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Query: [S] COG5427 Uncharacterized membrane protein, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEFGVVARWWVFFGVLLVAGLPVASRLLPDAPDRGASVAMPLSLVVVTLATLWVGQVAYGQLVVGGVFVAVLAAAAWLARGGVEIPRKPLLEVVGVFTVAFVFLIVVRAWADGVQPAGGEQFLDFGLLQALDRAGQLPPRDMWFAGERVVYYYGGQLMASIGAHLTDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNGGESRPVGVPTAIGGAGVALAVVVLATGVNWLVVAVPAAAAAVVVTRPRRVRAGVLGAFAFGFASNLGPVIRLLAARVDVVRAAVVAAGINADRRPAITPEAFDMWHASRFMETGLNEFPLFAYLNGDLHAHMVSVPVLFVAVAVGVAYYRTPARQRRRRWALLWGGFPVAGAAILTVNTWSLPTVFGVAALAVALADPAPATLLPTGVQRWTRRESAVGQSVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHLAVLPVPSQAGALVFVHGLFLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVVGGVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVLVEYVYLADAASYERFNTVFKVYAQVWALWSVAGGVALAGVSERRASTGGLGAVFVVGLVVAASVYGGLAVTTHAANADDASLDALEYAGNAHPGEAAAARWLGDRRRGTRIVAAPGVDPYTWQNPAASLSGVPTVAGWAHAANYHSQAAWEQRVDDIGVVYETTDAASRAAILEKYDVTYVWVGPVERARYEIPDLSADPGIEPVHRTPAVTIYRVTDDELVAPRSGPITVTTTPQAATATAPGAQTARSPARFVTVTSSASTAVTSSQWGTKLRFSLast
1 -21.100sp|Q6NUT2|D19L2_HUMAN Protein dpy-19 homolog 2 OS=Homo sapiens GN=DPY19L2 PE=2 SV=2  ali   11  14...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFNNLPQEELLQWIKYSTTSDAVFAG----AMPTMASIKLSTLHPIVNHPHYE-----DADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEYFTTVFQNSVYRVLKVN............................................................ 158
2 -19.000sp|Q7Z388|D19L4_HUMAN Protein dpy-19 homolog 4 OS=Homo sapiens GN=DPY19L4 PE=2 SV=1  ali   12  16.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IIYHVIHTILLGSLAMVIE--------GLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILSMAVPTIIGLSLWKEFFPRLMTELMELQ--EFYDPDTVELMTWIKRQAPVAAVFA----GSPQLMGAIKLCTGWMVTSLPLYN-----DDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDA--HEVKINYSPYVNYFTRVYWNRSYFVYKINT........................................................... 267
3 -18.800sp|Q6ZPD9|D19L3_HUMAN Protein dpy-19 homolog 3 OS=Homo sapiens GN=DPY19L3 PE=2 SV=1  ali   7  10...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPETAYNLIHTILFGFLAL-----------------STMRMKYLWTSHMCVFASFGLCSPELYNPKRICIMRYSVPILILLYLCYKFWPGMMDELSELR---------EFYDPDTVELMNWINSNTPRKAVFA----GSMQLLAGVKLCTGRTLTNHPHYE-----DSSLRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDS--EEIKRNLPPYVAYFTRVFQNKTFHVYKLSRNK......................................................... 266
4 -18.500sp|Q2PZI1|D19L1_HUMAN Protein dpy-19 homolog 1 OS=Homo sapiens GN=DPY19L1 PE=2 SV=1  ali   11  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LVYHALQLLAYTALGIL-------------IMRLKLFLTPHMCVMASLICSRQLFGWLFCKVHPGAIVFAILAAMSIQGSANLQTQWNIVG----------EFSNLPQEELIEWIKYSTKPDAVFA----GAMPTMASVKLSALRPIVNHPHYE-----DAGLRARTKIVYSMYSRKAAEEVKRELIKLKVNYYILEESWCVRRSKPGCSMKPHFTTVFQNSVYKVLEVVKE.......................................................... 225
5 -13.900sp|Q6NUT2|D19L2_HUMAN Protein dpy-19 homolog 2 OS=Homo sapiens GN=DPY19L2 PE=2 SV=2  ali   8  50..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALA------LIMRLKMFLTPHMCVMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIG----------EFNNLPQEELLQWIKYSTTSDAVFA----GAMPTMASIKLSTLHPIVNHPHYE-----DADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMRPYFTTVFQNS.................................................................... 300
6 -13.100sp|P46977|STT3A_HUMAN(removed signalp:1-30) Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens GN=STT3A PE=1 SV=2  ali   10  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMS-----WDYGYQITAMANRTILVD---------NNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMVRIGGSTDTGKHIKENDYYTPTGEFRVDREGSPVLLNC..................................... 157
7 -13.100sp|Q8TCJ2|STT3B_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1  ali   11  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VYFA---------VMVRLMLTLTPVVCMLSAIAFSNVFEEEGLGPNIKSIVTMLMLMLLMMFAVHCTWVTSNAYSSPSVVLASYNHDGTRN-REAYFWLRQNTDEHARVMS-----WDYGYQIAGMANRTTLVD---------NNTWNNSHIALVGKAMSSNETAAYKIMRTLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIRESD........................................................... 244
8 -12.300sp|P46977|STT3A_HUMAN(removed signalp:1-30) Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens GN=STT3A PE=1 SV=2  ali   9  15.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMYFSA-----------------VMVRLMLVLAPVMCILSGIGVSQVLSKNEVASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMS-----WDYGYQITAMANRTILVD---------NNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMVRIGGSTDTG-FRVDREG......................................................... 300
9 -9.220sp|Q2KHR2|RFX7_HUMAN DNA-binding protein RFX7 OS=Homo sapiens GN=RFX7 PE=1 SV=1  ali   8  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPL----------SAADFGK----MKNVFPN----KARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDF-----HKTGDGLEGAEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMA 169
10 -9.170sp|Q8TCJ2|STT3B_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1  ali   14  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VMSW------------------WDYGYQIAGMANRTTLVD---------NNTWNNSHIALVGKAMSSNETAAYKIMRTLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIR.............................................................. 91
11 -9.140sp|P22670|RFX1_HUMAN MHC class II regulatory factor RFX1 OS=Homo sapiens GN=RFX1 PE=1 SV=2  ali   12  109.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPV----------NAASFGK----IRSVFMG----RTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQ-HMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVL.... 296
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 2 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.