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Query: [E] COG0019 Diaminopimelate decarboxylase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTFERLGTMNVNAEGHLEIGGVDTLKLTEKYGTPLYVYDVALIRDRARGFKKTFEELGVKAQVAYASKAFSAVAIYQLMAEEGLSLDVVSGGELYTAIKANFPPERIHFHGNNKSAEEIHMALDYGIGCFVIDNYYEISLLEDILIERNEKAAVLIRVTPGIEAHTHDYILTGQDDSKFGFGLTNGQAEKAIKQVLHASASFDLIGLHCHIGSQIFETTGFKLAARRIMDKLVEWHGTLGFDSKVLNLGGGFGVRYTAEDEPLEPSEYVRQIMDEVRDVANSNDIAIPEIWIEPGRSLVGEAGTTLYKVGSRKEVPGIRNYIAVDGGMSDNIRPALYDAHYDAVLAANPEKVAEETVAIAGKCCESGDMLIWDLPLPKSDAGEILAVFCTGAYGYAMASNYNRIPRPPVVFVENGMDKLIVARETYENLVQNDLSLLast
1 -100.000IDP90886 diaminopimelate decarboxylase [Vibrio cholerae O1 biovar eltor str. N16961] VC0125 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  33  2......DYFNYQEDGQLWAEQVPLADLANQYGTPLYVYSRATLERHWHAFDKSVGDY--PHLICYAVKANSNLGVLNTLARLGSGFDIVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQLKIKCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTHPYISTGLRDNKFGITFDR---AAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSL-KAEGIHIRHLDVGGGLGVVYRDEL-PPQPSEYAKALLDRLERH------RDLELIFEPGRAIAANAGVLVTKVEFLKHTEH-KNFAIIDAAMNDLIRPALYQAWQDIIPLRP-RQGEAQTYDLVGPVCETSDFLGKDRDLV-LQEGDLLAVRSSGAYGFTMSSNYNTRPRVAEVMVDGNKTYLVRQREELSSLWALES.. 413
2 -99.900IDP90618 gene: lysA; diaminopimelate decarboxylase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0314 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  32  1.....................MDYKQLKQEFNTPFYIYNFDFIKERFLNLKEAFKAR--KSQIFYAVKANSNLSLLQMLANLDSGFDCVSIGEVKRALKAGAKAYKIIFSGVGKTKEELRQALEYDILYINLESEAEMMLLESVAKELNLKARISIRVNPNVDAKTHPYISTGLNENKFGVEIDI---ARKMYLYAKNSSFLEPVGVHFHIGSQLLDISPIHEAAAIVAKLVREL-KALQIDLKFFDIGGGLGVAYEKNECEPDLYDYAQGILAQLHGL-------DLTIGMEPGRYLVAKSGEFVCSVLYEKQNKT-KRFVVVDGAMNDLIRPSLYEAYHEIILPYN--QGEESLCDVVGGICESGDFFAKARSLPSTQSDDIMVIKNTGAYGFSMSSNYNTRNKVCELALEEGQVRLIRQRENFEDQIALEEKF 399
3 -95.400IDP00434 gene: lysA; diaminopimelate decarboxylase YPO0796 [Yersinia pestis CO92]  ali follow..  27  3.........RALNDRSSALTAQNLIALPERFGCPVWAYDGDIIAERINQLRHFDV-------IRFAQKACSNIHILRLMREQGVKVDSVSLGEIERALHAGYQPAEIVFTADLLDQATLLRVTELNI-PVNAGSIDMLDQLGQQAPG----HPVWLRVNPGFGHGHSQKTNTGGENSKHGIWHEELPRALKKIEH----YGLTLVGIHMHIGSGVDY-----QHLEQVCDAMVQQVITLGHDISAISAGGGLSIPYQFGDDVIDTEHYYGLWNSARERIAAHLGHP-VSLEIEPGRFLVAESGVLIAQVRAVKDMGR-RHYVLVDAGFNDLMRPAMYGSYHHISLLPADTSAPLIDTVVAGPLCESGDVFTQQEALPAAVIGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEKGQPRLIRRRQTIEELIDLER.. 419
4 -12.600IDP91529 alanine racemase, putative [Vibrio cholerae O1 biovar El Tor str. N16961] VC_1312 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  14  43............SAAPLHIDTALPDAAQIQQSNSWLEISLGQFQSNIEQFKSHMNA---NTKICAIMKADAIRGLMPTIIAQGIPVGVASNAEARAVRESGFKGELIRVRSA--SLSEMSSALDLNI-EELIGTHQQALDLAELAKQSGKTLKVHIALN-----------DGGM--GRNGIDMTTEAGKKEA-VSIATQPSLSVVGIMTHFPNYNADEVRAKLAQFKESSTWLMQQANLKREEITLHVANSYTA------------NVPEAQLDMVRPGGVLFGDLPTNPEYPSIVSF--------TRVSSLHHLPKDSVLANLPVGYSDGYPRKMGNKAEVLI--------NGQRAKVVGVTS---NTTVVDVTIKGVLPGQEVVLFGQ.............................................. 392
5 -12.200IDP01513 gene: alr; alanine racemase VC1312 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  14  26................LHIDTALPDAAQIQQSNSWLEISLGQFQSNIEQFKSHMN---ANTKICAIMKADAIRGLMPTIIAQGIPVGVASNAEARAVRESGFKGELIRVRSA--SLSEMSSALDLNI-EELIGTHQQALDLAELAKQSGKTLKVHIALN-----------DGGM--GRNGIDMTTEAGKKEA-VSIATQPSLSVVGIMTHFPNYNADEVRAKLAQFKESSTWLMQQANLKREEITLHVANSYTA------------NVPEAQLDMVRPGGVLFGDLPTNPEYPSIVSF--------TRVSSLHHLPKDSVLANLPVGYSDGYPRKMGNKAEVLI--------NGQRAKVVGVTS---NTTVVDVTIKGVLPGQEVVLFGQ.............................................. 371
6 -11.700IDP01202 gene: dal-2; alanine racemase BA_2079 [Bacillus anthracis str. Ames]  ali follow..  16  13.....................................VDLNAVKHNVKEFKKRVND--ENIAMMAAVKANGAVEVAKAAIEAGINLAIAFVDEAIELREAGINVPILILGYT--SVAAAEEAIQYDV-MMTVYRSEDLQGINEIANRLQKKAQIQVKIDTGM--------------SRIGLQEEE---VKPFLEELKRMEYVEVVGMFTHYSTADEIDKSYTNMQTSLFEKAVNTAKELGIHIPYIHSSNSAGSMEPSNTF-------MVRVGIGIYGMYPSKEVNHSVVSLQPALSL--------SKVAHIKHTTGEEWIATVPIGYADGYNRQLSNKGHALI--------NGVRVPVIGRVC---DQLMLDVKAMPVQVGDEVVFYGLGTINYEVTCMLDR--RIPRVYKENNETTAVVN.............. 386
7 -11.700IDP02469 gene: alr; alanine racemase [Francisella tularensis subsp. tularensis SCHU S4] FTT0573 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  13  6.....................................ISKQTLRNNIKIIREYIG----NAKMCFPVKANAGHGIEDIVENTHDLVDFFAVANSLEAFRVTAVAKNPVLVFGVIYYEYIEKMISENI-RVSIQDYEDIEKLEQIAKELDKKVYAHININTGM--------------NRMGVDYND---ACRTIQRAYESDWLILEGVYSHLAADNRDHPTNIKQKNRFDSIVKFTKGLSQDIICHLSNSYGFGILSYGFLPEFYVDRVIREIKPIARLLSKVVKIIT----LQEGEGV---------GYSLIYRGFEDEQLAVIPIGYGDGFPRELGDRGFVNI--------NDVMYPMAGRMSMDGLTVSLGINEYDVKVGDTVELISTNTIEYDIMSTLNDRIIRKII.......................... 365
8 -10.900IDP00688 gene: alr; alanine racemase SACOL2060 [Staphylococcus aureus subsp. aureus COL]  ali follow..  13  1..........................MSDKYYRSAYMVDLNAVASNFKVFSTLHP----NKTVMAVVKANASVKVARHLMENGATFAVATLDEAIELRMHGITAKILVLGVL--PAKDIDKAIQHRVALTVPSKQWLKEAIKNISGEQEKKLWLHIKLDTGM--------------GRLGIKDTK--TYQEVIEIIQQYEQLVFEGVFTHFACADEPGDMTTEQYQRFKDMVNE----------------AIKPEYIHCQNSAGSLLMDCQFCNAIRPGISLYGYYPSEYVQQKVKVHLKPSVQLIANVVQTKTLQAGESVYTATDPTTIALLPIGYADGYLRIMQGSFVNVNGHQCEVIGRVC---DQTIVKVP-DQVKAGDSVILIDQHTINYEVLCNLSR--RLPRIYHDGDQRFVTNE.............. 379
9 -10.700IDP06249 hypothetical protein SP_1665 [Streptococcus pneumoniae TIGR4] NP_346104 [Streptococcus pneumoniae TIGR4]  ali follow..  13  8........................................ELVFREVAEASLSAHRESGSVSVIAVTKYVDVPTAEALLP---LGVHHIGENRVDKFLEEALKDRDVTWHLIGTLQRRKVKDVIQYVDY--FHALDSVKLAGEIQKRSDRVIKCFLQVN------------ISKEESKHGFSREE---LLEILPELARLDKIEYVGL-MTMAPFEASSEQLKEIFKAAQDLQREIQEKQIPNMPMTELSMGMSRDY--------------------------------KEAIQFGSTFV-RIGTSFFK................................................................................................................................ 223
10 -10.000IDP91049 gene: vanTrL; serine racemase [Enterococcus faecalis] EFE0005 [Enterococcus faecalis]  ali follow..  12  1..........................MVENKMRAYKEFYVESLLHNVQVIKKNIPK---STKIMAVVKANAAVNVAIILEYIGIDFAVATIDEAIALRKNGITSNILILGYTTPTKVDDLIHYELTQTIVSKEHAYFLN-------KTGKKIMCHLKVDTGM--------------HRLGV-----EPTLEEICPIFNYPFLKIKGVYSHLGSA--EGKQRTIKQISRYNTIIAELKRKRVDVGLTHLQSSYGI------------NYSELAYDYVRPGIILYGLLSNNDHNVKLHLDLQPVVAVKAQLISKKKLTSSKTIGVLSIGYADGIPRNLSNGEYCVVFEDK-------QIPQIGRIC---DMMLVDLSCSDIPLGVMVDVLPNSTITNEIISCLGSR................................ 360
11 -9.730IDP91048 gene: vanT; serine racemase VanT [Enterococcus gallinarum] EGA0001 [Enterococcus gallinarum]  ali follow..  11  344.....................................FSKTALLHNLQEIQRIIS---PKTKVMAVVKADAAKEVAPVLEQAGIDFAVATIDEGIRLRKNAVKSPILVLGYTSPKRIKELRRYSLTQSIISEGHAVALS-------QRKVAIDCHLAIDTGM--------------HRLGVTPTI-----DSILSIFDLPFLTISGVYSHLGSA-PDSMIRTQKQIACFDQILLELDQRQISYGITHLQSSYGI------------NYPDLNYDYVRPGILLTGSLSDTNEPTKQRVSLQPILTLKAQLITKRVANQETTVGVVSIGYCDGLPRSLSNQEFCLSYRGQ-------SLPQIGLIC---DMLLIDLSCPTIPIESEIEILTVQTITNELICRIGPR................................ 692
12 -9.660IDP91046 gene: vanTG; serine racemase [Enterococcus faecalis] EFE0004 [Enterococcus faecalis]  ali follow..  12  349.....................................INLNNLEHNVNTLQKAMS---PKCELMAVVKAEAMYEVTTYLEQIGVSFAVATIDEGIRLRKYGISSEILILGYTSPSRAKELCKYELTQTLIDYRYSLLLN-------KQGYDIKAHIKIDTGM--------------HRLGFSTEDKDKILAAFS----LKHIKVAGIFTHLCAA--NDVAFTNKQIGSFYKVLDWLKSSGLNIPKVHIQSSYGL------------NYPELECDYIRVGVALYGVLSSTNDKTKLELDLRPVLSLKAKVVLIRKIKQGELIAILPIGYADGFPRNLSCGNSYVLIGGR-------QAPIVGKIC---DQLAVDVTIPNVKTGSIATLIGKDG............................................ 678
13 -9.020IDP00718 alanine racemase family protein SACOL1434 [Staphylococcus aureus subsp. aureus COL]  ali follow..  5..........................................WSVNKKIFLQNAITVKNNQPLMAVVKNNALEFAVTQFIHAGIDFSTTSLREAIQIRQLAPDATIFLMNAVYEFDLVREHQIHMTLPSLT---------YYYNHKNDLAGIHVHLEFENLL--------------HRSGFKDLNEIKEVLKDHHHNQNAKMIISGLWTHFGYADEFDVSDYNVERSQWMEIVEALLSEGYQFDLIHAQNSASFYREGQILLPHHT------------------------HARVGIALYGQSLTLKAHVIQVREVQASFAFEVTKNNTKLAVVDIGYGDGILRTRAKHEALINGKRYPIRA-LM---SHMFVEVD-GNVHAQDEVILYNNDIRIDEYTFKGVGANSEQLSAMNHDSLKKEYISND........... 360

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.