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Query: [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst METIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLKTVSGHAAVAKAADIIITMVPDTPQVADVLFGDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGERMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSALVRALERMANFEVGGAVAEVKGKAALast
1 -89.100sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2  ali follow..  31  39KTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF.............. 336
2 -75.000sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapiens GN=GLYR1 PE=1 SV=3  ali follow..  26  267DKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH.................. 553
3 -56.700sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  17  4.ADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFI---EKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYG-PSLMPGGNKEAWPHIKTIFQGIAAKCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGP............... 307
4 -25.100sp|Q8NFT2|STEA2_HUMAN Metalloreductase STEAP2 OS=Homo sapiens GN=STEAP2 PE=1 SV=3  ali follow..  15  30KVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVT-HHEDALTKTNIIFVAIHREHYTSLWDLRHL-------VGKILIDVSSNAEYLASLFPDSLIVKGFNVVSAWALQLG-PKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLAT................................................................................................................ 224
5 -22.700sp|Q687X5|STEA4_HUMAN Metalloreductase STEAP4 OS=Homo sapiens GN=STEAP4 PE=1 SV=1  ali follow..  13  19QETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAE--VLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGKAFNTISAWALQSG-ALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCV................................................................................................................ 212
6 -18.000sp|Q658P3|STEA3_HUMAN Metalloreductase STEAP3 OS=Homo sapiens GN=STEAP3 PE=1 SV=2  ali follow..  14  28APKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVT-FQEEAVSSPEVIFVAVFREHYSSLCSLSDQ-------AGKILVDVSSNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQV-PICGDQPEAKRAVSEMALAMGFMPVDMGSLASAWEVEAMPLRLLPAWKVPTLLALGLF................................................................................................................. 223
7 -17.400sp|O60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase OS=Homo sapiens GN=UGDH PE=1 SV=1  ali follow..  13  4IKKICCIGAGYVGGPTCSVIAHMCPEIRVVDVNESRINAWRGKNLFFSTNIDDAIKEADLVFISVNTPADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIVLIGGETPEGQRAVQALCAVYEHWILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKAS---------VGFGGSCFQKDVLNLVYLCEALNLPWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSS 350
8 -14.000sp|Q53H96|P5CR3_HUMAN Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens GN=PYCRL PE=1 SV=2  ali follow..  18  9.RRVGFVGAGRMAGAIAQGLIRAGKHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCLLVIFAT-KPHVLPAVL---AEVAPVVTTEHILV--SVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETNLLQHLLEACGRCEIHTGLSGSGVA-------FVCAFSEALAEG---AVKMGMPSSLAHRIAAQTLLGTAKM......................................................................................... 219
9 -13.700sp|Q6NXP6|CN148_HUMAN Pyrroline-5-carboxylate reductase-like protein C14orf148 OS=Homo sapiens GN=C14orf148 PE=2 SV=2  ali follow..  14  78..KVGIIGGGHLGKQLAGTLLQLGPSLRISTRRPETLGELQKLGIKCFYHNADLVSWADVIFLCC--PSQLPNIC---VEIYTSLEKASIVY--SFVAAIPLPRLKLLLNHTNI-QYQYDEDSVSVWGANKGVIAAL--DPTILQATCPYLEGVFYAALNICNMAHSQVLQLLSELFLSVHFEDCGK----------DTASCPKLQLTDFVSKAYGKNLSQ---ERPFPWFDLTAVQLKETPFSQHLSSSPVLQDHLTHLYCASFGISLTK.................................. 347
10 -11.900sp|Q16836|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3  ali follow..  17  27VKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKG-IATSTDAASVVHSTDLVVEAIVENLKVKNELFKR---LDKFAAEHTIFASNTSSLQITSIANATTRQDGLHFFN-PVP---------KLVEVIKTSQKTFESLVDFSKALGKHPVSCKDTPG-----IVNRLLVPY----LMEAIRLYERGDASKEDIDTAMKLGAG.............................................................................................. 253
11 -11.500sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   13  30RRKVLVLGSGYISEPVLEYLSRDGIEITVGSDMKNQIEQLGKK-CKQEEKLGFLVAKQDLVISLLPY-------VLHPLVAKACITNKVNMVTASYITPA-LKELEKSVEDAGITII-------ELGLDPGLDHMLAMETIDKAKEVGATIESY....................................................................................................................................................... 179
12 -9.990sp|P56545|CTBP2_HUMAN C-terminal-binding protein 2 OS=Homo sapiens GN=CTBP2 PE=1 SV=1  ali follow..  15  181.ETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQD-GIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLI--NDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIR-LDVPFSFAQGPLKDAPNLICT--AWYSEQASLEMREAAATEIRRA----TGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPP................................................................................................ 389
13 -9.630sp|Q9UBQ7|GRHPR_HUMAN Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1  ali follow..  15  154.STVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFV-STPELAAQSDFIVVACSLTPATEGLC--NKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIA-LDVPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLL.................................................................................................................................................. 314
14 -9.550sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   20  61VKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALNDKVKKKALTSFERDSIFEKADMVIEAVFEDLSLKHRVLKE--VEAVIPDHCIFASNTSALPEIAAVSKRPEKVIGMHYFS-PVD---------QLLEIITTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMM--------SEVIRILQE-GVDPKKLDSLTTS................................................................................................. 277
15 -9.530sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   14  180RRKVLVLGSGYISEPVLEYLSRDGIEITVGSDMKNQIEQLGKK-CKQEEKLGFLVAKQDLVISLLPYVLHPLVA--------ACITNKVNMVTASYITPAL-KELEKSVEDAGITIIG........................................................................................................................................................................................... 299
16 -9.380sp|Q9Y2S2|CRYL1_HUMAN(removed signalp:1-22) Lambda-crystallin homolog OS=Homo sapiens GN=CRYL1 PE=1 SV=3  ali follow..  13  3...................FASGGFQVKLYDIEQQQIRNALEN-ISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQ---LDSIIDDRVILSSSTSCSKLFAGLVHVKQCIVAHPVNPP-----------PLVELVPHAPTTVDRTHALMKKIGQCPMRVQKEVAG----VLNRLQYAI----ISEAWRLVEEGIVSPSDLDLVMSEGLG.............................................................................................. 207
17 -9.370sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   16  147VSSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLAT-WSGPKPRLTSSVKELGGVDLVIEAVFEEMSLKKQVFAE--LSAVCKPEAFLCTNTSALDEIASSTDRPHLVIGTHFFS-PAH....................................................................................................................................................................................... 288
18 -9.360sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   16  1....GVVGLGTMGRGIVISFARARIPVIAVDSDKNQLAT-WSGPKPRLTSSVKELGGVDLVIEAVFEEMSLKKQVFAE---LSAVCKPEAFLCTNTSADEIASSTDRPHLVIGTHFFS-PAH---------KLLEVIPSSPTTIATVMNLSKKIKKIGVVVGNCFG-----VGNRMLNPY----YNQAYFLLEE-GSKPEEVDQVLEE................................................................................................. 211
19 -9.320sp|A6ND91|ASPD_HUMAN Putative L-aspartate dehydrogenase OS=Homo sapiens GN=ASPDH PE=2 SV=2  ali follow..  13  8..RVGVVGYGRLGQSLVSRLLAQGPEVFVWNRDPGRMAGSVPPSLQLQNLAALGERRPDLVVEVAHPKESGAQILRHANLLVGSPS--------ALSDQTTERQLLEASQHWDHAVF---VARGALWGAEDIRRLDAAGGLRSLR................................................................................................................................................................ 147
20 -9.100sp|Q13363|CTBP1_HUMAN C-terminal-binding protein 1 OS=Homo sapiens GN=CTBP1 PE=1 SV=2  ali follow..  16  175.ETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSD-GVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLI--NDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIR-LDTPHAAWYSEQASIEMREEAAREATHWASMDPAVELNGAAYRYPPGVVGVAPTGIPAAVEGIVHGLPPVAHPPHAPSPGQTVKP........................................................................................................ 429
21 -9.070sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   12  93.KQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKL-NEVIRQVDIVITCTGNKNVVTR------EHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERV--RSQVDHVIWPDGKRIVLLAEGRLLNL................................................................................................................................................................. 226
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.