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Query: [T] KOG2980 Integral membrane protease of the rhomboid family involved in different forms of regulated intramembrane proteolysis, from COG1018

Results of FFAS03 search in HGM_OVER
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSGVSSVMLGLRPATRIFFRSNISVSPSRTFVSYIGRSQSTSILKNAPNLEDNVTNLQKIIPKRFFSQTSILKSRWKPIFNEETTNRYVRLNRFQQYQQQRSGGNPLGSMTILGLSLMAGIYFGSPYLFEHVPPFTYFKTHPKNLVYALLGINVAVFGLWQLPKCWRFLQKYMLLQKDYVTSKISIIGSAFSHQEFWHLGMNMLALWSFGTSLATMLGASNFFSLYMNSAIAGSLFSLWYPKLARLAIVGPSLGASGALFGVLGCFSYLFPHAKILLFVFPVPGGAWVAFLASVAWNAAGCALRWGSFDYAAHLGGSMMGVLYGWYISKAVEKQRQRRLQAAGRWFLast
1 -3.990PB012991 Q2RHT0_MOOTA/1-175 PB012991; Pfam-B_12991;  ali follow..  14  4................................................................................................................................................................................................HEEVRTGWSRWDSLWPFLLFYCNFLKGVFLLRIAVVDGQGGGIGKHITARLRQEEVEILALGTAGANEGATGERAIIYNAPRVEAITGSLAIILADAMLGELTPAMAAAIAASPA....................................... 131
2 -3.790PB028090 gi|167758043|ref|ZP_02430170.1| hypothetical protein CLOSCI_00381 [Clostridium scindens ATCC 35704]gi|167663940|gb|EDS08070.1| hypothetical protein CLOSCI_00381 [Clostridium scindens ATCC 35704]  ali follow..  12  20................................................................................................................................................VFAGLILANVGGIFCFLIVPAALTVYFIAIYVGAANGAEWALMNSWFHYAKLYAATAGCIGFMML--KYKWKIGKTNWFKVFPFVIVAINILIAVVSDFESGVRGAMALAEYGGIAGILNCFIIAYDLWNFEYTYNNLPTHAWYCGLALLLAPTFANALWNKGGWIQNRANTLALWCMFAQVFPMFQDTSR........... 269
3 -3.590PB044572 Q8A533_BACTN/1-343 PB044572; Pfam-B_44572;  ali follow..  10  163................................................................................................................................................YFMIIFALFVGVYLFRAFRRKQLQLVYFNDIDSVYPLFLCLLMASATVYESMQVFVPDTWEHFYFNPTLSP-FKVPFILSVFLLS-LFLIVALAVLDDLFRQLTPAAAVFYLLGLMSSCIFCYFFFILMTHIYIGYLF-------LAFFIWVFAKKVHRNISYKYRCGHCGEKL............................ 330
4 -3.520HGC00690 gi|162868815|dbj|BABB01001192.1|3.0 TMP00870;  ali follow..  8  1...................................................................................................................................................................................................MFEYILREIFLSVIAFLAGAGVSAG-VFAFVLVIGVVPRILRCSRIENIILIENVMICGV--VAGNISSVLDTAYNLGFANMPKVPVSNICGNIIIAIYGL-----------------CVGIFVGCIAVALAE.................. 113
5 -3.060PB053244 _HOMD.0087087_ pint_c_2_2642 Prevotella intermedia 17 [158005 - 157583] (REVERSE SENSE) ORF  ali follow..  9  1.........................................................................................................................................................................................................SIVLLMAVGTGLYAFFIIQDVACIVMLIGAICFATMQMRQQYLGTNLTIRRLRKIADIGFILAGLFMVEDSYGFVKQYLANSIGGYTTYVNIFYHNWVVILLIATALEVYT.................................. 119
6 -2.980HGC00593 gi|162858151|dbj|BABB01011554.1|1.0 TMP00709;  ali follow..  12  10......................................................................................................................................................................VLVKKFFSENRI------DVPDDGFSRRVMRRLPDRTRRISRLWTAVCVVIG----LLIFFRNKGFSVLVSCFDGIFSDVLARHEQLNNPHLLLPVAMVLILLW............................................................................ 103
7 -2.960PB032242 Q8FLW6_COREF/1-257 PB032242; Pfam-B_32242;  ali follow..  12  39...............................................................................................................................................TMTAGLILSLLGPAYLVFFADLQITAGMVW--------VAFLAVAAIFGVLWFVEPL-----------TYFPILGSA---AMYQ-AFMIGNISNKLVAAIVAQSSIGAKAGSRGDLAAVMAIGGAATMHLLSLLIFV-----------GFLGTWLVSLVPVEVIEVARLYIMPSLMGAVLVQAIVSM................ 193
8 -2.930PB047496 gi|150008556|ref|YP_001303299.1| hypothetical protein BDI_1942 [Parabacteroides distasonis ATCC 8503]gi|149936980|gb|ABR43677.1| conserved hypothetical protein [Parabacteroides distasonis ATCC 8503]  ali follow..  12  53..........................................................................................................................................................................................LQGTWMYVNPALQLEGDNALKNVAGSLAATEAEKKMKEYCAKVGIVEGVFNYVFNSDSTFTSALKRGSLKGTYS-VTLRYTVGNKKLTVSTLTAHVVLSGNELTLLFNADKLLKFLSTVSSISSNTTLKGMMLGF......................... 203
9 -2.410PB010473 Q8A4J5_BACTN/121-234 PB010473; Pfam-B_10473;  ali follow..  12  10............................................................................................................................................................................................................MEYEINKGAGNPLGLKSQYLFIFAGGLVAVLLVVVILYIAGVNQWICI--PFGLLSGSLLVWLTFRLNARY....................................................................... 81
10 -2.380HGC00164 gi|163636082|dbj|BABG01000191.1|4.0 TMP00833;  ali follow..  12  1......................................................................................................................................................................................................MNDLIVDVKLWGESVGSLYNAALF---FIRSGLDISPIIMPISQYRNTPYRFLENRTDCF--GLPGLFADSLPDT-------------GNQIINEWFASKGLSGEEITPLDRLCYVGKRGMGAL........................ 118
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.