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Query: [P] COG3067 Na+/H+ antiporter, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEISWGRAMWRNFLGQSPDWYKLALLVFLIVNPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMTSAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLVCGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKIKLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLSSISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTLIGLLCVEFTLAPATEWMTQAGWLATLSLast
1 -59.200sp|Q04671|P_HUMAN P protein OS=Homo sapiens GN=OCA2 PE=1 SV=2  ali   18  1.........................................................................................................................................................................................PVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVHLDLGWIAILGAIWLLILA--DIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIEQRLIAAIVLVVWVSALASSLIDNIPFTATMIP.................................................................................................... 300
2 -50.300sp|Q04671|P_HUMAN P protein OS=Homo sapiens GN=OCA2 PE=1 SV=2  ali   15  12.........................................................................................................................................................................................................................................................................................QKKHRISDGILLAKCLTVLGFVIFMFFLNSFV-IHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVG-LPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVV.............. 235
3 -48.600sp|Q04671|P_HUMAN P protein OS=Homo sapiens GN=OCA2 PE=1 SV=2  ali   12  30......................................................................................................................................................................................................................................................................................................QVTIATAILAGVYALIIFEIVHRTLAAMLGSLAAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDP---RQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLY................. 231
4 -36.800sp|Q86YT5|S13A5_HUMAN(removed signalp:1-38) Solute carrier family 13 member 5 OS=Homo sapiens GN=SLC13A5 PE=1 SV=1  ali follow..  10  1...........................................AYVIILMAIY---CTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLL-----------------------------WVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEAT-KAMTLCICYAASIGGTATLTGTGPNVVLLGQMNVNFASWFAFAFPNMLVMLLFAWLWLQFVYSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSETKYVSDATVAIFVATLLFIVPSQKPLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPL---YIMLPCTLSASFA--MLPVATPPNAIVFTYGH-----LKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTH 527
5 -35.500sp|Q13183|S13A2_HUMAN(removed signalp:1-33) Solute carrier family 13 member 2 OS=Homo sapiens GN=SLC13A2 PE=2 SV=1  ali follow..  12  5..........................................CAYAIILMALF---CTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLL-----------------------------IVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSS-QCMSLCVCYSASIGGIATLTGTAPNLVLQGQINVNFASWFSFAFPTMVILLLLAWLWLQILFNFGIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTGESMVSDGTVAIFIGIIMFIIPSKFPLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPL---YVMLPCTLATSLA--MLPVATPPNAIVFSFGD-----LKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNT 543
6 -35.500sp|Q8WWT9|S13A3_HUMAN(removed signalp:1-33) Solute carrier family 13 member 3 OS=Homo sapiens GN=SLC13A3 PE=1 SV=1  ali follow..  10  8..........................................CLFVILLMAVY---CTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILM-----------------------------LVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQ-KGFLISIPYSASIGGTATLTGTAPNLILPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTNPGFLSDAVTGVAIVTILFFFPSQRPS--KKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPL----LMIPGTVGCSFA--MLPVSTPPNSIAFASGH-----LLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYS 551
7 -34.000sp|Q9BZW2|S13A1_HUMAN(removed signalp:1-32) Solute carrier family 13 member 1 OS=Homo sapiens GN=SLC13A1 PE=1 SV=1  ali follow..  12  5..........................................CAYTLFVVATF---LTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVM-----------------------------MVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINA-KLTCLCIAYSSTIGGLTTITGTSTNLIFPDCRCLNFGSWFTFSFPAALIILLLSWIWLQWLFMFKCGKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSYPGFATDSTVALLIGLLFFLIPAKTLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPL----ILIPSTLCTSFA--LLPVANPPNAIVFSYGH-----LKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWAPAMS 558
8 -25.700sp|Q04671|P_HUMAN P protein OS=Homo sapiens GN=OCA2 PE=1 SV=2  ali   14  180......................................................................................................................................................................................................................................................................................................QVTIATAILAGVYALIIFEIVHRTLAAMLGSLAALAALAVDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFT..................................................................................................... 300
9 -22.600sp|Q9UKG4|S13A4_HUMAN(removed signalp:1-25) Solute carrier family 13 member 4 OS=Homo sapiens GN=SLC13A4 PE=2 SV=2  ali   11  1.......................................................................................................................................................................................................................................................................................................................................................................LASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPL---YTLIPVTMCISFA--MLPVGNPPNAIVFSYG-----HCQIKDMVKAGLGVNVIGLVIVMVAI..................... 125
10 -21.500sp|Q9UKG4|S13A4_HUMAN(removed signalp:1-25) Solute carrier family 13 member 4 OS=Homo sapiens GN=SLC13A4 PE=2 SV=2  ali   16  13.............................................AYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLL-----------------------------LCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAEKCLSLSISYSATIGGLTTIIGTSTSLIFPAAEVVNFGTWFLFSFPISLIMLV....................................................................................................................................................................................................................................................................... 300
11 -18.000sp|Q9UKG4|S13A4_HUMAN(removed signalp:1-25) Solute carrier family 13 member 4 OS=Homo sapiens GN=SLC13A4 PE=2 SV=2  ali   11  1.......................................................................................................................................................................AEPISLDVKNSQPSLELIFVNEESNADLTTL-KCLSLSISYSATIGGLTTIIGTSTSLIFPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFCSLSKKKKTKREQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTKKGYRTDATVSVFLGFLLFLIPAKKPITWKDFQKTMPWEIVILVGGGYA........................................................................................................................................................... 300
12 -17.700sp|Q9UKG4|S13A4_HUMAN(removed signalp:1-25) Solute carrier family 13 member 4 OS=Homo sapiens GN=SLC13A4 PE=2 SV=2  ali   12  44.............LGDISYPEMVTGFFFILMTVLWFTREPFVPGWDSFF--------KGYRTDATVSVFLGFLLFLIPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLL-----------------------------ACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISF-AVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAI................................................................................................................................................................................................................................................................. 275
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang Y, Stec B, Godzik A. Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins. Structure. 2007 Sep;15(9):1141-7.