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Query: [R] KOG3518 Putative guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLGLast
1 -9.170IDP00192 putative virulence determinant YPO0947 [Yersinia pestis CO92]  ali follow..  11  3...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NGNEMAGFYIDKLSLSQRLSIVSETVNKNNKYSKRFVKYIDAQLYSLIRPATLTQEEKIKI---IDAANDYERELIIYISS-------LGISV-QEEGGSRLYIYFSGD--------------------IHAYMDVWRGDLLLGS------TELSRFMIDMAESLKLNIINPADKAMVDLINHLRYEMISYASSFCATYSAERGGTVYLSSPDGLRI-NNYFWNSELPVLRALQKK--LIGDIRILHKPLEF----YKD-TPLDELGLTAKDISMTVEYQFLPVWLQEKLLVRHAPEVELLRYFLRKIHEQLDEITEF-LKEAERIDSIKKKLAVGSE.. 371
2 -7.750IDP92557 membrane protein [Francisella novicida U112] FTN_0757 [Francisella tularensis subsp. novicida U112]  ali follow..  10  403......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GVKDQDKK-YKDLCNELKQKIPPYLDNNNRKPPKCQSLILNLDNQYPNWQQYLQELKKLQSI------------------QNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFK-ELLLNEILKQKASSELEKLESSKKLDEVIANSQLSQILKSQHTNGIFEQGT-YKQRQRARDSRLYIMPEYRYDKKNNTGRFDDDNQLL-CNHKPRQ----KRYQLLNDLAGVKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGSEDK. 755
3 -7.480IDP05752 peptidoglycan binding protein [Listeria monocytogenes EGD-e] lmo0435 [Listeria monocytogenes EGD-e]  ali follow..  13  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MI--RKIFIGILSFTI------------LIQ---TVIVSNFNVVYEHKQEAIKEKKSTNNNIICIKGAVKDKEYKLSL--------PKSFNL-----DEKKTGK-YNKEKNELGEEITL--YLL--ASQTGKYELELKE-------DKVQAKLDL---IIKNVDEEVAKTV--------EKSNRQLLRSSISDKLFLADSSKATLANYTEQITFNYNGKLVIDFNNSNLELVNYPKDTAANRNIKLTSLTGKLTINL........................................................... 234
4 -7.480IDP93854 hypothetical protein [Yersinia enterocolitica subsp. palearctica Y11] YP_006005375 [Yersinia enterocolitica subsp. palearctica Y11]  ali follow..  8 1289............................................................................................................................................SPETSHDFKANSEQLSKIDKPDIDSERKNAEKALEDTSNNKNSNNHRMNTDNNVSLENNKSAIQHDKTKAENDGARLRQEEERHRKNLHHVKNQLDSTDESALAKIGDEYRQQVNQEAAELVNDHQAAIQSLNELSESDTSSSVYGDVGFQVRDPFANGILSDVDKQVAQARNIANEKLEQTNTDSKRYE--------SHMDEGLAKSESALVEGRKNVEKAKVEENTRVSAAKDREAEA----EEQKINAKTAENKAENDAIQIQGDANSAVNAAENKASAANKNAKGVQQKEGDKPAGRKEAGGSGRRVDQMAYVTSAAAVSDESITDSGNTPDSI-------------MLAKADNSITGGTNRNTTSDIINSGKNAINQAVVSEPQDTLPIPGQSTPKYTKYGRLSSKYLNLGMH--KDD----KSLSFKFSQTLKIIRRAWYTNYNEILESLQFNFGTCYALSA-----------YMIAERNYGVYMSWLQD------IAKGSSHKMKISSNVDKTQKSI-----LSGY-MISILKI-QHS-FSNEIAKRRDKMAASETVFKEGNAIDIINNLEKKLKHKNELTKFDRLRGEFKHTDTATPSDIIE---------------TLSSYSEDEKFRGYDGYLARNGVKRAE--GFNSFNPKRSNYIEFIENPDKNTFVVSIIKKGSGYQWS-NYGGVTFNNYQ---DFKSFMDNFTKNRNSYAKSG 1997
5 -7.160IDP04550 sensor histidine kinase [Clostridium perfringens ATCC 13124] CPF_0460 [Clostridium perfringens ATCC 13124]  ali follow..  10  462..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KYIDKWKKDYNKILEKTKEISNG---NLDSKDDEDCGFFNPMRDELNNI--------KGFKAAVD------------------------EEVKSQRMKTELISN-------------VSHDLK------TPLTSIIAYVDLLKG---EEDEEKRKAYLETLERKSQRLKH-------------------------------------------------LIEDLFEVSKATTGNINLNIMDVDISYLELDDKINEAGLDMRL---SLPEEKVILPL---DGQRTY-RVFENLIINVVKYALPNSRVYIDIKEGREN..... 671
6 -7.120CPX_91697_91752 Complex of LYN_HUMAN with TIP_SHV2C [Undefined organism]  ali follow..  13  152.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AFLIRESETLKGSFSLSVRDFIKHYKIRSLDNGGYYISP-RITFPCISDMIKHYQKQADGLCRRLEKA-EIPRESIKLVKRLEVWGYYNNSTKVAVKTLKP--GTMSVQAFLEEANKTLQHDVRLYAVVTRPIYIITEY---LLDFLKSDEGGKVL--LPKLIDFSAQIAEGMAYIERKNYIHR-----------DLRA-----------------ANVLVSESLMC----------------KIADFGLARVIEDNGAKFPIKWTAPEAINFGCFTIKSDV---WSFGI--LLYEIVTY-RTNADVMTALSQGYRMPRVEN 467
7 -6.950IDP06495 gene: A27L; A27L [Monkeypox virus Zaire-96-I-16] NP_536564 [Monkeypox virus Zaire-96-I-16]  ali follow..  10  420..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NDGEFKTDLEEAKRKLTELNEELSDKLKTERIDIKELRDMQQN-----DDGSDSSEIDKKTI-RELRESLDMEREMRSELEKELDT----GSC----QRELELSRMWLKQ--RDDDLRAEI-----------DKRRNVEWEL---SRLRMDIKECDKYK------------EDLDKDKTTISTYVSRISTLESEIAKYQQDRDTLSV----------VHREL---------EEERRHVRDLESRLDECTRNQEDT-ALRSRIRELENKLTDCIESGG---------NLTEISRLQSR--------ISDLERQLSECRG---NATEITI............. 696
8 -6.920IDP90302 sensory transduction histidine kinase, putative [Borrelia burgdorferi B31] BB_0420 [Borrelia burgdorferi B31]  ali follow..  9  741.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FEQKRRYSFVMNEKKIAEAANAAKTIFIANVSHD-IRTPINGIMAATELLKDYVRMINYSS-------DSLLSLIDDILYLSK-----IDV--------NELYVESQE-IDL-----------ESEMEMVLKAFQSQCAKKNIDLFSYSKSIFNNYIKGDIVKIKQVLILIGNAFKFTDDGVIVLNYEEVCRTRTDGNRVLVTVEF-----------------KVIDTG---------KGIEKENFSKIFEI---FKQEDDSSSRVHEGALSISR-ELIRLMGGLGIAVDSKVGEGTTFSFMLPGSELKSKKLSINRFQSVNGDNKVLNVLLSQKSIKI........... 1032
9 -6.870IDP04401 sensor histidine kinase [Vibrio cholerae O1 biovar eltor str. N16961] VC1831 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  10  334.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DTFNQKTIYLEAEKVKAQASTKAKSAFLATLSHE-IRTPMNGVLGTAQILDELTSKQRQHLTSLYESGEHMMSLLNEILDYSK-----IEQ--------GKFELDHSA-FPL-----------KSIIGSIKSIYSSLCVEKGLKFQLNSEITDGRWYYGDKARLRQIIFLLSNAVKFTEAGFVA------IGLSEESCDEENYLIIK------------------------VQDTGIGIAQESLGRIF-FEQALAIVKQ----------ELMNGTVLV-QSEVGQGSCFKVRVKLAITEPVTEDVKPTKAKT--YPGLRVLIVEDNRTNIMILEAFMRNKGFECHSVMDG 634
10 -6.820CPX_91686_91680 Complex of A1L467_HUMAN with INLB_LISMO [Undefined organism]  ali follow..  10 1577..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHISDLRALAGLKNLDVLELFSQECLNKPINHQSNLVVPNTVKNTDGSLVTPEIISDDGDYEKP----VKWHLPEFTNEVSVTIGKAKARFGRLKEVYDVDGTVIKKVEAAPKPPTKQGYVF--HENDFTLYAVFKAETTEKAVNLTRYVKYIRGNAGIYKLPRE-DNSLTLASHRCKAVDREARYRL--KNILDRYDKMEYDKGVTAYARVAKHVNKLSYQGKNMRILREAKTPITTWYQ--FSIGGKVI---------TRALNTF-YKQSM---KPTRLTRYVYK-------VPVADN-RGTLAKY-------KNQKLIVDCQATIEGQLW.................................... 1999
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 2 6 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.