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Query: [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIDMKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKKLast
1 -37.100IDP91227 gene: tyrA; T-protein [Escherichia coli CFT073] NT04EC3201 [Escherichia coli CFT073]  ali follow..  10  15.VDKALNLLAKGEVKSRFGLPIYVPEREASMLASRRAEAEALTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRI------------------------------------------------LEQHDWDRAADIVSDAGMVIVSVPI-HVTEQVIGKLPP-LPKDCILVDLASVKNGPLQAMLA---------AHDGPVLGLHPMFGPDSGSLAVVWCDGRKPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPLYADIIMSSERNYYKRFGEAIELLEQGDKQAFIDSFRKVEH 348
2 -36.700IDP00461 gene: tyrA; bifunctional chorismate mutase/prephenate dehydrogenase YPO3285 [Yersinia pestis CO92]  ali follow..  10  15.VDKALDLLAKGEVKSRYGLPIYVPDREAAMLASRRQEAGALTLCPELRPVVIIGGQGQMGRLFSRMLNLSGYQVRT------------------------------------------------LEQEDWSQAESILADAGMVIVSVPI-HITEEVINRL-PKLPADCILLDLASVKNKPLQAMLAAHE---------GPVLGLHPMFGPDVGSLAVVYCDGRDPQAYQWLLEQLQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPLYADIIMSSEDNYYKRFGEALTLLEHHDKQAFVQSFEKVEH 348
3 -33.500IDP05722 gene: tyrA; prephenate dehydrogenase [Bacillus anthracis str. Ames] BA_2954 [Bacillus anthracis str. Ames]  ali follow..  11  7.........................................................................SLEMRQMRKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALF-------SKEISFIGGHPMAGSHKTGVELTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAA----GGFKDITRIASSSPMWSDIVKQNREHLMSEMEDLYDTVSSGDAGEIQNYFADAKE 290
4 -31.300IDP05101 gene: hbd; 3-hydroxybutyryl-CoA dehydrogenase [Clostridium difficile 630] CD1058 [Peptoclostridium difficile 630]  ali follow..  13  2..................................................KLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDKNLTKLVTK-------------GKMDEATKAEILSHVSTTNYEDLKDMDLIIEASVEDNIKKDVFKLLDELCKEDTILTNTSSLSITEIASSTKRPD-------KVIGMHFFNPV--PMMKLVEVISGQLTSKVTFDTVFELSKSINKVPVDVS-ESPGFVVNRILIPMINEAVGIYADGVASKEEIDEPMGPLALGDLIGLDVVLAIMNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTK-IGFYDYNK.... 281
5 -24.200IDP02583 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/isomerase family protein [Bacillus anthracis str. `Ames Ancestor`] GBAA5249 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  2..............................................FQIKKAAVLGSGVMGSGIAAHLANIGIPTLLLDIVPPALTKEEEAKGLTLEHKSVRNRFSNTAVQKLLKQKTVKGNLALIEAGNLEDDLERLADVDWIIEVVVENDIKKKLFEKVDAVRKPGSIVSNTSGISVEKMAEGRSD-----DFQKHFLGTHFFNPP--RYLKLLEVIPTKKTDPQVLSFMKLFGEDVLGKGVVIAKDTPNFIGNRIGTYGLLVTLQEMVKRGYSIGEVDSVTATFRTLDVVGLDTFVYVANN........................................... 267
6 -22.900IDP00999 gene: fadJ; multifunctional fatty acid oxidation complex subunit alpha STM2388 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  9  262.SSSGYDAEARAFGELAMTPQSQALRAIFFASTEVKKDPGSDAPPGPLNSVGILGGGLMGGGIAWVTACKGGLPVRIKDINTQGINHALKYSWDLLETKVRR-------------RHIKASERDKQLALISGSTDRGFSHRDLVIEAVFEDPLKQQMVAEVEQNCAAHTIFSNTSSLPIGDIAANAARPE-------QVIGLHFFSPV--EKMPLVEVIPHASTSAQTIATTVKLAKKQGKTPIVVS-DKAGFYVNRILAPYINEAIRMLTHIDAALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFSAPANVVASILNDDRKGRKNG-RGFYLYGEKGRK 592
7 -22.600IDP00503 gene: fadB; multifunctional fatty acid oxidation complex subunit alpha YPO3766 [Yersinia pestis CO92]  ali follow..  9  266.RTEALNLETNSFVPLAGSNEARALVGIFLNDQYVKAQAKKLSKGVAAPKLAAVLGAGIMGGGIAYQSALKSVPVIMKDINENSLDLGMNEAAKLLNKQLER-------------GKVDGLKMASILATIRPTLDAGIERAQVIVEAVVENKVKAAVLAEVEALIGEDTVLSNTSTIPIDQLAKSLKRPE-------NFCGMHFFNPV--HRMPLVEIIRGAKTSDKTLAAVVAYATQMGKTPIVVN-DCPGFFVNRVLFPYLAGFGMLVRIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPERMNKDYRDAVDVMFDNQRFGQKNGQGFYRYTQDAKG 598
8 -21.600IDP04044 gene: fadB/acbP; fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein [Francisella tularensis subsp. tularensis SCHU S4] FTT1530 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  11  54MVERAKWMAIKGMSKEDAMRGYLRVFGEEYLTIASKLEPVESKSQRKAIDKIAVLGAGTMGAQIAAHFANAKFPVVLFDLKSQQGSANV-IIEDSLAKLTKLNPAPFGS----------KDSIKYITPANYEDNLELLADCDLIIEAVAERDIKESLYTKISSHIKENAILSNTSGLSITKLAQVLPE-----NLKVNFCGVHFFNPP--RYMPLVELIPHADTNSEILDKLETFLVEKLGKSIIRAKDTPNFIANRLGVFSMLVTCYYTEQMSIPLEVVDEKSATYRTADLVGLDVLSHVVET---DGWQKLYNTPNWIQNLINNGSLGQKTK-KGLYIKASDGIK 410
9 -20.000IDP00545 gene: fadJ; multifunctional fatty acid oxidation complex subunit alpha YPO2747 [Yersinia pestis CO92]  ali follow..  10  296.GPSGYEAEARAFGELAMSPQSAALRSLFFATTSLKKETGSAATARAIHRVGVLGGGLMGGGIANVTATRAGLPVRIKDINPQGINQALKYTWDALGKRVRS-------------KRMRPTEQQRQMMLISGSTDRGFERVDIVVEAVFEDSLKQQMVADIERFGAAHTIFSNTSSLPISQIAALAQRPE-------QVIGLHYFSPV--DKMPLVEVIPHEKTSEETIATTVALARKQGKTAIVVA-DRAGFYVNRILAPYINEAARCLLSVDNALVDFGFPVGPMMLLDEVGIDVATKIMPI........................................... 584
10 -19.600IDP04410 fatty oxidation complex, alpha subunit [Vibrio cholerae O1 biovar El Tor str. N16961] VC1047 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  12  311..............................FATTEMKKDLGADAKPAPVAAVGVLGGGLMGAGISHVVAKAKTSVRIKDVANDGVLNALNYNYKLFDKQRQR-------------KILTKAQLQAQMSQLSGGTGVGFDRCDVVIEAVFEDKLKQQMVADIEANAKPTTIFTNTSSLPIHQIASQAQRPQ-------NIVGLHYFSPV--EKMPLVEVIPHATTSDETIATVVTLARKQGKTPIVVK-DCAGFYVNRILAPYMNEAAQVLMKLDAALLDFGFPVGPITLLDEVGVDIGAKIMPILVKELGPRFQGPDVFDVLLKDNRKGRKSG--KGFYTYKGSKKK 612
11 -15.600IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  13  1...MKIGWIGLG----------------------------------------------AMGTPMATRLRDAGLEVSV------------------------------------NRTESKAAPLKEKGVAVYTSPIDLAAKVDLVFTMLSDKAAIDAVLAPKFWEQMSKKIVVNMSTIAPLESLSLEKIAQK------HQATYLEA-PVSGSVGAAKALLILAAGDEEVISKLKPVLAHLGSQTFYLGKVGQGTGAKLSINSLLAQMGVAYSEALLLAKRLG.................................................................. 192
12 -14.400IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  13  15LKEKKVAIIGYG----------------------------------------------SQGHAHAQNLRDNGFDVVV-----------------------------------GLRKGKSWDKAKEDGFSVY-TVAEAAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLETTFKEETETEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEGGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQD 283
13 -14.200IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  10  9.........................................ANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVV-----------------------------------GVRPGKSFEVAKADGFEVM-SVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGTEGGYRPEIAYFECLHELKLIVDLMYEGGLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQ 282
14 -13.000IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  10  1MANLREQLDQLG------------------RCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVS-----------------------------YALRQAAIDEQRQSFKNAKNNGFNVG-SYEQLIPTADLVINLTP-DKQHTSVVNAVMPLMKQGAALGYSHGFNIVEEGMQI----------RKDITVVMVAPKCPGTETLIAVHPENDPQGEGWEIAKAWAAATGGHCLASSFVAEVKSLMGEQTILCGMLQAGSIVCYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDRPLYNKHMDDIISGH. 311
15 -12.700IDP00140 pyrroline-5-carboxylate reductase, putative BA_0197 [Bacillus anthracis str. Ames]  ali follow..  13  2..............................................LTKHRILFIGAGRMAEAIFSGLLKTSK-----------------------------EYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMP-PSAHEELLAELSPLLSNQLVVTVAAGISPSYLEERLPGGTPVAWIMPNTAAEIG--------KSISLYTMGQFVNETHQETLQLLLRGIG-TSQLCTEEEVHQLTAVTGSAPAFLYY-FAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQ--------DPANLREQVTT...................... 232
16 -12.600IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  12  2...........................AITVYYDKDCDLNLIKSKKVAI-----IGFGSQGHAHAMNLRDNGVNVTI-----------------------------------GLREGSVSAVKAKNAGFEVVSVSEASKIADVIMILAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESKNAKNLALSYASAIGIIETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVE-AGYEPEMAYFECLHEMKLIVDLIYQGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQN 285
17 -11.800IDP02492 gene: proC; pyrroline-5-carboxylate reductase [Francisella tularensis subsp. tularensis SCHU S4] FTT1559c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  10  1...MKICFIG----------------------------------------------GGNMAAAMIAGMTSHGYKSQDIIVFDR-------------------------------NEHKCLNLIKKYNINTSTSLLNTIKLADVLILAIK-PQNMFELIKNIRDTVTSTQVIVTVAAIQTSAYEELFNKEISFARTIPNTPSSLG--------YGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVEDEKEIDIVAAIASSGPAYYFQ-FMEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTN-------ENMSELRKNVTS...................... 229
18 -10.900IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  12  1MTKANFGVVGMA----------------------------------------------VMGRNLALNIESRGYTVAIYNRSKEKT-------------------------------EDVIACHPEKNFVPSYDVESFVNSIEKIMLMVQAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELAN------SGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKA........................................................................................................ 163
19 -10.800IDP02179 gene: proC; pyrroline-5-carboxylate reductase [Coxiella burnetii RSA 493] CBU_2090 [Coxiella burnetii RSA 493]  ali follow..  10  1..............................................MNTSNITFIGGGNMARNIVVGLIANGYDPNRICVTNR-------------------------------SLDKLDFFKEKCGVHTTQDNRQGALNADVVVLAVK-PHQIKMVCEELKDILSETKVISLAVGVTTPLIEKWLGKASRIVRAMPNTPSSVR--------AGATGLFANETVDKDQKNLAESIMRAVGLVIWVSSEDQIEKIAALSGSGPAYIFL-IMEALQEAAEQLGLTKETAELLTEQTVLGAARMALETE-------QSVVQLRQFVTS...................... 233
20 -10.700IDP02226 gene: yqjI; 6-phosphogluconate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA0164 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  1MENLQIGVVGVG----------------------------------------------VMGKSLALNFESKGYSVALYDISKEKV-------------------------------DETIEENRGKNLVGTHIVEEFVNSLESILLMVNAGEITDKAIDSLVPHLDKGDILIDGGNTYFVDTIRRNKRLAE------EGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKCSYIGPNGAGHYVKMVNGIEYGDMQLICEAY.......................................................................... 200
21 -10.600IDP04467 putative nucleotide sugar dehydrogenase [Yersinia pestis CO92] YPO2174 [Yersinia pestis CO92]  ali follow..  11  1...MKVTVFGIG-----------------------------------------------VGLVQATVLAEVGHDVLCIDIDANKV---------------ADLKKGRIAIFEPGLAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRGEKIDFVVSNPEFLKEGAAVAVIGIDTDDSGALELISELYEPFNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLG.................................................................. 237
22 -9.740IDP00702 gene: cap5O; capsular polysaccharide biosynthesis protein Cap5O SACOL0150 [Staphylococcus aureus subsp. aureus COL]  ali follow..  9  1...MKLTVVGLG-----------------------------------------------IGLPTSIMFAKHGVDVLGVDINQQTI---------------DKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTT----PDASDVFIIAVPTPSLVMRALDSILSFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCP-VLPGKILEELVHNNRVTEACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLN.................................................................. 229
23 -9.630IDP01235 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase BA_5512 [Bacillus anthracis str. Ames]  ali follow..  10  1...MKICTMGLG-----------------------------------------------IGLPTSAMFAKYGTEVVGVDIHQKVV---------------DKLNNGEIHIEEPGLGEVVKEVVANGKFRASLT----PEEADAFIISVPTPSYVLTATEKVLPFVKKGNVIIVESTIAPRSMDDYVKPLVEEAGFTVGEDIYLVHCP-VLPGQILHELVHNNRVTPACAEAGARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLD.................................................................. 229
24 -9.300IDP00425 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase YPO3863 [Yersinia pestis CO92]  ali follow..  10  1..............................................MSFETISVIGLGYIGLPTAAAFASRKKKVIGVDVNAHAV---------------ETINRGAIHIVEPDLDKVVKIAVEGGYLQAVTK----PQAADAFLIAVPTPIFVESAAKSIAPVLKKGDLVILESTSPVGATEQMAQWLAEARPDLSFPQQAIAYCP-VLPGQVMVELIQNDRMTPKCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICDEQG.................................................................. 237
25 -9.140IDP01406 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase VC0918 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  9  1...............................................MFNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAV---------------DTINKGEIHIVEPDLDIVVRSAVMTGKLKATLT----AEPADAFLVAVPTPSYIEAAAKTIAPVLAKGNLVVLESTSPVGTTEKLAQWLAEARPDLTFPQQKIAYCP-VLPGYVLQELVSNDRVSKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLK.................................................................. 237
26 -9.000IDP02668 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1526 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  15  1................................................MTKITVVGAGSWGTALAMVLADNGHDVR----------------------IWGNRSELMDEINTKHENSRYLPGITPSTIVAYSSLEEALVDVNVVLIVVP-TKAYREVLQDMKKYVAGPTTWIHASGIEPGTSKRISEVIEEEIPEDLIKDVVVLSGPSHAEEVG--TTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPDIVGVELGGALKNIIALAA--------GITDGLGLGDNAKAALMTRGLTEIARL.............................................. 226
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.