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Query: [G] KOG2653 6-phosphogluconate dehydrogenase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPGPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPECASDNLPVDKDIHINWTGHGGNVSSSTYQALast
1 -111.000IDP02226 gene: yqjI; 6-phosphogluconate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA0164 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  48  3.NLQIGVVGVGVMGKSLALNFESKGYSVALYDISKEKVDETIEENRG-KNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKGDILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYIGPNGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVILDTAQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKTAIGVEKAELIEAVRQALYMSKICSYAQGFTQLKAASEEYNWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAVQQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGT--------FHTKW.............. 468
2 -108.000IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  48  3.KANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPE-KNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKAPGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADILSRKDDEGQPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHA-SKVLPKPAAFNFEGDKAELIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGT--------FHYSWYDEK.......... 474
3 -55.800IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  18  1..MKIGWIGLGAMGTPMATRLRDAGLEVSVYNRTESKAAPLKEKGVA-----VYTSPIDLAAKVDLVFTMLSDKAAIDAVLAPKFW---EQMSKKIVVNMSTIAPLESLSLEKIAQKHQATYLEAPVSGSVGAAKAGLLILAAGDEEVISKLKPVLAHLGSQ------TFYLGKVGQGTGAKLSINSLLAQMGVAYSEALLLAKRLGVDA----ESFLQIIGQSGMNSPLFQAKKGMWLQDNYPAAFSLKLMAKDIRLAKNEA-GEAMKLPFLFQAEELYSQAEKSGLGGLDMAAVY................................................................................................................................................................................................ 277
4 -23.400IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  13  18..KKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFS------VYTVAEAAKQADV---VMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNPVNVDVFLVAPKGPGHLVRRTFSEGG--AVPALFAVYQDATGVATEKALSYADGIGA------TRAGVLETTFKEETETEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELK........................................................................................................................................................................................................................................................................... 232
5 -20.400IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  13  19..KKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKNAG-----FEVVSVSEASKIADV---IMILAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTLIAIHQDESKNAKNLALSYASAIGGGRTGIIETTFKAETETDLEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMK........................................................................................................................................................................................................................................................................... 234
6 -18.700IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  10  17..KTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFE------VMSVSEAVRTAQVVQMLLPDEQQAHVY---KAEVEENLREGQMLLFSHGFNPSYVDVAMVAPKSPGHLVRRVFQEGN--GVPALVAVHQDATGTALHVALAYAKGVGCTR------AGVIETTFQEETET-QAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELK........................................................................................................................................................................................................................................................................... 231
7 -14.600IDP04467 putative nucleotide sugar dehydrogenase [Yersinia pestis CO92] YPO2174 [Yersinia pestis CO92]  ali follow..  12  1..MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRIDFSVVSNPEFLKEGAAVIVIGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMREAPSRVVMESLWEAGATIQAEAMDETQRIYGARDDLRLMGTKESALQGADALIICTEWQSFR--------APDFDMIKSRLKHPVIFDGR....................................................................................................................... 421
8 -14.500IDP01406 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase VC0918 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  15  1MFNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTIVRSAVMTGKLKATLTAEPFLVAVPTPFKGDNHEPDLSYIEAAAKTIAPVLAKGNLVVLESTSPVGTTEKLAQWLAEARPDLTDVKIAYCPERVLPGYVVIGGVSKACSEKAVALYKTFVKGE------CIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINVWELIRLA................................................................................................................................................................................................................................................................................ 247
9 -13.500IDP01235 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase BA_5512 [Bacillus anthracis str. Ames]  ali follow..  10  1..MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEEPGLGEVVKEVVANADAFIISVPTPCDLSYVLTATEKVLPFVKKGNVIIVESTIAPRSMDDYVKPLVEEA----DIYLVHCPERVLPGQIIVGGVTPACAEAGARVYGVFVEGE------IIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMANKHPRVNLVGGHCLAVDPYFIVAKAPELANIIK-----------------LSRETNVSMPHYVTEKVKELLAGVENPKVAAFGVTYKGNVDDMRESPAMDVIDLISDFFELHSAEEAVKDAHLILVLTDHDEFTMNYDSLAPYMAKTVVFDTR....................................................................................................................... 397
10 -13.300IDP00425 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase YPO3863 [Yersinia pestis CO92]  ali follow..  12  3.FETISVIGLGYIGLPTAAAFASRKKKVIGVDVNAHAVETINRGAIHIVEPDLDKVVKIAVEGADAFLIAVPTPPDMIFVESAAKSIAPVLKKGDLVILESTSPVGATEQMAQWLAEARPDLADINIAYCPERVLPGQVVIGGMTPKCSARASALYKIFLEGE------CVVTNSRTAEMCKLTENSFRDVNIAFANELSLICDEQGINVWELIRLA................................................................................................................................................................................................................................................................................ 247
11 -13.200IDP00702 gene: cap5O; capsular polysaccharide biosynthesis protein Cap5O SACOL0150 [Staphylococcus aureus subsp. aureus COL]  ali follow..  14  1..MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSSDVFIIAVPTPCDISLVMRALDSILSFLEKGNTIIVESTIAPKTMDDFVKPVIENL----DIYLVHCPERVLPGKIIIGGVTEACIEAGKRVYRTFVQGE------MIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMA................................................................................................................................................................................................................................................................................ 239
12 -12.400IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  11  37.GKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPD----KQHTSVVNAVMPLMKQGAALG----YSHGFNIVEEGMQIRKDITVVMV-KRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGHRAG---CLASSFVAEVKSDLMGEQTILCGMLQAGSIVYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDN---GILMIAMVRAGVEAFEAMTASIDESAYYESLHELPLIAN---TVARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMP---------------KVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEE............................. 479
13 -11.400IDP01730 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [Francisella tularensis subsp. tularensis SCHU S4] FTT0871 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  11  1MQKNILVLGAGAWGTALALQLAYRGHNVRINSWKAEHNEQMLKDNNNHSRLKAIQDWQANIIEFDSILVATPS----SGFKNTILELKECILPQQNIISATKGFCHDSYALLSEIAEDILPTTKFALLTGPSFAKETAVVVASKDINYARYVQELFSNENFRCYTTTDIIGAQVGGAVKNVLAIVNAHAALITRGLAEIKKLGLKLGANSET-LGDLLLTCSDNQSRNRRFGLY---------GQGMTIQQALKEVNNVVEGYFTAKAVYNLA........................................................................................................................................................................................................................ 293
14 -11.000IDP01969 gene: kfiD; putative UDP-glucose 6-dehydrogenase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1441c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  8  1..MKIVIVGIGYVGLANAILFSKNNNEVVLLDIDENKIQSINNHVQNISKLHATSNIKEAYFNADFAVIATPTDYDEQLNFFDTRSIIKNINSKINVIIKSTVPIGYTKTIKQKFNMSNIVFSPEFLREGSADSLYPSRIIIGDKSV---LGKTIGDLFLKNIEKKNVDIFYMDSDEAESVKLFSNTYLAMRVGFFNEVDSYARKHNLNSADIIKGI................................................................................................................................................................................................................................................................................ 234
15 -10.700IDP01494 UDP-glucose 6-dehydrogenase VCA0780 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  11  1..MKIAIAGTGYVGLSNGILLAQ-HNEVVALDIVVSRVEQLNDKQHQPLNFRATCDKRDAYQDAQFVVIATPTDYDPQTNHFDTRTVVLAINPQAIMVIKSTVPVGYTKRIKQRLCCNNLIFSPEFLREGRADNLYPSRIIVGEKSE---RGQAFATLLAQGAKKMDIPILLTHSTEAEAVKLFSNTYLAMRVSFFNELDTYAETHGLDTKQIIEGV................................................................................................................................................................................................................................................................................ 232
16 -10.600IDP05722 gene: tyrA; prephenate dehydrogenase [Bacillus anthracis str. Ames] BA_2954 [Bacillus anthracis str. Ames]  ali follow..  13  13MRKKVVLIGTGLIGGSLALAIKKDHVTITGYDIFQEQVERAKELHVVDE---IAVDLQHACEEAHL---IVFASPVEETKKLLHKLASFHLREDVIVTDVGSTK-GSIMNEAEALFSKEISFIGGPMAGSHKGVESAKAHLFENPNEHVEELKDWLKGTGSH------FLVLNTEEHDYVTGIVSH-FPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKM---SDIVKQNREHLMVLLKEWISEMED....................................................................................................................................................................................................................................... 268
17 -10.100IDP00951 gene: ycdW; putative oxidoreductase STM1135 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  13  137..FSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGV-------ESYVGREELRAFLNQTRVLINLLPNTAQTVGIIN--SELLDQLPDGAYVLNLARGVHVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQV-DRARGY...................................................................................................................................................................................................................................................................................................................... 312
18 -10.000IDP02492 gene: proC; pyrroline-5-carboxylate reductase [Francisella tularensis subsp. tularensis SCHU S4] FTT1559c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  13  1..MKICFIGGGNMAAAMIAGMTSHGYDIIVFDRNEHKCLNLIKK-----NINTSTSLLNTIKLAD----VLILAIKPQNMFELIKNIRDTVTSTQVIVTVAAGIQTSAYEELFNKEISFARTIPSSLGYGATGIFFNKVI----AADKKDLVIDIMQTMGEDEKEIDIVAAIASSGPAYYFQFMEHMVEAAIKQGLDKAAQMALNTNENMSELRKNVTSKKGITYEALNIFE................................................................................................................................................................................................................................................................. 242
19 -10.000IDP04504 2-dehydropantoate 2-reductase [Vibrio cholerae O1 biovar eltor str. N16961] VC2307 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  12  1..MNIVVLGPGAVGSLWALHLHSAGHQVALWSRQAQPTITLQLDEEAPISFRNQN-----LDTLIHADLLLITVKAWQ-VEAALQPLLPHLNRETILL-FATTTHGALKATLNQVSHTGFGQTQVGPFNALGARCDFIADVFNHALAPVTWNPEIQQALWRKLAVNCAINPLTAIHQCANGALVAPEFTPIITAILDEVTAVMQAEAISGEDGVYQVIQA-TAANLSSMHQDVFHRRPTEIDFITGYVVRK.............................................................................................................................................................................................................................................. 268
20 -9.960IDP01976 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD+) [Coxiella burnetii RSA 493] CBU_1518 [Coxiella burnetii RSA 493]  ali follow..  12  4FKHPIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAEGVNNETLKAYCDLKASLEGVTDILIVVPS----FAFHEVITRMKPLIDAKTRIAWGTKGLAKGSRLLHEVVATE-LGQVPMAVISGPSLATETAVSLASNNSQFSKDLIERLHGQRFRVYKNDDMIGVELCGSVKNILAISNARAALITRGLTEMGRLVSVFGGKQET-LGDLVLTCTDNQSRNRRFGLA---------GEGVDKKEAQQAIGQAIEGLYNTDQVHALA........................................................................................................................................................................................................................ 294
21 -9.570IDP02668 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1526 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  13  1.MTKITVVGAGSWGTALAMVLADNGHDVRIWGNRSELMDEINTKHENSSTIVAYSSLEEALVDVNVVLIVVPT----KAYREVLQDMKKYVAGPTTWIHASKGIEPGTSKRISEVIEEEIP--DVVVLSGPSHAEETTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPDIVGVELGGALKNIIALDNAKAALMTRGLTEIARLGRKMGGNPLT-MGDLIVTCTSVHSRNWRAGNM---------GKGHSLEEVLESMGMVVEGVRTTKAAHELA........................................................................................................................................................................................................................ 294
22 -9.310IDP91227 gene: tyrA; T-protein [Escherichia coli CFT073] NT04EC3201 [Escherichia coli CFT073]  ali follow..  13  98LRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQHDW------------------DRAADIVSDAGMVIVSVPIHVTEQVIGK-----LPPLPKDCILVDLASVK---NGPLQAMLAAHDGPVLGLPMFGPDSGSLAKQVVVWGRKPEAYQWFLEQIQVWGARLHRISAVEH-------AFIQALRHFATFAYGLHLAEE.................................................................................................................................................................................................................................................................................................. 270
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.