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Query: [M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIDVNTVVEKFKSRQALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAKIAKARASGFEATTDFSRVSECDALILCVPTPLNKYREPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEGGLVVGRDIYLVYSPEREDPGNPNFETRTIPKVIGGHTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEYVLGKLMDGLNEAGRALKGSRVLVLGIAYKKNVDDMRESPSVEIMELIEAKGGMVAYSDPHVPVFPKMREHHFELSSEPLTAENLARFDAVVLATDHDKFDYELIKAEAKLVVDSRGKYRSPAAHIIKALast
1 -80.400sp|O60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase OS=Homo sapiens GN=UGDH PE=1 SV=1  ali follow..  18  2............FEIKKICCIGAGYVGGPTCSVIAHMCPRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESRGKNLFFSTNIDAIKEADLVFISVNTPTKTYGAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIF--DANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGETPEGQRAVQALCAVYEEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPARYWQQVIDMNDYQRRRFASRIIDSL---FNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHLVTISKDPYEACDGAHAVVICTEWDMFKELDYMLKPAFIFDGRRVLDGLHNELQTI 455
2 -21.100sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2  ali follow..  13  27..SFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQD-----------------AGEQVVSSPADVAEKADRIITMLPTS------INAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKM-------GAVFMDAP----SGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDLAKILNMSSGRCWSSDTYNPQGGFGTTLMAKDLGLAQDSATSTKSPILLGSLAHQI....................................................................................................................................... 309
3 -17.800sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapiens GN=GLYR1 PE=1 SV=3  ali follow..  15  261........GSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLF-----------------IQEGARLGRTPAEVVSTCDITFACVSDP------KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFL--EAPVSGNQQLSNDGMLV--------ILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLD-KPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEV....................................................................................................................................... 530
4 -13.200sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  16  2.............AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLAN---------EAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAG---------QAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG------GSGVSGGEEGARYGPS---------LMPGGNKEAWPHIKTIFQGIAAKCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQA....................................................................................................................................................................................... 219
5 -10.300sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   16  1..................GVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATITSVLEKEASKMQQSGHPWSGPKPRLTSSVKELGGVDLVIEAV---------EEMSLKKQVFAELSAVCKPEAFLCTNTSALD----DEIASSTDRPHLVIGTHF---FSPAHVMK-----------EVIPSSSPTTIATVMNLSKKIKKIGVVVGNCFGFVGNRML--------NPYYNQAYFLLEE-GSKPEEVDQVLE--KMGPFRVSDLAGL....................................................................................................................................................................... 227
6 -10.200sp|Q16836|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3  ali follow..  12  28...............KHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVE--------NLKVKNELFKRLDKFAAEHTIFASNTSSLQITS---IANATTRQDRFAGLHF---FNP----------PVMKLVEVIKTTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLL--------VPYLMEAIRLYERGDASKEDIDTAMKLGPMGPFELLDYVGL....................................................................................................................................................................... 267
7 -9.840sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   13  63................HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKK-RDSIFSNLTGQLDYQGFEKADMVIEAV---------EDLSLKHRVLKEVEAVIPDHCIFASNTSALP----SEIAAVSKRPEKVIGMHY---FSP----------DKMQLLEIITTTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCL--------APMMSEVIRILQE-GVDPKKLDSLTTS-PVGAATLVDEVGV....................................................................................................................................................................... 293
8 -8.810sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   16  149................SVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASK-HPWSGPKPRLTSSVKELGGVDLVIEAV---------EEMSLKKQVFAELSAVCKPEAFLCTNTSALD----DEIASSTDRPHLVIGTHF---FSPAHVMK........................................................................................................................................................................................................................................................................... 291
9 -8.470sp|Q8NFT2|STEA2_HUMAN Metalloreductase STEAP2 OS=Homo sapiens GN=STEAP2 PE=1 SV=3  ali follow..  10  27...........DARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEF------------------FPHVVDVTHHEDALTKTNIIFVAIHREHYTS-----------LWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASPDSLIVKGFNVVSAWALQLGPKD----ASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGL-YYGTKYRRFPPWLLQCRKQLGLLSFFFAMVHVANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQS.................................................................................. 396
10 -8.450sp|Q687X5|STEA4_HUMAN Metalloreductase STEAP4 OS=Homo sapiens GN=STEAP4 PE=1 SV=1  ali follow..  13  16...........SEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSG-------------------AEVLSYSEAAKKSGIIIIAIHREHYD------FLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQ--------FVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGV-YRGTKYRRFPDWLMLCRKQLGLVALGFAFLHVLKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQS.................................................................................. 384
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.