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Query: [R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAVILLEISELEGKKAPRGEVTLVGAGRLGLRTALNLMQIHRGGPERINVIDGQRVSADDLIFRLMGATPGEYKVKFIESLATPGFSRTVRGIPEYIDRDNLHLLRGDVVCVEIAGGDTLPVTAEIIKYAQKRGSATISTMGVFGIGEEEVNAISIEEADPGNPIVEYLLDEGVTDHLLVGTGKLIRDWEPVTPYVLDRVSEVMTAEILKLLRRKLGLast
1 -54.800sp|O95396|MOCS3_HUMAN Adenylyltransferase and sulfurtransferase MOCS3 OS=Homo sapiens GN=MOCS3 PE=1 SV=1  ali follow..  16  66.QLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAA---AGVGRLGLVDYDVVEMSNLARQVLHGLAGQAKAFSAASLRRLNSAVECVPYTQALTPATALDLVRR-YDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITVYHYD------GGPCYRCIFPQPPPAETVTN-----CADGGVLGVVTGVLGCLQALEVLKIAAG... 266
2 -50.300sp|Q9GZZ9|UBA5_HUMAN Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens GN=UBA5 PE=1 SV=1  ali follow..  15  56.LMALKRMGVSDYEKIRTFAVAIVGVGGVGSVTAEMLT---RCGIGKLLLFDYDKVELANMNRLFFQHQAGLSKVQAAHTLRNINPDVLFEVHNYNITTNGGLEEGKP-VDLVLSCVDNFEARMTINTACNELGQTWMESGVSAVSGHIQLIIPGE------SACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLN... 275
3 -47.300sp|Q9UBT2|SAE2_HUMAN SUMO-activating enzyme subunit 2 OS=Homo sapiens GN=UBA2 PE=1 SV=2  ali   12  2..ALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVL---TGFSHIDLIDLDTIDVSNLNRQFLFKHVGRSKAQVAESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKG------VTECYECHPKPTQR-------TFPGCTIRNTPSEPIHCI--VWAKYLFNQLFGE.. 199
4 -43.600sp|P22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3  ali   10  2.DGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAM---IGLGEIIVTDMDTIEKSNLNRQFLFWDVTKLKSDTAAAVRQMNPHIRVTSHQNRVGPDTERIYFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPF------LTESYSSSQDPPEK-------SIPICTLKNFPNAIEHTLQWARDEFEGLFKQP... 209
5 -41.900sp|A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens GN=UBA6 PE=1 SV=1  ali   9  1........GDTLCQKLQNLNIFLVGCGAIGCEMLKNFAL---LGVGMITVTDPDLIEKSNLNRQFLFHHIQKPKSYTADATLKINSQIKIDAHLNKVCPTTETIYFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPH------LTESYNSHRDPPEE-------EIPFCTLKSFPAAIEHTI--QWARDKFESSFSH.. 201
6 -41.300sp|O95352|ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1  ali   14  39.LMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMG---WGVRHITFVDNAKISYSNPVRQPLYEGGGKPKALAADRLQKIFPGVNARGFNMSIDVEQLEQLIES-HDVVFLLMDTRESRWLPAVIAASKRKLVINAA-LGFDTFVVMR------HGLKKPKQQGAGDLCPN----HPVASADLLGSSLFANIPGKLGCYFCNDVVAPGDS... 262
7 -41.300sp|Q8TBC4|UBA3_HUMAN NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens GN=UBA3 PE=1 SV=2  ali follow..  15  53.HPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLAL---SGFRQIHVIDMDTIDVSNLNRQFLFKDIGRPKAEVAEFLNDRVPNCNVVPHFNKIQDFNDTFY--RQFHIIVCGLDSIIARRWINGMLISSIVPLIDGGTEGFKGNARVILPGM------TACIECTLELYPPQVNFP-----MCTIASMPRLPEHCIEYVRMLQWPK....... 260
8 -41.200sp|P41226|UBA7_HUMAN Ubiquitin-like modifier-activating enzyme 7 OS=Homo sapiens GN=UBA7 PE=1 SV=2  ali   12  116.DGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFAGLGAGNSGGLTVVDMDHIERSNLSRQFLFQDVGRPKAEVAAAARGLNPDLQVIPLTYPLDPTTEHIYFFSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFMPH------VTEAYRAPASAAASED........................................ 293
9 -39.500sp|P41226|UBA7_HUMAN Ubiquitin-like modifier-activating enzyme 7 OS=Homo sapiens GN=UBA7 PE=1 SV=2  ali   13  16.SRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVL---MGVGSLTLHDPHPTCWSDLAAQFLLQDLERSRAEASELLAQLNRAVQVVVHTGDITED-----LLLDFQVVVLTAAKLEEQLKVGTLCHKHGVCFLAADTRGLVGQLFCDF------GEDFTVQDPTEAEPLT-----------AAIQHISQGSPGILTLRKGANTHYFRDG... 206
10 -38.900sp|P22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3  ali   14  56.SRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIIL---GGVKAVTLHDQGTAQWADLSSQFYLEDIGKNRAEVSPRLAELNSYVPVTAYTGPLVEDFLSG-----FQVVVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEM----------ILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFS..... 251
11 -38.300sp|A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens GN=UBA6 PE=1 SV=1  ali   13  45.SRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVL---AGIKAVTIHDTEKCQAWDLGTNFFLSE-KRNRAEAVKHIAELNPYVHVTSSSVPFNETTDLSFLDK-YQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLF................................................................. 196
12 -37.300sp|A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens GN=UBA6 PE=1 SV=1  ali   12  144.DALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFAL---LGVGMITVTDPDLIEKSNLNRQFLFHHIQKPKSYTADATLKINSQIKIDAHLNKVCPTTETIYFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT.................................................................... 300
13 -37.300sp|P22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3  ali   12  152.DGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAM---IGLGEIIVTDMDTIEKSNLNRQFLFWDVTKLKSDTAAAVRQMNPHIRVTSHQNRVGPDTERIYFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESG............................................................................ 299
14 -36.100sp|Q9UBE0|SAE1_HUMAN SUMO-activating enzyme subunit 1 OS=Homo sapiens GN=SAE1 PE=1 SV=1  ali follow..  15  20.DRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLIL---AGVKGLTMLDHEQVTPEDPGAQFLIGSVGRNRAEASERAQNLNPMVDVKVDTEDIEKKPESFF--TQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHG...................................................................... 163
15 -35.000sp|P41226|UBA7_HUMAN Ubiquitin-like modifier-activating enzyme 7 OS=Homo sapiens GN=UBA7 PE=1 SV=2  ali   10  2...................................ALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRDVGRPKAEVAAAARGLNPDLQVIPLTYPLDPTTEHIYFFSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFM------PHVTEAYRAPASAAASEDAPYP-----VCTVRYFPSTAEHTLQWARHEFEELFRLS.. 176
16 -32.700sp|Q13564|ULA1_HUMAN NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens GN=NAE1 PE=1 SV=1  ali follow..  15  14.DRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVL---PGIGSFTIIDGNQVSGEDAGNNFFLSSIGKNRAEAAEFLQELNSDVSGSFVEESPENDNDPSFFCR-FTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRII................................................................. 165
17 -28.700sp|O95352|ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1  ali   21  189.LMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMG---WGVRHITFVDNAKISYSNPVRQPLYEGGGKPKALAADRLQKIFPGVNARGFNMSIP....................................................................................................................... 288
18 -12.400sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   16  29................TRRKVLVLGSGYISEPVLEYLS---RDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLKQDLVISLLPYVLHPLVAKACITNKVNM-VTASYITPALKELEKSVEDAGITIIGELGLD......................................................................... 154
19 -9.810sp|A6ND91|ASPD_HUMAN Putative L-aspartate dehydrogenase OS=Homo sapiens GN=ASPDH PE=2 SV=2  ali follow..  15  1............MADRGPWRVGVVGYGRLGQSLVSRLLAQGPEGLELVFVWNRDP-------GRMAGSVPPSLQLQNLAALGERRPDLVVEVAHPKIIHESGAQILRHANLLVGSALSDQTTERQLLEASQHWDHAVFVARGA.......................................................................... 127
20 -9.350sp|Q8IXQ9|CL072_HUMAN(removed signalp:1-25) UPF0516 protein C12orf72 OS=Homo sapiens GN=C12orf72 PE=2 SV=1  ali follow..  10  75.GQALSRYLLDNPDVVRGKSVLDLGSGGATAIAA------KMSGASRILANDIDPIAGMAITLNCELNRLNPFPILIQNILNLEQDKWDLVVLGDMFYDEDLADSLHQWLKKCF....................................................................................................... 182
21 -9.140sp|Q8NHU2|CT026_HUMAN Uncharacterized protein C20orf26 OS=Homo sapiens GN=C20orf26 PE=2 SV=3  ali   10  65.................NAKIIVVGASSVGISFLETLVFCSHMKFNNLTLISTHGLPGKKLLDTEQRKFLASDHCFNDKDYALMSLCSWVN-----VVVGRMTGIDRAAKHVVLSTDEIVPYDHLILCTGQQYQVPCPTEA............................................................................ 183
22 -9.100sp|Q7Z624|CLNMT_HUMAN Calmodulin-lysine N-methyltransferase OS=Homo sapiens GN=CLNMT PE=1 SV=2  ali follow..  10  131.EEVLAYYCLKHNNIFRALAVCELGGG-MT--CLAGLMVAISADVKEVLLTDGNEKAIRNVQDII-----------TRNQKAGVFKTQKISSCVLRWDNETDVSQLEGHFDIVM-CADCLFLDQYR---------SLVDAIKRLLQPRGKAMVFAPRRGNTLNQFCNLAEKAGFCIQRHENYDEHISNFHSKLKKENPDIYEENLHYPLLLILTKHG 323
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 5 1 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205