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Query: [S] COG5495 Uncharacterized conserved protein, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVQFDGLRSARLNIAILSTGRVGVALERADQVVVACSAVSHASRQWVQFRLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTSVPRPGTIVAHTSWANGVGILAQLGKDGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARAACENTLQRGQAGLTKLVARGDLDALAGHLVALMRIGPELAQAYRVNALRKTQRAHAPYDVVEALAPLast
1 -24.200IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  11  17.........KSKKVAIIGFGSQGHAHAMNGVNVT-IGLREGSVSAVKAKN-AGFEVVSVSEASKIADVIMILAPDEIQADIFNV-EIKPNLSEGKAIAFAHG-FNIHYGQIVVPKGVDVIMIAPKAPGHTRNEFTLGGGTPCLIAIHQDESKNAKNLALSYASAIGIIETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECL---------------------HEMKLIVDLIYQGGADMRYSISNTAEYGDYITGPKIITE---ETKKAMKGVLKDIQNGVFAKDFILERRA. 298
2 -16.700IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  11  1...........MKIGWIGLGAMGTPMADAGLEVS-VYNRTESKAAPLKEK-GVAVYTSPIDLAAKVDLVFTMLSDKAIDAVL--APKFWEQMSKKIVVNMS-LESLSLEKIAQKHQATYLEA-PVSGSVGAAK-------AGALLILAAGDEEVISKLKPVLAHLGSQTFYLGKVGQG---TGAKLSINSLLAQYSEALLLAKRLGVDAESFLQIISPLFQAKKGMWLQDNYPAAFSLKLMAKDIRLAKNEAGEAMKLPFLF-DMAAVYHYLEKGEH................................ 285
3 -16.600IDP02492 gene: proC; pyrroline-5-carboxylate reductase [Francisella tularensis subsp. tularensis SCHU S4] FTT1559c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  9  1...........MKICFIGGGNMAAAMIAGMTS-IIVFDRNEHKCLNLIKKYNINTSTSLLNTIKLADVLILAIKPQNMFELIKNIRDT--VTSTQVIVTVAAGIQTSAYEELFNKEISFARTIP-------NTPSSLGYGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVEDEKEIDIVAAIASSGPAYYFQFMEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSTYEALNIFEQFNLGGIVDKAIQANIARAQQLAIEFTKLIDN......................... 274
4 -16.200IDP05722 gene: tyrA; prephenate dehydrogenase [Bacillus anthracis str. Ames] BA_2954 [Bacillus anthracis str. Ames]  ali follow..  11  5.KESLEMRQMRKKVVLIGTGLIGGSLALA-VTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHL--REDVIVTDVGSTKGSIMNEAEALFSKEISFHPMAGSHKTGVESAKAHLENAFYILHHVPNEHVEELKDWLKGTGSHFLVLNTEE----HDYVTGIVSHFPHLIAAG--LVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVL--EDLYDTVSSGDAGEIQNYFADAKEYRDSL........................... 295
5 -16.000IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  9  36.........KGKKVVIVGCGAQGLNMRDSGLDVSYALAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPL--MKQGAALGYSHGF-NIVEEGMQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVNDPQGEGWEIAKAWAAATGGHRSSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMM-----------------DRLSNPAKIKAFELSEELKDLMR---PLYNKHMDDI.................... 307
6 -15.500IDP02179 gene: proC; pyrroline-5-carboxylate reductase [Coxiella burnetii RSA 493] CBU_2090 [Coxiella burnetii RSA 493]  ali follow..  9  2.........NTSNITFIGGGNMARNIVVGLIA-ICVTNRSLDKLDFFKEKCGVHTTQDNRQGALNADVVVLAVKPHQIKMVCEELKDI-LSETKILVISLAVGVTTPLIEKWLGKASRIVRAMP-------NTPSSVRAGATGLFANETVDKDQKNLAESIMRAVGLVIWVSSEDQIEKIAALSGSGPAYIFLIMEALQEAAEQLGLTKETAELLTEQTVLGAARMALETEQSVVQLR-------QFVTSPGGTTEQAIKVLESGNLRELFIKALTAAVNRAKELSKTVDQ.................. 274
7 -15.500IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  13  16.........KEKKVAIIGYGSQGHALRDNGFDVV-VGLRKGKSWDKAKE--DGFSVYTVAEAAKQADVVMILLPDELQPEVYEE---APNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEGGLEN------MRYSVSDTAQWGDFVSGPRVVTEDTKKARGWIAEHKAGKPNFYATNEKENEHEIEVVGRK......... 319
8 -15.500IDP91227 gene: tyrA; T-protein [Escherichia coli CFT073] NT04EC3201 [Escherichia coli CFT073]  ali follow..  12  95......CPSLRPVVIVGGGGQMGRLFEKM-----------LTLSGYQVRILEQHDWDRAADIVSDAGMVIVSVPIHVTEQVIGKLPPL---PKDCILVDLASVKNGPLQAMLAAHDGPVLGLHPM--FGPDSGSLAKQVV----VWCDGRKPEAYQWFLEQIQVWGARLHRISAVE----HDQNMAFIQALRHFATFAGLHLAEENVQLEQLLALSSPIYRLELAMVGLFAQDPQLYADIIMSSLIKRYYKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRVLLRQANDNRQ....... 373
9 -15.300IDP00140 pyrroline-5-carboxylate reductase, putative BA_0197 [Bacillus anthracis str. Ames]  ali follow..  11  3.........TKHRILFIGAGRMAEAIFSG--EIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHEELLAELSPL---LSNQLVVTVAAGISPSYLEERLPGGTPVAWIMP-------NTAAEIGKSISLYTMGQFVNETHQETLQLLLRGIG-TSQLCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANL---------EQVTTPGGSTAEG................................................... 240
10 -15.000IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  10  18............TVAVIGYGSQGHAQAQSGVEVV-VGVRPGKSFEVAKA--DGFEVMSVSEAVRTAQVVQMLLPDEQQAHVYKA-EVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEGGLGSRIVTDETKKEMKRVLT---EIQQGEFAKKWILENQAGRPTYNAQNHQLEKVGEELREMMSWIHAPKELVKK.... 335
11 -14.900IDP00461 gene: tyrA; bifunctional chorismate mutase/prephenate dehydrogenase YPO3285 [Yersinia pestis CO92]  ali follow..  11  102.............VIIGGQGQMGRLFSRM-----------LNLSGYQVRTLEQEDWSQAESILADAGMVIVSVPIHITEEVINRLPKL---PADCILLDLASVKNKPLQAMLAAHEGPVLGLHPM--FGPDVGSLAKQVV----VYCDGRDPQAYQWLLEQLQVWGARLHRISAVEQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSEDNLALIKRYYKRF-----GEALTLLEHHDKQAFVQSFEKVEHWFGDYAERFLVESRSLLRQANDNRQ....... 373
12 -12.900IDP05101 gene: hbd; 3-hydroxybutyryl-CoA dehydrogenase [Clostridium difficile 630] CD1058 [Peptoclostridium difficile 630]  ali follow..  13  1...........MKLAVIGSGTMGSGIVSCGHDVCLKVTKGKMDEATKAEILSHVSSTTNYEDLKDMDLIIEASVEDM-KDVFKLLDEL--CKEDTILATNTSSLSITEIASSTKRPDKVIGMH----FFNPVPMMKLVEV----ISGQLTSKVTFDTVFELSKSINKVPVDVSE-------SPGFVVNRILIPMINEAVGIYADGVASKEE---------------------------------IDEAMKLGANHPMGPLALGDLIGLDVVLAIMNVLYTEFGD......................... 250
13 -12.800IDP04504 2-dehydropantoate 2-reductase [Vibrio cholerae O1 biovar eltor str. N16961] VC2307 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  11  1...........MNIVVLGPGAVGSHLHSAGHQVA-LWSRQAQPTITLQLEAPISFRNQNLDTLIHADLLLITVKAWQVEAALQPLLPH-LNRETILLFMHNGMGAVEAISESLTHFPVLFATTTHGALKATLNQVSHTGFGQTQVGPFNALGARCDFIADVFNHALAPVTWNPEIQQALWRKLAVNCANPLTAIHQCANGALVAPEFTPTAILDEVTAVMQAEAISGEAEALRDGVYQ-VIQATAANLSSMHQDVFHR--RPTEIDFITGYVVRKGEQHGIATPVNSALYQQIKTLEQSWSK....... 295
14 -11.000IDP00126 gene: mviM; putative virulence protein NT01ST1449 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  12  2.........RTLRIGIVGLGGIAQKANTAGWTLQGAWSPSRDKALRICESWRIPYVDSLANLASSCDAVFVHSSTA---------------------SH------YAVVSELLNAGVHVCVDKPLENLRDAERLVALAAQKKLTLMV-GFNRRFAPLYRELKTRLGT.............................................................................................................................................. 138
15 -10.900IDP05340 putative oxidoreductase [Clostridium difficile 630] CD3450 [Peptoclostridium difficile 630]  ali follow..  8  2.........KNIKMGMIGLGSIAQKAKSERFEFVGAFTPNKVKREKICSDYRIMPFDSIESLAKKCDCIFLHSSTET---------------------H------YEIIKILLNLGVHVYVDKPLSTVSQGEELIELSTKKNLNLMV-GFNRRFCPMYKEIKNNAT-EIVSINICKHGLNSLRNVRFDSTLIDDYIHVIDTA........................................................................................................... 172
16 -10.600IDP92082 glycerol-3-phosphate dehydrogenase, putative [Toxoplasma gondii ME49] TGME49_107570 [Toxoplasma gondii ME49]  ali follow..  12  13.SLFQVLQKGPLRVAVIGSGNWGSVIGKIGQKLTDIINQKHENVKYLPGH-NLVAVPDVVEACRGADLLVFVMPHQFVAKVCDQLAKANVVPSHARAISLLKGLYVE-PQLFSDTIRSKLNIVECAALSGANNDVAREEFAEATIGHSPDETDTALIWQQLFDKPYFKVNTLPD-------VAGVQLCGAVKNVVALAAGFCDGLGLGTN-----------------TKSAIIRLGVEEMKQFGMIFFDNVIAETFFDSAGYADVIT.......................................... 286
17 -10.400IDP92023 glycerol-3-phosphate dehydrogenase, putative [Toxoplasma gondii ME49] TGME49_010260 [Toxoplasma gondii ME49]  ali follow..  12  7.SLFQVLQSGPLKVSVVGSGNWGSVIAKIGEKLTDIINKTHENRKYLPGH-NLVALPDVVEACRDSDLLIFIMPHQFATKVCEQLAEARVVPGHARAITLLKGLHVE-PTLFSDIFKTKLDIVDCCVLSGANNDVAREEFAEATIGYSPEETDAALIWQQLFDTPYFKVNALPD-------VAGVQVCGAVKNVIAIAAGFCDGLGLGTNAKTAIIRLGVEEMKQFAMIFFDNIM-YADVITTVFATWDQIEADLLKGQKLQGTLTTKEVYEVIVERLFPLFSVTYEIA.................... 348
18 -10.400IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  10  2.........TKANFGVVGMAVMGRNLASRGYTVA-IYNRSKEKTEDVIAC-NFVPSYDVESFVNSIEKPRRIMLMPGTDATIQALLPH--LDKGDILIDGGNTDTIRRNEELANSGI---------NFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKA---EDGKPCVTYIGPDGAGHYVMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADILSPIVDYILDAAGNKGTGKWT.................................................... 269
19 -10.400IDP01730 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [Francisella tularensis subsp. tularensis SCHU S4] FTT0871 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  11  4............NILVLGAGAWGTALALQLAY-VRINSWKAEHNEQMLKD-RLKAIQDWQANIIEFDSILVATPSSGFKNTILELKEC--ILPQQNIISATKGFCHDSYALLSEIAEDILPTTKFALLTGPSFAKELANQLPTAVVVASKDINYARYVQELFSNENFRCYTTTD-------IIGAQVGGAVKNVLAITAGIAAGMEFGVNAHAALITRGLAEIKKLGLKLGANS--------ETFIGLSCLGDLLLTDNQSRNTIQQALKEVNNVVEGYFTAKAVYNLAKKHNVEM............. 300
20 -9.950IDP01976 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD+) [Coxiella burnetii RSA 493] CBU_1518 [Coxiella burnetii RSA 493]  ali follow..  11  1......MEPFKHPIAILGAGSWGTALALVLAR-VRLWSYESDHVDEMQAE-TLKAYCDLKASLEGVTDILIVVPSFAFHEVITRMKPL--IDAKTRIAWGTKGLAKGSRL-LHEVVATELGQVPMAVISGPSLATEVAANLPTAVSLASNNSQFSKDLIERLHGQRFRVYKNDD-------MIGVELCGSVKNILAIATGISDGLKLGSNARAALITRGLTEMGRLVSVFGGKQ--------ETLTGLAGLGDLVLTDNQSRNDKKEAQQAIGQAIEGLYNTDQVHALAQKHAIEM............. 301
21 -9.610IDP02668 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1526 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  10  3............KITVVGAGSWGTALADNGHDVR-IWGNRSELMDEINTK-TIVAYSSLEEALVDVNVVLIVVPTKAYREVLQDMKKY--VAGPTTWIHASKGIEPGRISEVIEEEIPEDLIKDVVVLSGPSHAEEVGLRQATTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPD-------IVGVELGGALKNIIALAAGITDGLGLGDNAKAALMTRGLTEIARLGRKMGGNP--------LTFAGLTGMGDLIVTSVHSRNSLEEVLESMGMVVEGVRTTKAAHELAEKMEVEM............. 301
22 -9.020IDP00503 gene: fadB; multifunctional fatty acid oxidation complex subunit alpha YPO3766 [Yersinia pestis CO92]  ali follow..  12  315............LAAVLGAGIMGGGIALKSVPVIKQLERGKVDGLKMASILATIRPTLDYAGIERAQVIVEAVVENP-AAVLAEVEAL--IGEDTVLASNTSTIPIDQLAKSLKRPENFCGMH----FNPVHRMPLVEIIRG-----AKTSDKTLAAVVAYATQMGKTPIVVND-------CPGFFVNRVLFPYLAGFGMLVRD-----------------------------------GDFHQIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPERMNKDYRDAVDVMFDNQRFGQKNG. 586
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.