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Query: [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIKLLast
1 -85.600sp|Q9UBQ7|GRHPR_HUMAN Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1  ali follow..  27  6.LMKVFVTRRIPAEGRVALARAA-DCEVEQWDSIPAKELERGVAGAHGLLCLLSDHVDKRILDA-AGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKPLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEP--------------PTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL 328
2 -84.200sp|O43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase OS=Homo sapiens GN=PHGDH PE=1 SV=4  ali follow..  25  6.LRKVLISDSLDPCCRKILQDG--GLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVIN--AAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWE-RKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP--------------RDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNA 318
3 -80.000sp|Q13363|CTBP1_HUMAN C-terminal-binding protein 1 OS=Homo sapiens GN=CTBP1 PE=1 SV=2  ali follow..  27  26PRPLVALLDGRDCTVEMPILKDVATVAF-CDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFK--ALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRV-EVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGRALGLQRVTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPF------------SFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKN. 349
4 -79.900sp|P56545|CTBP2_HUMAN C-terminal-binding protein 2 OS=Homo sapiens GN=CTBP2 PE=1 SV=1  ali follow..  25  32PRPLVALLDGRDCTVEMPILKDLATVAF-CDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFK--ALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRV-EVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPF------------SFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNC 356
5 -14.700sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   11  6.........................................MILDDGGDLTHWIYKKYPNMFKKIKG----IVEESVTGVHRLQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRT---------------TDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPIQACMDGFRLVKLNEVIRQVDIVIT----CTGNKNVVTREHLDRMKNSCIVCNMG................................................................................................. 179
6 -13.200sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2  ali follow..  13  225.........................................MILDDGGDLTHWVYKKYPNVFKKIRG----IVEESVTGVHRLQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRT---------------TDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPIQACMDGFRVVKLNEVIRQVDVVIT----CTGNKNVVTREHLDRMKNSCIVCNMGH----NTEIDVTSLRT................................................................................. 411
7 -12.900sp|P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4  ali follow..  16  127.........................................MILDDGGDLTNLIHTKYPQLLPGIRG----ISEETTTGVHNLKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRA---------------TDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPIQAAMEGYEVTTMDEACQEGNIFVT----TTGCIDIILGRHFEQMKDDAIVCNIGHFDVIDVKWLNENAVEKVNIKPQVDRYRLK................................................................... 331
8 -12.200sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   13  180.....................................................................KGIVEESVTGVHRLYLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRT---------------TDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDP-QACMDGFRLVKLNEVIRQVDI.................................................................................................................................. 300
9 -11.300sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   14  1................................................LISFIYPAQNPELLNKLSQRKTTVLA-----MDQVPRVTIAQG------YDALSSMANIAGYKAVVLAANH-----------GRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEFAQQCKEVDILTALIP-GKKAPVLFNKEMIESMKEGSVVVDLAAGGNFETTKPGELYIHKGITHIGYTDLPSRMA--------TQASTLYSNNITKLLKAISPDKDNFVKDDFDFGTMGHVIRGTVVMKDGKVIFPAP.. 289
10 -8.780sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  14  1...............................................................................................................................................MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANLKEMVSKLKKPRRIILLVKAGQAVDDFIE-KLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGE................................................................... 132
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 0   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.