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Query: [E] COG2902 NAD-specific glutamate dehydrogenase, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGYRNNPKREKQIEKARQQAIAENVQFLDPGILYGRASADDIEYYSAEMLAASAAHSFEALSHWTGDAPHISITTVEGVSPRDIPVTVLTIIGRNMPFLYDSVMGEVTSSYRGLYLAVHPILVRDDEAQGYRLAEPEDDPAENISLIQLHIAPLTPQAASALEERLRFVLTQVQSAYRDWRPMLTKLDEALDELSKRGSSRRKTERTEAVEFLNWLRNDNFTFLGMRDYTYSGKGKNAKIERGDGVGLGSLSDPDVRVLRLGKNAVTTTPEILAFLDGPDFLIVTKANVKSIVHRRAYMDYIGIKRFDEDGNVIGELRIVGLFTATAYTRSVKQIPLLRAKVADVERHFGFDPNSHSGRILQNTLEAYPRDDLFQIETDLLIRFIEQIMELSDRPRVRVLARIDRFDRFVSAIIFVPREEYNSYVREKIGDYLSRVYDGHISAYYPAFPEGAVARVHFIVGRTEGKTPRIAQDKLEDAVSDIAARWIDHFVALSEPGAPVLDVDQAYQEAFTPEEAIGDMPDILAAANGEPVRIEFYQQEGQSDDTLSLKIFHRDGHLPLSRRVPLLENLGFNVISERTFDIGVVSEGEKRDIVLHDMELSVAAGTTLDLPHYGPKLEEAFLAAFSGKVDNDNFNRLILACGLNVREVSVLRAYARYLRQTGIVYSQEHISETLYKYPDISRNIFALFKAGFDPSIEEKKRVKKLAEIHKAIEAALSGVPNLDEDRTLRRYVNAIDATLRTNYFQKNADGTPRDLLAFKFDPKHLDGLPDPRPFREIFVYGTEVEGVHLRFGKVARGGLRWSDRGQDYRTEVLGLVKAQQVKNAVIVPVGAKGGFFPKNLPAGGSRDEVFNAGREAYKTYIRTLLSITDNIVDDAIVPPADTLRLDGDDPYFVVAADKGTATFSDTANGLAHEAGFWLDDAFASGGSAGYDHKKMGITARGAWETVKRHFREMDTDIQTTPFTVAGVGDMSGDVFGNGMLLSEKIRLIAAFDHRDIFIDPDPDTDKSFAERKRLFELPRSSWQDYDRSTLSAGAMIISRSEKSVTLTPEAVAAIGLDKSVATPFEIMTAILKAPTDLLWFGGIGTYIKAAVETNAEVGDRANDPIRVNATELRAKVIGEGANLGITQKGRIAYALAGGRCNSDAIDNSAGVNSSDVEVNIKIALASAVNSGRLTMPKRNQLLASMTPDVAQLVLRNNYQQSLAISLTERLGLANREELGRLMGALEATGQLNRKVETLPNNAEFSERYASGKPLTRPEIGVLLSYAKLTLFDALVASPLPDEPYLQHLLLDYFPAKMQKNYANDIKAHRLHREIVATALANAVVNRGGPGFVQKLADASGLLAADVVKAAVIVEDGFGLKRLWTEVDALDGKVGGQVQNGLYATITRIFSDASRLYLQTGSAGAAAGDMATEIERLKTAIKTLSPAATKYRRELGVTEIDGVPSGLLEELDTLSLLVYVPEIMRIAESAGTTLARAAESYATVSSTFRVARLLDASQRITPADHYESLALLRSQDQISSSRRRIVISALTEYAKEKDPVQAWYAADRVRVNRIVSELGALSESGDTNLARLTVAAGLLGDIVQARLast
1 -21.900sp|P00367|DHE3_HUMAN Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens GN=GLUD1 PE=1 SV=2  ali follow..  14  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSF--EVIEGYRAQHSQHCKGGIRYSTDVS--VDEVKALASLMTYKCAVVPFGGAKAGVKINP------KNYTDNELEKITRRFTMELAK--------GFIGPGIDV-----------APDMSTGEIADTYASTIGHYACVTGKPISQGGIHG----RISATGRGVFHGIENFINEASYGFGDKTFVVQGFGNVGLHSM--RYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKL-----------------------------------QHGSILGFPKAKPYEGSILEA------------DCDILIPAASE---------KQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKN--LNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTI-------PIVPTAEFQDRISGASEKDIVHSGLAYTSARQIMRTAMKYNLGLDLRTAAYVNAIEKV............................................................................................................................................................................................................................................................................................................................. 546
2 -21.500sp|P49448|DHE4_HUMAN Glutamate dehydrogenase 2, mitochondrial OS=Homo sapiens GN=GLUD2 PE=1 SV=2  ali follow..  16  59...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DREDDPNFFKMVEGFFDRGASIDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSF--EVIEGYRAQHSQHCKGGIRYSTDVS--VDEVKALASLMTYKCAVVPFGGAKAGVKINP------KNYTENELEKITRRFTMEL-------------AKKGFIGPGVD----VPAPDMNTGEMSWIADTYASTIGH--GKPISQGGIHG----RISATGRGVFHGIENFINEASYGFRDKTFVVQGFGNVGLHSM--RYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKL----QHGSILGFPKAKPYEG-----------------------------------SILEVDCDIL--------IPAATE---------KQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKN--LNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTI-------PIVPTAEFQDSISGASEKDIVHSALAYTSARQIMHTAMKYNLGLDLRTAAYVNAIEKV............................................................................................................................................................................................................................................................................................................................. 546
3 -7.010sp|Q3LI64|KRA61_HUMAN Keratin-associated protein 6-1 OS=Homo sapiens GN=KRTAP6-1 PE=2 SV=1  ali follow..  19  3..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GSYYGNYYGTGFCGYGGLGYGYGGLGC---GYGSCCGCGFRRLGCGYGYGSRSLCGYGYGCGSGSG................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 68
4 -6.340sp|Q13627|DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens GN=DYRK1A PE=1 SV=2  ali   15  10...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAA----TLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEG-HLTMRQGAREESPMTGVCVQQSPVASS..................................................................................................................................................................................................................................................................................................................................................................................................................................................... 163
5 -5.350sp|Q5FYB0|ARSJ_HUMAN Arylsulfatase J OS=Homo sapiens GN=ARSJ PE=2 SV=1  ali follow..  11  75........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QPHLIFILADDQGFRDVGYHGSEIKTPTL--DKLAAEGVKLE---NYYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVG------------------------HLGFYRKECMPT----------RRGFDTFFGSLLGSGDYYTHYKCDSPGMC------------GYDLYENDNAA----DYDNGIYSTQMYTQRVQQILASHNPTKPIF-PLQAPGRYFEHYRSIININRRRYAAM-LSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRALKNKGTVCKEHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIAIQSAIRVQHW----KLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRR..................................................................................................................................................................................................................................................................................................................................................................... 522
6 -5.350sp|O43280|TREA_HUMAN(removed signalp:1-23) Trehalase OS=Homo sapiens GN=TREH PE=1 SV=2  ali follow..  10  14..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELLNQVQMAKLYQD--DKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPREQLQAFVHEH-----------------QAKGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGK------------KMKPEVLSHPERFSLIYSEHPF---IVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFL--DLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLL---RPESYSKDVELADTLPEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLS--------GIRTSKLVPV-------DL--NAFLCQAEELMSNFYSRLG-----NDSQATKYRILRSLWDEQTGAWFDYDLEK--------KKKNREFYPSNLTPLWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRG-------LAKAPLRRAQEVAF-QLAQNWIRTNFDVYSQK-SAMYEKYDV........................................................................................................................................................................................................................................................................................................................................................................................................................................... 495
7 -5.220sp|Q6W349|CD011_HUMAN Putative uncharacterized protein C4orf11 OS=Homo sapiens GN=C4orf11 PE=2 SV=1  ali follow..  20  3..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TSETSWWPGACLCSSCAWTSDSRFFNLWTLGLAPAASQGFS--GLKPQTDDCT---VSFPGFEAFGLGL.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 66
8 -5.120sp|P23368|MAOM_HUMAN NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens GN=ME2 PE=1 SV=1  ali follow..  12  35...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NKGMAFTLQELQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGL----GDLGVYGMGIPVGKLCLYTACAGIRPDRCL--PVCIDVGTDNIALLKDPFYMGLYQKRDRT--QQYDDLIDEFMKAITD-----------------------RYGRNTLIQFEDFGNHNAFRFLRKYREKYCT-----FNDDIQG-TAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANNGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVI-------------RAMASINERPV-----------IFALSNPTAQAECTAEEAYTLTEGRC---LFASGSPFGPVKLT------DGRVFTPGQGNNVAVILCNTRHISDSVFLEAAKALTSQLTDEELA-IQEVSINIAIKVTEYLYANKMA.............................................................................................................................................................................................................................................................................................................................................................................................. 540
9 -4.930sp|Q9Y6Z4|CF054_HUMAN Uncharacterized protein C6orf54 OS=Homo sapiens GN=C6orf54 PE=2 SV=2  ali follow..  13  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GDIFKNNGVLQGRLRAVACAPH------------------------PRLRCLHHDQGLTELAWGTWPRHQPQMPSARECCSIVCMAAKEVSAPKAPGSPWMVPGDVAMSGHRVGALDERGHPNPQTGHCRGGSVSVTWSSVSCRGRLAAVRVMIARDPSTCHLAKGCSPAWGFLPQARG--CSSHEA........................................................................................................................................................................................................................................................................................................................................................................................................................................... 181
10 -4.870sp|P30622|CLIP1_HUMAN CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2  ali   15  37..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ISSEKASSTPSSETQEEFVDDFRVGEVWVNGNKPGF--QFLGETAPGQW---------AGIVLDEP------IGKNDGSVAG--------VRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASES--------------ISNLSEAGSIKKGERELKIGD-----RVLVGGTKAGVVR-GETDFAKGGVELDEPLGKNDGAVAGTRY............................................................................................................................................................................................................................................................................................................................................................................................................................................. 262
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.