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Query: [O] COG5596 Mitochondrial import inner membrane translocase, subunit TIM22, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLSGLLPPNLGGNSPNADGNLTPEEKAALQQAKIIGYMNRISESCVFKSSMAGVLGFGLGGIFGMFISSLDLQHIDPKIYEKPFREQIRIQARDMGSRSFSTAKNFGLLGLIYSGSECCIEAFRAKTDIYNAIAAGVFTGGALAVRSGPKAIVLGGAGFGLFSYGIEKYMHWGELast
1 -59.300sp|Q9Y584|TIM22_HUMAN Mitochondrial import inner membrane translocase subunit Tim22 OS=Homo sapiens GN=TIMM22 PE=1 SV=2  ali follow..  35  56................................SEEQKMIEKAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDP-KDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLIESYRGTSDWKNSVISGCITGGAIGFRAGLKAGAIGCGGFAAFSAAIDYYLR... 194
2 -55.600sp|Q99595|TI17A_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-A OS=Homo sapiens GN=TIMM17A PE=1 SV=1  ali follow..  23  1.....................................MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAIKGFRN----SPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAG.... 130
3 -55.600sp|O14925|TIM23_HUMAN Mitochondrial import inner membrane translocase subunit Tim23 OS=Homo sapiens GN=TIMM23 PE=1 SV=1  ali follow..  18  56.........................DTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKE------TQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEH 199
4 -54.600sp|O60830|TI17B_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-B OS=Homo sapiens GN=TIMM17B PE=1 SV=1  ali follow..  26  1.....................................MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAP----VGIRHRLRGSANAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSGPLAMVGSAMMGGILLALIEGV..... 129
5 -52.800sp|Q5SRD1|TI23B_HUMAN Putative mitochondrial import inner membrane translocase subunit Tim23B OS=Homo sapiens GN=TIMM23B PE=5 SV=2  ali follow..  15  54.......................VQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKE------TQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTETAQANFQSEIIFRFLTRFFYAKKKAS. 203
6 -48.000sp|Q9NPL8|CC001_HUMAN(removed signalp:1-24) Transmembrane protein C3orf1 OS=Homo sapiens GN=C3orf1 PE=1 SV=2  ali follow..  12  10.VLEERQKRLPYVPEPYYPESGWDRLRELFGKDEQQRISKDL-ANICKTAATAGIIGWVYGGIPAFIHAKQQYIEQSQAEIYHNVQSAHRAATRGFIRYGWRWGWRTAVFVTIFNTVNTSLNVYRNKDALSHFVIAGAVTGSLFRINVGLRGLVAGGIIGALLGTPVGGLL.... 182
7 -36.700sp|Q86Y39|NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 OS=Homo sapiens GN=NDUFA11 PE=1 SV=3  ali follow..  14  16...........................................TDCHRKAYSTTSIASVAGLTAAAYRVTLNP----------------PGTFLEGVAKVGQYTFTAAAVGAVFGLTTCISAHVREKDDPLNYFLGGCAGGLTLGARTHYGIGAAACVYFGIAASLVKMGRLEG. 132
8 -18.200sp|Q86UB9|TM135_HUMAN Transmembrane protein 135 OS=Homo sapiens GN=TMEM135 PE=2 SV=2  ali follow..  17  248...........................................DNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHL-------FTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFY--KSTTISMYLASKLVETMYFKGIEAG. 369
9 -15.400sp|Q9Y6I8|PXMP4_HUMAN(removed signalp:1-25) Peroxisomal membrane protein 4 OS=Homo sapiens GN=PXMP4 PE=1 SV=3  ali follow..  10  3............................................AVLKGFRNGAVYGAKIRAPHALVMTFLF------------RNGSLQEKLWAILQATYIHSWNLARFVFTYKGLRALQSYIQGKTYPAHAFLAAFLGGLVFGENNNINSQINMYLLSRVLFALSRLAVEKG. 121
10 -10.600sp|O75746|CMC1_HUMAN Calcium-binding mitochondrial carrier protein Aralar1 OS=Homo sapiens GN=SLC25A12 PE=1 SV=2  ali   15  175................................................ESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIV..................... 300
11 -10.400sp|Q9UJS0|CMC2_HUMAN Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens GN=SLC25A13 PE=1 SV=2  ali   13  177................................................ESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVI............................. 294
12 -9.770sp|Q7Z469|YK019_HUMAN Putative mitochondrial carrier protein LOC494141 OS=Homo sapiens PE=5 SV=2  ali follow..  7  42.........................................................YLCGCCAAFNNVAITFPIQKVLFPQQLYGIKTGDAILQLRTDG-QKTTTLALTFGLYEDLSYLLHKHVSAPEFATCGVAAVLAGTTEAI............................. 142
13 -9.680sp|P60602|ROMO1_HUMAN Reactive oxygen species modulator 1 OS=Homo sapiens GN=ROMO1 PE=1 SV=1  ali follow..  20  13...........................................PSCFDRVKMGFVMGCAVGMAAGALFGTFSCLR---------IGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC........................................................ 79
14 -9.310sp|P41247|PLPL4_HUMAN(removed signalp:1-24) Patatin-like phospholipase domain-containing protein 4 OS=Homo sapiens GN=PNPLA4 PE=1 SV=3  ali follow..  14  13....................................................KAFAGASAGSLVASVLLTAPEKIEECNQFTYKFAEEIRRQSFGAVTPGYDFMARLRSITNAKTRENHLVSTFSSREDLIKVLLASSFVPIYAGLKKG-QKWVDGGLT................ 143
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.