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Query: [J] COG0012 Predicted GTPase, probable translation factor, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEIGVVGKPNVGKSTFFSAATLVDVEIANYPFTTIDANVGVTYAIAEHPCKELGCKPNPQNYEYREGLALIPVKMIDVAGLVPGAHEGRGLGNKFLDDLRMASALIHVVDVTGKTDAEGQPTENHDPIEDIEFLEREIDYWIYGILSKGWDKFAKRIKLQRIKLESAIAEHLSGIGVTENDVWEAMHRLGLPSDPTLWSQEDLLAFASEIRRINKPMIIAANKADAASEEQINRLIKEGEKRGYIVVPTSAAAELTLRKAAKAGFIDYIPGSSEFKILKDMNERQKKALLMIKEKVLDRFGSTGVQEVINKAVFELLNLIPVYPVQDENKLTDQFGNVLPHVFLMKKGSNPRDLAFKVHTDLGRGFLYAINAKTKRRIGEDYELQFNDIIKIVAVTKLast
1 -99.800IDP02675 GTP-binding protein YchF [Coxiella burnetii RSA 493] CBU_1842 [Coxiella burnetii RSA 493]  ali follow..  26  3FKCGIVGLPNVGKSTLFNALTKAGIEASNYPFCTIEPNVGVVSV-PDKRLEKIAQIVNPKQ------IIPTTVNFVDIAGLVAGASKGEGLGNQFLANIRETQAIAHVVRCFQDEN-VTHVAGSINPIADIEVVNTELALADLETLDKILVKLAKDVKRGDKKARDTY---------ALLEKFKKLLDEGTPIRSVNLTEEEEILLRPYQLLTSKPVLYVANVAEDGFTDNSSQVYEFAAKEKAKVVPVCAAIESEIADLSASDQQDFLQ---------------------------SLGLEEPGLHRVIQAGYQLLGLITFFTA----------GPKELRAWTCPKNSTAPQAAGVIHTDFEKRFIRAEDAGKWRLEGKEYLVQDGDIMYFRAGN. 363
2 -99.400IDP04096 gene: ychF; conserved hypothetical protein [Yersinia pestis CO92] YPO2010 [Yersinia pestis CO92]  ali follow..  24  3FKCGIVGLPNVGKSTLFNALTQAGIEAANFPFCTIEPNTGVVPM-PDPRLDQLAEIVKPQR------ILPTTMEFVDIAGLVKGASKGEGLGNQFLTNIRETEAIGHVVRCFENDN-IIHVAGKVDPADDIETINTELALSDLETCERAIHRVQKKAKGGDKDAKAEL---------EALEKCLPHLENAGMLRALDLTAEDKAAIRYLSFLTLKPTMYIANVNEDGFENNPDQVRAIAAAEGSVVVAVCAAVESDIAEMEDEDRAEFMA---------------------------ELGIEEPGLNRVIRAGYELLNLQTYFTA----------GVKEVRAWTIPVGATAPQAAGKIHTDFEKGFIRAQEAGKMRSEGKEYIVKDGDVMNFLFN.. 362
3 -34.500IDP01790 gene: obgE; GTPase ObgE [Francisella tularensis subsp. tularensis SCHU S4] FTT1731c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  32  161.DVALLGLPNAGKSTLIRSVSEATPKVADYPFTTMYPHLGVVKVGVD------------------------SFVMADIPGVIEGAAEGAGLGLRFLKHLTRARCVLHVVDICPFNES--------DPVENYFAVEKELEKYSQELFDKPRFLVINKIDLLADKVEQKCQEFVEQIG............................................................................................................................................................................................................................. 303
4 -33.500IDP02063 gene: cgtA; GTP-binding protein, GTP1/Obg family [Coxiella burnetii RSA 493] CBU_0387 [Coxiella burnetii RSA 493]  ali follow..  27  161.DVGLLGLPNAGKSTFIHAVSKATPKIADYPFTTLYPHLGVVRVEEYRS-----------------------FVIADIPGLIEGASEGAGLGVQFLKHLERTQLLLHIVDIAPLDGS--------DPVQSIQAIISELEQFSQNLSQKPRWLVFNKIDLLPPDVAQARCQEIINRLNWKGPVYKISAIKRQGTELL......................................................................................................................................................................................................... 324
5 -31.600IDP01757 gene: obgE; GTPase ObgE [Yersinia pestis CO92] YPO3509 [Yersinia pestis CO92]  ali follow..  23  161.DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRMDYEQS-----------------------FVIADIPGLIEGASDGAGLGIRFLKHLERCRVLLHLVDLAPIDES--------DPAENAKVIVNELQQYSENLAE-------------------------------------------------------------------KPRWLVFNKIDLIDPEEAEKRAKAIVETEGKYYMISAANRDNVNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQLAEVEAEAEDDWDDDWDEEDDDGVEII.......................................................................... 387
6 -30.900IDP04532 gene: obgE; GTPase ObgE [Salmonella typhimurium LT2] STM3301_1_390 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  23  161.DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKS-----------------------FVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGS--------DPVENARIIIGELEKYSQDLAA-------------------------------------------------------------------KPRWLVFNKIDLMDKTEAEEKAKEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFI.......................................................................... 387
7 -30.500IDP04204 gene: obgE; GTPase ObgE [Clostridium perfringens ATCC 13124] CPF_2382 [Clostridium perfringens ATCC 13124]  ali follow..  26  160.DVGLLGFPNVGKSTLLSVVTKAKPKIANYHFTTLKPNLGVVAVPGIEP-----------------------FVMADVPGIIEGASEGVGLGLDFLRHIERTRLLIHVVDISGVEGR--------DAVEDFKRINEELKNYSVKLWD-------------------------------------------------------------------RPQIVVANKCDMLFDEEIFENFKAEKMGFDKVFKMSAATSQGVEEVIKEAARMLKDIPVTDLEIPEDERFIPEDKKFTYTINPIEEDGLKVYVVEGSFVDRLLLAVNVNDPDSLRYFHKVLNNKGIFHELREMGIEDGDMVRLNDFEFE.................................. 425
8 -30.200IDP00679 gene: obgE; GTPase ObgE SACOL1699 [Staphylococcus aureus subsp. aureus COL]  ali follow..  24  160.DVGLVGFPSVGKSTLLSIVSKAKPKIGAYHFTTIKPNLGVVSTPDQRS-----------------------FVMADLPGLIEGASDGVGLGHQFLRHVERTKVIVHMIDMSGSEGR--------EPIEDYKVINQELAAYEQRLED-------------------------------------------------------------------RPQIVVANKMDLPESQDNLNLFKEEIGEDVPVIPVSTITRDNIDQLLYA-------------IADKLEEYKDVDITVEEEESVGINRVLYKHTPSQDKFTISRDDDGAYVVSGNA----------IERMFKMTDFNSDPAVRRFARQMRSMGIDDA----LRERG----CKNGDIVRI..... 421
9 -15.700IDP04510 gene: era; GTP-binding protein Era [Clostridium perfringens ATCC 13124] CPF_2272 [Clostridium perfringens ATCC 13124]  ali follow..  15  7..ITIVGRPNVGKSTLTNLLMGEKLSVSNKPQTTRNNIQTIL------------------------TGEDYQMIFVDTPGIHKPKHKGEYMVNSATDSIKDVDLVLFLSNPCEEVG------------------------------------------------------------------------------------RGDKFIIEQLKNQKAPVIFVLNKVDESSPEKVAKTLELFSKE-AEMIPISAMKAKNTDKLLELMVKYLPEGPKYYP------------DDMITDVQERFVVAEIVREKALKNLSQEVPHGIAVDVIQMKQDDNGKYNIEVDLIC-KNGQTLKKIGSTARYELERFLRAKVNIKIWVKVRKEWRDNTSLLKELGYKKL 295
10 -15.600IDP00678 gene: era; GTP-binding protein Era SACOL1624 [Staphylococcus aureus subsp. aureus COL]  ali follow..  16  9..VSIIGRPNVGKSTFVNRVIGHKIAMSDKAQTTRNKIQGVM------------------------TRDDAQIIFIDTPGIHKPKHKGDYMMKVAKNTLSEIDAIMFMVNANEEIG------------------------------------------------------------------------------------RGDEYIIEMLKNVKTPVFLVLNKIDLVHPDELMPKIEEYQSY-TEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDDQISDHPEQ-VGEIIREKILHLTSEE-NVDRMVKESEDRVHIEATIYVERDSQKGIVIG---------KGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVED 297
11 -15.300IDP00540 gene: era; GTP-binding protein Era YPO2719 [Yersinia pestis CO92]  ali follow..  18  12..IAIVGRPNVGKSTLLNELLGQKISTSRKPQTTRHRIMGIH------------------------TEGPYQAIYVDTPGLHIEEKRNRLMNRAASSSLGDVELVIFVVEGTHWT-------------------------------------------------------------------------------------ADDEMVVNKLRSLQCPVLLAINKVDNVTDKTKLLPHMQFLSQQLDVVPISAEKGMNVDTIASIVRKHMPEAEHHFPEDYITDRSQR-ASEIIREKLMRFLGEE-EIEQFVPNERGGYNIHGLILVEREGQKKMVIG---------NKGSKIKVIGTEARQDMERMFEAKVHLELWVKVKSGWADDERALRSLGYTDD 301
12 -14.800IDP02279 gene: era; GTP-binding protein Era [Francisella tularensis subsp. tularensis SCHU S4] FTT1164c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  16  7..ISIIGRPNVGKSTLLNNILKYKVSTSRKPQTTRHQITGIK------------------------TLGDTQFIYVDTPGIHIKEPKNKFMNKAATTMFKDVDVILFVVEMGKWT-------------------------------------------------------------------------------------ELEDNIVEKLKHSEIPIFLVVNKVDKKKSLEAAMFIESIKEK-YDVIYVSAKQGHNINELESRIEKLLPESEYFFYEEDQITDRSIKFM-----------VAEIIREKIMRTIGSEVPYQIAVEIDSYKVDQE-------------KNIVYIYASILVERDSQKGIVIGAKGAKLKKIGTDSRIDIERLV....... 266
13 -14.700IDP02682 gene: era; GTP-binding protein Era [Coxiella burnetii RSA 493] CBU_1502 [Coxiella burnetii RSA 493]  ali follow..  19  9..AAIIGRPNVGKSTLLNQLLEQKISTSRKPQTTRYQILGVK------------------------TFKDIQVIYVDTPGLHAGTERNRYMNRTARGALRDVDAIVFVIEPHWESQD--------------------------------------------------------------------------------------AWVLDNLKEIETPVFLVINKVDKIKNRAELLPLIEKVSS-QKITPLSAKTGDQVGTLEQAVHQLMPESPFYFP----------------PEQVTDRSDQFMASEIIREKLMRLLGQEIPYSLA-----------VTLIEFRKEEKIIRISAVIWVEKKSQKGIVIGKGGERLKRVGTNARLDMEKWF....... 265
14 -11.400IDP02835 gene: hflX; protease, GTP-binding subunit [Francisella tularensis subsp. tularensis SCHU S4] FTT0631 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  23  204..ISFVGYTNAGKSTLFNKITNADVLAKDQLFATLDPTLRKVIVPKLGE-----------------------VIFSDTVGFIKNLPHN--LVEAFLEEAIESDLLVHVIDYA-------------DEDHKSYIEQVEKVLSEIGIADKETICVYNKIDKLENIKPSFVPLEDSDSSVVSRVYLSAQNGDGLV............................................................................................................................................................................................................. 358
15 -11.100IDP06094 gene: engB; ribosome biogenesis GTP-binding protein YsxC [Helicobacter pylori J99] NP_224193 [Helicobacter pylori J99]  ali follow..  21  26.EMVILGRSNVGKSTFINTLLGKNAKSSATPGKTRLANFFST------------------TWEDKENALTTTFNVIDLPGF-SLKKEWEGFLWELLSVRVSIKLFIHLIDARHLDLEI-----------DKNAKE-------YLSLFTKFDKLNKNEQHRLFLNAPK...................................................................................................................................................................................................................................... 173
16 -10.900IDP02375 gene: engB; GTPase EngB [Bacillus anthracis str. `Ames Ancestor`] GBAA4701 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  20  25.EIALAGRSNVGKSSFINKILNRKVRISSKPGKTQTLNF----------------------------LINEMMHFVDVPGY-TERAAWGKMIETYFTTREQLDAAVLVVDLRHKPTND-----------DVMMYD-KHYDIPTIIIATKADKIPKGKWQKHLKVVKETLD................................................................................................................................................................................................................................... 164
17 -10.600IDP04530 gene: engA; GTP-binding protein EngA [Salmonella typhimurium LT2] STM2519_1_490 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  16  5..VALVGRPNVGKSTLFNRLTRTRALVADFPGLTRDRKYGRAEVE-------------------------REFICIDTGGIDGTEDG-TRMAEQSLLAIEEADVVLFMV----------------DARAGLMPADEAI--------------------------------------------------------------------AKHLRSREKPTFLVANKTDGLDPDQAVVDFYSLG---GEIYPIAASHGRGVLSLLEHVLLPWMDDVAPQEEVDEDAEYWAQFEAEQNGEEAPEDDFDPQSLPIKLAIVGRPNV-------GKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERD-EREYVLIDTAGVRKRGKITQAIEDANVVLLVIDAR 295
18 -10.000IDP06265 gene: engA; GTP-binding protein EngA [Streptococcus pneumoniae TIGR4] NP_346147 [Streptococcus pneumoniae TIGR4]  ali follow..  15  5.TIAIVGRPNVGKSTLFNRIAGERSIVEDVEGVTRDRIYATGEWL-------------------------RSFSMIDTGGIDDVDAPMEQIKHQAEIAMEEADVIVFVV----------------SGKEGITDADEYV--------------------------------------------------------------------ARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALG---GEPLPISSVHGIGTGDV-----------DAIVENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVA--------------------------GTTRDAIDTHFTDTDGQEFTMIDTAGMRKSGKVYRAIDRSDVVLMVINAE 268
19 -9.870IDP04257 gene: engA; GTP-binding protein EngA [Clostridium perfringens ATCC 13124] CPF_2008 [Clostridium perfringens ATCC 13124]  ali follow..  17  5.IVAMVGRPNVGKSTLFNKLAGKRSIVQDTPGVTRDRVYAESEWL-------------------------RKFTMIDTGGIEPESSDIKQMRRQAQIAIEMADVIVFVV----------------DGKEGLTAADQEV--------------------------------------------------------------------AQMLRKSKKPVVLVVNKIDRLALEENSYEFYNLG---GDPITISASQGLGLGDMLDE------------YFNDPSEDEEDDEYIRIAMIGKPNVGKSSLINRLLGEERVIVSNVPGTTRDSIDSYLETEDGKF----------ILVDTAG-----LRRKSKVKEEIERYSVIRTYAAIEKADVAILVIDAE 269
20 -9.810IDP02160 GTP-binding protein [Coxiella burnetii RSA 493] CBU_1245 [Coxiella burnetii RSA 493]  ali follow..  17  5..IAIVGRPNVGKSTLFNYLTKSRALVADVPGVTRDRQYGETTID-------------------------QRLLLVDTGGLVDTENKEPLAETQVEQAIDESDCILFLV----------------DAKAGLVPADEII--------------------------------------------------------------------AERLRKKGKKIFLAVNKADRARAAVVQSDFYKLG---GEPYVIAAASGRGVKDLMTQ------------NLPEEKEVIEKEVGIKIAMIGRPNVGKSTLINRLLGEERVIVYDQPGTTRDSIYIPFARNDENY----------TLIDTAG-----IRRRAKIQDYVEKFSMIKSLQAMHAADVVIFLLDAR 268
21 -9.390IDP04605 ribosomal biogenesis GTPase [Bacillus anthracis str. Sterne] BAS3689 [Bacillus anthracis str. Sterne]  ali follow..  25  121IRALIVGIPNVGKSTLINKLAKKNAKTGDRP--------GVTTAQQWIKVGK-------------------EMELLDTPGILWPKFEDELVGLRL--------ATTGAIK............................................................................................................................................................................................................................................................................................... 196
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.