEKQAVWDEVAQQLQAEVAQGRQVGFITLGDAMLFSTWVFLLERIGR-PDWLEIVPGVTSFAAIASRAALPLAMEQQSLAVMSCTAPEA--------ELERALRDHDCVVLMKVYGRFAQIQALLGRLNL--FPHALLMSEASLPGEVC----WRQLDSIAADQPLPYFSTILVNKQQLVNE............................. 237
17 -35.600IDP93851 cobalt-precorrin-6Y C(5)-methyltransferase [Yersinia enterocolitica subsp. enterocolitica 8081] YP_001006912 [Yersinia enterocolitica subsp. enterocolitica 8081]  ali follow..  21  2..........................ITVVGIGPGDADYLTPAARRAIDRAEVLVGGK----RHLATLSSDSK--------ESRLLDADLLGLLEWLDSNKHRAIVVLASGDPLLYGIGKLLAANFSAEEL--HIVPGISAIQYLCAKAALDMND------LFLTSSHGRE------PDFDWIFQHDKVAMVTDGIIGPRAIADALQQRGL--SRTLIIGENLSQPNERIYRLPAKQVAARYD-----MNVVVILNE................................... 199
18 -30.600IDP01415 siroheme synthase component enzyme VC1363 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  16  194....DRESLERIYIHLLTQSTDKVSATTWIEFG-ADVELLSLKALRYMQQAELVLHTQDCPFVFVDLCRRDAQRQSFNS--------SVELSTLLLQAQQETQNVCVLSGSSEYALLQGKATVLKMAQQG.................................................................................................................................................................. 312
19 -22.100IDP01659 tetrapyrrole (Corrin/Porphyrin) methylase domain protein [Coxiella burnetii RSA 493] CBU_1739 [Coxiella burnetii RSA 493]  ali follow..  17  1.....................MNRGSLYITATPIGNREDITLRAIDTLRSVDLIA-DTRHSKKLLEHYGIKTPLL------SLHEHNEAARATLLCEKLKQGLNVALISAGTPLISDPGYRLVNAVREAGIEVVPIPGACAAIAALVASGLPTDR--------IFEGFIPSKGEVRRKKLEDLKNQRRTIIFYESVHRIVNLIDLLNEI-FGTERRATIARELTKKFETIHTATLAELKNWINENPVQEKGEFVV..................................... 222
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.