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Query: [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain), from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDKKIVIPGDLLSENQKKAGYGTYVKNDKIYSSLCGIENLKEDKVGVIPLAGAYIPSANDVVIGIVIVVTPSNWIFDIAAPYDGLLHVSEYPRRVESREMPEILNVGDSVILRVKDVDSSMKVELALRDPSLHKLKTGQIIKVESVKVPRVIGHGGSMISMLKKETNCSIFVGQNGRIWIDGKDEDIELLSKALRKIELEAQRSGLTDRIYNFLKNERIRQKESKPVGFFKNETEGVTATKEDHSEEIYRKIDVLLDPKNLast
1 -72.100sp|Q13868|EXOS2_HUMAN Exosome complex exonuclease RRP4 OS=Homo sapiens GN=EXOSC2 PE=1 SV=2  ali follow..  20  23.KKHLVVPGDTITTTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKR------QKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEP------------------VSLADREVISRLRNCIISLVTQRMMLYDTSIYCYEASLPHQ. 267
2 -68.000sp|Q9NQT5|EXOS3_HUMAN Exosome complex exonuclease RRP40 OS=Homo sapiens GN=EXOSC3 PE=1 SV=3  ali follow..  19  23VLGQVVLPGEELSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYL--SFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRAGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAES............................................ 275
3 -43.200sp|Q9Y3B2|EXOS1_HUMAN 3`-5` exoribonuclease CSL4 homolog OS=Homo sapiens GN=EXOSC1 PE=1 SV=1  ali follow..  16  4.PVRYCIPGERLCNEEGSPGSGTYTRHGYIFSSLAGCLMKSSEVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSVRATEKDKVEIYKSFRPGDIVLAKVISLGDQSNYLLTTAENEL-----GVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEF.................................................................................. 192
4 -11.700sp|Q9Y535|RPC8_HUMAN DNA-directed RNA polymerase III subunit RPC8 OS=Homo sapiens GN=POLR3H PE=1 SV=1  ali follow..  12  7MVDTVRIPPWQFERKKVVYNVGLCICLFDITKLEDAYVFPGDGASHVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSE----------------------ELPKKEAPYTLVGSISGLLWWTSN............................................................................. 204
5 -10.700sp|Q8N5C6|SRBD1_HUMAN S1 RNA-binding domain-containing protein 1 OS=Homo sapiens GN=SRBD1 PE=1 SV=2  ali   20  167........................................................QIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTLSKTKKRRSLGLGPGERVEVQVLNIDPRSRITLDLIR................................................................................................................................... 243
6 -10.400sp|Q96N46|TTC14_HUMAN Tetratricopeptide repeat protein 14 OS=Homo sapiens GN=TTC14 PE=1 SV=1  ali   13  124........................................................ERGDIVIGRISSIREFGFFMVLICLGTALCPLRDVPSHSNHGDPLSYYQTGDIIRAGIKDIDRYHELAVSLYSSSLPPHLSGIKLGVISSEELPLYYRRSVELNSNSLESYENVMQSSLGF-----VNPGVVEFLLEKLGIDESNPPSLMRGLQSKNFSEDDFASALRK................................... 300
7 -10.200sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   11  93.....YARLSHLSDSKNVFNPEAFKPGNTHKCRIID-YSQMDELALLSLRTSIIEAEPGAVVKGTVLTIKSYGMLVKVGEQMRGLVPPMHLA-DILMKNPEKKYHIGDEVKCRVLLCDPEAKKLMMTLKKTLIESKLPVITCYADAKPGLQT--HGFIIRVKDYGCIVKFYNNVQGLVPKHELSTEYIPDPERVFYTGQVVKVVVLN..................................................... 298
8 -10.200sp|Q14562|DHX8_HUMAN ATP-dependent RNA helicase DHX8 OS=Homo sapiens GN=DHX8 PE=1 SV=1  ali   21  112.......................................................PTIGDIYNGKVTSIMQFGCFVQLEGLREGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTG-TKTSLSMKD................................................................................................................................... 187
9 -10.100sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   14  1........................................................EPGAVVKGTVLTIKSYGMLVKVGEQMRGLVPPMHLA-DILMKNPEKKYHIGDEVKCRVLLCDPEAKVITCYADAKPGLQTHGFIIRVKDYGC---LVPKHELSTEYIPDPERVFYTGQVVKVVVLNCEPSKERMLLSFKLSSDPEPKKEPAGHSQKKGKAINIGQLVDVKVLEKTK............................ 198
10 -9.840sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   14  81........................................................CEGMRILGCVKEVNELELVISLPNGLQGFVQVTEICDAKDLLHLPELFSPGMLVRCVVSSLGITKSVKLSLNPKNVNREDHGYLVDIGVDGTRAFLPLLKAQEYIRQKNKGAKLKVGQYLNCIVEKVKGNGGVV--SLSVGHSEVSTAIATEQQSWNLNNLLPGLVVKAQVQKVTP............................ 293
11 -9.600sp|P62487|RPB7_HUMAN DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens GN=POLR2G PE=1 SV=1  ali follow..  15  7LEHEILLHPRYFGPNTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEKTMDEDIVIQQDDEIRLKIVGTKNDIFAIGSLMDDYLGLVS............................................................................................................................ 172
12 -9.330sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   19  134........................................................SIGDMVTGTVKSIKPTHVVVTLEDGIIGCIHASHILDDPEGTSPTTKLKVGKTVTARVIGGRDMKT-ELEDGHTALNTHSVSPMEKIKQYQAGQTVTCFLKKYNVVKKWLEVEIAPDIRGRIPLLLTSLSFKVLKHPDKKFR.............................................................. 298
13 -9.120sp|Q9NP64|NO40_HUMAN Nucleolar protein of 40 kDa OS=Homo sapiens GN=ZCCHC17 PE=1 SV=1  ali follow..  14  12......................................................LPALYTIFQGEVAMVTDYGAFIKIGCRKQGLVHRTHMSSCRVD-KPSEIVDVGDKVWVKLIGREMKNDRIKVSLSMKVVNQGTGKDLDPNNVIIEQEERRRRSFQDYTGQKITLEAVLNTT-CFMQPGGTKYSLIPDEEEEKEEAKSAEFEKPDPTRNPSRKRKKEKKKKKHRDRKSS............................ 201
14 -9.060sp|Q8TCS8|PNPT1_HUMAN Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=PNPT1 PE=1 SV=2  ali   13  77........................................................EFGAVYTATITEIRDTGVMVKLYNMTAVLLHNTQLDQRKIKHPTALGLEVGQEIQVKYFGRDPAD........................................................................................................................................... 142
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.