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Query: [R] KOG3518 Putative guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLGLast
1 -68.300sp|Q86VW2|ARHGP_HUMAN Rho guanine nucleotide exchange factor 25 OS=Homo sapiens GN=ARHGEF25 PE=1 SV=2  ali follow..  22  131..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM-AAQGVPEGRDRIVFGNIQQIYEWHRDFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGD-----SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYDTADLEQAVEVMCFVPKRCNDMMTLGRLRG------------FEGKLTAQGKLLGQDTFWVSRGRERRVFLFEQIIIFSEALGGPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGQRYVLQAADPAISQAWIKHVAQILESQRDF-LNALQSPIEYQRRESQTNSLG 492
2 -64.100sp|Q9ULL1|PKHG1_HUMAN Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2  ali   40  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIRAKNERTLFLFDKLLLITKKRD-DTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAIPAKAKQAILEMDAIHHP..... 290
3 -58.900sp|Q9H7P9|PKHG2_HUMAN Pleckstrin homology domain-containing family G member 2 OS=Homo sapiens GN=PLEKHG2 PE=1 SV=3  ali   38  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NIEDIYEFSSELLEDLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGLRGGERLLFLFSRMLLVAKRRG-LEYTYKGHIFCCNLSVSESPRDPLGFKVSDL-TIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPIPAKAKQVLLENSLHCAPKSK.. 288
4 -57.700sp|A1L390|PKHG3_HUMAN Pleckstrin homology domain-containing family G member 3 OS=Homo sapiens GN=PLEKHG3 PE=1 SV=1  ali   36  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRVRVRNERTFFLFDKTLLITKKRG-DHFVYKGNIPCSSLMLIESTRDSLCFTVTHY-KHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHIPQKAKEAILEMDSYYPNRYR.. 271
5 -57.300sp|O75962|TRIO_HUMAN Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2  ali   22  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALM-KEDGVPDGKDKIVFGNIHQIYDWHRDFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSE-----YIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSDTSELERAVEVMCIVPRRCNDMMNVGRLQG------------FDGKIVAQGKLLLQDTFLVPRCRERRIFLFEQIVIFSEPLDKPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFI............................................... 300
6 -56.900sp|Q5VST9|OBSCN_HUMAN Obscurin OS=Homo sapiens GN=OBSCN PE=1 SV=3  ali   21  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LLSSEQAFVEELQFLQSHHLQHLERCPHVPIGQKAVIFRNVRDIGRFHSSFLQELQQC-DTDDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTAIQ----EFYKKYAEEQPPPPPLQHYLEQPVERVQRYQALLKELIRNKNCALLEQAYAVVSALPQRAENKLHVSLMEN------------YPGTLQALGEPIRQGHFIVWKGHNRHVFLFRNHLVICKPRRDSSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQEREDSRKYLLQARTAIIKSSWVKEIC............................... 300
7 -56.500sp|O60229|KALRN_HUMAN(removed signalp:1-25) Kalirin OS=Homo sapiens GN=KALRN PE=1 SV=2  ali   23  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GNIHQIYDWHKDFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY------DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKSDIEKAVELMCLVPKRCNDMMNLGRLQG------------FEGTLTAQGKLLQQDTFYVSRTKERRVFLFEQIVIFSELLRKPGYMFKRSIKMNYLVLEENVDNDPCKFALMN-RETSERVVLQAANADIQQAWVQDINQVLETQRDF-LNALQSPIEYQRKERSTAVMR 276
8 -56.200sp|Q58EX7|PKHG4_HUMAN Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1  ali   22  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LEYTMENYFPEL-DRPDVPQGQRAHLFGNLEKLRDFHCHFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSS-----YGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACELSALREAQSLVHFQLRHGNDLLAMDAIQG------------CDVNLKEQGQLVRQDEFVVRHKSVRRIFLFEELLLFSKPRHGDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMVSMGVGNK........ 299
9 -55.300sp|Q8TER5|ARH40_HUMAN Rho guanine nucleotide exchange factor 40 OS=Homo sapiens GN=ARHGEF40 PE=1 SV=3  ali   14  3...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPE----RGTWAAALSARERLRSFHRTFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAA---------LSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAECRALGAAVQLLREQEARGRDLLAVEAVRG------------CEIDLKEQGQLLHRDPFTVRKKCLRHVFLFEHLLLFSKLKGPEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAR................................................... 297
10 -55.200sp|O15068|MCF2L_HUMAN Guanine nucleotide exchange factor DBS OS=Homo sapiens GN=MCF2L PE=1 SV=2  ali   23  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHHNKKDVLFGNMEEIYHFHNRFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREEPSYSYKQSLNMAAVG......................................................................... 300
11 -54.900sp|A1L390|PKHG3_HUMAN Pleckstrin homology domain-containing family G member 3 OS=Homo sapiens GN=PLEKHG3 PE=1 SV=1  ali   32  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPNSNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVEDYLLKIIDTPGLKPEQVSALFGNIENIYALNSQLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTY.......................................................................................................................... 300
12 -54.300sp|Q9ULL1|PKHG1_HUMAN Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2  ali   29  2................................................................................................................................................................................................................................................................................................................................................................................................................................................ELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLGYDVVLDAIDTMQRVAWHINDMKRKHEHA............................................................................................................................................... 300
13 -53.800sp|Q86YR7|MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 OS=Homo sapiens GN=MCF2L2 PE=2 SV=3  ali   21  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHQNNKDFLFGNIRELYEFHNRFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCA----YFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEELQQALAVIEDLIKSCELAVDLAAVTE------------CPDDIGKLGKLLLHGPFSVFKPSQRQIYLFERGIVFCKIRMEPHYSFK.................................................................................. 300
14 -53.600sp|P10911|MCF2_HUMAN Proto-oncogene DBL OS=Homo sapiens GN=MCF2 PE=1 SV=3  ali   23  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDRNKKDILFGNMAEIYEFHNDFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECA----FFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVEGSDRY................................................................................... 299
15 -53.600sp|O75962|TRIO_HUMAN Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2  ali   23  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HNNFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-----SYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGEIKDGLEVMLSVPKRANDAMHLSMLEG------------FDENIESQGELILQESFQVRKGRERHLFLFEMSLVFSKEVKDSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPAT.... 264
16 -53.000sp|Q96PX9|PKH4B_HUMAN Pleckstrin homology domain-containing family G member 4B OS=Homo sapiens GN=PLEKHG4B PE=2 SV=4  ali   21  7...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VTSTVATEKKLPLWQHARSPPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEM-ERMDLPQGKHHVIFGNLEKLHDFHQQFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSS-----HGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEAELGELRAAEVVVCFQLRHGNDLLAMDAIRG------------CDVNLKEQGQLRCRDEFIVRKKYLRHVFLFEDLILFSKTQKVDVYLYKQSF............................................................................... 300
17 -52.900sp|O43307|ARHG9_HUMAN Rho guanine nucleotide exchange factor 9 OS=Homo sapiens GN=ARHGEF9 PE=1 SV=3  ali follow..  23  76....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQIDIAIDGFLLTPVQKICKYPLQLAELLKYTDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDSSELIYTGEMAWGRNQQRVFFLFDHQMVLCKKDRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEI............... 437
18 -52.800sp|O60229|KALRN_HUMAN(removed signalp:1-25) Kalirin OS=Homo sapiens GN=KALRN PE=1 SV=2  ali   22  10.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEIPPNKEHIIFGNIQEIYDFHNNFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGELKDGLEVMLSVPKKANDAMHVSMLEG------------FDENLDVQGELILQDAFQVRKGRERHLFLFEISLVFSKEIKDTKYVYKNK................................................................................ 300
19 -52.800sp|Q9H7P9|PKHG2_HUMAN Pleckstrin homology domain-containing family G member 2 OS=Homo sapiens GN=PLEKHG2 PE=1 SV=3  ali   38  57..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TVGSEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGVEQVGTLFANIEDIYEFSSELLEDLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL..................................................................................................................................... 300
20 -50.000sp|Q13009|TIAM1_HUMAN T-lymphoma invasion and metastasis-inducing protein 1 OS=Homo sapiens GN=TIAM1 PE=1 SV=2  ali   24  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFLIAEQTGEKKEVADLSMGDLLLHTTVIWKKEPELAAFVFKTAVVLVYKDDWDPFRFRHMIPTEALQVRALASADA................................................................ 300
21 -49.500sp|Q14155|ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 OS=Homo sapiens GN=ARHGEF7 PE=1 SV=2  ali   19  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSE--ELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQEKNERYLLLFPNVLLMLSASRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPS...... 299
22 -49.000sp|P15498|VAV_HUMAN Proto-oncogene vav OS=Homo sapiens GN=VAV1 PE=1 SV=4  ali   20  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR---LKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGNLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREVQMKLEECSQRNNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENL-DQSLAHYGRPKIDGELKIRSKMDRYAFLLDKALLICKR-RGDSYDLKDFVNLH............................................................................ 300
23 -47.900sp|Q70Z35|PREX2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Homo sapiens GN=PREX2 PE=2 SV=1  ali   24  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAVTEETVKMLFSNIEDILAVHKEFLKVVEECLHAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGTDVPLEGYLVTPIQRICKYPLILKELLKRTDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIDTCTEMLMCGVLLKISSQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI.................................................................... 300
24 -47.800sp|O75962|TRIO_HUMAN Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2  ali   21  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEIPPNKELIIFGNMQEIYEFHNNFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILE-----HAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGEIKDGLEVMLSVPKRANDAMHLSMLEG------------FDENIESQGELILQESFQVWDPKT.......................................................................................................... 299
25 -47.700sp|O60229|KALRN_HUMAN(removed signalp:1-25) Kalirin OS=Homo sapiens GN=KALRN PE=1 SV=2  ali   21  58..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRI-EEKGVPEGKDKIVFGNIHQIYDWHKDFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY------DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSECSDIEKAVELMCLVPKRCNDMMNLGRLQG------------FEGTLTAQGKLLQQ.................................................................................................................... 300
26 -47.500sp|Q58EX7|PKHG4_HUMAN Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1  ali   21  7..........................................................................................................................................................................................................................................................................................................................................................................................................................................................RKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPAASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR-PDVPQGQRAHLFGNLEKLRDFHCHFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-----TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACELSALREAQSLVH............................................................................................................................................................... 299
27 -47.300sp|Q7Z628|ARHG8_HUMAN Neuroepithelial cell-transforming gene 1 protein OS=Homo sapiens GN=NET1 PE=1 SV=1  ali follow..  17  35....................................................................................................................................................................................................................................................................................................................................................................................................................TSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP-EQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRSYQVYRQPIPVQELVLEDLQDGAKNIFRIRFHPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEG.... 524
28 -46.900sp|Q9NR80|ARHG4_HUMAN Rho guanine nucleotide exchange factor 4 OS=Homo sapiens GN=ARHGEF4 PE=1 SV=3  ali   26  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KHLRDICEGYVRQCRKRADFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKIDISLDGFLLTPVQKICKYPLQLAELLKYTDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLVRSSELIYSGELTRAKSQQRMFFLFDHQLIYCKKDRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVLHRGATGDSHLLCTRKPEQKQRWLKA................................. 300
29 -45.900sp|Q8N4T4|CI100_HUMAN Vav-like protein C9orf100 OS=Homo sapiens GN=C9orf100 PE=2 SV=1  ali follow..  18  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGC-----WGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKNKGFRRFVRLQEGRPEGGLQLQDLLPLPLQRLQQYENLVVALAENTDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVGEPRPRMFFLFTDVLLMAKPRRSGTFACKALYPMAQCHLSRVFGHSGGPCGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN....................... 335
30 -45.900sp|Q8TCU6|PREX1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein OS=Homo sapiens GN=PREX1 PE=1 SV=3  ali   26  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVALTEENVKVLFSNIEDILEVHKDFLAALEYCLHSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKIPLEGYLLSPIQRICKYPLLLKELAKRTDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICQLLLQGTLLKISAQERAFFLFDNLLVY.............................................................................................. 300
31 -45.400sp|Q15052|ARHG6_HUMAN Rho guanine nucleotide exchange factor 6 OS=Homo sapiens GN=ARHGEF6 PE=1 SV=2  ali   17  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QALEECSKFPENQHKVGGCLLSLMPHFKMYLAYCANHPSAVNVLTQHSD--ELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMDHQDILKAIVAFKTLMGQCQDLRKRKQL--ELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQEKEERYLMLFSNVLIMLSASRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSS... 272
32 -45.100sp|P52735|VAV2_HUMAN Guanine nucleotide exchange factor VAV2 OS=Homo sapiens GN=VAV2 PE=1 SV=2  ali   21  27..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---LSPADMAAVFINLEDLIKVHHSFLRAIDVVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRDFRQKVEECTLKVQGKFKLQDLLVVPMQRVLKYHLLLKELLSHSERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENL-QVKLEEFGRPKIDGELKVHTKQDRYLFLFDKVVIVCKR-KGYSYELKEII............................................................................... 300
33 -44.700sp|Q9UKW4|VAV3_HUMAN Guanine nucleotide exchange factor VAV3 OS=Homo sapiens GN=VAV3 PE=1 SV=1  ali   21  4.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR---LTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEVKLKLEECSKRANGKFTLRDLLVVPMQRVLKYHLLLQELVKHTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENL-NQPVLLFGRPQGDGEIRIHTKQERHIFLFDLAVIVCKR-KGDNYEMKEIIDLQQY.......................................................................... 300
34 -44.300sp|Q13009|TIAM1_HUMAN T-lymphoma invasion and metastasis-inducing protein 1 OS=Homo sapiens GN=TIAM1 PE=1 SV=2  ali   30  113....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL................................................................................................................................................................................... 300
35 -44.000sp|O60229|KALRN_HUMAN(removed signalp:1-25) Kalirin OS=Homo sapiens GN=KALRN PE=1 SV=2  ali   23  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CKNKPDSNQLILEHAG-----TFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGELKDGLEVMLSVPKKANDAMHVSMLEG------------FDENLDVQGELILQDAFQVRKGRERHLFLFEISLVFSKEIKDTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQR... 229
36 -43.600sp|Q8IVF5|TIAM2_HUMAN T-lymphoma invasion and metastasis-inducing protein 2 OS=Homo sapiens GN=TIAM2 PE=2 SV=4  ali   24  30............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFL.......................................................................................................... 289
37 -43.500sp|Q96PX9|PKH4B_HUMAN Pleckstrin homology domain-containing family G member 4B OS=Homo sapiens GN=PLEKHG4B PE=2 SV=4  ali   20  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPQSDALLSSHGN-----AFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEAELGELRAAEVVVCFQLRHGNDLLAMDAIRG------------CDVNLKEQGQLRCRDEFIVRKKYLRHVFLFEDLILFSKTQKVDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKDTYILQASSAEVKSAWTDVIGRILWRQALRELRIQEMA.............. 219
38 -43.300sp|Q5VST9|OBSCN_HUMAN Obscurin OS=Homo sapiens GN=OBSCN PE=1 SV=3  ali   22  117.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLSPEWGAAEAPEFPGEAVSEDEYKARLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPAGQKAVIFRNVRDIGRFHSSFLQELQQCDTDD-DVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTAIQEFYKKYAEEALPSQPPPPPLQHYLEQPVERVQRYQALLKELIRN............................................................................................................................................................................. 299
39 -43.100sp|Q6XZF7|DNMBP_HUMAN Dynamin-binding protein OS=Homo sapiens GN=DNMBP PE=1 SV=1  ali   19  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QLREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQ-VPNIDFEGLFGNMQMVIKVSKQLLAALEIS----DAVGPVFLGHRDELETYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKNYINLGSFLIKPVQRVMRYPLLLMELLNSTDKVPLTNAVLAVKEINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRV---SSHLKHLTGFAPQIKDEVFEE--EKNFRMQERLIKSFIRD...................................................................... 293
40 -42.500sp|A1IGU5|ARH37_HUMAN Rho guanine nucleotide exchange factor 37 OS=Homo sapiens GN=ARHGEF37 PE=2 SV=2  ali   18  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQ---LPQGDLDVLFSNIDDIIKVNSRFLHDLQETASQVQLVGNIFLEFQEELQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQSGLSFLLVIPLQRITRYPLLLQKILENTAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINTHTKTTRLSQLLKQEIPRTEDKEFDDLEERFQWVKNNVAAYLDNLQ.............................................................................. 298
41 -42.400sp|Q6ZNL6|FGD5_HUMAN FYVE, RhoGEF and PH domain-containing protein 5 OS=Homo sapiens GN=FGD5 PE=1 SV=3  ali   18  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSSEKAYVEMLQHLNLDFHGAVMRALDLAREELRQGLSELPAIHDLHQGILEELEERLESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCHSPRLAAAVREFEQSVQGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGD--LQPGREFLKEGTLMKKNRRPRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKPYALKI---ETSESCLMLSASSCAERDEWYG.................................. 300
42 -42.300sp|O75962|TRIO_HUMAN Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2  ali   23  143.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKE-DGVPDGKDKIVFGNIHQIYDWHRDFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYID-----TFFEDLKQRLGHRLQLTDLLIKP.............................................................................................................................................................................................. 300
43 -42.000sp|Q96N96|SPT13_HUMAN Spermatogenesis-associated protein 13 OS=Homo sapiens GN=SPATA13 PE=2 SV=1  ali   26  57..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKESEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDI............................................................................................................................. 299
44 -41.600sp|Q5JSP0|FGD3_HUMAN FYVE, RhoGEF and PH domain-containing protein 3 OS=Homo sapiens GN=FGD3 PE=1 SV=1  ali   19  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTD-AGIPPEVIMGIFSNISSIHRFHGQFLPELKTRITTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQSPLFKDVVHSIQKQEVGNLTLQHHMLEPVQRVPRYELLLKDYLKRLDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEED--VNPANELIKEGQIQKGTPQDRHLFLFNSMILYCVPKMGQKFSVREKMDISGLQVQDIVKPNAHTFII---TGRKRSLELQ.............................................. 300
45 -41.100sp|Q96PE2|ARHGH_HUMAN Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1  ali   19  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQT-QKVGALLVQSFSKVNIYSAYIDNFLNAKDAVRVAKEARAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMQAPLRRFLRQEMVIEGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASK................................................................. 296
46 -41.100sp|P10911|MCF2_HUMAN Proto-oncogene DBL OS=Homo sapiens GN=MCF2 PE=1 SV=3  ali   21  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWKKGATKMKDARFKPMQRHLFLYEKAIVFCKRRVEPSYSFKHCWKMDEVGITEYVKGDNRKFEIWY-GEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELVKKRKQQ............... 223
47 -41.100sp|Q9NR81|ARHG3_HUMAN Rho guanine nucleotide exchange factor 3 OS=Homo sapiens GN=ARHGEF3 PE=2 SV=1  ali follow..  18  54...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP-EHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLES--RKLDLWNFLDIPRSRLVKYPLLLREILRHTDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNYQLYRQPIPVKDLLLEDLQDGIKNFFRVSFKNGSQQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSE............ 464
48 -40.700sp|Q9HCE6|ARGAL_HUMAN Rho guanine nucleotide exchange factor 10-like protein OS=Homo sapiens GN=ARHGEF10L PE=1 SV=3  ali   22  7......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPLSARKCQVVFFRVKEILHCHSMFQIALSSRVAETEKIGDLFVASFSKLDVYSDYVNNFTSAMSIIKKACLTKAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNTSGQRQLLLCETLTLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVK...................................................................... 300
49 -40.400sp|Q96N96|SPT13_HUMAN Spermatogenesis-associated protein 13 OS=Homo sapiens GN=SPATA13 PE=2 SV=1  ali   23  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQIDIAIDGFLLTPVQKICKYPLQLAELLKYTDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDIDRSSELIHSGELTKGKSQQRTFFLFDHQLVSCKKDRRDMLYYKGRLDMDEMELVDLGDGRDKDFKL-VSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEISENQKKLAMLNAQKAGHGKSKG 295
50 -39.700sp|O15068|MCF2L_HUMAN Guanine nucleotide exchange factor DBS OS=Homo sapiens GN=MCF2L PE=1 SV=2  ali   23  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSGAEDLQEALSSILGILKAVNDSMHLIAITG------------YDGNLGDLGKLLMQGSFSVFKPMQRHLFLHEKAVLFCKKREEPSYSYKQSLNMAAVGITENVKGDAKKFEIWY-NAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQ................ 206
51 -39.400sp|Q8IVF5|TIAM2_HUMAN T-lymphoma invasion and metastasis-inducing protein 2 OS=Homo sapiens GN=TIAM2 PE=2 SV=4  ali   19  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDVAEQSGTEKEVTELSMGELLMHSTVSWRKDLELTVFVFKRAVILVYKEDLDPFKFRWLIPISALQVRLGNPAGTENNSIWEEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDR....... 275
52 -39.300sp|Q7Z6J4|FGD2_HUMAN FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens GN=FGD2 PE=2 SV=1  ali   22  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FSNISSIYQFHSQFLPELQRRLDD-PRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDSPLFQEVLTRIQSSEAGSLTLQHHMLEPVQRIPRYELLLKEYIQKLDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDD--VDPSNTLLREGPVLKNDPMERYLFLFNNMLLYCVPRVGAQFQVRTRIDVAGMKVRELMDAEPHSFLV---SGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAGDIQEQELQSEELG 299
53 -39.100sp|Q15052|ARHG6_HUMAN Rho guanine nucleotide exchange factor 6 OS=Homo sapiens GN=ARHGEF6 PE=1 SV=2  ali   22  69.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPHKVGGCLLSLMPHFSMYLAYCANHPSAVNVLTQHSD--ELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMDHQDILKAIVAFKTLMGQCQDLRKRKQL--ELQILSEPIQAWEGEDIKNLGNV....................................................................................................................... 300
54 -38.800sp|Q07889|SOS1_HUMAN Son of sevenless homolog 1 OS=Homo sapiens GN=SOS1 PE=1 SV=1  ali   18  8.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKFSANDVENIFSRIVDIHELSVKLLGHIEDTVEPHPLVGSCFEDLAEAFDPYESYARDILRPGFHDRSQLSKPGAALYLQSIGEGFKEQYVLPRLLLAPVYHCLHYFELLKQLEEKSDKECLKQAITALLNVQSGMEKIKGKQLAIKKMNEIQKNIDGWEGKDIQCCNEFIMEGTL................................................................................................................. 300
55 -38.700sp|Q07890|SOS2_HUMAN Son of sevenless homolog 2 OS=Homo sapiens GN=SOS2 PE=1 SV=2  ali   21  28...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLKPSDIEKIFSNISDIHELTVKLLGLIEDTVEPHPLAGSCFEDLAEAFDPYETLSQDSPEFHEHFNKLMARPAVALHFQSIADGFKERYVLPRLMLVPVYHCWHYFELLKQLKACSDRECLNQAITALMNLQGSMDRIRSKHLAIKKMNEIQKNIDGWEGKDIQCCNEFIMEGPLTR............................................................................................................... 300
56 -38.700sp|O94887|FARP2_HUMAN FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Homo sapiens GN=FARP2 PE=1 SV=3  ali   19  24..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKSPQPSPSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIEN................................................................................................................................ 298
57 -38.500sp|Q14155|ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 OS=Homo sapiens GN=ARHGEF7 PE=1 SV=2  ali   23  92..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSE--ELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMDRQDIQKSMAAFKNLSAQCQE....................................................................................................................................................... 300
58 -38.500sp|Q6ZV73|FGD6_HUMAN FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens GN=FGD6 PE=1 SV=2  ali   19  8..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKNPGFAAVVREFEMSPRANLALKHYLLKPVQRIPQYRLLLTDYLKNLDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHE--VQPGRVFLKEGILMKKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAQNELKI---ESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPS............... 295
59 -38.400sp|P11274|BCR_HUMAN Breakpoint cluster region protein OS=Homo sapiens GN=BCR PE=1 SV=2  ali   18  4...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKP--TSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANQFAEISENLRARSNKKNSLETLLYKPVDRVTRSTLVLHDLLKHTDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHR-------QLLKDSFMV---ELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ................................................................................. 300
60 -38.300sp|Q9Y4F1|FARP1_HUMAN FERM, RhoGEF and pleckstrin domain-containing protein 1 OS=Homo sapiens GN=FARP1 PE=1 SV=1  ali   17  44.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLADYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHDFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGI.................................................................................................................................. 300
61 -38.200sp|Q86YR7|MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 OS=Homo sapiens GN=MCF2L2 PE=2 SV=3  ali   18  6..............................................................................................................................................................................................................................................................................................................................................................................................................................QSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHQNNKDFLFGNIRELYEFHNRFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCA----YFGVCQRQLDHNLPL..................................................................................................................................................................................................... 298
62 -38.000sp|Q9NR80|ARHG4_HUMAN Rho guanine nucleotide exchange factor 4 OS=Homo sapiens GN=ARHGEF4 PE=1 SV=3  ali   22  103................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQH........................................................................................................................................................................ 295
63 -37.500sp|Q7Z6J4|FGD2_HUMAN FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens GN=FGD2 PE=2 SV=1  ali   17  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................KGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARFPEDVVRVIFSNISSIYQFHSQFLPELQRRLDD-PRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSLFQEVLTRIQSS--GSLTLQHHMLEPVQRIPRYELLLKEYIQKLDQADAQKALDMIFSAAQHSNAAITEMERLQDL............................................................................................................................................ 300
64 -37.300sp|Q8TER5|ARH40_HUMAN Rho guanine nucleotide exchange factor 40 OS=Homo sapiens GN=ARHGEF40 PE=1 SV=3  ali   15  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RALQQPLEQLTRYGRLLEELLREAGPEALGAAVQLLREQEARGRDLLAVEAVRG------------CEIDLKEQGQLLHRDPFTVRKKCLRHVFLFEHLLLFSKLKGPEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAH-NKELRVQQMVSMGIGNK.... 194
65 -36.800sp|Q008S8|ECT2L_HUMAN Epithelial cell-transforming sequence 2 oncogene-like OS=Homo sapiens GN=ECT2L PE=2 SV=2  ali   19  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIAFRTFLKRHDKT--KMLSLPELLLYPSRRFEEYLNLLYAVRLHTDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPT--SEVNRYLIRVQDVAQEHIHDLSLFLFNDALLVSSRGTSTTYQFIASVALHRLLIENIPDSKYVKFIL---QGPKYKWICATEIEDDKFLWLSVLRNAI............................ 298
66 -36.800sp|P98174|FGD1_HUMAN FYVE, RhoGEF and PH domain-containing protein 1 OS=Homo sapiens GN=FGD1 PE=1 SV=2  ali   18  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARFPADVVHGIFSNICSIYCFHQQFLPELEKRMEE-PRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTESTQFKVIIHEVQKE--GNLTLQHHMLEPVQRIPRYELLLKDYLLKLDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEED--VSPTKELIKEGHILK............................................................................................................... 299
67 -36.000sp|Q96M96|FGD4_HUMAN FYVE, RhoGEF and PH domain-containing protein 4 OS=Homo sapiens GN=FGD4 PE=1 SV=2  ali   20  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANFPAEMVNKIFSNISSINAFHSKFLPELEKRMQE-PRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTEIPQFKSVVEEIQKQ--GSLTLQHHMLEPVQRIPRYEMLLKDYLRKLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEED--VNPSNELIKEGQILKTSAQERYLFLFNNM................................................................................................. 300
68 -36.000sp|Q86YR7|MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 OS=Homo sapiens GN=MCF2L2 PE=2 SV=3  ali   16  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YLKGPSQRLIKYQMLLKGLLDFESPEELQQALAVIEDLIKSCELAVDLAAVTE------------CPDDIGKLGKLLLHGPFSVFKPSQRQIYLFERGIVFCKIRMEPHYSFKKTMKLMTLSIRQLGRGSHRKFEIAS-RNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQFEMSTSKGSGAGSG 231
69 -35.800sp|Q13972|RGRF1_HUMAN Ras-specific guanine nucleotide-releasing factor 1 OS=Homo sapiens GN=RASGRF1 PE=1 SV=1  ali   12  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................ETEKTVAKQLRQQIEDGEIEIERLKAEITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASITHDDVSSIFLNSETIMFLHQIFYQGLKARISSTLVLADLLDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKHYEAKPDEERTLETFLTYPMFQIPRYILTLHDVLAHTERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMI..................................................................................................................................... 293
70 -35.800sp|Q96DR7|ARHGQ_HUMAN Rho guanine nucleotide exchange factor 26 OS=Homo sapiens GN=ARHGEF26 PE=1 SV=4  ali   20  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARHQN-DDISDIVEKHTASFDPYVKYCTNEVYQQRTLQKLLATNSFKEVLSRIESH--RNLPMISFLILPMQRVTRLPLLMDTICQKTKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKP-VSSSRWLVKRGELTATSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEE-----LNSSPGKNSSTMLYSRQSSASHLFTLTV................................ 299
71 -35.700sp|A8MVX0|ARG33_HUMAN Rho guanine nucleotide exchange factor 33 OS=Homo sapiens GN=ARHGEF33 PE=3 SV=2  ali   11  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................VLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKQGVLGDLFLKLTNDLDYYVAYLRDLPECISLV----------HVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTDYYLLLVCVQRLRVFISHYTLLFQCNED................................................................................................................................................ 296
72 -35.600sp|Q12979|ABR_HUMAN Active breakpoint cluster region-related protein OS=Homo sapiens GN=ABR PE=1 SV=1  ali   14  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKP--TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNQFQKISEELKVKGPTSVTMEALLYKPIDRVTRSTLVLHDLLKHTDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGET....................................................................................................................................... 299
73 -35.600sp|O75962|TRIO_HUMAN Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2  ali   17  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VQRIMKYQLLLKDFLKYSKKSELERAVEVMCIVPRRCNDMMNVGRLQG------------FDGKIVAQGKLLLQDTFLVPRCRERRIFLFEQIVIFSEPLDKPGFLFKNSIKVSCLCLEENVENDPCKFALTSRGDVVETFILHSSSPSVRQTWIHEINQILENQRNF-LNALTSPIEYQRNHSGGGG.. 195
74 -35.600sp|O15013|ARHGA_HUMAN Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4  ali   19  5...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSE-EMIGDVFVASFSKLDAYSEYVNNFSTAVAVLKKTCATKAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGYLIRSDDMIIVKTKERRVFMLNDVLMCATVSSRQRYLLKWSVPLGHVDAIEYGSSGTGEHSRHLAVHPPESLAVVANAKPNKVMGPGQL................................ 299
75 -35.400sp|O14827|RGRF2_HUMAN Ras-specific guanine nucleotide-releasing factor 2 OS=Homo sapiens GN=RASGRF2 PE=1 SV=2  ali   16  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LHEIFHQGLKARIANTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPAEGRMLETFLTYPMFQIPRYIITLHELLAHTERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQKKEGERQCFLFTKHFLICTRSKLHLLKTGGVLSLIDCTLIEEPDASDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGL.................... 295
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.