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Query: [I] KOG2833 Mevalonate pyrophosphate decarboxylase, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MATEKWVFMVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNGKEISLSGSRYQNCLREIRGRAGDVEDMEKGIKIRKKDWEKLNLHIASHNNFPTAAGLASSAAGFACLVFSLAKLMNVDEDPSHLSAIARQGSGSACRSLFGGFVKWTMGSKEDGSDSVAVQLADEKHWDDLVIIIAVETSSTSGMRESVETSLLLQHRAKEVVPKRILQMEEAIKNRDFASFTQLTCTDSNQFHAVCLDTSPPIFYMNDTSHRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIARNRKVAVQLLQGLLYYFPPKSDTDMKSYVVGDNSILKEAGLDGASGVENLQPPPEIKDNIGSQDQKGEVSYFICTRPGKGPIVLHDQTQALLDPETGLPKLast
1 -19.400IDP05324 putative cobalamin biosynthesis kinase [Clostridium difficile 630] CD3431 [Peptoclostridium difficile 630]  ali follow..  13  1.......MKSYGICPASCGEF-VQGIIDDEEYL-----CSYAID---MYSKVYIEEKLV-----------DINLGRYKSRLAIEKVFEKFNLPKK------------YTKNISLNINSKIPVGKGMASSTADIGATIKATLSLIDKDLSSEEISKLAAEIEPTDS--FIDKNSIFNPLNGTVIKYLGNLT--------KVVILEPNKVLDTMKIRLRQDYNK-LKVENKEVIKKSFALLEEGLKKNNLSLVGEACTLSSLANENIEKKEY-------------LNEIIKISKKYGAYGVNIA-HSGTVVGILIDKFMNDKKMIDALCES.................................................................................... 268
2 -16.600IDP02093 gene: thrB; homoserine kinase [Bacillus anthracis str. `Ames Ancestor`] GBAA1970 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  14  1......MIPLSIRVPASTA--------------PGFDSVGIALS---LYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLS-------------------PHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTIDQKVQIATNFEGNVAASILGGTVI------GALDGKNVSVVRIESKELGVISLIPNEELNTDESRSVLPDVFPFHEAVKAS--AISNVLVAALCQKKWKVVGEMMERDH---------------FHEPYRLELVPLLPSIRKKEFGAYGTALSGAGPSIFILTPYEKRQEI-AEQLARVFTSMKVCELEIDHRGITVNKKEH............................................................. 294
3 -15.300IDP90702 gene: thrB; homoserine kinase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0134 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  14  1.........MKILVPATSANL------------PGFDCLGLSLK---LFNETQIQKSGVFSISIGGEGSDNIFLKKNNI--FVNIFYEIYEKLSG------------KKDNFRFIFQNNIPLSRGLGSSSAVIVGAIASAYYMSGFKVEKECILDEALIYENNIAPATLGGFVC----SLVEKNKVYSIKKEIDKDLA-AVVVIPNLAMSTEQSRQALAKNLSFNDAVFNL--SHASFLTACFLEKKYEFLKFASQD---KLH-------------EINRMKNLPELFEVQKLENKALMSTLSGSGSSFFSLAFKDDALAL............................................................................................ 266
4 -15.200IDP01943 putative sugar kinase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1425c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  10  1......MKTIRTQTPLRLGLA---GGTDINLNATISLYIHCTLIKREDGKIIFDSPDTNSYCEYESKEFLGNDGKLDIFKSIYNRIVKDFTKKPL---------------SFSLHTYSDVPSGSGLGGSSTLVVGVIKAFAEWLNLPLGEYEIAKLAYEGAQDQYAATFGGFNFMEFYNNKRVIVN-NWIASELEARTVLYFTNITREAKDIEEHKKGKLGDEKSLEAMHAIKQDAIKMKEALFRADFGTLAQILGKSWRSKKIIS----------EIVSNDELERIYKLAIDNGAYSGKTSGAGAGGFMFFFVDPTKKYNLIKALRKEQGYVQDFSFTKEGVKSWRI................................................................. 339
5 -12.100IDP90649 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1104 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  11  1.........MKAYAKANIFL-KLTGFDSRK----YHLLESRFILLKDVFDELELVDKESDSKKEFEIISNFKCENN--IQKAYLLLSRRYNNELK-----------ELFSKKSLKLTKNIPVCAGLGGGSSDCASFLLLINETLNLKLNLQELINLSIQLGSDIAFFLSGFHSANVSSCGEIIEE--------EDDIPNLKWTFPQISCQTKAVYDEFDRGIF-----FQKNNNQAQIYKKLSTKELLQNFKNKELND---LFTPCATLYPKMKSYLQEDFFL-------------------SGSGSSVFKVDR................................................................................................... 255
6 -11.000IDP90543 gene: ipk; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Vibrio cholerae O1 biovar eltor str. N16961] VC2182 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  11  1MDAAPMIHGTVWPSPAKLNLLYITGRRANGYH-----DLQTLFQFLDHGDELTITANNSGN--TLSPALADVALEDNLIYKAAMALKNAAQS----------------PLGADIQLHKVLPMGGGIGGGSSNAATTLVALNYLWQTGLSDDQLAEIGLA--GADVPVFTRGFAAFAEGVGEELSAVEPEEK--------YLVVRPAVSIATKDIFTHPQLM-------RNTPKRDLASLLTTPYENDCEKI----------------------------VRSLYPEVDKQLSWLLQYAPSRLTGTGSCVFAEFSSRKDAQAVFAQLSDNV................................................................................... 267
7 -11.000IDP90560 gene: ipk; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Yersinia pestis CO92] YPO2014 [Yersinia pestis CO92]  ali follow..  10  1MTTANCPSPAKWPSPAKLNLLYITGQRADGYH-----QLQTLFQFLDYGDQLTIEPRDDNQ--RLLTPIAGVENEQNLIVRAAKMLQKHPGNTP-------------VPRGADISIDKCLPMGGGLGGGSSNAATVLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAF---------AEGIGEKLQPAEPVEKWYLVIHPGVN--------IPTPIIF---------SDPELKRNTPIRPLAALLSTPYAND-----------------CEPIARKRFREVEQALSWLLEYAPSRLTGTGACVFAEFDTESSARQVLSIAPEWL................................................................................... 272
8 -7.270IDP90942 gene: ispE; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Vibrio cholerae 1587] A55_2372 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  12  2..........................................................................................................................GGGIGGGSSNAATTLVALNYLWQTGLSDDQLAEIGLA--GADVPVFTRGFAAFAEGVGEELSAVEPEEK--------YLVVRPAVSIATKDIFTHPQLV-------RNTPKRDLASLLATPYENDCEKI----------------------------VRSLYPEVDKQLSWLLQYAPSRLTGTGSCVFAEFSSRKDAQAVFAQLSDNV................................................................................... 166
9 -4.720IDP04116 gene: sepZ; hypothetical protein Z5122 [Escherichia coli O157:H7 EDL933] Z5122 [Escherichia coli O157:H7 str. EDL933]  ali follow..  16  38...................................................................................................................TNRTVRVIAGLALTTTALAALGTGIAAACSETSSTEYLALGITSGVLGTLTAVGGALAM............................................................................................................................................................................................................................................... 96
10 -4.600IDP01960 CBS domain protein [Coxiella burnetii RSA 493] CBU_0565 [Coxiella burnetii RSA 493]  ali follow..  8  1.............................................................................................................................MNEDPHPHRSWLERLSHALLWEKDREQLIELLHDAKER-------NLLDQDALAMIEGVLRVSEKKVRDVMIPRAQMVVVDHDATPQSTLPIIIES---AHSRFPIISESRDEVIGILLAKDLLQYTVGEKQAKAQIKDLARPA-----IFIPESKRLDVLLNEFRLKRYHMAI--VVDEYGSVSGLITIEDVLEQIVGSIQDETDIVEEEPITKLNPKEFTVKALTPIDVFNNYFGTKINDEDFDT---------IGGYVMQQIGHLPKR................. 246
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.