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Query: [E] COG0345 Pyrroline-5-carboxylate reductase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MENQKIGFIGAGKMGSALMQGTIKAGIVTPENIGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEAASGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRASERSKELGKKLast
1 -95.000IDP02492 gene: proC; pyrroline-5-carboxylate reductase [Francisella tularensis subsp. tularensis SCHU S4] FTT1559c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  30  1...MKICFIGGGNMAAAMIAGMTSHG-YKSQDIIVFDRNEHKCLNLIKKYNINTSTSLLNTIKLADVLILAIKPQNMFELIKNIRDTVTSTQVIVTVAAGIQTSAYEELFNKEISFARTIPNTPSSLGYGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVDEKEIDIVAAIASSGPAYYFQFMEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNIFEQFNLGGIVDKAIQANIARAQQLAIE 267
2 -94.700IDP02179 gene: proC; pyrroline-5-carboxylate reductase [Coxiella burnetii RSA 493] CBU_2090 [Coxiella burnetii RSA 493]  ali follow..  37  1MNTSNITFIGGGNMARNIVVGLIANG-YDPNRICVTNRSLDKLDFFKEKCGVHTTQDNRQGALNADVVVLAVKPHQIKMVCEELKDILSETKLVISLAVGVTTPLIEKWLGKASRIVRAMPNTPSSVRAGATGLFANETVDKDQKNLAESIMRAVGLVIWVSEDQIEKIAALSGSGPAYIFLIMEALQEAAEQLGLTKETAELLTEQTVLGAARMALETEQSVVQLRQFVTSPGGTTEQAIKVLESGNLRELFIKALTAAVNRAKELSKT 271
3 -89.200IDP00140 pyrroline-5-carboxylate reductase, putative BA_0197 [Bacillus anthracis str. Ames]  ali follow..  29  2LTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHEELLAELSPLL-SNQLVVTVAAGISPSYLEERLPGGTPVAWIMPNTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIGTSQLCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASML-EQTQDPANLREQVTTPGGSTAEGLKAL.......................... 244
4 -27.800IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  11  35LKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPLMKQGAALG-YSHGFNIVEEGMQIRKDITVVMVAPKCPGTEGFGVPAVHPENDPQGEGWEIAKAWAAATGGHSSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDRPLYNKHMDDIISGHFSST...... 315
5 -17.100IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  13  16IKSKKVAIIGFGSQGHAHAMNLRDNGV----NVTIGLREGSVSAVKAKNAGFEVV-SVSEASKIADVIMILAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGH-GGGTPCLIA-QDESKNAKNLALSYASAIGIETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLIYQGGIADMRYSISNTAEYGDYITGPKIITEE-MKGVLKDIQNGVFAKD...... 291
6 -14.700IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  18  1...MKIGWIGLGAMGTPMATRLRDAGL----EVSVYNRTESKAAPLKEK-GVAVYTSPIDLAAKVDLVFTMLDKAAIDAVLAPKFWEQMSKKIVVSTIAPLESLSLEKIAQKHQATYLEAPVSGSVGAAKAGALLILAAGDEEVISKLKPVLAHLGSQTF---------LGKVGQGTGLLAQMGVAYSEAAKRLGVDAESFLQIIGQSGMNSPLF....................................................... 212
7 -14.300IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  15  15LKEKKVAIIGYGSQGHAHAQNLRDNGF----DVVVGLRKGKSWDKAKED-GFSVY-TVAEAAKQADVVMILLPDELQPEVYEEIAPNLQAGNSLV-FAHGFNVHFDQVKPPVNVDVFLVAPKGPGSEGGAVPAFAVYQDATGVATEKALSYADGIGATRAFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEGG.................................................. 242
8 -13.000IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  14  14LQGKTVAVIGYGSQGHAQAQNLRDSGV----EVVVGVRPGKSFEVAKAD-GFEVM-SVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGQEGNGVPAVAVHQDATGTALHVALAYAKGVGCTTTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEGGLTNMRHSISDTAEFGDYVTGLTEIQQGEFAKKWILENQAGRPTYNAMKKA 306
9 -13.000IDP01976 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD+) [Coxiella burnetii RSA 493] CBU_1518 [Coxiella burnetii RSA 493]  ali follow..  13  5..KHPIAILGAGSWGTALALVLARKGQ-HVDEMQAEGVNNRYLPNYPFPETLKAYCDLKASLEGVTDILIVVPSFAFHEVITRMKPLIDAKTRIAWGTKGLAKGSVATELGQVPMAVISGPSLATEVAANLPTAVSLASNNSQFSKDLIERLHGQRFRVYKND---DMIGVELCGSVKNILAIATGISDG---LKLGSNARAALITRGLTEMGRLVSVFGGKQE------------TLTGLAGLGD------LVLTCTDNQSRNRRFGLA 263
10 -12.900IDP04504 2-dehydropantoate 2-reductase [Vibrio cholerae O1 biovar eltor str. N16961] VC2307 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  13  1...MNIVVLGPGAVGSLWALHLHSAG----HQVALWSRQAQPTITLQLD--ISFRNQNLDTLIHADLLLITVKAWQVEAALQPLLPHLNRETILLFMHNGMAVEAISESLTHFPVLFATTLNQVSHTGFGQTQVGPFNA-LGARCDFIADVFNHALAPVTWNPEIINPLTAIHQC--PIITAILDEVTAVMQAEAISGEAEALRDG-----VYQVIQATAANLSSMHQDVFHRRPTEIDFIRKGEQHGIATPVNSALYQQIKTLEQSWSK 295
11 -12.600IDP01730 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [Francisella tularensis subsp. tularensis SCHU S4] FTT0871 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  15  2..QKNILVLGAGAWGTALALQLAYRG----HNVRINSWKAEHNEQMLKD-RLKAIQDWQANIIEFDSILVATPSSGFKNTILELKECILPQQNIISATKGFCHDSAEDILPTTKFALLTGPSFAKELANQLPTAVVVASKDINYARYVQELFSNENFRCYTTT---DIIGAQVGGAVKNVLAITAGIAAG---MEFGVNAHAALITRGLAEIKKLGLKLGANS------------ETFIGLSCLGD------LLLTCSDNQSRNRRFGLY 262
12 -12.400IDP02668 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1526 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  16  2...TKITVVGAGSWGTALAMVLADNGH-LMDEINTKHENSRYLPGITLPSTIVAYSSLEEALVDVNVVLIVVPTKAYREVLQDMKKYVAGPTTWIHASKGIEPGTIEEEIPEDLIKDVVVLSGPSHAEEVGLRQATTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPDIVGVELGGALKNIIALAAGITDG---LGLGDNAKAALMTRGLTEIARLGRKMGGNP------------LTFAGLTGMGD------LIVTCTSVHSRNWRAGNM 263
13 -12.400IDP05722 gene: tyrA; prephenate dehydrogenase [Bacillus anthracis str. Ames] BA_2954 [Bacillus anthracis str. Ames]  ali follow..  14  15...KKVVLIGTGLIGGSLALAIKKDHDV---TITGYDIFQEQVERAKELHVVEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKMNEAEALFSKEISFIGGHPAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGHFLVLNTEEHDYVTGIVSHFP---HLIAAGLVKQVEKHAGDNPLIHQLAAG---GFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISE-VSSGDAGEIQNYFADAKEYRDS 294
14 -10.900IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  12  1MTKANFGVVGMAVMGRNLALNIESRGY----TVAIYNRSKEKTEDVIAEKNFVPSYDVESFVNSIEKPRRIM--PGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFI---GTGVSGGEKGALEGPSIQKEAYELVADVLEEISA--KAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYD..................................................................... 203
15 -10.800IDP05340 putative oxidoreductase [Clostridium difficile 630] CD3450 [Peptoclostridium difficile 630]  ali follow..  11  1MKNIKMGMIGLGSIAQKAYLPILTK-SERFEFVGAFTPNKVKREKICSDYRIMPFDSIESLAKKCDCIFLHSSTEIIKILLNLGVHVYVDKPLASTVSQGEELIELSTKKNLNLMVGFNRRFCPMYKEIKNNATEIVSINICKHGLNSLRNVRFDSTLIDDYIHVIDTALWLANEDVEISVSHKLKGKNFSINTSMHRDSGTKLEQVEILSKGKIQRVKNLNVLEIEEGGNLTLKQSGAWVNILKQKGFEDISNHFIDCIENNIKPA... 284
16 -10.700IDP92023 glycerol-3-phosphate dehydrogenase, putative [Toxoplasma gondii ME49] TGME49_010260 [Toxoplasma gondii ME49]  ali follow..  14  15.GPLKVSVVGSGNWGSVIAKIVALNAQKSYDIINKTHENRKYLPGHKLPENLVALPDVVEACRDSDLLIFIMPHQFATKVCEQLAEAVPGHARAITLLKGLHVENFKTKLDIVDCCVLSGANVANDVAREAEATIGYSPEETDAALIWQQLFDTPYFKVNALPDVAGV--QVCGA--------VIAIA-AGFCDGLGLGTNAKTAIIR-LGVEEMK------------QFAMIFFDNIMAETFFDSAGYADVITTVFGGRNAR....... 289
17 -10.500IDP02226 gene: yqjI; 6-phosphogluconate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA0164 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  1MENLQIGVVGVGVMGKSLALNFESKGY----SVALYDISKEKVDETIEE-NLVGTHIVEEFVNSLESPRKIL--EITDKAIDSLVPHLDKGDILIDGGNTYFVDTIRRNKRLAEEGINFI---GAGVSGGEEGALKGPSIQKDAYEKVKDMLENISAKVNNEP----CCSYIGPNGAGHYVKMVHNGIEYGDMQLICE........................................................................ 198
18 -10.400IDP92082 glycerol-3-phosphate dehydrogenase, putative [Toxoplasma gondii ME49] TGME49_107570 [Toxoplasma gondii ME49]  ali follow..  15  21.GPLRVAVIGSGNWGSVIGKICAQNAERSTDIINQKHENVKYLPGHKLPDNLVAVPDVVEACRGADLLVFVMPHQFVAKVCDQLAKAVPSHARAISLLKGLYVEGIRSKLNIVECAALSGANVANDVAREAEATIGHSPDETDTALIWQQLFDKPYFKVNTLPD----VAGVQLCGAVKNVVALAAGFCDGLGLGTNTKSAINVIAETFFDSAGYVITTVFGGRNARCAAEFVRQKGSKTWDQIEAEMLNGQKLQGTLTARE........ 330
19 -10.200IDP05101 gene: hbd; 3-hydroxybutyryl-CoA dehydrogenase [Clostridium difficile 630] CD1058 [Peptoclostridium difficile 630]  ali follow..  14  1...MKLAVIGSGTMGSGIVQTFASCGH----DVCLKSRTQGAIDKCLALLDKNLSTTNYEDLKDMDLIIEASDMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMK-LVEVISGQLTSKVTFDTVFELSKSINKVPVDVSESPGFVVN------ILIPMINEAIYADGVASKEEIDEAMKLGANHPMGPLALGDLIG.................................................. 233
20 -10.000IDP00126 gene: mviM; putative virulence protein NT01ST1449 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  12  1MRTLRIGIVGLGGIAQKAWLPVLTN-TAGWTLQGAWSPSRDKALRICESWRIPYVDSLANLASSCDAVFVHSSTAVVSELLNAGVHVCVDKPLAENLRDAERLVALAAQKKLTLMV-RFAPELKTRLGTAASLRMDKHRTDSVGPHDLRFTLLDDYL------HVVDTALWLAGG---------EARLASGTLLTSESGEMCYAEHHFSADKLQITTSMHRRAGSQRESVQAVTDGGLYDVTDMRE........................ 240
21 -9.060IDP91227 gene: tyrA; T-protein [Escherichia coli CFT073] NT04EC3201 [Escherichia coli CFT073]  ali follow..  13  100...PVVIVGGGGQMGRLFEKMLTLSGY-------------------VRILEQHDWDRAADIVSDAGMVIVSVPIHVTEQVIGKLPP-LPKDCILVDLASVKNGPLQAMLAAHDGPVLGLHP--PDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGRLHRISAVEHDQNMAFIQALR---HFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRYYKQGDKQAFIDSFRKVEHWFGDYAQR 356
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.