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Query: [I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSRVVHRSSSVFRTNLSFRLFSQSAFAVHSTHRVEKQGDVAVMKIDLPNTTENVLNKALFAEMNETLDRLQSDQSVKAIVVMSGKPNSFVAGADIQMFKAEKTAAGVSNLLREGQKQLLTIELSQKPIVAAIMGSCMGGGLEIALACHYRIAVNDKKTLLGLPEVTLGIMPGDGGTQRLPKLTTVQNVLDLTLTGKRIKANKAMKIGIVDRVIQPLGDGICTSTETTHKYLEEIAVQSARELANGKLKINRDKGFVHNATQAVMTSKFVLDNVILKMAKNKLIKLTNGNYPAPLKILDVVRTAYLDPKNGYEAEAKAFGELSQTFQSKALFGLFEGSTNAKKNKYGKGLPVNEIAVVGAGFMGAGIANVTINKGIRTVLLDANQAGVERGQNHVATHLNRQLKRQKISKLEREKIYNHLVPTIDYSAMKNADVVIEAVFEDLPLKHKVIRQIENVVGPNTIIASNTSALPIKDIAAASSRSDKVIGMHYFSPVEKMQLLEIITHDGTSKETLATAAQLGLKQGKLVVVVKDCPGFFVVRCLSPMMSEIVRLLQEGVEPSELDKLTTKFGFPVGAATLADEAGLDVAEHVARYLGTALGPRVHGGSVDLLSELVRAGHKGRKTSKGIFVYGDGAKGSKKVNQEAAKLFEKYKLTPIKSVSSPEDRQLRLVSRFVNEALLCLEEGVISSPSDGDIASVFGLGFPPFWGGPFRFVDLYGAGKLVAAMDRFAGVYESVQFEPCQLLRNHAKSGGQFYSLast
1 -166.000IDP00999 gene: fadJ; multifunctional fatty acid oxidation complex subunit alpha STM2388 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  37  1..........................MTTTSAFMLNVLDNVAVVAIDVPGEKVNTLKAEFATQVRAILKQIRENKALQGVVFISAKADNFIAGADINMIGHCQNAQEAETLARQGQQLMAEIQALPVPVIAAIHGACLGGGLEMALACHRRICTDDVKTVLGLPEVQLGLLPGSGGTQRLPRLVGVSTALDMILTGKQLRARQALKAGLVDDVVPQTILL-------------EAAVELAKKERLAQRTLPVRERILAG---------PLGRALLFRLVRKKTAQKTQGNYPATERIIDVIETGAQGSSSGYDAEARAFGELAMTPQSQALRAIFFASTEVKKDPGSDAPLNSVGILGGGLMGGGIAWVTACKGGLPVRIKDINTQGINHALKYSWDLLETKVRRRHIKASERDKQLALISGSTDYRGFSHRDLVIEAVFEDLPLKQQMVAEVEQNCAAHTIFASNTSSLPIGDIAANAARPEQVIGLHFFSPVEKMPLVEVIPHASTSAQTIATTVKLAKKQGKTPIVVSDKAGFYVNRILAPYINEAIRMLTEGERVEHIDAALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFS-APANVVASILNDDRKGRKNGRGFYLYGEKGRKSKKQVDPAIY---KLIGVQGQSRLSAQQVAERCVMLMLNEAARCFDEKVIRSARDGDIGAVFGIGFPPFLGGPFRYMDALGPGEMVATLQRLAALYGP-RYAPCEQLVRMAERREHFWT 707
2 -166.000IDP04410 fatty oxidation complex, alpha subunit [Vibrio cholerae O1 biovar El Tor str. N16961] VC1047 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  37  13......................GGGIMDNNNAFQLSFEQHYAWLAIDVPGEKMNTLQAAFAEEMQAVFATLEKRGQIKGLIIHSLKPDNFIAGADVRMLEACQSVHEAQALASQGQQMFQQLADLPFPVVAAIHGPCLGGGLELALACDYRVCTEDEVTRLGLPEVMLGLLPGSGGTQRLPRLIGLLPALDLILTGKQLRAKKAKKLGVVDACVPHSVLL-------------DVAKRLLEEKGHKKRAQVTLPIKEKL-----LANTDLGRKLIFDQAAKKTQQKTRGNYPAAQAILEVIQYGEKGMHAGLEYEAKRFAELVMTRESKALRSIFFATTEMKKDLDAKPAPVAAVGVLGGGLMGAGISHVTVKAKTSVRIKDVANDGVLNALNYNYKLFDKQRQRKILTKAQLQAQMSQLSGGTGFVGFDRCDVVIEAVFEDLKLKQQMVADIEANAKPTTIFATNTSSLPIHQIASQAQRPQNIVGLHYFSPVEKMPLVEVIPHATTSDETIATVVTLARKQGKTPIVVKDCAGFYVNRILAPYMNEAAQVLMAGEPIEKLDAALLDFGFPVGPITLLDEVGVDIGAKIMPILVKELGPRF--QGPDVFDVLLKDNRKGRKSGKGFYTYKGSKKKEVDKSVYKLLKLTP------ESKLNDKEIAMRCLLPMLNEAVRCLDEGIIRSARDGDMGAIFGIGFPPFLGGPFRYMDTLGLTKVVEMMNQHTEKYGE-RFAPCDGLLTRAGLGEKFY. 723
3 -165.000IDP00545 gene: fadJ; multifunctional fatty acid oxidation complex subunit alpha YPO2747 [Yersinia pestis CO92]  ali follow..  35  11..NTAVSENAVSEPTVNNDVGASATNSVTHPAFTLNVPDNIGIITIDVVGDKVNTLKAEFADQIATILQQAHALPKLQGLVIVSGKPDSFIAGADITMIAACRTAHDARVLAQKGQSILAQIAAFPVPVVAAIHGACLGGGLELALACHSRICSLDDKTVLGLPEVQLGLLPGSGGTQRLPRLVGVSKALDMILTGKQIRPRQALKMGLVDDVVPRDILLDVAIQRAKAGWLNRRALPWQERLLSG----------------------PLGKALLFRIVRKKTLAKTRGHYPAAERIIDVVRKGDQGGPSGYEAEARAFGELAMSPQSAALRSLFFATTSLKKETATARAIHRVGVLGGGLMGGGIANVTATRAGLPVRIKDINPQGINQALKYTWDALGKRVRSKRMRPTEQQRQMMLISGSTDYRGFERVDIVVEAVFEDLSLKQQMVADIERFGAAHTIFASNTSSLPISQIAALAQRPEQVIGLHYFSPVDKMPLVEVIPHEKTSEETIATTVALARKQGKTAIVVADRAGFYVNRILAPYINEAARCLLDGEPIESVDNALVDFGFPVGPMMLLDEVGIDVATKIMPILVEQLGPRF--AAPPSFDVILKDGRKGRKNGRGFYLYSNPFKWRKNKVKPVDASIYTLLGVTPKAHLGAGVITQRCTMLMLNEAVRCLDESIIRNPRDGDIGAVFGIGFPPFLGGPFRYLDSLGADKVVQALRLLVQQYGE-RFEPCQRLVTMAEQQQQFYP 761
4 -158.000IDP00503 gene: fadB; multifunctional fatty acid oxidation complex subunit alpha YPO3766 [Yersinia pestis CO92]  ali follow..  31  12...................................WLENGIAELVFDAPG-SVNKLDTKTVANLGEALNVLEKQSELKGLLLRSAK-TALIVGADITEFLSLAPPEKLHQWLVFANTIFNRLEDLPVPTISAINGYALGGGCECILATDFRIA--SPEARIGLPETKLGIMPGFGGSVRLPRLLGADSALEIIATGKDVTANDALKIGLVDAVVDPEKLVGS-----------------ALTMLKQAIDGKLDWQAARRPKLEPLKLNPTEAAMCFTIAKGRVMQVAGKHYPAPLTAVKTIEAAKFGRTEALNLETNSFVPLAGSNEARALVGIFLNDQYVKAQASKGVAAPKLAAVLGAGIMGGGIAYQSALKSVPVIMKDINENSLDLGMNEAAKLLNKQLERGKVDGLKMASILATIRPTLDYAGIERAQVIVEAVVENPKVKAAVLAEVEALIGEDTVLASNTSTIPIDQLAKSLKRPENFCGMHFFNPVHRMPLVEIIRGAKTSDKTLAAVVAYATQMGKTPIVVNDCPGFFVNRVLFPYLAGFGMLVRDGGDFHQIDKVMKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPERMNKDYRDAVDVMFDNQRFGQKNGQGFYRYTQDAKGKPRKENDEQVDKLLAEISQPLQEFSDEDIIARTMIPMINEVVRCLEEGIIASAAEGDMALVYGLGFPPFHGGVFRYLDTLGSANYVEMAQRYAHL--GALYHVPAGLRAKAEHNESYYP 715
5 -76.900IDP05101 gene: hbd; 3-hydroxybutyryl-CoA dehydrogenase [Clostridium difficile 630] CD1058 [Peptoclostridium difficile 630]  ali follow..  33  1................................................................................................................................................................................................................................................................................................................................................................MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDKNLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVTFDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGASKEEIDEAMKGANHPMGPLALGDLIGLDVVLAIMNVLYTEFGDT-KYRPHPLLAKMVRANQLGRKTKIGFYDYNK........................................................................................................................... 281
6 -71.600IDP02583 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/isomerase family protein [Bacillus anthracis str. `Ames Ancestor`] GBAA5249 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  23  2.............................................................................................................................................................................................................................................................................................................................................................FQIKKAAVLGSGVMGSGIAAHLANIGIPTLLLDIVPPALTKEEEAKGLTLEHKSVRNRFSNTAVQKLLKQKPAEDDLERLADVDWIIEVVVENLDIKKKLFEKVDAVRKPGSIVSSNTSGISVEKMAEGRSDQKHFLGTHFFNPPRYLKLLEVIPTKKTDPQVLSFMKLFGEDLGKGVVIAKDTPNFIGNRIGTYGLLVTLQEMVKGYSIGEVDSVTGPIGRPSATFRTLDVVGLDTFVYVANNVYENVQEKERDKVPAFMHDMLDKKWLGSKTGQGFFLKQGKEKAASIELSKQEKGLSNKLKALVYAKDRAGELLWNIITPTLLYSAKLHKE-IADDIVAIDQAMKWGFGWEQ---GPFEVWDAIGVEKSVQKMEESGAVI------PAWVKEMLEKGFTTFYK 438
7 -67.800IDP04044 gene: fadB/acbP; fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein [Francisella tularensis subsp. tularensis SCHU S4] FTT1530 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  21  23.........................................................................................................................................................................................................................................................................KPDNSQKLKLYAFYKQVKEGDNNTKKPSALKMVERAKWMAWDAIKGMSKEDAMRGYLRVFGEEYLPAGE--ASKLEPVESKSQRKAIDKIAVLGAGTMGAQIAAHFANAKFPVVLFDLKSQQGSAN-VIIEDSLAKLTKLNPFGSKDSIKYITPANYEDNLELLADCDLIIEAVAERIDIKESLYTKISSHIKENAILASNTSGLSITKLAQVLPENVNFCGVHFFNPPRYMPLVELIPHADTNSEILDKLETFLEKLGKSIIRAKDTPNFIANRLGVFSMLVTCYYTEQSIPLEVVDELTKKLGRASATYRTADLVGLDVLSHVVETMKDNLEDGWQKNTPNWIQNLINNGSLGQKTKKGLYIKASDGIKVLDLGTNEYRPADKKAEGLRNSDNHQAQFLWATFREMFLYAAHLVGD-ISNFPKDMDLAIRWGFGWKQ---GIFEIWQLAGWHKVASWLKDDIS---TGKALSTNTLPSWIDTLD.... 535
8 -51.900IDP04689 enoyl-CoA hydratase [Bacillus anthracis str. `Ames Ancestor`] GBAA4761 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  28  1............................MLKFLSVRVEDHIAVATLNHA--PANAMSSQVMHDVTELIDQVEKDDNIRVVVIH-GEGRFFSAGADIKEFTSVTEAKQATELAQLGQVTFERVEKCSKPVIAAIHGAALGGGLEFAMSCHMRFATES--AKLGLPELTLGLIPGFAGTQRLPRYVGKAKACEMMLTSTPITGAEALKWGLVNGVFAEETFL-------------DDTLKVAKQIAGKSPATARAVLEL------------------------------------------LQTTKSSHYYEGVQREAQIFGEVFTSEDGREGVAAFLEKRK............................................................................................................................................................................................................................................................................................................................................................................................................................... 252
9 -49.500IDP02329 enoyl-CoA hydratase [Bacillus anthracis str. `Ames Ancestor`] GBAA2551 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  27  11...................................YATPHVVKISLNRE-RQANSLSLALLEELQNILTQINEEANTRVVILTGAGEKAFCAGADLKERAGM-NEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELSLACDFRIAAES--ASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKEYGLVEFVVPVHLLE-------------EKAIEIAEKIASNGPIAVRLAKE------------------------------------------AISNGIQVDLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRT............................................................................................................................................................................................................................................................................................................................................................................................................................... 256
10 -46.200IDP04059 naphthoate synthase [Vibrio cholerae O1 biovar El Tor str. N16961] VC1973 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  16  5MGTTMAKTTGISEQELYAPVIWQDCTGDYQDIHYHKSDDGIAKITIARP-QVRNAFRPLTVKEMIHALADARYDDKVGVIILTGLGEDAFCSGGDQKIRGDYGGRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGWAVGGGHVLHMMCDLTIAAEN--AQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYNAQEALDMGLVNTVVPVEE-------------LERETVRWCREVLQHSP--------------------------------------------AIRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRR............................................................................................................................................................................................................................................................................................................................................................................................................................... 286
11 -45.100IDP00995 gene: menB; naphthoate synthase STM2307 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  17  16......................HDCSEGYTDIRYEKSTDGIAKITINRP-QVRNAFRPLTVKEMIQALADARYDDNVGVIILTGEGDKAFCAGGDQKVRGDYGGYQDDSGHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAEN--AIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLAD-------------LEKETVRWCREMLQNSP--------------------------------------------ALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQ............................................................................................................................................................................................................................................................................................................................................................................................................................... 275
12 -10.500IDP00666 TrkA potassium uptake family protein SACOL1096 [Staphylococcus aureus subsp. aureus COL]  ali follow..  13  3................................................................................................................................................................................................................................................................................................................................................................KEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKS---------------LGIRNFDHVIVAIGENIQ-SSTLTTLILKELGVKKVTAKAQNDYHAKILADTVVHPERDMGLDYLELADEHSIVELKATEKMAGQSIID-LDIRAQYGINIIAIKRGKEFIISPNPNINLEIGDILIMIG-HDNDLNRFEKNIA......................................................................................................................................................................................... 218
13 -9.960IDP01104 potassium uptake protein, TrkA family BA_4191 [Bacillus anthracis str. Ames]  ali follow..  16  6................................................................................................................................................................................................................................................................................................................................................................KEFAVIGLGRFGGSICRELAQLGMEVMAIDSDEDKINEFANIASHAVIADSTDEMVLKS---------------LGIRNFDHVVVAIGDNLN-SSILTTLILKELGVKNITVKAQNDYHEKVLADHIVHPERDMGLDYLELSDEHSIVEIIANKKIDGHSLIE-LDIRAKFGLNIVAIKRGKEVIVSPRATENIQAGDILIVIG....................................................................................................................................................................................................... 208
14 -9.200IDP02538 peptidase [Francisella tularensis subsp. tularensis SCHU S4] FTT1746 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  17  53...................................ELVPHIALIKVN---GVIADDAEANAERINQSLDDAYANKSVKGVIVEINSPGGSPVQSD-----------EIYSHMQYLQH-----KYPTIPMYAVCTDVCASGGYYIAAGAKDIYA--NKMTITG----SIGVIGSGFGFTGLMDKLGIEKNIDTTFSGEPFSGIQAQQMGLIDGFASVDQIRNEKFN.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 269
15 -9.020IDP91958 Trk family potassium uptake protein [Streptococcus pneumoniae str. Canada MDR_19A] SpneCM_010100004562 [Streptococcus pneumoniae str. Canada MDR_19A]  ali follow..  13  4................................................................................................................................................................................................................................................................................................................................................................RTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEPVLARGVIGDITDEELLRS---------------AGIDTCDTVVVATGENLE-SSVLAVMHCKSLGVPTVIAKVKSQTAKKVLADSVISPEYEMGVDVFQLDKNVSIVEMKIPQSWAGQSLSK-LDLRGKYNLNILGFREQENLDVEFGPDDLLKADTYILAVI-NNQYLDTLVA............................................................................................................................................................................................ 218
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.