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Query: [M] COG1209 dTDP-glucose pyrophosphorylase, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKMRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGGDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDKNGTAISLEEKPLEPKSNYAVTGLYFYDNDVVQMAKNLKPSARGELEITDINRIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMTKDSNLast
1 -71.200sp|Q9Y5P6|GMPPB_HUMAN Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens GN=GMPPB PE=1 SV=2  ali follow..  17  1...MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSEADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEDTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQ------LQPTSIEKEVFPIMAKEGQLYAMELQGF-WMDIGQPKDFLTGMCLFLQSLRQK--QPERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDG 283
2 -66.700sp|Q96IJ6|GMPPA_HUMAN Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens GN=GMPPA PE=1 SV=1  ali follow..  18  1..MLKAVILIGGKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQPGMQEILLIGFY-QPDEPLTQFAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQIGSPEAFFVLNADVCSDFPLSAMLEAHRRQRHPFLLLGTTANRTQSGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRDVFQRNQQDGQLEDVFSALAGQGQ-IYVHLTDGI-WSQIKSAGSALYASRLYLSRYQDTHPLAKHTPGGPWIRGNVYIHPTAKVAPSAVLGPNVSIGKGVTVGEG 316
3 -44.800sp|Q9NR50|EI2BG_HUMAN Translation initiation factor eIF-2B subunit gamma OS=Homo sapiens GN=EIF2B3 PE=1 SV=1  ali follow..  13  3...FQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAE--FKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTD--VLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSEQRDFIGVDSTGKRLLFMANEARFHTGLVDAHLYCLKKYIVDFLME---NGSITSIRSELIPYLVRKQFSSASSQQGQENTLNLATLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSS. 378
4 -44.400sp|Q13144|EI2BE_HUMAN Translation initiation factor eIF-2B subunit epsilon OS=Homo sapiens GN=EIF2B5 PE=1 SV=3  ali   10  41.PPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWK-AAQIKEHLLKSSLNVVRIITSELYRSLGDVLRDVDAKALVRSD--FLLVYGDVISNINITRALEEHRLRRKLVMTMIFKESSPDNVVVAVDSTTNRVLHFQKTQGEVRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTAKEYGARV.................................................................. 300
5 -21.200sp|Q13144|EI2BE_HUMAN Translation initiation factor eIF-2B subunit epsilon OS=Homo sapiens GN=EIF2B5 PE=1 SV=3  ali   5  1............................................................................................................VYGDVISNINITRALEEHRLRRSVMTMIFKESSPSHPVVVAVDSTTNRVLHFQKTQGEVRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYPLTPEVSLGHGSILEENVLLGSGTVIGSNCFITNSVIGPGCHIGDNV 239
6 -18.300sp|A4D126|ISPD_HUMAN 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein OS=Homo sapiens GN=ISPD PE=3 SV=2  ali follow..  16  47...VAAVLPAGGCGERM----VPTPKQFCPILERPLISYTLQALERVCIKDIVVAVTGENMEVMKSIIQKYQHKRISLVEAGVTRHRSIFNGLKALAEDQINKPEVVIIHDAVVEEGVLLKVVTAAKEHGAAGAIR------PLVSTVVSPSADGCLDYSLERARHRASEMPQA----FLFDVIYEAYQ-QCSDYDLEFGTECLQLALKYCCTKAKLVEGSPDLWKVTYKRDLYAAESIIKERISQE.............................................. 284
7 -15.900sp|Q8N0W3|FUK_HUMAN L-fucose kinase OS=Homo sapiens GN=FUK PE=2 SV=2  ali   9  1..............................................................................................................TDMLLSVPANPGISWDSFRGARVIALPGSPAYAQNHGVYLTDPQGLVLDIYYQGTEAERVPLVSGVVFFSVETAERLLATHVSPPLDACTFDILHCMAENVTRFLVGRPPELGQGDADVAGYLQSARAQLWRELRDQPLTMAYVSSGSYVEEQQLLAAGSSVVSCLLEGPVQLGPGSVLQHC. 237
8 -13.100sp|Q16851|UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens GN=UGP2 PE=1 SV=5  ali follow..  10  105LNKLVVVKLNGGLGTSM----CKGPKSLIGVNENTFLDLTVQQIEHLNKTPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRPPGHGDIYASFYN--GKEYIFVSNIDNLGATVDLNHLMNPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLVEIAQVPKAHVDEIFNTNNLWISLAAVKRLAKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIGDRIDIPPGAVLENK 497
9 -12.700sp|Q8NFW8|NEUA_HUMAN N-acylneuraminate cytidylyltransferase OS=Homo sapiens GN=CMAS PE=1 SV=2  ali follow..  12  47.....ALILARG-GSKGIP------KNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDH-----DEIENVAKQFGAQVHRRSSEVSKDSSDAIIEFLNYHNEVDIVGNITSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQF-RWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFY-------------FAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGD.................. 296
10 -11.900sp|Q16222|UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens GN=UAP1 PE=1 SV=3  ali follow..  17  100QNKVAVLLLAGGQGTRL----VAYPKGMYDVSRKTLFQIQAERILKLQ--PWYIMTSGRTMESTKEFFTKHKYFGLNVIFFQQGMPDGNGGLYRALAA--GIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLF.................................................................................................................. 323
11 -11.700sp|Q3KQV9|UAP1L_HUMAN UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens GN=UAP1L1 PE=2 SV=2  ali follow..  17  103LNKVAVLLLAGGQGTRL----VTYPKGMYRVSRKTLYQLQAERIRRVE--PWYVMTSEFTLGPTAEFFREHNFFHLNVVMFEQRLPDGNGGLYCALED--GVEFVHVYCVDNILVRLADPVFIGFCVLQGADCGAKVVEKAYPEEPVVCQVDGVPQVVEYSEISPETAQLRASDGSLLYN................................................................................................................. 327
12 -9.950sp|Q8N0W3|FUK_HUMAN L-fucose kinase OS=Homo sapiens GN=FUK PE=2 SV=2  ali   10  10....TVIILTCQYKDSVQELEVRQKREQIPAVEDPALLVAAEHLSARAGFTVVTSDVLHSAWILILHMGRDFPFGRAFTCLPVENPEAPVEALVCNLDCLGSPPGVWVCSTDMLLSVPANPGISWDSFRGARVIALPGSPAYAQNHGVYLTDPQGLVLDIYYQGTEAEIQPLVSGVVFFSVETAERL.......................................................................................................... 236
13 -9.160sp|O14772|FPGT_HUMAN Fucose-1-phosphate guanylyltransferase OS=Homo sapiens GN=FPGT PE=1 SV=2  ali follow..  9  104WNSFTILLIHSGGYSQRLPNASALGKIFTALPLGNPIYQMLELKLAM------------------------------YIDFPLNMNPG-----------------ILVTCADDIELYSIGEFEFIRFDKPGFTALAHSSLTIGTTHGVFVLDPFDDLKHFLHKPSLDSDYVYTDSLFYMDHKSAKMLLAFYEKIGTLSCEIDAYGDFLQKGTSLNVVVLNNSKFYHIGTTEEYLF--YFTSDNSLKSELGLQSITFSIFPDIPECSGKTSCIIQSILDSRCSVAPGSVVEYS. 422
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Damiano JS, Stehlik C, Pio F, Godzik A., Reed JC. CLAN, a novel human CED-4-like gene. Genomics. 2001 Jul;75(1-3):77-83.