current user: public

If you have questions about the server, please let us know.

Query: [C] KOG1257 NADP+-dependent malic enzyme, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580
# Score Template Links and tools%idFirst MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITELast
1 -133.000IDP01873 gene: maeA; malate dehydrogenase [Francisella tularensis subsp. tularensis SCHU S4] FTT0917 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  34  5..EKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFDLIGYLPEKVESLEEQAIRVRRQLDLKPNSLEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLVLVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEFVTQVKARF-PNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTASTIRINIKVVIFGAGSAGCGIARQLADVIADAGVSIEKARSSIYLVDRYGLVCDRLRAKRKTREEIDKWKVEDFNYITLEETVKNTKCDILIGTSGQPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY-NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAASYRLSELSPMVEDITQPLLARITDLVDVTKEITKAVAKQAILEGVHGVDIDLEDIERLINLSSWTPTYAPYMP................. 603
2 -72.000IDP91816 gene: maeB; fused malic enzyme predicted oxidoreductase/predicted phosphotransacetylase [Escherichia coli str. K-12 substr. MG1655] b2463 [Escherichia coli str. K-12 substr. MG1655]  ali follow..  18  1..........................................................................................MDDQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLKAYKYTARGNLVAVISNGTAVLGLGNIGAAGKPVMEGKGVLFKKFAGIDVFDIEVDELD------------------------------PDKFIEVVAALEPTFGGINLEDIKAPECFYIEQKLRERIPVFHDDQHGTAIISTAAILNGLRVVEKNISDVRMVVSGAGAAAIACMNLLVALGL--------QKHNIVVCDSKGVIYQGREPNMAETKAAYAVVDD-----GKRTLDDVIEGADIFLGCSGPKVLTQEMVKKMA---RAPMILALANPEPEILPPLAKEVRPD--------------AIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMESGVATRPIADFDVNLFMKPIFSQARKAPKRVVLPE 449
3 -6.750IDP92108 NADP-specific glutamate dehydrogenase, putative [Toxoplasma gondii ME49] TGME49_093180 [Toxoplasma gondii ME49]  ali follow..  12  6................................................NLSVVTPPELVTDDPGDMPDCKISVADPEEVDAFVKQIETANRFQPEFLQAFHEVFDSVRPVLCSNP-------------KYLRAFKVIVEPERCITFRVPWVDDQGKQHVSR-GYRVQYSSAAGPYKGGLPSVTLSVMKFLGFEQIFKNSLTGLSIGGAKGGSDFDP-------KGRSDNEVMRFCQAFMTELSRYIGPNRDVPAGDIGVREIGYLFGQYKLLKDKNWGGSAMRPEATGYGCVYFVLELKEGIKGMRCAISGSGNVALYAGEKLATLGAK-----------MTFSDSSGYIVNEKGFPLGQIQRLKEMKETRSSTRVSEFAAKYSTPCDIAFPCATQNEISEEDAQLLIDNGCRIVAEGANMPTT----------------------RDAIRLFKQHGVILCPGKAANA--------GVAVSGLEMSQEVVDEKLRQIMASIFSKCRSYAAKFGENEFDLVTGANVAGFKVADCVIDQGY............................................. 488
4 -6.550IDP91166 gene: aroE; shikimate 5-dehydrogenase STM1359 [Salmonella enterica subsp. enterica serovar Typhimurium]  ali follow..  15  3...............................................................................................................................................................VTAKYELIGL------AYPIRHSLSPEMQNKAGLPAFEVDNTTFASAIEGLKALK---MRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDG---------------YLRGYNTDGTG--------HIRAIKESGFDMRGKTMVLLGAGGAATAIGAQAAIEGI----------KEIKLFNRKDDFFEKAVAFAKRVNENTDCVVTVTDLADQHAFTEALASADILTNGTKVGMKNESLIGDVSLLRPELLVTEC-NPTKLLQQAQQAGCKTIDGYGMLL............................................................................................................................................ 260
5 -6.450IDP92093 adenosylhomocysteinase, putative [Toxoplasma gondii ME49] TGME49_025050 [Toxoplasma gondii ME49]  ali follow..  168........................................................................................................................................................................................................VVYKILAEGLQKDPQ--------------KWSRMAANLKGVSEET--TTGVHRLLQMAKKKEFPAINVNDCVTKSKFDNVYGCRHSLPDGIM---RATDVMLGGKRVVICGFGDVGKGCAAAMKGAGA-----------RVVVTEVDPI-------------CALQAAMEGYSVSTLESQL--ATADIFISATGNKDIITARHMSQMK---NNAIVGNIGHFDNEVDMAGLLAWPGIQKVNIKPQVDRF--IFPEDNHGVIVLAEGRLLNL--GCATGHPSFVMSCSFTNQTLAQLDLWDNVATKRYQND--------VYLLPKELDEKVARPALGCELTTMSQEQAAYVGIKPEGPYKSASYRY................... 477
6 -6.440IDP02337 gene: gdhA; glutamate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1511 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  12  24..................................................................................................................STQIVISEALEKLGYPNEVYELLKEPIRMMTVKIPVRMDDGTVKIFT-GYRAQHNDAVGPTKGGIPNVTENEVKALSIWMSLKCGIVDLPYGGGKGGIICDP-------REMSFRELERLSRGYVRAISQIVGPTKDIPAPDVFTQIMAWMMDEYSRIDEFNSPGFTATAKGVTICIREAAKKRDIDIKGARVVVQGFGNAGSFLAKFMHDAGAK--IAISDAYGALH--DPNGLDIDYLLDRRDSFGTVTKLFNNTISNKELLEL-----DCDILVPAAIENQITEENANDIKA----KIVVEAANGPTTLEA---------------------TKILTDRGILLVPDVLASA--------GVTVSYFEWVQEKVMVRSFDSIYETAQVRKV----------NMRLAAYMVGVKMAEASRFRGWV............................................ 428
7 -6.390IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum]  ali follow..  13  182........................................................................................................................................................................................................CMYKVLKMELLKNPFKDLYGVSEETTTG------VLRLKIMESEGKLLLPAINVNDSVTKSKF--------------DNTYGCRQSLLHGLF---NGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGA-----------RVIVTEIDPI-------------CALQASMEGYQVSVLEDVVS--EADIFITATGNKDVITVEHMRKMK---ENAYIANIGHFDDEIDVYGLENYPGIKVIILLCKGRLV-----------------NLGCATGHPPLVMS-----MSFTNQVLAQMDLWKSRELVD-RSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY................... 495
8 -6.320IDP91169 similar to shikimate 5-dehydrogenase lmo0490 [Listeria monocytogenes]  ali follow..  13  9...............................................................................................................................................................ITGHTELIGL------ATPIRHSLSPTMHNEAGLDAFEVGDKELKDVVQGFRAMN---LRGWNVSMPNKTNIHKYLDKLSPAAELV---------------GAVNTVVNDDGVLTGHITDGTG--------YMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGV----------KEISIFNRKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKGETLLPSADMLRPELIVSDV-KPTRLLEIAEEQGCQTLNGLGMML............................................................................................................................................ 266
9 -6.140IDP02649 putative glutamic dehyrogenase-like protein [Salmonella typhimurium LT2] STM1795 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  10  34..................................................................................................................TYLQQIERVAPYLGELSPWVDTLRHPKRALIVDIPVQMDDGTIRHFE-GYRVQHNLSRGPGKGGVPDVDLNEVMALSAWMTIKCAALNLPYGGAKGGIRVDP-------FSLSEGELERLTRRYTSEIGIIIGPQKDIPAPDVGTKVMAWMMDTYSMNHGTTVTGVKATGRGVFVSGLEAARRANIAVEGARVAVQGFGNVGSEAARLFAGAGAR-----------VAIQDHTATLFNATGIDMKALTAWQTEHKQIAGFPGAETIASD-LEMDILIPAALEGQITRQRAEALTC----KLVLEGANGPTYPDA---------------------DDVLASRGILVVPDVVCNA--------GVTVSSEEEINARMDKIMTDAIVHVWEKAAEKS-------CSLRTAAYIVACRILLARKDRGI............................................. 438
10 -5.970IDP02372 gene: mdh; lactate dehydrogenase [Francisella tularensis subsp. tularensis SCHU S4] FTT0535c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  11  1.............................................................................................................................................................................................................................................................................................................MARKKITLVGAGNIGGTLAHLALIKQLGD----------VVLFDIAQGMPNGKALDLLQTCPIEGVDFKVRGTNDYKDLENSDVVIVTAGVPRKPGMVMQTVGEGIKHNCPNAFVICITNPLDIMVNMLQKFSGVPDNK-IVGMAGVLDSARF------------RTFLADELNVSVQQVQAYVMGGKMSNVAGVSLEQLVKEGKLKQERLDAIVSRTRSGGGEIVALLKTGSAYYAPA............................................ 236

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.