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Query: [S] KOG2632 Rhomboid family proteins, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRPNIVTEAGVQTRVGQWWNAIPFLTSSVVVVCGVIYLICLLTGYDTFYEVCFLPSAIISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIMGSVRLLYLTVLLATTNAVLHLLIASLAGYNPFYQYDHLMNECAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVPAKLYPWILLIVFQLLMTNVSLLGHLCGILSGFSYSYGLFNFLMPGSSFFTTIESASWMLIVTHPVSMSSSSLASLGDPSSLCVLAGILPAIFPLILHKTQHPGNAWRSLSSWLPQREASNQSSEDSRFPGRGRTLSTARDPTAPAGETDPNLHARLLEDSSSPDRLSDATVNTVADSRQAPIANAAVLPQSQGRVAASEEQIQKLVAMGFDRTQVEVALAAADDDLTVAVEILMSQQVLast
1 -77.400sp|Q9Y3P4|RHBD3_HUMAN(removed signalp:1-33) Rhomboid domain-containing protein 3 OS=Homo sapiens GN=RHBDD3 PE=2 SV=1  ali follow..  20  3.................................................GLVLAPELLLDPWQVHRLLTHALGHTALPGLLLSLLLLPTVGWQQECHLGTLRFLHASALLALASGLLAVLLAGLGLS---------SAAGSCGYMPVHLAMLAGEGHRPR------RPRGALPPWLSPWLLLALTPLLSSEPPFLQLLCGLLAGLAYAAGAFRWLEPSERRLQVLQEGVLCRTLAGCWPLRL-------------LATPGSLAELPVTHPAGVRPPIPGPPYVASPDLWSHWEDSALPPPSLRPVQPTWEGSSEAGLDWAGASFSPGTPMWAALDEQMLQEGIQASLLDGPAQEPQSAPWLSKSS----VSSLRLQQLERMGFPTEQAVVALAA-TGRVEGAVSLLVGGQV 331
2 -63.800sp|Q8TEB9|RHBD1_HUMAN Rhomboid domain-containing protein 1 OS=Homo sapiens GN=RHBDD1 PE=2 SV=1  ali follow..  20  1MQRRSRGIN-LSQIFHVGINNIPPVTLATLALNIWFFLNPQKP----LYSSCLSVEKCYQQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYLLLQFAVAE--FMDEPDFKRSCAVGFSGVLFALKVLNNHYCPGGFVNILG-FPVPNRFACWVELVAIHLFSPGTSFAGHLAGILVGLMYTQGPLKKIM--EACAGGFSSSVGYPGRQYYFNSSGSSGYQDYYPHGRPDHYEEAPRNYDTYTAGLSEEEQLERALQASLWDRGNTRNSPPPYGFHLSPEEMRRQRLHR................................................................................................ 311
3 -63.600sp|Q8NBM4|UBAC2_HUMAN Ubiquitin-associated domain-containing protein 2 OS=Homo sapiens GN=UBAC2 PE=2 SV=1  ali follow..  14  10..................LYKAP-LSKSLLLVPSALSLLLALLLPHCQKLFVYDLHAVKNDFQIWRLICGRIICLDLKDTFCSSLLIYNFR-IFERRYGSRKFASFLLGSWVLSALFDFLLIEAMQYFFGIT---AASNLPSGFLAPVFALFVPFYCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAISGLMSGLCYDSKMFQ---------------------------------------------------VHQVLCIPSWMAKFFSWTLEPIFSSSEPTSEARIGMGATLDIQRQQRMELLDRQLMFSQFAQGRRQRQQQGGMINWNRLFPPLRQRQNVNYQGGRQSEPAAPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH.. 344
4 -55.400sp|Q6NTF9|RHBD2_HUMAN Rhomboid domain-containing protein 2 OS=Homo sapiens GN=RHBDD2 PE=2 SV=2  ali follow..  16  1.....MAASGPGCRSWCLCPEVPSATFFTALLSLLVSGPRLFLQQPLAPSGLTLKSEALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAVSSLSKLG-----EVEDARGFTPVAFAMLGVTTVRSRMRRALVFG-MVVPSVLVPWL-LLGASWLIPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSR........................................ 360
5 -42.700sp|Q6PJF5|RHDF2_HUMAN Rhomboid family member 2 OS=Homo sapiens GN=RHBDF2 PE=1 SV=2  ali   13  10............................ITTREYCEFMHGYFSQVHCLDKVCGLFLNPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLP--------------YRAEVGPAGSQFGLLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLL................................................................................................................................................................................. 210
6 -40.600sp|Q96CC6|RHDF1_HUMAN Rhomboid family member 1 OS=Homo sapiens GN=RHBDF1 PE=1 SV=2  ali   14  9............................ITSREYCDFMRGYFHEEATLCS-LLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLP--------------YRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGK................................................................................................................................................................................................ 194
7 -38.200sp|Q9H300|PARL_HUMAN Presenilins-associated rhomboid-like protein, mitochondrial OS=Homo sapiens GN=PARL PE=1 SV=2  ali follow..  13  162..................LSDGQRTVTGIIAANVLVFCLWRVPSLQRTM-IRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATG----------RYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLFTFTAGNALKAIIAMDTAGMKFFDHAAHLGGALFGIWYVT.......................................................................................................................................................................................................... 347
8 -38.100sp|Q12893|TM115_HUMAN(removed signalp:1-46) Transmembrane protein 115 OS=Homo sapiens GN=TMEM115 PE=1 SV=1  ali follow..  14  7.........................................................FPPNFWIWTLATHGLMEQHVWDVAISLTTVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAY-LLTYMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVMPMLLLALLLLLRLAQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFF-------------------PEILQPVVGLLANLVHSLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLANERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSLITFEAAPPT........................................... 304
9 -38.000sp|P58872|RHBL3_HUMAN Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1  ali follow..  15  163......................PWFMITVTLLEVAFFLYNGVSLGQPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADM--------------TAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMPSAYPPCPHPSFVAHLGGVAVGITLGVVVLR...................................................................................................................................................................................................... 359
10 -36.900sp|Q9NX52|RHBL2_HUMAN Rhomboid-related protein 2 OS=Homo sapiens GN=RHBDL2 PE=1 SV=2  ali follow..  15  72......................PVFIISISLAELAVFIYYAVWKPQITLDTGILESPFIKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDP--------------LRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIFFVPEDGSPVSFAAHIAGGFAGMSIGYTVFS...................................................................................................................................................................................................... 266
11 -36.200sp|O75783|RHBL1_HUMAN Rhomboid-related protein 1 OS=Homo sapiens GN=RHBDL1 PE=2 SV=1  ali follow..  14  197......................PVFMASVTLAQIIVFLCYGARLNKPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDM--------------RAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEER................................................................................................................................................................................................. 398
12 -33.900sp|Q96CC6|RHDF1_HUMAN Rhomboid family member 1 OS=Homo sapiens GN=RHBDF1 PE=1 SV=2  ali   15  155....................GRCEITSREYCDFMRGYFHEEATLCSQVHCMLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLP--------------YRAEVGPAGSQFGILACLFV.............................................................................................................................................................................................................................................................. 282
13 -32.600sp|Q6PJF5|RHDF2_HUMAN Rhomboid family member 2 OS=Homo sapiens GN=RHBDF2 PE=1 SV=2  ali   14  156....................GSCEITTREYCEFMHGYFHEEATLCSQVHCLLLPFLNPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLP--------------YRAEVGPAGSQFGLLACLFV.............................................................................................................................................................................................................................................................. 283
14 -27.200sp|Q92681|RSCA1_HUMAN Regulatory solute carrier protein family 1 member 1 OS=Homo sapiens GN=RSC1A1 PE=2 SV=1  ali   8  43..................................................................................................................................................................................................................................................................................................SPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNI 163
15 -27.000sp|Q96Q80|DERL3_HUMAN Derlin-3 OS=Homo sapiens GN=DERL3 PE=1 SV=2  ali follow..  20  4............QGLAAEFLQVPAVTRAYTAACVLTTAAVQL-ELLSPFQLYFNPHLVFRKFQVWRLVTNFLFFGPLFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL--------------GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSI--LVDLLGIAVGHIYYF.......................................................................................................................................................................................................... 184
16 -27.000sp|Q9BUN8|DERL1_HUMAN Derlin-1 OS=Homo sapiens GN=DERL1 PE=1 SV=1  ali follow..  16  2............SDIGDWFRSIPAITRYWFAATVAVPLVGKL-GLISPAYLFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDG-YLFMLLFNWICIVITGLAMDMQLL-------------MIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSV--INELIGNLVGHLY---FLMFRYPMDLGGRNFLSTPQFLY-------------------------------------PSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ.................................................................................................... 251
17 -26.400sp|P22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL OS=Homo sapiens GN=CBL PE=1 SV=2  ali   9  28...................................................................................................................................................................................................................................................................................................KPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILRE... 144
18 -24.700sp|Q9GZP9|DERL2_HUMAN Derlin-2 OS=Homo sapiens GN=DERL2 PE=1 SV=1  ali follow..  20  4............QSLRLEYLQIPPVSRAYTTACVLTTAAVQL-ELITPFQLYFNPELIFKHFQIWRLITNFLFFGPVFNFLFNMIFLYRYCRMLEEGS-TADFVFMFLFGGFLMTLFGLFVSLVFL-----------------GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLL--GNSIIVDLLGIAVGHIYFF.......................................................................................................................................................................................................... 184
19 -24.200sp|Q9NRR5|UBQL4_HUMAN Ubiquilin-4 OS=Homo sapiens GN=UBQLN4 PE=1 SV=2  ali   15  154.........................................................................................................................................................................................................................................................................PESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFNREANLQALIATGGDINAAIERLLGSQL 300
20 -23.400sp|Q9NRR5|UBQL4_HUMAN Ubiquilin-4 OS=Homo sapiens GN=UBQLN4 PE=1 SV=2  ali   15  4.........................................................................................................................................................................................................................................................................PESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFNREANLQALIATGGDINAAIERLLGSQ. 149
21 -22.600sp|Q9H347|UBQL3_HUMAN Ubiquilin-3 OS=Homo sapiens GN=UBQLN3 PE=1 SV=2  ali   18  76........................................................................................................................................................................................................................................................................................QIEQGLQVLATEAPRLLLWFMPCLAGTGSVAGGIESREDPLMSEDPLPNPPPEVFPALDSAELGFLSPPFLHMLQDLVSTNPQQLQPEAHFQVQLEQLRSMGFNREANLQALIATGGDVDAAVEKLRQS.. 205
22 -21.600sp|Q9Y5A7|NUB1_HUMAN NEDD8 ultimate buster 1 OS=Homo sapiens GN=NUB1 PE=1 SV=2  ali   25  17..........................................................................................................................................................................................................................................................................................................................................................LLSNPQMWWLNDSNPETDNRQESPSQENIDRLVYMGFDALVAEAALRVFRGNVQLAAQTLAHNG. 80
23 -20.300sp|Q13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens GN=CBLB PE=1 SV=2  ali   18  60........................................................................................................................................................................................................................................................GEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILRE... 219
24 -19.600sp|Q9UMX0|UBQL1_HUMAN Ubiquilin-1 OS=Homo sapiens GN=UBQLN1 PE=1 SV=2  ali follow..  20  467..................................................................................................................................................................................................................................................................................................QQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVRFQQQLEQLSAMGFNREANLQALIATGGDINAAIERLLGSQ. 587
25 -19.300sp|Q96S82|UBL7_HUMAN Ubiquitin-like protein 7 OS=Homo sapiens GN=UBL7 PE=1 SV=2  ali follow..  15  257.................................................................................................................................................................................................................................................................................................GYSGAAGPRPITQSELATALALASTPESSSHTPTPGTQGHSSGTSPMSSGVQSGTPITNDLFSQALQHALQASGQPSLQSQWQPQLQQLRDMGIDDELSLRALQATGGDIQAALELIFAG.. 377
26 -18.500sp|Q14596|NBR1_HUMAN Next to BRCA1 gene 1 protein OS=Homo sapiens GN=NBR1 PE=1 SV=3  ali   12  51..............................................................................................................................................................................................................................................................TSQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPVTIPEVSSVPDQIRGEPRGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISEDQTAALMAHLFEMGFDRQLNLRLLKKHNYNILQVVTELLQLN. 207
27 -18.000sp|Q9UHD9|UBQL2_HUMAN Ubiquilin-2 OS=Homo sapiens GN=UBQLN2 PE=1 SV=2  ali   16  13...........................................................................................................................................................................................................................................................QTLATEAPGLIPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGGPTGPTVSSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPNPEVRFQQQLEQLNAMGFLNREANLALIATGGDINAAIERLLGSQ. 172
28 -17.900sp|P22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL OS=Homo sapiens GN=CBL PE=1 SV=2  ali   11  130.........................................................................................................................................................................................................................................................TYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAASSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILRE... 294
29 -17.800sp|Q9Y5A7|NUB1_HUMAN NEDD8 ultimate buster 1 OS=Homo sapiens GN=NUB1 PE=1 SV=2  ali   25  169............................................................................................................................................................................................................................................................................................................................................................SNPQMWWLNDSNPETDNRQESPSQENIDRLVYMGFDALVAEAALRVFRGNVQLAAQTLAHNG. 230
30 -17.700sp|Q13501|SQSTM_HUMAN Sequestosome-1 OS=Homo sapiens GN=SQSTM1 PE=1 SV=1  ali follow..  11  264................................................................................................................................................................................................................................................KRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGLTRLLQTKNYDIGAALDTIQYSK. 435
31 -17.500sp|Q9H7E2|TDRD3_HUMAN Tudor domain-containing protein 3 OS=Homo sapiens GN=TDRD3 PE=1 SV=1  ali   15  5..........................................................................................................................................................................................................................................................................................................................................GGARSNLNMNAAGNRNREVLQKEKSTKSEGKHEGVYRELVDEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLTSN. 84
32 -17.000sp|Q6P158|DHX57_HUMAN Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens GN=DHX57 PE=1 SV=2  ali   22  1...................................................................................................................................................................................................................................................................................................................................................AGQEPSLVPDLDPLEYAGLASVEPYVPEFTVSPFAVQKLSRYGFNTERCQAVLRMCDGDVGASLEHLLTQ.. 70
33 -16.400sp|Q9UPU5|UBP24_HUMAN Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens GN=USP24 PE=1 SV=3  ali   28  3................................................................................................................................................................................................................................................................................................................................................................................SEEEQHMTTLLCMGFSDATIRKALRLAKNDINEAVALLTNER. 45
34 -16.000sp|Q8TF42|UBS3B_HUMAN Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens GN=UBASH3B PE=1 SV=2  ali   19  8.....................................................................................................................................................................................................................................................................................................................................................SPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALASTGRSVQAACDWLFSH.. 76
35 -15.500sp|Q15751|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens GN=HERC1 PE=1 SV=2  ali   15  1.................................................................................................................................................................................................................................................................................................................................TPPISSLPTSPSDEVGRRQSLTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEMGFSLRQIAKAMEATGGEADAQITVLAMWMI 93
36 -15.400sp|Q07912|ACK1_HUMAN Activated CDC42 kinase 1 OS=Homo sapiens GN=TNK2 PE=1 SV=3  ali   13  99........................................................................................................................................................................................................................................................RDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEEVEQLFGLGLPRGECHKVLEMFDWNLEQAGCHLLGS.. 280
37 -15.400sp|Q9Y5A7|NUB1_HUMAN NEDD8 ultimate buster 1 OS=Homo sapiens GN=NUB1 PE=1 SV=2  ali   12  203...........................................................................................................................................................................................................................................................................................................................................................SGNDVEAYEYLNKARQLFKELYIDPSKVDNLLQLGFTAQEARLGLRACDGNVDHAATHITNRR. 265
38 -15.300sp|Q5T6F2|UBAP2_HUMAN Ubiquitin-associated protein 2 OS=Homo sapiens GN=UBAP2 PE=1 SV=1  ali   18  1.........................................................................................................................................................................................................................................................................................................................................MMTSVSSDHCRGAREKPQISAAQSTQPQKQVVQATAEQMRLAQAKVKQLMEVGKNQDECIVALHDCNGDVNKAINILLEGN. 93
39 -15.200sp|Q13470|TNK1_HUMAN(removed signalp:1-19) Non-receptor tyrosine-protein kinase TNK1 OS=Homo sapiens GN=TNK1 PE=1 SV=3  ali   13  55................................................................................................................................................................................................................................................................................................RQARAVPQGPPGLPPRPPLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQEVDQLFHLSSSRADCWRILEHYQWDLSAASRYVLAR.. 196
40 -15.000sp|Q9BSL1|UBAC1_HUMAN Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens GN=UBAC1 PE=1 SV=1  ali follow..  16  168.........................................................................................................................................................................................................................................................................................................................................................ALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHA. 232
41 -14.800sp|P57075|UBS3A_HUMAN Ubiquitin-associated and SH3 domain-containing protein A OS=Homo sapiens GN=UBASH3A PE=1 SV=1  ali   22  2...............................................................................................................................................................................................................................................................................................................................................................AAGETQLYAKVSNKLKSRSSPSLLEPLLAMGFPVHTALKALAATRKTAEEALAWLHDHC. 61
42 -14.600sp|Q7Z6Z7|HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3  ali   17  82..............................................................................................................................................................................................................................................................................................................................................RGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDMGFTREHAMEALLNTST-MEQATEYLLTHP. 156
43 -14.200sp|P54725|RD23A_HUMAN UV excision repair protein RAD23 homolog A OS=Homo sapiens GN=RAD23A PE=1 SV=1  ali follow..  20  285...............................................................................................................................................................................................................................................................................................................................................NEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQN. 359
44 -14.100sp|Q92681|RSCA1_HUMAN Regulatory solute carrier protein family 1 member 1 OS=Homo sapiens GN=RSC1A1 PE=2 SV=1  ali   7  162...................................................................................................................................................................................................................................................................KSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGN............. 300
45 -14.100sp|Q14157|UBP2L_HUMAN Ubiquitin-associated protein 2-like OS=Homo sapiens GN=UBAP2L PE=1 SV=2  ali   15  9..........................................................................................................................................................................................................................................................................................................................................RARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISDHNDADEEKVKQLIDIGKNQDECVIALHDCNGDVNRAINVLLEGN. 90
46 -13.600sp|P54727|RD23B_HUMAN UV excision repair protein RAD23 homolog B OS=Homo sapiens GN=RAD23B PE=1 SV=1  ali follow..  14  293......................................................................................................................................................................................................................................................................................................QQNPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQ---EKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQ.. 404
47 -13.600sp|Q6P158|DHX57_HUMAN Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens GN=DHX57 PE=1 SV=2  ali   24  165.................................................................................................................................................................................................................................................................................................................................................................EYAGLASVEPYVPEFTVSPFAVQKLSRYGFNTERCQAVLRMCDGDVGASLEHLLTQCF 222
48 -13.100sp|Q5THJ4|VP13D_HUMAN Vacuolar protein sorting-associated protein 13D OS=Homo sapiens GN=VPS13D PE=1 SV=1  ali   14  199...........................................................................................................................................................................................................................................................................................................................................AAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLELQLARLQELGFSMDDCRKALLACQGQLKKAASWLFKN.. 276
49 -12.700sp|Q9NZ09|UBAP1_HUMAN Ubiquitin-associated protein 1 OS=Homo sapiens GN=UBAP1 PE=1 SV=1  ali follow..  17  431.......................................................................................................................................................................................................................................................................................................................................................GQLCEKGFDPLLVEEALEMHQCSEEKMMEQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARA. 499
50 -12.500sp|Q9HCJ0|TNR6C_HUMAN Trinucleotide repeat-containing gene 6C protein OS=Homo sapiens GN=TNRC6C PE=1 SV=3  ali   13  68......................................................................................................................................................................................................................................................GEPSSPSTLVDNGTAAWGKPPSSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGGDEMNLSTSQWEDEEGDVWNNAASQESTSSCSSWGNAPKKGLQKGMKT--SGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKK. 229
51 -12.400sp|Q7Z6Z7|HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3  ali   17  232..............................................................................................................................................................................................................................................................................................................................................RGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDMGFTREHAMEALLNTST-MEQATE....... 300
52 -12.300sp|Q7KZI7|MARK2_HUMAN Serine/threonine-protein kinase MARK2 OS=Homo sapiens GN=MARK2 PE=1 SV=2  ali   13  5...............................................................................................................................................................................................................................................................................................................................................................NVGHEDDELKPYVEPLPDYKDPRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYK. 64
53 -12.300sp|Q7Z478|DHX29_HUMAN ATP-dependent RNA helicase DHX29 OS=Homo sapiens GN=DHX29 PE=1 SV=2  ali   11  19..........................................................................................................................................................................................................................................................................AVSASRAKSAEAGIAGEAQSKKPVSRPATAAAAAAGSREPRVKQGPKIYSFNSTNDSSGPANLDKSILKVVINNKLEQRIIGVINEHKKQNNDKGMISGRLTAKKLQDLMALQAFSFKTKDIEDAMTNTGGDLHSALDWLCDDAL 171
54 -12.200sp|A5PKW4|PSD1_HUMAN PH and SEC7 domain-containing protein 1 OS=Homo sapiens GN=PSD PE=2 SV=2  ali   14  125..............................................................................................................................................................................................................................................SLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKLYRLGFRKADVARHLG-KNNDFSVAGEYLK.... 296
55 -12.000sp|Q04323|UBXN1_HUMAN UBX domain-containing protein 1 OS=Homo sapiens GN=UBXN1 PE=1 SV=2  ali follow..  31  2.................................................................................................................................................................................................................................................................................................................................................................................AELTALESLIEMGFPRGRAEKALALTNQGIEAAMDWLMEHE. 43
56 -12.000sp|Q9H0K1|SIK2_HUMAN Serine/threonine-protein kinase SIK2 OS=Homo sapiens GN=SIK2 PE=1 SV=1  ali   13  1......................................................................................................................................................................................................................................................................................................................................................................................LRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERL 37
57 -12.000sp|Q9NRM7|LATS2_HUMAN Serine/threonine-protein kinase LATS2 OS=Homo sapiens GN=LATS2 PE=1 SV=2  ali   15  1..................................................................................................................................................................................................................................................................................................MRPKTFPATTYSGNSRGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMRATPKFGPYQKAANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSSIEAALEYISKMG. 140
58 -11.800sp|Q9NX55|HYPK_HUMAN Huntingtin-interacting protein K OS=Homo sapiens GN=HYPK PE=1 SV=1  ali follow..  12  1.........................................................................................................................................................................................................MTGFLLP----------------------------------ASRASRTGAERRCGPGPAPPPPRAEAVSVAGSRREVGLMRRRGEIDMATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMEMEISRAAAERSLREHMGNVVEALIALTN... 175
59 -11.500sp|O75113|N4BP1_HUMAN NEDD4-binding protein 1 OS=Homo sapiens GN=N4BP1 PE=1 SV=4  ali   20  1.........................................................................................................................................................................................................................................................................................................................................LENVQEGEILHDAKTLAGNVIADLSDSSADSENLSPDIKETTEEEYNILVTMGYSQEIVEKVIKVY-GPSTEPLLLLIEKE. 87
60 -11.400sp|O75152|ZC11A_HUMAN Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens GN=ZC3H11A PE=1 SV=3  ali   12  48.........................................................................................................................................................................................................................................................KPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLIEISGGKLEAEIDLDPGKDEDDLLLEL--SEMI 208
61 -11.300sp|O95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2  ali   17  22..............................................................................................................................................................................................................................................................................................................................................SSPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALPIVVQLMEMGFSRRNIEFALKSLTGGVEALVGWLLDHS. 106
62 -11.300sp|Q5T8P6|RBM26_HUMAN RNA-binding protein 26 OS=Homo sapiens GN=RBM26 PE=1 SV=3  ali   7  10................................................................................................................................................................................................................................................PRRDSYRDRYNRRRGRSRSYSRSRSRSWSKERLRERDRDRSRTRSRSRTRSRERDLVKPKYDLDRTDPLENNYTPVSSVPSISSGHYPVPTLSSTITVIAPTHHGNNTTESWSEFHEDQVDHNSYVRPPMPKKRCRDYDEKGF----------CMRGDMDHGSDPVVVEDV 173
63 -11.200sp|P98088|MUC5A_HUMAN(removed signalp:1-27) Mucin-5AC (Fragments) OS=Homo sapiens GN=MUC5AC PE=1 SV=3  ali   9  137.........................................................................................................................................................................................................................................................PPTSSTSSTPQTSKTSAATSSTTSGSGTTPSPVPTTSTASVSKTSTSHVSVSKTTHSQPVTRDCHPRCTWTKWFDVDFPSPGPHGGDKETYNNIIRSGEKICRRPEEITRLQCRAESHPEVSIEHLGQVVQC-----SREEGLVCRNQDQQGPFKMCLNYEV 293
64 -11.100sp|Q8NDT2|RB15B_HUMAN Putative RNA-binding protein 15B OS=Homo sapiens GN=RBM15B PE=1 SV=3  ali   11  21................................................................................................................................................................................................................................................KRPREREREAEAGGRRAAHKASGGAKHPVPARARDKPRGSGSGGGGHRDGRGTGDANHRASSGRSSGSGAGGGGRGGKASGDPGASGMSPRASPLPPPPPPPGAEPACPGSSAAAPEYKTLLISSLSPALPAEHLEDRLRFGFRHPQAREARQHALADRPLKVEPVYLRG. 221
65 -11.100sp|O95835|LATS1_HUMAN Serine/threonine-protein kinase LATS1 OS=Homo sapiens GN=LATS1 PE=1 SV=1  ali   15  11................................................................................................................................................................................................................................................................................................RQMRPKTFPASNYTVSSRQM--SKPSDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNSIEAAIEFISKMS. 142
66 -11.100sp|Q9H467|CUED2_HUMAN CUE domain-containing protein 2 OS=Homo sapiens GN=CUEDC2 PE=1 SV=1  ali follow..  15  84.....................................................................................................................................................................................................................................................................................................................SGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVTCSVEQAQWVLAKARGDLEEAVQMLVEGKE 187
67 -11.000sp|Q9P2N5|RBM27_HUMAN RNA-binding protein 27 OS=Homo sapiens GN=RBM27 PE=1 SV=2  ali   11  3........................................................................................................................................................................................................................................................NELYREKYDWRRGRSKSRSKSRGLSRSRSRSRGRSKDRDPNRNVEHRERSKFKSERNDLESSYVPVSAPPPNSSEQYSSGAQSIPSTVTVIAPAHHSENTTESWSNYYNNHSSSNSFGRNLPPKRRCRDYDERGF----------CVLGDLDHGNDPLVVDEV 158
68 -10.900sp|Q86UW6|N4BP2_HUMAN NEDD4-binding protein 2 OS=Homo sapiens GN=N4BP2 PE=1 SV=2  ali   19  7..........................................................................................................................................................................................................................................................................................................................................NLGGNPFRKTANPKEVVVSSVASREEPTTTLPSMGETKVDQEELFTSISEI-FDPDVVYLMLSECDFKVENAMDCLLE... 86
69 -10.900sp|P57059|SIK1_HUMAN Serine/threonine-protein kinase SIK1 OS=Homo sapiens GN=SIK1 PE=1 SV=2  ali   16  3................................................................................................................................................................................................................................................................................................................................................................................DYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERL 45
70 -10.900sp|P62995|TRA2B_HUMAN Transformer-2 protein homolog beta OS=Homo sapiens GN=TRA2B PE=1 SV=1  ali follow..  11  1.......................................................................................................................................................................................................................................................MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCSLYTTERDLREVFSRGFNVDDAKEAKERANGGRRIRVDFSITKR. 198
71 -10.800sp|Q9NWM3|CUED1_HUMAN CUE domain-containing protein 1 OS=Homo sapiens GN=CUEDC1 PE=1 SV=1  ali follow..  17  1....................................................................................................................................................................................................................................................................................................................................MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTM-FDYDIIECVLRANSGAVDATIDQLLQMN. 88
72 -10.700sp|Q96T37|RBM15_HUMAN Putative RNA-binding protein 15 OS=Homo sapiens GN=RBM15 PE=1 SV=2  ali   11  52................................................................................................................................................................................................................................................PVKAKRSRGGEDSTSRGERSKKLGGSGGSNGSSSGKTDSGGGSRRSLHLDKSSSRGGSREYDTGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGAEYKTLKISELGSQLSDEAVEDGLFHEFKREDARAAKHARGRDRPLKIEAVYVSR. 254
73 -10.700sp|Q13595|TRA2A_HUMAN Transformer-2 protein homolog alpha OS=Homo sapiens GN=TRA2A PE=1 SV=1  ali follow..  12  2........................................................................................................................................................................................................................................................SDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLYTTERDLREVFSRGFRIDDSKEAMERANGGRRIRVDYSITKR. 199
74 -10.600sp|Q68D10|SPT2_HUMAN Protein SPT2 homolog OS=Homo sapiens GN=SPTY2D1 PE=1 SV=3  ali   6  31................................................................................................................................................................................................................................................GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIRFGYDRKKYKDESDYALRYMESSWKEQQKEE. 202
75 -10.600sp|O95071|UBR5_HUMAN E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens GN=UBR5 PE=1 SV=2  ali   17  82.............................................................................................................................................................................................................................................................................GKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVEELAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRD. 227
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 3 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.