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Query: [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIKLLast
1 -93.200IDP91791 gene: vanH; vancomycin resistance protein [Enterococcus faecium] AAA24789 [Enterococcus faecium]  ali follow..  29  4IGITVYGCEQDEADAFHALSPRF-GVMATIINANVSESNAKSAPFNQCISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVA-YSPDSVADYTMMLILMAVRNVKSIVRSVEKHDFR-LDSDRGKVLSDMTVGVVGTGQIGKAVIERLRGFGCKVLAYSRSRSI----EVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQGAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQFLLKLQRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDFERRQEHE..... 322
2 -88.100IDP02277 glycerate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1434 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  27  4....ILVAGKIPEIGLELLKDHDVEM-YDKEELISLDELTERVKDKDALLSLLSTKVTKEVID--AAPSLKIVANYGAGYDNIDYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFN-PLFFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPESELEATYVTLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEPK--------------ITEELKGLKNVVLAPHVGNATFETRDAMAEMAVRNILAVLKGEEPVTPVN. 316
3 -83.800IDP00460 gene: serA; D-3-phosphoglycerate dehydrogenase YPO0914 [Yersinia pestis CO92]  ali follow..  22  10.RIKFLLVEGVHQSAVDNLRAAGYSNIEYHKGALDAESLKASIRDAHFIGIRSRTHLSEDVFA--AAEKLVAVGCFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFRGIPSANAKAHRGEWN-KLAVGSFEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDIENKLSLGNAQQVRQLSDLLNMSDVVSLHVPENHTTKNMIGAEQLAQMKPGALLINASRGTVVDIPALCDALSSNHLSGAAIDVFPEEPA---------TNKDPFNSPLCEFDNVLLTPHIGGSTQEAQENIGDEVAGKLAKYSDNGSTLSAVNF 327
4 -66.500IDP90773 erythronate-4-phosphate dehydrogenase [Vibrio cholerae O1 biovar eltor str. N16961] VC2108 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  26  7MKILIDENMPYAQALFSQLGE--------VILKPGRTLTADDLIDVDALMIRSVTKVNDALLA--KANRLKFVGTATAGMDHVDQALLRERGIFFTAAPGCNKVGVAEYVFSVLMVLAQQQ-------------------GFSVFDKTVGIIGAGQVGSYLAKCLSGIGMKVLLNDPPKQAQ-GDEREFTELETLLKQADVITLHTPITRGTHHLIDAAILEQLRSDQILINAARGPVVDNAALKARLQQGDGFTAVLDVFEFEPQV--------------DMELLPL-LAFATPHIAGYGLEGKARGTTMIFNSYCEFLGSAHCANPASL 296
5 -64.200IDP90820 gene: pdxB; erythronate-4-phosphate dehydrogenase [Salmonella typhimurium LT2] STM2370 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  25  1MKILVDENMPYARELFSRLGE--------VKAVPGRPIPVEELNHADALMVRSVTKVNESLLS---GTPINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERD-------------------GFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAAR-GDEGDFRTLDELVQEADVLTFHTPLYKDTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDL--------------NVALLEAVD-IGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETL 289
6 -63.700IDP04474 gene: pdxB; putative D-isomer specific 2-hydroxyacid dehydrogenase [Yersinia pestis CO92] YPO2763 [Yersinia pestis CO92]  ali follow..  25  1MKILVDENMPYAEELFRRLGD--------VQAVPGRPIPRDALVDADALMVRSVTKVNEALLH---GTSIGFVGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVFSALMMMAERD-------------------GFQLRDKTVGIIGVGNVGSRLNARLQALGVRTLLCDPPRADR-GDNEAFWPLEKLVREADVLTFHTPLNKTSLHMADDELLAALPDGRILINACRGAVVDNAALLRALEKGKKLSVVLDVWEPEPDL--------------SLPLLARVD-IGTPHIAGYTLEGKARGTTQVFEAFSQHLGQPQSVELASL 289
7 -50.300IDP00951 gene: ycdW; putative oxidoreductase STM1135 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  21  1MEIIFYHPTFNAAWWVNALEKALPHARVREWKV-------GDNNPADYALVWQPPV------EMLAGRRLKAVFVLGAGVDAI--PEMLDASIPLFRLEDTGGLQMQEYAVSQVLHWFRRFDDYQALKNQALWK---PLPEYTREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAALDSGKLKGAMLDVFSQEP--------------PQESPLWRHPRVAMTPHIAAVTRP--AEAIDYISRTITQLEKGEPVTGQVD. 307
8 -15.100IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  21  14...............................................................................................................................................LQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKVAKADGFEVMSVSEAVRTAQVVQMLLP-DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPS.................................................................................... 119
9 -14.000IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum]  ali follow..  18  208.......................................................................VSEETTTGVLRLIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNG---------------CIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQAGYQVSVLEDVVSEADIFIT----ATGNKDVITVEHMRKMKENAYIANIGH---FDDEIDVYGLEN................................................................................. 368
10 -13.400IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  20  16...............................................................................................................................................IKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKGFEVVSVSEASKIADVIMILAP-DEIQADIFNVEIKPNLSEGKAIAFAHGFNI............................................................................................. 113
11 -13.200IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  20  15...............................................................................................................................................LKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKKAKEDGFSVYTVAEAAKQADVVMILLP-DELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPV.................................................................................... 120
12 -12.400IDP92093 adenosylhomocysteinase, putative [Toxoplasma gondii ME49] TGME49_025050 [Toxoplasma gondii ME49]  ali follow..  21  182...........................................................QKWSRMAANLKGVSEETTTGVHRLQMAKKKELLFPAINVNDCVTKSKFDNVYGCRHSLPDGIMRA---------------TDVMLGGKRVVICGFGDVGKGCAAAMKGAGARVVVTEVDP-QAAMEGYSVSTLESQLATADIFIS----ATGNKDIITARHMSQMKNNAIVGNIGH---FDNEVDMAGLLA................................................................................. 354
13 -9.580IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  15  1.........................................................................................................MANYFNTLNLREQLDQLGRCRFMAREEFATEADY----LKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYARQSFKNAKNNGFNVGSYEQLIPTADLVINLTP--DKQHTSVVNAVMPLMKQGAALGYSHGFNIVAPKCPGTEVREEYKRGFGVPTL...................................................................... 174
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.