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Query: [A] KOG3013 Exosomal 3`-5` exoribonuclease complex, subunit Rrp4, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVTILKPEEFYVSSEADIVNDVSMTEMEDEIMEDEQMGLVDGEDVLEEFDKSIHQNLVTPGQLVTDDPQFMRGHGTYFEDGGIYASVAGSVQRVNKLISVKPLRSKYVPEIGDLIIGKIAEVQPKRWKVDIGAKQNAVLMLSSINLPGGIQRRKLETDELQMRSFFQEGDLLVAEVQQYFSDGSVSIHTRSLKYGKLRNGVFLKVPPALVVRSKSHAYALAGGVDIILSVNGYVWVSKHNENQHSSVSITRLEEEASESIYSNENDEIDGYTRLNISRVSICIKGLASRSLPLTQASITNFYESSLVFSNLQDLTVPKNMDQIAMEAMQLast
1 -94.000sp|Q13868|EXOS2_HUMAN Exosome complex exonuclease RRP4 OS=Homo sapiens GN=EXOSC2 PE=1 SV=2  ali follow..  45  10........................................ARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEP-----------VSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPH-QIKDILKPEIMEEIVMETRQ 286
2 -59.200sp|Q9NQT5|EXOS3_HUMAN Exosome complex exonuclease RRP40 OS=Homo sapiens GN=EXOSC3 PE=1 SV=3  ali follow..  16  1..............................MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLSRVRVVCGPGLRRCGDRLLVTKCGRLRHKGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYL-----------SFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRAGQDGLLFKVTLGLIRKLLAPDCEILYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMT----------SDQRKQIFSRLAES............................................... 275
3 -53.500sp|Q9Y3B2|EXOS1_HUMAN 3`-5` exoribonuclease CSL4 homolog OS=Homo sapiens GN=EXOSC1 PE=1 SV=1  ali follow..  19  2...................................................APPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSEVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSYLLTTAENELGVVVAHSESGIQ--MVPISWCEMQCPKTH.......................................................................................................... 178
4 -11.400sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   14  81.............................................................................................................CEGMRILGCVKEVNELELVISLPNGLQGFVQVTEICLNEQVTQEQPLKDLLHLPELFSPGMLVRCVVSSLGITKSVKLSLNPKSAEALKPGMLLTGTVSSLED----------GYLVDIGVDG--------------TRAFLPLLKAQEYIRQKNKGAKLKVGQYLNCIVEKVKGNGGVVSLSVGHSEVSTAIATEQQSWNLNNLLPGLVVKAQVQKVTP 293
5 -11.100sp|Q9Y535|RPC8_HUMAN DNA-directed RNA polymerase III subunit RPC8 OS=Homo sapiens GN=POLR3H PE=1 SV=1  ali follow..  15  8.....................................................VDTVRIPPWQFERKNKVVYNVGLCICLFDITKLEDAYVFPGDGASHVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKKEAPYTLVGSISE---------------GLLWWTSN.......................................................................................... 204
6 -10.900sp|P62487|RPB7_HUMAN DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens GN=POLR2G PE=1 SV=1  ali follow..  11  6...................................................SLEHEILLHPRYFGPNGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNP--KTMDEDIVIQQDDEIRLKIVGTKNDIFAIGSLMDDYLGLVS................................................................................................................................... 172
7 -10.900sp|Q8N5C6|SRBD1_HUMAN S1 RNA-binding domain-containing protein 1 OS=Homo sapiens GN=SRBD1 PE=1 SV=2  ali   15  167.............................................................................................................QIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVT-------AKLSKTKKRRSLGLGPGERVEVQVLNIDPRSRITLDLIR.......................................................................................................................................... 243
8 -10.400sp|Q96N46|TTC14_HUMAN Tetratricopeptide repeat protein 14 OS=Homo sapiens GN=TTC14 PE=1 SV=1  ali   15  124.............................................................................................................ERGDIVIGRISSIREFGFFMVLICLGSGIIAHLEITALCPLRDVPSHSNHGDPLSYYQTGDIIRAGIKDIDYHEKLAVSLYSSS........................................................................................................................................ 211
9 -10.200sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   13  1......PSKERMLLSFKLSSDPEPKKEPAGHSQKKGKAINIGQLVDVKVLEKTKDGLFLPTSHLSDHVANGPLLHHWLQAGDILHRVLGRVLLCRKPALVSTVEGGQDPKPGMLLIGFVKSIKDYGVFIQFPSGLSGLAPKAIMS----------DKFVTSTSDHFVEGQTVAAKVTNVDEKQRMLLSLRLSD........................................................................................................................................ 201
10 -9.430sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   13  1.............................................................................................................EPGAVVKGTVLTIKSYGMLVKVGEQMRGLVPPMHLA----------DILMKNPEKKYHIGDEVKCRVLLCDEAKKLMMTLKKTKPGLQTHGFIIRVKDYGC-------------VKFYNNVQGLV............................................................................................... 119
11 -9.420sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   14  12..........................................SSKTLLCLSLTGPHKLEEGEVAGRVVKVTPNEGLTVS---FPFGKIGILSTADNVLTLSLRSSRTNPEEGQLLRGYVGSIQPHGVFFRLGPSVVGLARYSHVS--------HSPSKKALYNKHLPEGKLLTARVLRLNQKNLVELSFLPGDTGK..................................................................................................................................... 202
12 -9.070sp|P05198|IF2A_HUMAN Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens GN=EIF2S1 PE=1 SV=3  ali follow..  11  10........................................................................................................QHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNEGMILLSELS----------RRRIRSINKLIRIGRNECVVVIRVDKEKGIDLSKRR.......................................................................................................................................... 89
13 -9.040sp|Q14690|RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3  ali   13  97...........................................SHLSDSKNVFNPEAFKPGNTHKCR-------DYSQMDELALLSLRTSIIEAQYLRYHD--------EPGAVVKGTVLTIKSYGMLVKVGEQMRGLVPPMHLA----------DILMKNPEKKYHIGDEVKCRVLLCDEAKKLMMTLKKTKPGLQTHGFIIRVKDYGC-------------VKFYNNVQGLV............................................................................................... 269
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 0   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.