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Query: [T] KOG2290 Rhomboid family proteins, from COG1018

Results of FFAS03 search in NEW_HUMAN_DOMAINS
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRARRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKFCEKYELDAQLHLast
1 -75.800sp|Q96CC6|RHDF1_HUMAN Inactive rhomboid protein 1 OS=Homo sapiens GN=RHBDF1 PE=1 SV=2  ali   100  1...............................................................................................................................................................................................................................................................................................................................................................................KRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEV.............................................................................................................................................................................................................. 282
2 -70.400sp|Q6PJF5|RHDF2_HUMAN Inactive rhomboid protein 2 OS=Homo sapiens GN=RHBDF2 PE=1 SV=2  ali   64  1.....................................................................................................................................................................................................................................................................................................................................................................KVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHVIITLLVICTYGIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGAKFSPCIRKDGQIEQLVLRERDLERDSGCCVQNDHSGCIQTQRKDCSETLATFVKWQDDTGPPMDLGQKRTSGAVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQARSNHTGFLHMDCEIKGRPCCIGTKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEV.............................................................................................................................................................................................................. 295
3 -15.100tr|E9PGJ1|E9PGJ1_HUMAN Uncharacterized protein OS=Homo sapiens GN=RHBDF1 PE=4 SV=1  ali   96  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEMT............................................................................................................................................................................................................. 61
4 -6.290sp|Q9BX84|TRPM6_HUMAN Transient receptor potential cation channel subfamily M member 6 OS=Homo sapiens GN=TRPM6 PE=1 SV=2  ali   11  27LSRPSVPDVLATEQDIQTEVLVHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPLSQAKIMQTGGGYAFSEGDETKKKWQT................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 137
5 -5.430tr|B7Z676|B7Z676_HUMAN Uncharacterized protein OS=Homo sapiens GN=SLC9B2 PE=2 SV=1  ali   11  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRQMLACPPHGLLDRVITNGMLLAGFLIRNIPVINDN-----VQIKHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEAC................................................................. 90
6 -5.310tr|E9PPM1|E9PPM1_HUMAN Uncharacterized protein OS=Homo sapiens GN=TP53I11 PE=4 SV=1  ali   12  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKILGV--DDGEVH------------SKISQVLGNEIKFTIREPLGL--QFVSAVL-----------SGIAIMALAFPDQLYDAVFDGAQVTSKTPIRLYGGALLKVETESDRGEVTCLRSQLVSGEAKIGTQAIQLGRTKDGVSETSPASALLLAFSLIQ------TWLQPLGWDWPPYLPFNPVLP--CQ......... 167
7 -5.260tr|B0QYN4|B0QYN4_HUMAN L(3)mbt-like (Drosophila) (Fragment) OS=Homo sapiens GN=L3MBTL PE=4 SV=1  ali   12  3...................LVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSA--SSSTSTVRLLEWTEGGLRFRISEYKPLN.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 108
8 -5.100tr|D6RG03|D6RG03_HUMAN Uncharacterized protein OS=Homo sapiens GN=SRD5A1 PE=4 SV=1  ali   6  6......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRFWLVVNGHVDKHPFRSYPKESQK--------RRYWIQNTKGRLI......................................................................... 135
9 -4.830sp|Q24JP5|T132A_HUMAN Transmembrane protein 132A OS=Homo sapiens GN=TMEM132A PE=2 SV=1  ali   11  5.................................................................................................................................................................................................................................................................................................................................................................................................QQVGHYPPANSSLSSRSETFLLLQPWPRAQPLLRAS-----YPPFATQQVVPPRVTEPHQRPVPWDVRAVSVEAAVTPYARVLFHLKGQ-LPCAR--------LHATHPAGTAHQACRFQPSLGA-------CVVELELPSHWFSQASTTRA.............................................................................................................................................................................................................................................................................................................................. 146
10 -4.690sp|Q96CB9|NSUN4_HUMAN Putative methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 PE=1 SV=2  ali   16  22......................................................PRRHRYKKKWAATEPKFPAVRLALQNFDMTYSVQFG--------DLWPSIRVSLLSQKYGALVNNFAAWDHVSAK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 89
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;