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Query: [E] KOG2380 Prephenate dehydrogenase (NADP+), from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAETLITKPPLSLSFTSLSSMLPSLSLSTANRHLSVTDTIPLPNSNSNATPPLRIAIIGFGNYGQFLAETLISQGHILFAHSRSDHSSAARRLGVSYFTDLHDLCERHPDVVLLCTSILSIENILKTLPFQRLRRNTLFVDVLSVKEFAKTLLLQYLPEDFDILCTHPMFGPQSVSSNHGWRGLRFVYDKVRIGEERLRVSRCESFLEIFVREGCEMVEMSVTDHDKFAAESQFITHTLGRLLGMLKLISTPINTKGYEALLDLAENICGDSFDLYYGLFVYNNNSLEVLERIDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVFPNCGENDASLDMMRSEDVVVKYEYNSQVSGSVNDGSRLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFSDLDDLFEEHPEVIILCTSILSTEKVLESLPFQRLKRSTLFVDVLSVKEFPRNLFLQTLPQDFDILCTHPMFGPESGKNGWNNLAFVFDKVRIGMDDRRKSRCNSFLDIFAREGCRMVEMSCAEHDWHAAGSQFITHTVGRLLEKLSLESTPIDTKGYETLLKLVENTAGDSFDLYYGLFLYNPNAMEQLERFHVAFESLKTQLFGRLHSQHSHELAKSSSPKTTKLLTSLast
1 -50.800IDP05722 gene: tyrA; prephenate dehydrogenase [Bacillus anthracis str. Ames] BA_2954 [Bacillus anthracis str. Ames]  ali follow..  16  1..............................................................................................................................................................................................................................................................................................................................................................MKIKKESLEMRQMRKKVVLIGTGLIGGSLALAIKKDHVTITGYDIFQEQERAKELHVVDEIAVDQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNRELMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRK 299
2 -47.400IDP91227 gene: tyrA; T-protein [Escherichia coli CFT073] NT04EC3201 [Escherichia coli CFT073]  ali follow..  17  54LASRRAEAEALGVPPDLIEDVLRRVMRESYSSENDKGFK------TLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQHDWDRAAD-------------IVSDAGMVIVSVPIHVTEQVIGKLP--PLPKDCILVDLASVKNGPLQAMLA--AHDGPVLGLHPMFGPDSGSLAKQ----------VVVWCDGRKPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRYYKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRVL............................................................................................................................................................................................................................................................................................................... 364
3 -47.100IDP00461 gene: tyrA; bifunctional chorismate mutase/prephenate dehydrogenase YPO3285 [Yersinia pestis CO92]  ali follow..  16  54LASRRQEAGALGVPPDLIEDVLRRVMRESYTSENDKGFKT------LCPELRPVVIIGGQGQMGRLFSRMLNLSGYQVRTLEQEDWSQA-------------ESILADAGMVIVSVPIHITEEVINRL--PKLPADCILLDLASVKNKPLQAMLA--AHEGPVLGLHPMFGPDVGSLAKQ----------VVVYCDGRDPQAYQWLLEQLQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENALSSPIYRLELAMVGRLFAQDPQLYADIIMSSEDNLALIKRYYKRFGEALTLLEHHDKQAFVQSFEKVEHWFGDYAERFLVESRSL............................................................................................................................................................................................................................................................................................................... 364
4 -16.900IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  10  1............................................................................................................................................................................................................................................................................................................................................................................MKIGWIGLGAMGTPMATRLRDAGLEVSVYNRTESKAAPLKEKGVAVYTSPIDLAAKVDLVFTMLSDKAAIDAVLAPKFWEQMSKKIVVNMSTIAPLESLSLEKIAQKQATYLEA-PVSGSVGAAKAGALLILA---------AGDEEVISKLKPVLAHLGSQTFYLGKVGQGTGAKLSINS----ALLLAKRLGVDAESFLQIIGQSGMNSPLFQAKKGMWLQDNYPAAFSLKLMAKDIRLAKNEAGEAMKLPFLFQAEELYSQAEK......... 265
5 -15.100IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  8  19............................................................................................................................................................................................................................................................................................................................................................................KKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKNAGFEVVSVSEASKIADVIMILAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESKNAKNLALSYASAIGGRTGIIETTFKAETETDLFGEQAVLCGGLSALIQAGDMRYSISNTAEYGDYITGPKIITEETKKAMKGVLQNGVFAKDFILERRAGFARMHAERKNMNDSLIEKTGRNLRAMMPWISAKK 333
6 -13.900IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  16..........................................................................................................................................................................................................................................................................................................................................................................KEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAE-AAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFN---VHFDQVKPPVNVDVFLVAPKGGHLVRRTFSEGGAV---ALFAVYQDATGVATEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKA----------GFETLVDAGYQPELAYFECLHELKLIVDLMYE...................................... 240
7 -13.700IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  9  36..................................................KGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFKNAKNNSYEQLIPTADLVINLTPDKQHTSVVNAVM-PLMKQGAALGYSHGFN---IVEEGMQIRKDITVVMVAP--CPGTEVREEYKRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGGCLASSFVAEVKSCGMLQAGSIVCYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPELSEELKDLMRPLYNKHMDDIISG-------------HFSSTMMADWANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGILMIAMVRAGVELAMTASGII-SLHELPLIANTVARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRN-------HPV---EYIGEELRGYMKDMKRIAVGD....................................................................................................................................... 494
8 -13.500IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  9  17............................................................................................................................................................................................................................................................................................................................................................................KTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSE-AVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFN---IHFGQINPPSYVDVAMVAP--GHLVRRVFQEGNGV---ALVAVHQDATGTALHVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAG--DTAEFGDYVTGSRIVTDETKKEMKRVLQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELREMMSWIHAPK 330
9 -13.300IDP02492 gene: proC; pyrroline-5-carboxylate reductase [Francisella tularensis subsp. tularensis SCHU S4] FTT1559c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  9  1....................................................MKICFIGGGNMAAAMIAGMTSHGDIIVFDRNEHKCLNLIKKYNINTSTSLLNTIKLADVLILAIKPQNMFELIKNIRDTVTSTQVIVTVAAGIQ---TSAYEELFNKEISFARTIPSLGYGATGI---------------FFNKVIAADKKDLVIDIMQTMGVVTVVEDEKEIDIVAAIASSGPAYYFQFMEHMVKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNIFEQ--FNLGGIVDKAIQANIARAQQLAIEFTKLIDN........................................................................................................................................................................................................................................................................................................................ 274
10 -13.200IDP02179 gene: proC; pyrroline-5-carboxylate reductase [Coxiella burnetii RSA 493] CBU_2090 [Coxiella burnetii RSA 493]  ali follow..  13  2..................................................NTSNITFIGGGNMARNIVVGLIANGYICVTNRSLDKLDFFKEKCGVHTTQDNRQGALNADVVVLAVKPHQIKMVCEELKDILSETKILVISLAV----TTPLIEKWLGKASRIVRAMPSVRAGATGL---------------FANETVDKDQKNLAESIMRAVGLVIWVSSEDQIEKIAALSGSGPAYIFLIMEALQETAELLTEQTVLGAARMALETEQSVVQLRQFVTSPGGTTEQAIKVLES--GNLRELFIKALTAAVNRAKELSKTVDQ............................................................................................................................................................................................................................................................................................................................ 274
11 -12.300IDP00140 pyrroline-5-carboxylate reductase, putative BA_0197 [Bacillus anthracis str. Ames]  ali follow..  11  3..................................................TKHRILFIGAGRMAEAIFSGLLKTSKEVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHEELLAELS-PLLSNQLVVTVAAGIS---PSYLEERLPGGTPVAWIMPEIGKSISLY---------------TMGQFVNETHQETLQLLLRGIG-TSQLCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVD------ATAKHLVIQMISGSASMLEQTQDPANLREQVTT......................................................................................................................................................................................................................................................................................................................................................... 232
12 -11.900IDP02226 gene: yqjI; 6-phosphogluconate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA0164 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  1.........................................................................................................................................................................................................................................................................................................................................................................MENLQIGVVGVGVMGKSLALNFESKGYSVALYDISKEIEENRGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDVPHLDKGDILIDGGNTYFVDTIRRNKRLEEGINFIGA-GVSGGEEGAL--KGPSIMPG---------QKDAYEKVKDMLENISAKVNNEPCCSY----HYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFA............................................................ 219
13 -11.800IDP04467 putative nucleotide sugar dehydrogenase [Yersinia pestis CO92] YPO2174 [Yersinia pestis CO92]  ali follow..  10  1....................................................MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGLKYVLDVASTIG-TYMDSPKVIIDKSTVPVGTADKVHQVIQAILE-VVSNPEFLKEGAAVADCKRPERIVI---IDTDDSGALELISELYEPFNRNHDRMLVMDIRSAELTISFMNEIANIAERLVRQGIGSDSRIGYHFIYSGCGYGGSCFPKDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAG----------------------------------------------KTFAVWGLAFKPNTVMESLWEAGATIQAYDMDETQRIYGARDDLRLMGTKESALQGADALIICTEWQSFRAPDFDMIKSRLK-HPVIFDGRNL....................................................................................................................................................................................... 423
14 -11.700IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  11  1.........................................................................................................................................................................................................................................................................................................................................................................MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEIACHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQLPHLDKGDILIDGGNTFYKDTIRRNEELANGINFIGT-GVSGGEKGAL--EGPSIMPG---------QKEAYELVADVLEEISAKAPEDGKP-------YVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTE........................................................... 222
15 -11.400IDP04504 2-dehydropantoate 2-reductase [Vibrio cholerae O1 biovar eltor str. N16961] VC2307 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  14  1............................................................................................................................................................................................................................................................................................................................................................................MNIVVLGPGAVGSLWALHLHSAGHQVALWSRQAQPTITLQLDPISFRNQNLDTLIHADLLLITVKAWQVEAALQPLL-PHLNRETILLFMHN-----VEAISESLTHF-PVLFATTTHGALKATLNQVSHT--FGQTQVGPFNALGARCDFIADVFNHALAPVTEIQQALWRKLACAINPLTAIHQCANGALVAPEFTPIITAIDGVYQVIQATAANLSSMHQDVFHRRPTEIDFITGYVVRKGE-QHGIATPVNSALYQQIKTLEQSWSK..... 295
16 -11.200IDP00503 gene: fadB; multifunctional fatty acid oxidation complex subunit alpha YPO3766 [Yersinia pestis CO92]  ali follow..  10  5...............................................................SETLQLHWLENGIAELVFDAPGSVNKLDTKTVANLGEALNVLEKQSELLLLRSAKTALIV-ITEFLSLFNAPPEKLHQWLVFANTIFNRLEDLPVPTISAINGYALGG------------ECILATDFRIASPEARIGLPETKLGIMPGFGG----------------SVRLPRLLGADSALEIIATGKDVTANDALKIGLVDAVVDPEKLVGSALTIAKGRVMQVAGKHYPAPLTAVKTIEAAAKFGRTEALNLETNSFVPLA-----GSNEARALVGIFLNDQYVKAQAKKLSKGVAAPKLAAVLGAGIMGGGIAYQSALKSVPVIMKDINENSNKQLERGKVDGLKMASILIERAQVIVEAVNPKVKAAVLAEVE-ALIGEDTVLA--SNTSTIPIDQLAKSLKRPENFCGMHPIRGAKTSDKTLAAVVAYMGKTPIVVNDCPGFFVNRVLFPYLAGFGMLVRGDFHQIDKVMEKQFGWP.............................................................................................. 534
17 -11.100IDP00425 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase YPO3863 [Yersinia pestis CO92]  ali follow..  9  2..................................................SFETISVIGLGYIGLPTAAAFASRKKKVIGVDVNAHAVETINRGAIHIVEQAVTKPQAADAFLIAVPMIFVESAAKSIA-PVLKKGDLVILESTSPVGATEQMAQWLAEARPDLSFP-AYCPERVLPGQVMVELIQNDRVI----GGMTPKCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICDEQGINVWELIRLANRILQPGPGVGGHCIAVDPWFIVSQNPQLARLIHTARLVNDGKPLWVVDRVKAA-------------------------------VADCLAASDKRASEVKIACFGLAFKPDIVARLIAEWHVGETLVVEPNVEQLPKSLMGLVTLKDTATALQQADVLVMLVD-----KQFKAIKPEDIK-QQWIVDTKGV....................................................................................................................................................................................... 418
18 -11.100IDP00951 gene: ycdW; putative oxidoreductase STM1135 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  13  137............................................................................................................................................................................................................................................................................................................................................................................FSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVES--YVGREELRAFLNQTRVLINLLPNTQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAALDSGLDVFSQEPL----------QESPLWRHPRVAMTP...................................................................................................................................... 274
19 -10.900IDP01235 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase BA_5512 [Bacillus anthracis str. Ames]  ali follow..  7  1....................................................MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEERASLTPEEADAFIISVPLSYVLTATEKVL-PFVKKGNVIIVESTIAPRSMDDYVKPLVEEAGFTVGEDIHCPERVLPGQILHELVHNNRIV----GGVTPACAEAGARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMANKLHYPGPGVGGHCLAVDPYFIVAKAPELANIIKLSRETNVSMPHYVTEKVKE---------------------------------------LLAGVENPKVAAFGVTYKGNVVIDLIRNEGITVSAHDPHVESDFFE-------LHSAEEAVKDAHLILVLTDHDEFKTMNYDSLAPYMA-KTVVFDTRNCVQAVSTGEMKIINFGTLYEA................................................................................................................................................................... 419
20 -10.800IDP01730 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [Francisella tularensis subsp. tularensis SCHU S4] FTT0871 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  11  2...........................................................................................................................................................................................................................................................................................................................................................................QKNILVLGAGAWGTALALQLAYRGHNVRINSWKAEHNEQMLKD-LKAIQDWQANIIEFDSILVATPSSGFKNTILELKECILPQQNIISATKGFCHDSYALLSEIAEDILPTTKFALLTGPSFAKELANQL-----PTAVVVASKDINYARYVQELFSNENFRCYTTTDIIGAQVGGAVKNV--AITAGIAAGMEFGVNAHAALITRGLAEIKKLGGANSETFIGLSCLGDLLLTCSDNQSRNRRFGLYLGQGMTIQQALKEVNNVVE......... 281
21 -10.500IDP05101 gene: hbd; 3-hydroxybutyryl-CoA dehydrogenase [Clostridium difficile 630] CD1058 [Peptoclostridium difficile 630]  ali follow..  12  1....................................................MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQDEATKAEILSHVSSTTNYEDLKDMDLIIEASVMNIKKDVFKLLDELCKEDTILATNTSSLS---ITEIASSTKRPDKVIGMH-FFNP-----------VPMMKLVEVISGQLTSKVTFDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDE................................................................................................................................................................................................................................................................................................................................................................................................. 213
22 -10.500IDP02668 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1526 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  9  1...........................................................................................................................................................................................................................................................................................................................................................................MTKITVVGAGSWGTALAMVLADNGHDVRIWGNRSELMDEINTK-IVAYSSLEEALVDVNVVLIVVPTKAYREVLQDMKKYVAGPTTWIHASKGIEPGTSKRISEVIEEEIPEDLIKDLSGPSHAEEVGLRQ-----ATTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPDIVGVELGGALKNI--ALAAGITDGLGLGDNAKAALMTRGLTEIARLGGGNPLTFAGLTGMGDLIVTCTSVHSRNWRAGNMLGKGHSLEEVLESMGMVVE......... 282
23 -10.500IDP01976 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD+) [Coxiella burnetii RSA 493] CBU_1518 [Coxiella burnetii RSA 493]  ali follow..  10  1.......................................................................................................................................................................................................................................................................................................................................................................MEPFKHPIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAE-LKAYCDLKASLEGVTDILIVVPSFAFHEVITRMK-PLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQVPMAVISGPSLATEVAANL-----PTAVSLASNNSQFSKDLIERLHGQRFRVYKNDDMIGVELCGSVKNI--AIATGISDGLKLGSNARAALITRGLTEMGRLVGGKQETLTGL................................................... 240
24 -10.500IDP01969 gene: kfiD; putative UDP-glucose 6-dehydrogenase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1441c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  9  1....................................................MKIVIVGIGYVGLANAILFSKNNNEVVLLDIDENKIQSINNHKSHATSNIKEAYFNADFAVIATPTRSIENVLKDIK--NINSKINVIIKSTVPIGYTKTIKQKFNM------SNIVFSPEFLREGSALYDSLYPSRIIIGDKSVLGKTIGDLFLKNIEKKNVDIFYMDSDEAESVKLFSNTY-----LAMRVGFFNEVDSYARKHNLNSADIIKGISADDRIGKYYNNPSF--------LPKDTKQLLANFYNIPNSLIKAIVETNEIRKKFITQLILEKKPN-----------------------------ILGIYRLIMKQNSIIKYLQEYNSNIELIIYEPLVKEKKFLNIKVENDFNV-FGAKVDLIIANRFDDKLKEIKDKVFSADVFYTDI.............................................................................................................................................................................................. 393
25 -10.500IDP01494 UDP-glucose 6-dehydrogenase VCA0780 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  10  1....................................................MKIAIAGTGYVGLSNGILLAQHNEVVALDIVVSRVEQQHQPLNFRATCDKRDAYQDAQFVVIATPTRTVEAVIDDVL--AINPQAIMVIKSTVPVGYTKRIKQ------RLCCNNLIFSPEFLREGRALYDNLYPSRIIVGEKSERGQAFATLLAQGAKKMDIPILLTHSTEAEAVKLFSNTY-----LAMRVSFFNELDTYAETHGLDTKQIIEGVGLDPRIGNHYNNPSF--------LPKDTRQLLRNFEDVPNNLIRAIVDANTTRKDHIAFSILNRNPK-----------------------------VVGIYRLIMKSGSIMKRIKAQGVEVVIYEPVLNESTFYGSPVI---RDLAQFKAMAEVIVTNRRVAELEDVAEKIYTRDL................................................................................................................................................................................................... 384
26 -10.400IDP00702 gene: cap5O; capsular polysaccharide biosynthesis protein Cap5O SACOL0150 [Staphylococcus aureus subsp. aureus COL]  ali follow..  7  1....................................................MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEKVSTTPDASDVFIIAVPISLVMRALDSIL-SFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIHCPERVLPGKILEELVHNNRII----GGVTEACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQ---------------------------------------IIKVLSGNKVTVFGLT---DIYELLNQEPDIEVCAYDPHVELDF--------VEHDMSHAVKDASLVLILSDHSEFKNL--SDSHFDKMKHKVIFDTKNV....................................................................................................................................................................................... 398
27 -10.300IDP01406 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase VC0918 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  11  3....................................................NKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTINKGEIHIVEKATLTAEPADAFLVAVPLSYIEAAAKTIA-PVLAKGNLVVLESTSPVGTTEKLAQWLAEARPDLDVKIAYCPERVLPGYVLQELVSNDRVI----GGVSKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINVWELIRLANRILNPGPGVGGHCIAVDPWFIVNSCPDEAQLIRTAREVNDGKPHWVVDQVKQA---------------------------------------ADQFKKPIIACLGLAFKADIITKHLAESKGQLLAVEPNITELPSKLAKQGIELVSLERALELANIVVVLVDHKEFKAA----------AKKVVIDTRGV....................................................................................................................................................................................... 411
28 -9.950IDP02583 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/isomerase family protein [Bacillus anthracis str. `Ames Ancestor`] GBAA5249 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  9  2.................................................FQIKKAAVLGSGVMGSGIAAHLANIGIPTLLLDIVPPALTKEEEAKGLTLEHKSVRLADVDWIIEVVVLDIKKKLFEKVD-AVRKPGSIVS--SNTSGISVEKMAEGRSDDFHFLGTH-FFNP------------RYLKLLEVIPTKKTDPQVLSFMKLFGEDLGKGVVIYSIGEVDSVTGPLIGRPKSATFRTLDVV---------GLDTFVYVANNVYENVQEKERDVFKVPAFMHDMLDKLELNPETMEYEARKKLKAASIELSKQEKGLSNKLKALVYAKDRAGELLWNIITPTLLYSAKLHKEIADDIVAIDQAMWGFGAIGVEKSVQKMEESGAVIPAWVKEMLEKGFTTFYKHDNGEYKLIECNKKAISLKQLKAKNGVLKKNSGASLIDLGDGILKSNAIGMDITQMINYAVDEVEKNYKGLVIGNQSKNFCVGANLAMILMEAQDDNYFEIEWVVKNFQDAMMKIKYSSKPVVAAPYGMTLGVCLPAASIQASSETYMGLVEVGVGLIPGGGGNKELYIKHLNKNKVFETVAMAKVLTSGQEAVSHNFLGDKDGISVNGD-----HLLYDAKQKALALYEAG 696
29 -9.730IDP04044 gene: fadB/acbP; fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein [Francisella tularensis subsp. tularensis SCHU S4] FTT1530 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  10  61MAWDAIKGMSKEDAMVFGEEYLPAGESDNDSPSSTIASKLEPVESKSQRKAIDKIAVLGAGTMGAQIAAHFANAKFPVVLFDLKSQQGSANVIIEDSLAKLTKLLLADCDLIIEAVAIDIKESLYTKIS-SHIKENAILA--SNTSGLSITKLAQVLPENLKFCGVH-FFNPPR-----------YMPLVELIPHADTNSEILDKLETFLEKLGKSIIRIPLEVVDELTGKKLGRAKSATYRTADVGLDVLSHVVETMKDNLEDGWQKLYNTPNWIQNLINNGSLGQKTKKGLYIKASDGIKVLADKKADKEILDILAERDWSKKLEGLRNSDNHQAQFLWATFREMFLYAAHLVGDISNFPKDMDLAIWGFGLAGHKVASWLKDDISTGTSTLATQTLYENDGVKLWQIDDYSNIGILSFKSKMCAIGDDVLDGISESINYAEEKLDGLVINLEEFGEEVIRKGHSIISKKLRYSKIPVVAAVKGFAFGGGCETILHSDAAVAAYESYIGLVEAAVGIIPGWGKEMAVRASQAQDHWKDFERRYKNLALAQVAKSAYEAKEM------GFLRDDDIVVMNTKEI....................................................... 786
30 -9.700IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum]  ali follow..  9  7.................................................................................................IKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEICSCNIYSTQDHAAAALVKKN-----ATVFAWKNETIEDYWVCLNDAMTWRNPNDKDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKC---MYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPCALQASMEG--YQVSVLEDVVSEADIFITATG----KDVITVEHMRKMKENAYIANIGHFDDEI----------DVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKG-----RLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKS-TRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYR....................................... 494
31 -9.690IDP02277 glycerate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1434 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  145............................................................................................................................................................................................................................................................................................................................................................................KTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPEAESELEATYVT---EELLQTADFITINCAYNKLHHMIDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNLDVFEFEP-----------ITEELKGLKNVVLAPHVGNATFETRDAMAEMAVRNILAV.............................................................................................................. 305
32 -9.680IDP00666 TrkA potassium uptake family protein SACOL1096 [Staphylococcus aureus subsp. aureus COL]  ali follow..  9  2...........................................................................................................................................................................................................................................................................................................................................................................GKEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNAVVADTTDEAVMKSLGIRNFDHVIVAIGENIQSSTLTTLILKELGVKKVTA----------KAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELADEHSIVELKATEKMAGQSIIDLDIRAQ......................................................................................................... 171
33 -9.450IDP91958 Trk family potassium uptake protein [Streptococcus pneumoniae str. Canada MDR_19A] SpneCM_010100004562 [Streptococcus pneumoniae str. Canada MDR_19A]  ali follow..  13  1.........................................................................................................................................................................................................................................................................................................................................................................MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINGVIGDITDEELLRSAGIDTCDTVVVATGENLESSVLAVMHCKSLGVPTVIA----------KVKSQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMLDLRGKYNLNILGFREQENSPLDV.................................................................................................... 190
34 -9.430IDP01104 potassium uptake protein, TrkA family BA_4191 [Bacillus anthracis str. Ames]  ali follow..  10  2........................................................................................................................................................................................................................................................................................................................................................................GEKEKEFAVIGLGRFGGSICRELAQLGMEVMAIDSDEDKINAVIADSTDEMVLKSLGIRNFDHVVVAIGDNLNSSILTTLILKELGVKNITV----------KAQNDYHEKVLSKIGADHIVHPERDMGKRIANNIASSNVLDYLELSDEHSIVEIIANKKIDGHSLIELDIRAK......................................................................................................... 174
35 -9.370IDP00906 gene: murC; UDP-N-acetylmuramate--L-alanine ligase STM0129 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  10  1.................................MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGGGIAEVLANEGYQISGSDLAPNTQQLTSLGATIFFNHRPENVRDASVVVVSSAISADNPEIHEARIPVIRRAEMLAELMRFRHGIA------------IAGTH---GKTTTTA------VSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDASFLH--------------------------LQPMVAIVTNIEADHMDTYHG-----ENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGR--------------------------------------------QTTTYGFSEDADVRVEDYQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIADDAILRALESFQGTGRR---------DFLGEFPLEPVNGKAGTAMLVGHHP--------------------------TEVDATIKAARAGWPDKNL-VMLFQPHRYTRTRDLYDDFANVLTQV-------DALLMLDVYPAGEAPIPGADSRS--LCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDARYLSEIKLKPQIQEEE..... 488
36 -9.370IDP92093 adenosylhomocysteinase, putative [Toxoplasma gondii ME49] TGME49_025050 [Toxoplasma gondii ME49]  ali follow..  9  1....................................................................................................................................MAEQSKVKDLTLSARKEIELAEGEMP---EFGPRQPLKGAKISGSLHMTVQTAVLIETLKALGAELRSTQDHAAAAIVKNNSAAVFAWKGETLEEYWWCTVMALTWGEGAGPDLLVDDGGDATLLIHEGVKAEKEFARSGALPDPAVYKILAEGLQKDPQKWSRMAANLKGVSEETTTGVHRLLQMAKKKELLFPAINVNDCVTKSKFDNVYGCRHSLPDGIMRATDVMLGGKRVVICGFGDVGKGCAAAMKGAGARVVVTEVDPICALQAAMEGYSVSTLESQLATADIFISATG-----KDIITARHMSQMKNNAIVGNIGHIKPQVDRFIFPEDNHGVIVLAGRLL-GHPSFVMSCSFTNQTLAQLDLWDNVATKRYQNDVYLLLPALGCELTTMSQEQAA........................................................................................................ 460
37 -9.300IDP00999 gene: fadJ; multifunctional fatty acid oxidation complex subunit alpha STM2388 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  9  16......................................................VAVVAIDVPGE--VNTLKAEFATQVRAILKQIRENKALQGVVFISAKADNFIAGADINMIGHCQNA-----QEAETLARQGQQLMAEIQALPVPVIAAIHACLGGGLEMLACHRRICTDDVKTVLGLPEVQLGLLP--------GSGGTQRLPRLVGVSTALDMILTGKQLRARQALKAGLDDVVPQTILLEAAVELAKKERLAQRTLPVRERILAGPLGRALLFRLVRKKTAQKTQGNYPATERIIDVIETGLAQGSSSGYDAEARAFGELA-----MTPQSQALRAIFFASTEVKKDPGSDAPPGPLNSVGILGGGLMGGGIAWVTACKGGLPVRIKDINTQGETKVRRRHIKASERDKQLFSHRDLVIEAVDLPLKQQMVAEVE-QNCAAHTIFA--SNTSSLPIGDIAANAARPEQVIGLH-FFSP------VEKMPLVE---VIPHASTSAQTIATTVKLAKKQGKTPIVVSDKA-NRILAPYIN-----AIRMLTEGERVEHIDAALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFSAPANVVASILNDD....................... 573
38 -9.290IDP90657 gene: murC; UDP-N-acetylmuramate--L-alanine ligase [Yersinia pestis CO92] YPO0556 [Yersinia pestis CO92]  ali follow..  10  1.................................MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGGGIAEVLANEGYQISGSDLAPNTQHLTALGAQIYFHHRPENVLDASVVVVSTAISADNPEIREARIPVIRRAEMLAELMRYR------------HGIAVAGTH---GKTTTTA------LSSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDASFLH--------------------------LQPMVAIVTNIEADHMDTYQG-----ENLKQTFINFLHNLPFYGRAVMCIDDPVVRELLPRVGR--------------------------------------------HITTYGFSDDADVQIASYREGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIEDEDILRALVGFQGTGRR---------DFLGNFPLAPVNGKEGSAMLVGHHP--------------------------TEVDATIKAARAGWPDKRI-VMLFQPHRYTRTRDLYDDFANVLSQV-------DVLLMLDVYAAGEPPIPGADSRA--LCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDARKLAEHKLQPQLKDEE..... 488
39 -9.190IDP01452 gene: murC; UDP-N-acetylmuramate--L-alanine ligase VC2400 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  10  26...................................TQDLAQIRAMVPEMRRVKAIHFIGIGGAGSGIAEVLLNEGYQISGSDLAANTDRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIREKRIPIVRRAEMLAELMRFR------------HGIAVAGTH---GKTTTTA------VTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADESDASFLH--------------------------LQPMVTIVTNIEADHMDTYGG-----ENLKQTFIDFLHNLPFYGQAILCIDDPVIRELIPRVSR--------------------------------------------QVITYGFSEDADVRIENYRNGQQGQFTVVRKGKANLDITLNIPGRHNALNAAAAIAVATEDDIRDEAILRAMANTQ-------------GTGRRFDHLGEFETGNGVAMLVGHHP--------------------------TEVDVTIKAARNGWAEKRL-VMIFQPHRYTRTRDLYDDFANVLEQV-------DVLIMLDVYAAGEKPIAGADGRS--LCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDARHLAALELNIGRMQQ...... 505
40 -9.170IDP91002 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase [Yersinia pestis KIM 10] y1919 [Yersinia pestis KIM10+]  ali follow..  10  1....................................................MKAIVFAYHDIGCVGLNALAEAGYDIQAV-----FTHTDNPGENRFFSSVARVAADLALPVFAPEDVNHPLWVERIRE--LQPDIIF--SFYYRNMLSDEILSLAPQGG--FNLHGSLLPQYRGRAP-------INWVLVNGETETGVTLHQMVKKADAGPIAGQYKVAISDVDTALTLHAKMRDAAQELLRNLLPRMKE-LTPQKEADASYFGRRTAADGEI--HWQKSAFTINNLVRAVTEPYPGAFSYLGQRKLTIWRSRPLDLVHNKLPITGQGEAGLYVQGDRLAQEMGIVTDVRLGNKPSNTLKRRTRVLILG-GFIGNHLTERLLQDDYEVYGLDIGSDAIHFVEGDISIHSEWIEYHIKKCDVILIATPIEYTRNPLRVFELDFEENLKIVRDCVKYNKRIV------FPSTSEVYGDKEIVGPINKQRWIYSVSKQLLDRVIWAYGVKEGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVGSPIKLVDGGAQKRCFTDIHDGIEALFRIIENRDGCCDGINIGNPTNEASIRELAEMLLTSFEN........................... 587
41 -9.020IDP91791 gene: vanH; vancomycin resistance protein [Enterococcus faecium] AAA24789 [Enterococcus faecium]  ali follow..  13  17...........................................................................................................................................................................................................DAFHALSPRFGVMATIINANVSESNAKSAPFNQCISVGHKSEI---SASILLALKRAGVKYISTRSIGCNHI-MGITVDN-SPDSVADYTMMLILMAVRNVKSIVRSVEKHDFRLDSDRGKVLSD------------------------------------MTVGVVGTGQIGKAVIERLRGFGCKVLAYSRSRSIEVNY-----------DELLQNSDIVTLHVPLTDTHYIISHEQIQRMKQGAFLINTGRGPLVDTYELVKALENGLDVLEGEEEF-TQKPIDNQFLLKLQRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDF.............................................................................................................. 315
42 -9.010IDP90690 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1196c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  11  2....................................................MRIAVIGAGKWGSALHLALKENHNCFISSLHQRDLEDFVSI----------KEALECEYLVFALSSQGMRAWLKENFIN--KGQKILIASKGIEDQSCQFLDEIFLDFVPKENFCVLSGPSFAELCKKFASFFPDFIKTYIDNDVRGAEICGAYKNVLAIASGISDGLKLGNNARAALISRGLIEMHRFGKFFGTKEETFLGLSGAGDLFLTATSVLSRNYRVGLKL--QNQKLDSILAELNEVAEGVKTA................................................................................................................................................................................................................................................................................................................................................. 257
43 -9.010IDP92023 glycerol-3-phosphate dehydrogenase, putative [Toxoplasma gondii ME49] TGME49_010260 [Toxoplasma gondii ME49]  ali follow..  11  2.............................................................................................................................................................................................................................................................................................................................................................EPRRPSLFQVLQSGPLKVSVVGSGNWGSVIAKIVALNAQEVRMWVYEEMVDGEKLTDIINKTHENVEACRDSDLLIFIMPHQFATKVCEQLAARVVPGHARAITLLKVENGKPTLFSDIFKTKLDIVDCCVLSGANVANDVAREEF---AEATIGYSPEETDAALIWQQLFDTPYFKVNALPDVAGVQVCGAVKNV--AIAAGFCDGLGLGTNAKTAIIRLGVEEMKQFANIMAETFFDSANARCAAEFLRRGGKATWDQIEADLLKGQ...................... 314
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;